Victim offender overlap is a relatively new area of research with most studies having focused on applying this concept to the study of assault and homicide. Research in intimate partner violence has found that there exists a group of victim offenders or individuals who are involved in initiating, sustaining, and engaging in intimate partner violence as both victims and offenders (Johnson & Ferraro, 2000; Steinmetz, 1980). This Master’s thesis explored the concept of victim offender overlap in connection to intimate partner violence (IPV). Bivariate analyses were conducted using Paul C. Friday, Vivian Lord, M. Lyn Exum, and Jennifer L. Hartman’s (2003-2005) data, Evaluating the Impact of a Specialized Domestic Violence Police Unit in Charlotte, North Carolina. The findings suggest that there is a separate group of individuals involved in intimate partner violence who are both victims and offenders. Furthermore, the three groups (offenders only of IPV, victims only of IPV, and victim/offenders of IPV) were found to be different across gender, past criminal involvement, and future criminal activity as predicted. Suggestions for future research and the implications of the findings are discussed.

Characterization of smallmouth bass (Micropterus dolomieu) interaction with native species assemblages, especially salmonids, in lakes throughout BC is prerequisite to identification of high-risk systems warranting on-going monitoring. Therefore this project addresses the following issues: How does smallmouth bass (SMB) trophic profile overlap with native species and does it vary across time and space? Schoener’s index of dietary overlap was not significant between SMB and rainbow trout (Oncorhynchus mykiss; α=0.406, 0.257), or cutthroat trout (Oncorhynchus clarkia; α=0.145, 0.29). Prey fish levels (Ei =35.4%) and the total energetic density (14.91±4.74J/g) of the cutthroat trout diet from Weston Lake (SMB free) were significantly higher compared to the diet of cutthroat trout from Cusheon Lake (Ei =3.3% and 7.69±1.93J/g) where non-native SMB have been introduced. Within the Vancouver Island study lakes, gut-content analysis revealed available signal crayfish serve as an important prey resource in the SMB diet (Ei =34%). What capacity do SMB have to take advantage of seasonal pulses of forage? SMB displayed the ability to rapidly (within 24hrs.) alter their diet and consumption levels (4.7 times higher) to maximize on pulses of rainbow trout fry following a stocking event. SMB did not spatially overlap with spring peaks in salmonid fry runs in the Okanagan lakes, as water temperature remained around the 10°C threshold when SMB are not yet active. Kokanee (Oncorhynchus nerka) fry did however make up Ei =83% of the yellow perch (Perca flavescens) diet. SMB are thriving in locations suspected to be on the limit for their environmental suitability through increased size at age for SMB in the Cariboo region in order to adapt to a longer (by 62 days) winter starvation period. SMB are a generalist predator able to adapt and thrive in very different systems; high vs. low productivity, few or many fish species, crayfish or no crayfish. The likely impacts of this in BC could include shifts in the diet of other fish species and increased costs associated with only stocking larger catchable sized trout in lakes containing non-native SMB. Policy recommendations based on our findings are that SMB introductions into systems that have rainbow/cutthroat trout are likely to cause the highest impacts on our native fisheries in BC if the systems are; highly productive, contain a high diversity of small bodied fish and invertebrate species, lack signal crayfish and large lakes with predominant littoral zones and complex shorelines. / Graduate / 0793 / 0329 / 0792 / mbeck@uvic.ca

Made available in DSpace on 2014-06-11T19:24:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2005-02-17Bitstream added on 2014-06-13T19:06:29Z : No. of bitstreams: 1 zhu_nxj_me_bauru.pdf: 4158261 bytes, checksum: bafc2c29b13e8c6fb309c4a1b184788a (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Atualmente tem-se verificado crescente demanda por processos de fabricação capazes de produzir peças sob estreitas faixas de tolerâncias dimensionais e geométricas. Dentre os processos utilizados para conferir acabamento superficial e correção de forma destacam-se a retificação e a lapidação. Porém, muitas peças mostram-se suscetíveis ao calor gerado pela retificação, como no caso da deformação de peças delgadas ou então naquelas peças passíveis de mudanças microestruturais, recorrendo-se nestes casos à lapidação que, por sua vez, é um processo de difícil seleção de parâmetros. Neste trabalho é iniciado o desenvolvimento de um processo híbrido capaz de aliar algumas importantes características da retificação e da lapidação, no qual do primeiro é usado a operação de dressagem e do segundo o movimento cinemático. Dessa forma dotou-se uma... / Lately, one can verify that there has been a growing demand for manufacturing processes capable of producing workpieces under tight dimensional and geometric tolerance rangers. Among the processes used to assure surface finish and shape correction to the part, grinding and lapping arise as the most used. However, many parts show themselves sensitive to the heat generated during the grinding process, as in the case of thin ones, or those susceptible to micro-structural changes. On these cases, one can use lapping, even though being a more difficult parameter selection process. In these studies, the development of a hybrid process capable of binding some important grinding and lapping features is initiated; the dressing operation, for the case of grinding and, for the case of lapping, the cinematic movement... (Complete abstract click electronic access below)

