Doctor of Philosophy (PhD) / This study was conducted to increase our understanding of children and young people’s experience of a hospital environment and to identify the salient attributes of the physical environment in their experience. There were three specific aims: to describe children and young people’s experience of a hospital environment and identify what constitutes a supportive paediatric environment; to examine the role of the physical environment in patients’ feeling of well-being; and to highlight the capacity of participatory research with children and young people to inform evidence-based paediatric design. At this stage, there has been very little healthcare design research carried out with populations of children and young people. Well-being research with children and young people in paediatric environments that identifies the potential supportive attributes in this environment is also very limited. Historically research on children’s health and well-being has been dominated by a focus on the prevalence of disorders, problems and disabilities. More recently, in response to the change to health promotion, positive attributes have been included in well-being and satisfaction measures. At this stage, there are still many fewer positive measures. Within the body of literature that exists in healthcare, healthcare design research, and well-being research, there are only a small number of participatory studies that focus on children and young people’s experience of hospitalisation, and an even smaller number that include children and young people’s experience of hospital environments. The picture that is created by the research that exists is patchy. There is a need for a more holistic understanding of children and young people’s experience of hospitalisation and of hospital environments from their own perspectives. Based on these gaps in current knowledge, two research questions were developed. The first was concerned with describing children and young people’s experience of the sociophysical environment of a paediatric hospital. The second question was concerned with understanding the role of the physical environment in children and young people’s feeling of well-being in a hospital environment. In addressing these questions, the intention was to identify attributes within the hospital setting which collectively comprise a supportive environment for children and young people and which contribute to children and young people’s feeling of well-being in a paediatric setting. The current study was conducted as an exploratory qualitative case study and carried out at the Children’s Hospital at Westmead, in Sydney, Australia. Using participatory research techniques, the sequence of the study included two pilot studies and the main study. The focus was on understanding the experiences of longer-term patients of a paediatric hospital environment. In the main study 25 children and young people, aged between 9-18 years, who had been in hospital for at least a week completed semi-structured interviews in which they talked about their response to the environment of the hospital and their experience of hospitalisation. Data analysis was completed using a combination of concept mapping and thematic analysis techniques. Preliminary findings were used as the basis of a further member-checking task carried out with a further six children and young people before conclusions were reached. The findings reveal that children and young people’s experience of a paediatric setting involves a number of major areas of influence including their personal situation, their social experience, their interaction with the physical environment, opportunities and characteristics of the organisation, and the effect of time. The findings also reveal that children’s feeling of well-being within this experience is linked to their ability to feel comfortable in the environment, to maintain a positive state of mind, and to remain positively engaged with the experience and the environment. This research reveals a dynamic relationship between children and young people and a paediatric environment that children and young people actively manage and shape. It reveals some of the key considerations in children and young people’s experience of hospitalisation. It also reveals why these considerations are important and what role they play in patients’ experience and feeling of well-being. These findings provide the basis for further research and they have implications for future design and research practice in paediatric healthcare settings.

