Diss.--Philosophische Fakultät I--Universität Bäsel, Wintersemester 1998/99. / Résumés en français, italien, anglais. Bibliogr. p. 188-195.

Th.--Méd.--Reims, 1978. N°: 88.

Thesis Ph. D.--St John's College--University of Cambridge, 2001. / Bibliogr. p. 127-157.

No description available.

No description available.

An alternative analgesic to morphine is methadone, which is used to control chronic pain and is used in opioid rehabilitation treatment programs due to methadone having a long half-life and being relatively inexpensive as compared to extended-release forms of morphine. Despite its benefits, methadone accumulates in adipose tissue due to being lipophilic, binds strongly to plasma proteins, and is metabolized in the liver by the cytochrome P450 system causing methadone levels to be variable and subject to influence according to the individual body compositions and concurrent use of cytochrome P450 inhibitors. In addition to methadone being able to cause both respiratory and central nervous system depression, methadone can also prolong the QT interval and cause potentially life-threatening arrhythmias including torsades de pointes. The susceptibility of unintentional overdosing of methadone due to its varied pharmacologic properties and potentially fatal induction of arrhythmias may cause the risks of methadone use to outweigh its benefits and therefore must be closely monitored.

No description available.

<div>My PhD thesis evolves around the potential protective effects of sex hormones progesterone and testosterone against drug-induced QT interval prolongation in premenopasual women and older men.<br></div>

Dans un contexte de développement spectaculaire des nano-objets, il est nécessaire de développer des moyens de caractérisation électrique haute fréquence sous pointes adaptés aux petites échelles. En particulier, deux verrous instrumentaux doivent être levés. D’une part, la principale difficulté pour caractériser des nano-composants est qu’ils présentent en régime dynamique de fortes valeurs d’impédances comparativement à celles des systèmes de mesure hyperfréquence usuels. D’autre part, Il existe une discontinuité de taille entre les nano-objets et les systèmes de mesure conventionnels. Compte tenu du challenge scientifique et d’un état de l’art relativement limité, plusieurs voies ont été explorées de concert. En premier lieu, dans le cadre d’un projet européen regroupant les acteurs de la métrologie, et du laboratoire commun IEMN-STMicroelectronics®, la traçabilité des mesures hautes impédances de nano-dispositifs est établie. Par ailleurs, il s’agit de développement de nouvelles générations de sondes GSG (Ground-Signal-Ground) en technologie MEMS (Microelectromechanical systems), miniaturisées et adaptées à la taille des nano-dispositifs. Les sondes sont montées sur une plateforme de nano-positionnement robotisée et intégrée dans un microscope électronique à balayage. / In the frame of the spectacular development of nano-objects, innovative on-wafer electrical measurement methods must be addressed at the nanoscale. In particular, two main issues have been identified. On one hand, nano-devices exhibit very high dynamic impedance in contrast with conventional measuring microwave instruments. On the other hand, there is an inherent size discontinuity between nano-objects and conventional measurement systems. Given the scientific challenge and a relatively limited state of the art, several avenues of investigation have been explored. First, as part of a European project bringing together metrology laboratories, and the joint laboratory IEMN-STMicroelectronics®, the traceability of nano-devices high impedance measurements is established. In a second step, the development of an electrical on-wafer measuring platform for nano-devices is described. This includes the development of new generations of GSG (Ground-Signal-Ground) miniaturized probes in MEMS (Microelectromechanical systems) technology with reduced access pads. The probes are mounted on a robotic nano-positioning platform integrated in a scanning electron microscope.

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第20978号 / 医博第4324号 / 新制||医||1026(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 井上 治久, 教授 木村 剛, 教授 瀬原 淳子 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM