“The Sixth Sense: Synaesthesia and British Aestheticism 1860-1900” is an interdisciplinary examination of the emergence of synaesthesia conceptually and rhetorically within the ‘art for art’s sake’ movement in mid-to-late Victorian Britain. Chapter One investigates Swinburne’s focal role as both theorist and literary spokesman for the nascent British Aesthetic movement. I argue that Swinburne was the first to practice what Pater meant by ‘aesthetic criticism’ and that synaesthesia played a decisive role in ‘Aestheticising’ critical discourse. Chapter Two examines Whistler’s varied motivations for using synaesthetic metaphor, the way that synaesthesia informed his identity as an aesthete, and the way that critical reactions to his work played a formative role in linking synaesthesia with Aestheticism in the popular imagination of Victorian England. Chapter Three explores Pater’s methods and style as an ‘aesthetic critic.’ Even more than Swinburne, Pater blurred the distinction between criticism and creation. I use ‘synaesthesia’ to contextualise Pater’s theory of “Anders-streben” and to further contribute to our understanding of his infamous musical paradigm as a linguistic ideal, which governed his own approach to critical language. Chapter Four considers Wilde’s decadent redevelopment of synaesthetic metaphor. I use ‘synaesthesia’ to locate Wilde’s style and theory of style within the context of decadence; or, to put it another way, to locate decadence within the context of Wilde. Each chapter examines the highly nuanced claim that art should exist for its own sake and the ways in which artists in the mid-to-late Victorian period attempted to realise this desire on theoretical and rhetorical levels.

Video codec compresses the input video source to reduce storage and transmission bandwidth requirements while maintaining the quality. It is an essential technology for applications, to name a few such as digital television, DVD-Video, mobile TV, videoconferencing and internet video streaming. There are different video codecs used in the industry today and understanding their operation to target certain video applications is the key to optimization. The latest advanced video codec standards have become of great importance in multimedia industries which provide cost-effective encoding and decoding of video and contribute for high compression and efficiency. Currently, H.264 AVC, AVS, and DIRAC are used in the industry to compress video. H.264 codec standard developed by the ITU-T Video Coding Experts Group (VCEG) together with the ISO/IEC Moving Picture Experts Group (MPEG). Audio-video coding standard (AVS) is a working group of audio and video coding standard in China. VC-2, also known as Dirac Pro developed by BBC, is a royalty free technology that anyone can use and has been standardized through the SMPTE as VC-2. H.264 AVC, Dirac Pro, Dirac and AVS-P2 are dedicated to High Definition Video, while AVS-P7 is to mobile video. Out of many standards, this work performs a comparative analysis for the H.264 AVC, DIRAC PRO/SMPTE-VC-2 and AVS-P7 standards in low bitrate region and high bitrate region. Bitrate control and constant QP are the methods which are employed for analysis. Evaluation parameters like Compression Ratio, PSNR and SSIM are used for quality comparison. Depending on target application and available bitrate, order of performance is mentioned to show the preferred codec.

Video codec compresses the input video source to reduce storage and transmission bandwidth requirements while maintaining the quality. It is an essential technology for applications, to name a few such as digital television, DVD-Video, mobile TV, videoconferencing and internet video streaming. There are different video codecs used in the industry today and understanding their operation to target certain video applications is the key to optimization. The latest advanced video codec standards have become of great importance in multimedia industries which provide cost-effective encoding and decoding of video and contribute for high compression and efficiency. Currently, H.264 AVC, AVS, and DIRAC are used in the industry to compress video. H.264 codec standard developed by the ITU-T Video Coding Experts Group (VCEG) together with the ISO/IEC Moving Picture Experts Group (MPEG). Audio-video coding standard (AVS) is a working group of audio and video coding standard in China. VC-2, also known as Dirac Pro developed by BBC, is a royalty free technology that anyone can use and has been standardized through the SMPTE as VC-2. H.264 AVC, Dirac Pro, Dirac and AVS-P2 are dedicated to High Definition Video, while AVS-P7 is to mobile video. Out of many standards, this work performs a comparative analysis for the H.264 AVC, DIRAC PRO/SMPTE-VC-2 and AVS-P7 standards in low bitrate region and high bitrate region. Bitrate control and constant QP are the methods which are employed for analysis. Evaluation parameters like Compression Ratio, PSNR and SSIM are used for quality comparison. Depending on target application and available bitrate, order of performance is mentioned to show the preferred codec.

The importance of interactions between transmembrane domains of integral membrane proteins has been well-established in a range of essential cellular functions. Most integral membrane proteins also possess regions that lie on the exterior of the membrane that may influence the ability of these transmembrane domains to interact. We sought to test this hypothesis by quantifying the energetics of transmembrane helix self-association in the absence and presence of an amphipathic helix that can bind to the membrane surface. The model chosen for this study was the major coat protein (MCP) of M13 bacteriophage, which has an N-terminal amphipathic helix linked to its single transmembrane segment via a flexible linker. Dimerization of both full-length MCP and a peptide containing only the transmembrane domain (MCPTM) was studied by solution NMR in SDS micelles. We found that there was an increase in the apparent dimerization affinity in the absence of the N-terminal helix. However, this increase in apparent affinity could be attributed to differences in detergent-binding properties of the two polypeptides in monomeric versus dimeric states when the empty micelle was considered to be a participant in the dimer dissociation. Preliminary results from the integral membrane protein, p7 of the hepatitis C virus are also presented in this thesis. It has been demonstrated that p7 enhances viral infectivity and accumulation, and that this function may require oligomerization in the membrane. While we encountered limitations due to challenges in the generation of sufficient quantities of pure p7 samples, we were able to perform circular dichroism spectroscopy under conditions that may favor different oligomeric states. These studies suggest that there is a change in the degree of helicity upon oligomerization, and suggest that SDS could be a suitable system to characterize the interactions of the p7 oligomer in the future.

No description available.

The behaviour of chiral 1,3-dioxolan-4-ones, derived from reaction of mandelic and lactic acid with pivalaldehyde, as chiral acyl anion equivalents has been examined. Addition of the corresponding 5-anions to a substituted nitrostyrene and to butenolide was achieved and the structure and stereochemistry of the adducts established by X-ray crystallography. Fragmentation under flash vacuum pyrolysis (FVP) conditions occurred in the expected way (loss of Bu([superscript]t)CHO and CO) in the latter case, but in the former reductive cyclisation was used to generate functionalised lactams. An unexpected reaction of a dioxolanone anion with the dioxolanone to afford an aldol-like dimer was observed in one case. Attempts to extend the range of dioxolanones by using amino acid-derived α-hydroxy acids met with limited success. Only the 5-benzyl compound derived from phenylalanine was obtained in reasonable yield and an attempt to alkylate it led again to aldol-like dimerisation. Cycloaddition to the double bond of 2-t-butyl-5-methylene-1,3-dioxolan-4-one was used to gain access to a range of novel spiro bicyclic and polycyclic systems and fragmentation of these was expected to provide products resulting from a chiral ketene equivalent. While the epoxide derived from the cyclopentadiene Diels Alder adduct did behave in this way to give the chiral ketone in high e.e., the corresponding aziridine underwent unexpected isomerisation pointing to a stepwise fragmentation mechanism of possible general applicability in these systems. Adducts were also formed with tetracyclone and 1,3-diphenylisobenzofuran and an interesting pattern of exo/endo selectivity was observed in these cases. With tetrachlorothiophene dioxide the adduct again fragmented in an unexpected way to give tetrachlorobenzoic acid, providing further support for the intermediacy of an oxonium carboxylate species. 1,3-Dipolar cycloaddition to 2-t-butyl-5-methylene-1,3-dioxolan-4-one was achieved for the first time and a range of adducts containing novel spiro heterocyclic ring systems derived from nitrile oxides, nitrones and diazo compounds were obtained and characterised. The regiochemistry of addition as well as the relative and absolute stereochemistry was demonstrated by X-ray structures of three adducts. Upon pyrolysis some of these compounds unexpectedly lost Bu([superscript]t)CHO and CO2 to give carbene-derived products, including a β-lactam in one case. Cycloaddition reactions of the achiral 2,2-dimethyl-5-methylene-1,3-dioxolan-4-one were also briefly studied.

In this thesis I focus on dismissivism in metaphysics. Some philosophers argue that at least some metaphysical disputes are not substantial, and as a consequence should be dismissed. In this work I restrict my attention to metaphysics and focus on debates about existence and grounding. In particular I am interested in finding out whether there is a difference between the possible options available for dismissing debates about what there is and the possible options available for dismissing debates about what grounds what. I will delve into this in two different steps. First of all I explore the possibility to dismiss debates about what there is, and as a case study I analyse the debate between three-dimensionalism and four-dimensionalism. Secondly I delve into whether it is possible to dismiss debates about what grounds what, thanks to the discussion of another case study, i.e. the debate between tropes ontologies and universals ontologies. It is worth exploring the nature of dismissivism, because it bears on the future of philosophy. If philosophy has to have a future, we have to make sure that at least some disagreements within it are substantial. My conclusions will be that metaphysical debates about what there is can be dismissed for a variety of reasons (semantic, epistemic, ...). I also argue there is no general formula to find out whether a specific debate should be dismissed. On the other hand I argue that debates about what grounds what should be dismissed. I offer two distinct arguments in favour of my claim. Firstly, I argue that disputants are having a verbal dispute when they talk about what grounds what, and thus their disagreement is non genuine. Secondly, I argue that the notion of grounding is underspecified, because it cannot be properly distinguished from causation.

Muscarinic acetylcholine receptors (mAChRs) mediate effects of acetylcholine (ACh) in many systems, including those involved in locomotion. In the stage 37/38 Xenopus laevis tadpole, a well-understood model system of vertebrate locomotion, mAChRs have been found to be located on motor neurons with evidence suggesting that mAChRs are involved in swimming behaviour. The current study aimed to further investigate the role of mAChR-mediated cholinergic transmission by employing extracellular and whole-cell patch clamp recordings to examine the effects of mAChR activation on the properties of different types of neurons in the Xenopus laevis tadpole swimming circuit. It was found that mAChR activation can increase the threshold for initiating swimming by skin stimulation and can lead to the generation of spontaneous motor output in the absence of physical stimuli. These effects were found to be a result of direct inhibition of dorsolateral sensory interneurons of the mechanosensory pathway, direct inhibition of glycinergic inhibitory interneurons in the CPG and a decrease in CPG neuron firing reliability during swimming. The data presented here comprise the first whole-cell patch-clamp investigation into mAChR-mediated cholinergic transmission in the Xenopus laevis tadpole swimming circuit and provide novel evidence that mAChRs modulate the properties of mechanosensory pathway and CPG neurons in this model system of vertebrate locomotion.

edited by Albert G. H. Dietz [and] Laurence S. Cutler. / Papers selected from 2 M.I.T. special summer sessions: Aug. 18-29, 1969 and June 16-20, 1970. / Bibliography: p. [253]-[255]