[Truncated abstract] Acute lymphoblastic leukaemia (ALL) is the most common form of cancer that affects children and the leading cause of child cancer-related death. There have been dramatic improvements in the 5-year event free survival (EFS) for childhood ALL in recent years, with EFS reaching 75-90% for some forms of the disease. Despite this success, treatment for the disease is aggressive with numerous long and short-term side effects. Many cases of ALL are characterised by chromosomal defects including translocations, variations in chromosome number and the deletion of the tumour suppressor genes. Although these gross chromosomal changes have been extensively studied in childhood ALL, the cascade of altered gene expression that results from these changes has not. Further improvements in survival and the quality of life of survivors relies on a better understanding of the underlying biology of ALL. The primary aim of this study was to determine the gene expression profile of pre-B ALL specimens and normal, or non-malignant, control cells using microarrays in order to further examine the underlying biology of childhood ALL. ... Analysis of the ALL profile with two normal haematopoietic populations demonstrated that ALL specimens have a profile similar to that of CD34+ cells. Specifically, specimens of the MLL subtype had a profile that uniformly resembled that of CD34+ cells. Other subgroups contained specimens with profiles that ranged in similarity to that of CD34+ cells, however, the gene expression profile of all ALL specimens analysed more closely resembled the CD34+ cells than the more differentiated CD19+IgM- cells. This study identified exceptionally high expression of connective tissue growth factor (CTGF/CCN2) in ALL specimens compared to control cells. CTGF expression was v restricted to B-lineage ALL specimens, however, specimens containing the E2A-PBX1 translocation showed low or no expression. Protein studies by Western blot analysis demonstrated the presence of CTGF in ALL cell-conditioned media. The study presented here provides insight into the biology of ALL including the observation that ALL cells have an immature gene expression profile similar to that of CD34+ cells and the possible existence of an autocrine loop involving CTGF. The findings may also have clinical application in the future treatment of ALL, such as the use of metabolic inhibitors or the blocking of CTGF expression. This study provides an important insight into many aspects of ALL disease biology and may offer potential new therapeutic targets for the treatment of ALL.

Background: Very occasionally, when a fetus is developing in the womb, problems occur with the normal processes controlling closure of the muscles of the abdominal wall and, as a result, some of the abdominal contents develop outside of the body. This is known as an abdominal wall defect. If the pregnancy continues to term, the newborn infant will need specialised surgical care. This situation occurs so infrequently that even a dedicated surgical centre will care for very few of these women and their babies in a year. Many centres have shared their experiences of managing these babies in the published literature but the majority of reports have included only a few infants. The focus of most previous studies has been to describe what happens to these newborn infants between birth and first discharge from hospital from a purely clinical perspective. Aim: To explore methodologies to holistically understand the short and longer-term outcomes of children born with abdominal wall defects and to use the information to improve the care of future affected infants. Methods: The quality of the published literature on short-term outcomes of children born with gastroschisis was scrutinised in a systematic review. The accompanying meta-analysis used published data as a means of identifying population outcome estimates. Two national population-based cohort studies were undertaken, exploring the short-term outcomes of children born with exomphalos and the outcomes at seven to ten years of children born with gastroschisis. The latter study included an assessment of childhood outcomes from the point of view of the children themselves, along with their parents. Further parental perspectives on experiences of care were explored in a qualitative analysis of in-depth interviews with parents of children born with exomphalos. Findings: Short-term outcomes of children born with gastroschisis have been published in a large number of small studies. Pooling the published data, where possible allowed the production of population estimates but heterogeneity between studies was marked. One in fourteen children born with gastroschisis died before their first birthday when managed in developed countries. Those who developed bowel complications in utero, had an increased risk of dying before one-year. The assessment of childhood outcomes for this latter group of children, who made up 11% of the population cohort, revealed a bleak outlook for many, of with one in three either dying or requiring complex surgery to gain allow them to be able to be fed via their gut, before their ninth birthday. Due to methodological limitations, the extent of neurological and gastrointestinal morbidity among survivors in the cohort is unclear, but the findings of both the highly selected responses from the parent report and those of the clinical study provide enough concern to suggest that alternative methodologies need to be explored to identify the extent of ongoing sequelae as children grow older. The live-born population of children with exomphalos is highly varied and a large burden of comorbidity was identified, however, two-thirds of infants were able to be have their abdominal wall defect surgically closed with a low-rate of early complications. A variety of techniques are employed by UK surgeons when the defect cannot be easily closed and evidence to guide management choice will be difficult to obtain using standard techniques due to the small number of these infants born annually in the UK. Parental experiences echoed the variability in management approach and in some cases highlighted a lack of respect for parental perspectives on management choice. Conclusion: Children born with abdominal wall defects represent a spectrum from those with severe comorbidity who will need ongoing care, to those who have a straightforward course and a relatively short stay in hospital. Methods of risk-stratifying infants for the purposes of outcome assessment have been explored. This approach is crucial to contextualising the progress of an individual infant and counselling their parents about their likely prognosis.

A multidimensionalidade e a consistência empírica da violência convidam aos questionamentos, debates e reflexões acerca desse fenômeno. A violência intrafamiliar contra a criança consiste em formas agressivas de membros da família se relacionarem adotando essa prática como solução de conflitos e estratégia para a correção e educação das crianças. Objeto de estudo: a violência intrafamiliar à criança na perspectiva de familiares. Objetivos: Identificar os atos considerados violentos contra a criança na perspectiva de familiares; descrever as implicações desses atos violentos na vida da criança sob a ótica de familiares; conhecer quais as atitudes que os familiares consideram importantes para a prevenção da violência contra a criança e discutir a violência intrafamiliar à criança na perspectiva de familiares a luz da fenomenologia sociológica de Alfred Schutz. Descrição metodológica: Trata-se de estudo de natureza qualitativo desenvolvido em um ambulatório de pediatria de um hospital universitário do município do Rio de Janeiro, com a participação de 12 familiares. Para a interpretação do material empírico foi utilizada a análise de conteúdo de Bardin na modalidade temática. O referencial teórico da fenomenologia sociológica de Alfred Schutz sustentou a discussão dos resultados. Resultados: Emergiram 6 (seis) categorias analíticas, a saber: Violência nas relações familiares; Palavras que ferem; Formas silenciosas de descuido e descaso para com a vida do outro; Violência gera violência; Implicações da violência intrafamiliar na vida da criança; Falar com a criança para evitar a violência. Os familiares a partir de uma relação anônima entendem a violência intrafamiliar contra a criança na perspectiva de um constructo teórico, na qual se situam como espectadores e não como perpetradores dos atos violentos. Para eles, os castigos físicos, a violência psicológica, a negligência e o abandono praticados pelas pessoas são considerados violência intrafamiliar contra a criança. Práticas como palmadinhas e tapinhas foram descritas como forma de correção e educação da criança. No se refere às implicações dos atos violentos na vida da criança apontaram aquelas que podem levar marcas profundas na memória da criança vitimizada, bem como em sua vida sócio-afetiva. O estudo possibilitou a aproximação ao conhecimento de uma realidade que afeta inúmeras crianças, onde os familiares sinalizaram que a melhor maneira de se prevenir a violência intrafamiliar é por meio do estabelecimento de uma conversa esclarecedora com a criança, abordando os assuntos pertinentes para cada ocasião com que se deparam. A inserção dessa temática desde os cursos de graduação para profissionais que lidam com a criança e sua família poderá ampliar os estudos neste campo e subsidiar a formação desses profissionais para lidar de forma adequada com o fenômeno da violência intrafamiliar. / The multidimensionality and empirical consistency of violence are an invite to questions, discussions and reflections on this phenomenon. The intra-family violence against children consists in aggressive forms of relation between family members adopting this practice as conflict resolution and strategy for children correction and education. Object of study: the intra-family violence from relatives perspective. Objectives: Identify considered violent acts against children from relatives perspective , describe the implications of these violent acts in the child's life from relatives perspective ; know what attitudes that relatives consider important for violence against children prevention and discuss intra-family violence from relatives perspective in the light of Alfred Schutzs sociological phenomenology. Methodological description This is a qualitative study conducted in an outpatient pediatric clinic of a university hospital in the city of Rio de Janeiro with the participation of 12 relatives. For the empirical material interpretation was used the content analysis of Bardin in thematic modality. The results have had the theoretical framework of sociological phenomenology of Alfred Schutz held to discuss. Results: emerged six (6) analytical categories entitled: Violence in family relationships , Words that hurt ; Silent forms of careless and disregard for the life of another ; Violence genarates violence ; Implications of intra-family violence on child's life; Talk the child to avoid violence . The relatives from an anonymous relation understand the intra-family violence against children in the perspective of a theoretical construct, in which lie as spectators and not as perpetrators of violent acts. For them physical punishment, psychological violence, neglect and abandonment are considered intra-family violence against children . Practices such as "little slaps" and "little spanks" have been described as a form of correction and education the child . In relation to the violent acts implications in child's life the relatives understand that can take a deep mark in the memory of victimized children as well as their socio- affective life The study enabled the approach to the knowledge of a reality that affects many children, where the relatives have signaled that the best way to prevent intra-family violence is through the establishment of an enlightening conversation with the child addressing relevant issues to specific occasion faced. The inclusion of this theme in graduate courses for professionals who deal with children and their families can expand the studies in this field and to subsidize their training to deal adequately with the phenomenon of intra-family violence.

