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An optimised assay for quantitative, high-throughput analysis of polysialyltransferase activityElkashef, Sara M., Sutherland, Mark, Patterson, Laurence H., Loadman, Paul, Falconer, Robert A. 07 August 2016 (has links)
Yes / The polysialyltransferases are biologically important glycosyltransferase enzymes responsible for the biosynthesis of
polysialic acid, a carbohydrate polymer that plays a critical role in the progression of several diseases, notably cancer.
Having improved the chemical synthesis and purification of the fluorescently-labelled DMB-DP3 acceptor, we report
optimisation and validation of a highly sensitive cell-free high-throughput HPLC-based assay for assessment of human
polysialyltransferase activity.
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