JGH Open: An open access journal of gastroenterology and hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley and Sons Australia, Ltd. Background and Aim: The United Kingdom-primary biliary cholangitis (UK-PBC) and global primary biliary cholangitis group (GLOBE) prognostic models have been recently developed to predict long-term outcomes in primary biliary cholangitis (PBC). However, these predictive scores have not yet been well evaluated in the U.S. population. Methods: We retrospectively reviewed newly diagnosed PBC patients at the Cleveland Clinic between November 1998 and February 2017. Adverse events were defined as liver transplantation, liver-related mortality, and all-cause mortality. Transplant-free survival (TFS) was estimated using the Kaplan–Meier method. Predictive performances of all prognostic models were evaluated using the C-statistic. Results: We identified 352 patients who used ursodeoxycholic acid therapy. Of them, 311 (88.4%) only had PBC, while 41 (11.6%) were diagnosed with PBC-autoimmune hepatitis overlap. A total of 22 (6%), 47 (13%), and 55 (16%) patients had adverse events within 5, 10, and 15 years after diagnosis, respectively. In patients with PBC only, the C-statistic in predicting 15-year adverse events was 0.75 per GLOBE compared to 0.74 per UK-PBC (P = 0.94), 0.73 per Rotterdam (P = 0.44), 0.66 per Barcelona (P = 0.004), 0.65 per Paris 1 (P = 0.005), 0.62 per Paris 2 (P < 0.0001), 0.60 per Toronto (P < 0.0001), and 0.60 per Mayo (P < 0.0001) scores. Median follow-up was 9.2 years. Ten-year TFS for patients who had optimal versus suboptimal treatment response was 92 versus 74% per Paris 1 (P < 0.0001), 95 versus 79% per Paris 2 (P = 0.0002), 93 versus 65% per Barcelona (P < 0.0001), and 96 versus 68% per Rotterdam (P < 0.0001) risk scores, respectively. Conclusion: In our cohort of PBC patients, the UK-PBC and GLOBE scores were both accurate and reasonably valid prognostic models in the U.S. population.

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The subject of this thesis is outdoor mathematics education for pupils aged 11- 15 in the con- text of the city of Pilsen. The main aim was to design a series of outdoor mathematics activities for lower secondary education students. A reference is made to the space within the Framework Educational Programme for Basic Education for the use of interdisciplinary integration and cross-curricular links, for which outdoor learning can be suitable. The work summarizes the findings on motivation, identifies the specifics of mathematics as a teaching subject and highlights the constructivist principles of teaching in the context of the results of the Czech School Inspectorate's investigation into mathematics.The most important barriers and benefits of outdoor education are summarised here as well as its conception and a few of the readily available sources of inspiration for outdoor mathematics for lower secondary education pupils. The designed activities described in the practical part of the thesis are tailored to specific locations of the city of Pilsen. They refer to the expected outcomes of the Framework Educational Programme for Basic Education and combine the selected mathematical topics into one piece together with the chosen outdoor environ- ment. The thesis highlights the positives of outdoor...

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I assessed the potential for trophic competition between age-0 largemouth bass and juvenile bluegills by quantifying food resource use similarity in a Virginia recreational small impoundment and by experimentally stocking the species sympatrically and allopatrically in 1.0 m cages and monitoring mortality, growth, and resource use. Niche breadth of bluegills in the small impoundment was greater than that of largemouth bass for eight out of nine sampling dates during the summer and fall of 1997. Virtually every type of item consumed by largemouth bass also was consumed by bluegills. In spite of this, diet overlap between the species was low. Largemouth bass fed primarily on Calanoida, Ephemeroptera, and fish, while bluegills consumed Diptera and Cyclopoida. The fishery of the impoundment consisted of relatively high and moderate densities of slow- and average-growing largemouth bass and panfish, respectively. If the fishery was managed to provide a high density of small bluegill, largemouth bass and bluegill might compete considering the number of prey items shared. Manipulative cage experimentation, which consisted of stocking 5 largemouth bass alone, 10 bluegill alone, 5 largemouth bass and 10 bluegill, 5 largemouth bass and 30 bluegill, and 15 largemouth bass and 10 bluegill in cages, indicated that largemouth bass and bluegills can compete and that there exists a strong asymmetry in their competitive relationship. Bluegills had a much stronger impact on largemouth bass than the reverse. When stocked alone, largemouth bass grew significantly larger than when stocked with either 10 or 30 bluegills. There were no significant differences in bluegill growth rates except between bluegills stocked alone and bluegills stocked with 15 largemouth bass. The analysis of food resource use indicates that Copepoda and Diptera larvae may be the limiting resources catalyzing the competitive interaction. This research suggests that a competitive juvenile bottleneck could occur, depending largely on whether overwinter survival of largemouth bass is size related. Competition between largemouth bass and bluegills may explain why enhancement stocking of fingerling largemouth bass typically is not successful. Further research is needed on the appropriate timing and length at stocking of introductory largemouth bass stockings. Additionally, I recommend that resource partitioning and competition between largemouth bass and bluegills be explored in connection with studies concerning overwinter survival and angling opportunities in small impoundments. Competition between the species may impose an ecological constraint that restricts achievable options in certain systems. / Master of Science

Anticorpos são moléculas de grande interesse científico e farmacêutico, principalmente, devido a sua alta especificidade contra antígenos determinados. Atualmente, anticorpos monoclonais estão entre os medicamentos (biofármacos) mais vendidos do mundo. São utilizados para o tratamento das mais diversas doenças, como câncer, retinopatias, doenças inflamatórias e do sistema imune, entre outras. Nos últimos 30 anos, as tecnologias para a obtenção de anticorpos monoclonais evoluíram muito, desde a tecnologia do hibridoma, até os processos de humanização de anticorpos murinos. Entre os métodos mais utilizados para a produção de anticorpos humanos, destaca-se a tecnologia do Phage Display. Nesta técnica, os genes que codificam as regiões variáveis de imunoglobulinas são inseridos no genoma de um bacteriófago, resultando na produção de partículas virais híbridas que contém fragmentos de anticorpos em fusão com uma das proteínas do capsídeo viral. Neste trabalho, desenvolvemos novos vetores para a apresentação de fragmentos ScFv em fusão com duas proteínas das proteínas do capsídeo viral, a pIII e pVIII. Os oligonucleotídeos utilizados para amplificar os genes de imunoglobulinas foram redesenhados e para minimizar a perda do repertório durante a produção da biblioteca, avaliamos em bancos de dados enzimas de restrição que não apresentam sítios de restrição nas sequencias gênicas. Esses sítios de restrição foram utilizados para construir as regiões de clonagem do vetor Phagemid. Outra etapa crítica na produção de bibliotecas de anticorpos é a reação do PCR de overlap, que pode restringir a diversidade de anticorpos e resultar na produção de amplicons codificando anticorpos truncados. Por isso, nossos vetores foram desenhados para permitir a clonagem direta das regiões variáveis das imunoglobulinas humanas ou murinas, sem a necessidade do PCR de overlap. Nossa expectativa, é que estes novos reagentes serão mais efetivos para a produção de novas bibliotecas de anticorpos pelo sistema do Phage Display. / Antibodies are molecules of great scientific and pharmaceutical interest, mainly because of their high specificity against certain antigens. Currently, monoclonal antibodies are among the best selling drugs (biopharmaceuticals) in the world. They are used for the treatment of the most diverse disorders, such as cancer, retinopathies, inflammatory and immune system diseases, among others. In the past 30 years, technologies for obtaining monoclonal antibodies has greatly evolved from hybridoma technology to the humanization processes of murine antibodies. Among the methods used for the production of human antibodies, the technology of Phage Display stands out. In this technique, the genes encoding the immunoglobulin variable regions are inserted into the genome of a bacteriophage, resulting in the production of hybrid virus particles which contain fragments of antibodies in fusion with one of the viral capsid proteins. In this work, we developed new vectors for the presentation of ScFv fragments in fusion with two proteins of viral capsid proteins, pIII and pVIII. The oligonucleotides used to amplify the immunoglobulin genes were redesigned and to minimize repertory loss during library production, we evaluated restriction enzymes in databases that lack restriction sites in the gene sequences. These restriction sites were used to construct the cloning regions of the Phagemid vector. Another critical step in the production of antibody libraries is the overlap PCR reaction, which may restrict the diversity of antibodies and result in the production of amplicons encoding truncated antibodies. Therefore, our vectors were designed to allow the direct cloning of human or murine Immunoglobulins variable regions without the need for overlap PCR. Our expectation is that these new reagents will be more effective for the production of new antibody libraries by the Phage Display system.