A multidimensionalidade e a consistência empírica da violência convidam aos questionamentos, debates e reflexões acerca desse fenômeno. A violência intrafamiliar contra a criança consiste em formas agressivas de membros da família se relacionarem adotando essa prática como solução de conflitos e estratégia para a correção e educação das crianças. Objeto de estudo: a violência intrafamiliar à criança na perspectiva de familiares. Objetivos: Identificar os atos considerados violentos contra a criança na perspectiva de familiares; descrever as implicações desses atos violentos na vida da criança sob a ótica de familiares; conhecer quais as atitudes que os familiares consideram importantes para a prevenção da violência contra a criança e discutir a violência intrafamiliar à criança na perspectiva de familiares a luz da fenomenologia sociológica de Alfred Schutz. Descrição metodológica: Trata-se de estudo de natureza qualitativo desenvolvido em um ambulatório de pediatria de um hospital universitário do município do Rio de Janeiro, com a participação de 12 familiares. Para a interpretação do material empírico foi utilizada a análise de conteúdo de Bardin na modalidade temática. O referencial teórico da fenomenologia sociológica de Alfred Schutz sustentou a discussão dos resultados. Resultados: Emergiram 6 (seis) categorias analíticas, a saber: Violência nas relações familiares; Palavras que ferem; Formas silenciosas de descuido e descaso para com a vida do outro; Violência gera violência; Implicações da violência intrafamiliar na vida da criança; Falar com a criança para evitar a violência. Os familiares a partir de uma relação anônima entendem a violência intrafamiliar contra a criança na perspectiva de um constructo teórico, na qual se situam como espectadores e não como perpetradores dos atos violentos. Para eles, os castigos físicos, a violência psicológica, a negligência e o abandono praticados pelas pessoas são considerados violência intrafamiliar contra a criança. Práticas como palmadinhas e tapinhas foram descritas como forma de correção e educação da criança. No se refere às implicações dos atos violentos na vida da criança apontaram aquelas que podem levar marcas profundas na memória da criança vitimizada, bem como em sua vida sócio-afetiva. O estudo possibilitou a aproximação ao conhecimento de uma realidade que afeta inúmeras crianças, onde os familiares sinalizaram que a melhor maneira de se prevenir a violência intrafamiliar é por meio do estabelecimento de uma conversa esclarecedora com a criança, abordando os assuntos pertinentes para cada ocasião com que se deparam. A inserção dessa temática desde os cursos de graduação para profissionais que lidam com a criança e sua família poderá ampliar os estudos neste campo e subsidiar a formação desses profissionais para lidar de forma adequada com o fenômeno da violência intrafamiliar. / The multidimensionality and empirical consistency of violence are an invite to questions, discussions and reflections on this phenomenon. The intra-family violence against children consists in aggressive forms of relation between family members adopting this practice as conflict resolution and strategy for children correction and education. Object of study: the intra-family violence from relatives perspective. Objectives: Identify considered violent acts against children from relatives perspective , describe the implications of these violent acts in the child's life from relatives perspective ; know what attitudes that relatives consider important for violence against children prevention and discuss intra-family violence from relatives perspective in the light of Alfred Schutzs sociological phenomenology. Methodological description This is a qualitative study conducted in an outpatient pediatric clinic of a university hospital in the city of Rio de Janeiro with the participation of 12 relatives. For the empirical material interpretation was used the content analysis of Bardin in thematic modality. The results have had the theoretical framework of sociological phenomenology of Alfred Schutz held to discuss. Results: emerged six (6) analytical categories entitled: Violence in family relationships , Words that hurt ; Silent forms of careless and disregard for the life of another ; Violence genarates violence ; Implications of intra-family violence on child's life; Talk the child to avoid violence . The relatives from an anonymous relation understand the intra-family violence against children in the perspective of a theoretical construct, in which lie as spectators and not as perpetrators of violent acts. For them physical punishment, psychological violence, neglect and abandonment are considered intra-family violence against children . Practices such as "little slaps" and "little spanks" have been described as a form of correction and education the child . In relation to the violent acts implications in child's life the relatives understand that can take a deep mark in the memory of victimized children as well as their socio- affective life The study enabled the approach to the knowledge of a reality that affects many children, where the relatives have signaled that the best way to prevent intra-family violence is through the establishment of an enlightening conversation with the child addressing relevant issues to specific occasion faced. The inclusion of this theme in graduate courses for professionals who deal with children and their families can expand the studies in this field and to subsidize their training to deal adequately with the phenomenon of intra-family violence.

THE INFLUENCE OF MOTIVATIONAL ELEMENTS IN PAEDIATRIC PHYSIOTHERAPY FOCUSED ON THE PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA - PILOT STUDY Abstract The efficacy of acute lymphoblastic leukemia (ALL) treatment in childhood is still increasing and the quality of life of these children is starting to be the focus of interest. The physiotherapy affects in preventive and reactive way the late effects of treatment which may reduce the quality of life. An insufficient motivation of children can be a reason of a reduced adherence to a physiotherapeutic intervention. The goal of this study was to ascertain the influence of the motivational elements in the paediatric physiotherapy in the improvement of motor functions, the quality of life, the motivation to the exercise and the frequency of exercise. There were 9 patients diagnosed with ALL in the maintenance phase of treatment (average age 7,3 years, age range 5,2 - 10,1, 5 girls and 4 boys). All probands underwent a 6- weeks-excercise programme that contains the exercise from the DNS method, yoga for children and stretching. The assessment was performed by Bruninks-Oseretsky Test (BOT2), 6 minute walking test (6MWT), goniometric measurement of ankle joint dorsiflexion, Pediatric Quality of Life Inventory (PedsQL), Intrinsic Motivation Inventory (IMI) and the...

The purpose of this thesis was to extend our understanding of the assessment and interpretation of aerobic exercise function of paediatric patients with cystic fibrosis (CF). The first investigation sought to establish (1) the validity of traditional criteria to verify maximal oxygen (V ̇O2max) during a maximal cardiopulmonary exercise test (CPET); and (2) the utility of supramaximal verification (Smax) to confirm V ̇O2max. Traditional criteria significantly underreported V ̇O2max, whilst Smax was shown to provide a valid measurement in this patient group. The reproducibility of this CPET protocol, over the short- (48 h) and medium- (4-6 weeks) term, was then established in study two. V ̇O2max was repeatedly determined with no learning effect over 48 h (typical error (TE): ∆150 mL; ∆9.3%) and 4-6 weeks (TE: ∆160 mL; ∆13.3%). Supplementary maximal and submaximal CPET parameters should be incorporated for a comprehensive evaluation of a patient, however they are characterised by greater variability over time. The influence of mild-to-moderate CF on aerobic exercise function and the matching of muscle O2 delivery-to-O2 utilisation during ramp incremental exercise to exhaustion were then examined in study three. Aerobic function was impaired in CF, indicated by very likely reduced fat-free mass normalised V ̇O2max (mean difference, ±90% CI: -7.9 mL∙kg-1∙min-1, ±6.1), very likely lower V ̇O2 gain (-1.44 mL∙min-1∙W-1, ±1.12) and a likely slower V ̇O2 mean response time (MRT) (11 s, ±13). Arterial oxygen saturation was lower in CF, supporting the notion that centrally mediated O2 delivery may be impaired during ramp incremental exercise. Although a faster rate of fractional O2 extraction would be expected in the face of reduced O2 delivery, this was not observed, suggesting additional impairment in O2 extraction and utilisation at the periphery in CF. The fourth study then demonstrated the clinical utility of CPET to assess the response to 12 weeks treatment with Ivacaftor, using a case-based design. Whilst one patient with relatively mild disease demonstrated no meaningful change in V ̇O2max, the second demonstrated a 30% improvement in V ̇O2max, due to increased O2 delivery and extraction. Furthermore, changes in aerobic function were detected earlier than spirometric indices of pulmonary function. This study demonstrated that CPET represents an important and comprehensive clinical assessment tool and its use as an outcome measure in the functional assessment of patients is encouraged. Study five investigated the V ̇O2 kinetics in this patient group. During moderate intensity cycling, the phase II V ̇O2 time constant (τ) (p = 0.84, effect size (ES) = 0.11) and overall MRT (p = 0.52, ES=0.33) were not slower in CF. However, both were slowed during very heavy intensity cycling (p = 0.02, ES = 1.28 and p = 0.01, ES = 1.40, respectively) in CF. Cardiac output and muscle deoxygenation dynamics were unaltered in CF, however, the arterial-venous O2 content difference (C(a-v ̅)O2) was reduced (p=0.03) during VH and ∆C(a-v ̅)O2 correlated with the phase II τ (r= -0.85; p=0.02) and MRT (r = -0.79; p=0.03) in CF. This study showed that impaired oxidative muscle metabolism in this group is exercise intensity-dependent and mechanistically linked to an intrinsic intramuscular impairment, which limits O2 extraction and utilisation. In conclusion, this thesis has provided guidelines for a valid and reproducible CPET protocol for children and adolescents with mild-to-moderate CF, demonstrated the utility of CPET as clinical outcome measure and furthered our understanding of the factors responsible for impaired aerobic exercise function in this patient group.

Please read the abstract in the thesis. / Thesis (PhD)--University of Pretoria, 2013. / gm2013 / Internal Medicine / unrestricted

Magister Scientiae (Physiotherapy) - MSc(Physio) / Neural tube defects (NTDs) are the world‘s second most common birth defects after cardiovascular defects. In developing countries, poor access to health care services among children with NTDs contributes to early infant deaths, while those who survive live with severe disabilities. In Zambia, all children with NTDs in need of surgery are referred to Lusaka and physiotherapy services are not available in health facilities below the first level hospitals. The aim of the current study was to determine the profile of children with NTDs and to explore the experiences of mothers with accessing health care services for these children. The study which was conducted at the University Teaching Hospital (UTH) in Lusaka consisted of both quantitative and qualitative methods. The quantitative phase consisted of a retrospective record review of children with NTDs, who were admitted to UTH from January to December, 2010. A sample of 50 medical records was used based on available records, and data collection was done using a data extraction sheet which was specifically designed for the study. Analysis of quantitative data was done using Statistical Package for Social Science (SPSS) version 20.0. The qualitative phase had two parts, with the first part involving in-depth interviews with a purposefully selected sample of 20 mothers of children who were admitted to UTH. The second part used a sample of convenience of four mothers who had brought their children for follow up visits. All interviews were audiotaped, transcribed verbatim and translated, and recurring ideas were coded and collapsed into categories and themes. Permission to conduct the study was obtained from the UWC Research Grant and Study Leave Committee, University of Zambia Research Ethics Committee, and University Teaching Hospital management. Informed written consent was obtained from the mothers who accepted to take part in the study. Results from the record review revealed that the majority of children were from Lusaka province, with ages ranging from one day to 48 months and a male predominance of 58%. Myelomeningocele was the most common type of NTD (44%) with the lumbar region being the common site (52%). Hydrocephalus was present in 74% of children, 30% of children had both paraplegia and incontinence and 22% (n=11) of the files had no information on the neurological impairments. Wound infection was present in 40% (n=20) of the children. The majority (66%) of children were lost to follow up. Mothers of children who were admitted in UTH cited transport to UTH and back home as the main challenge. Other challenges included the lack of a prenatal diagnosis, the need for information, uncertainty about future of their children, and concerns about their family. Interviews with mothers on experiences with accessing physiotherapy services found that the lack of knowledge among mothers was the main reason children were not accessing physiotherapy services. Findings on access to health care were related to the ―Four A‘s‖ access theory which consists of four dimensions of access namely geographical accessibility, availability, affordability and acceptability. It is recommended that health care providers and policy makers ensure that all children with NTDs are provided with free transport to and from referral hospitals. Policy makers need to consider involving physiotherapists in out-reach programmes and mobile clinics to ensure access to physiotherapy services for all children in need of the service. Health care providers must also ensure that they give adequate information to mothers of children born with birth defects as this enhances their access to appropriate health care services.

Master of Public Health - MPH / Background: The Western Cape's Comprehensive Service Plan (CSP) is committed to "treating the right patient at the right level right, with the right skills and at the right cost" (Page 1, Tygerberg Hospital Annual Report, 2007). Occupational therapy (OT) Managers in the Metro District, Western Cape Province are in the process of aligning the OT services to the new CSP document. A major problem is the high default rate (non attendance) and irregular attendance (patient attends but skips sessions) amongst paediatric out-patients. In order to properly improve the OT paediatric services, it is vital for the OT managers to know the reasons for the poor utilisation of the OT services at the paediatric out-patient units. Purpose of study: The irregular attendance and high default rates (where patients stop attending the OT sessions completely) among children are a major problem at three OT out-patient units in Cape Town, Western Cape Province. The occupational therapists who work at these units are adamant that this impacts negatively on the child's progress. This study sought to explore the factors influencing the utilisation of the OT service in these three OT paediatric out-patient units in the hope of providing relevant information to the OT managers of these units in order to rethink the current service and make appropriate changes to improve adherence and treatment progress. Study design: This was an exploratory study using qualitative research methods. In-depth interviews were conducted with ten parents of children who have to attend the OT out-patient services. One group discussion was conducted with the occupational therapists that provide the services at the out-patient units. Sampling: Purposive sampling methods were employed to select four occupational therapists (at least one from each unit) and ten parents (at least three from each unit, with at least two who attended poorly and one that attended regularly). Analysis: Thematic analysis was used to interpret the data. The data was coded and categorised according to themes that emerged during data analysis. Results: The results of this study revealed that the factors that impact the utilisation of the OT service at the three OT units is complex. Factors that influenced the utilisation of the OT services in this study were related to the OT service such as staff attitude, relationship between the occupational therapist and the mothers as well as their child, communication between the mother and the occupational therapist, treatment progress, parent involvement in the OT programme and access to the OT service. Other factors such as the mothers' perception of the severity of the child's health condition, family support, work factors and family support were important factors related to the mother. The findings also revealed that environmental factors namely stigma, discrimination and travelling to the OT units impacted utilisation of the OT service. The participants made recommendations on how to improve the service. Conclusion: This study describes the complexity of what impacted the utilisation of the OT services and how closely interlinked these different factors are. It is evident from the findings of this study that a comprehensive, client centred approach is required to properly deal with the factors that negatively impact the utilisation of this service. Recommendations: A multi-faceted approach is required. Important issues to address are the shortage of occupational therapists across the levels of health care in the Western Cape Province; improving on the client centred approach in OT intervention programmes; advancing advocacy against stigma and discrimination against children with disabilities; and making public transport more accessible to children and their mothers.