Introduction - This thesis focuses on the reaction of cardiovascular system to Lokomat therapy in patients with lesion of the spinal cord. It observes reaction of the heart rate and systolic blood pressure and compares with the cardiovascular response to the exercise on an upper body ergometer. Methods - We recruited 25 patients with spinal cord lesion under Th 5 and 4 patients with lesion above Th 5. The blood pressure was measured. The heart rate was measured by by ambulatory blood pressure monitor and an auscultatory method using a mercury manometer and a stethoscope a sporttester. Patients were measured during the Locomat therapy and the exercise on an upper body ergometer during the 6-minute arm test. Results - The parameters of systolic blood pressure and heart rate had a tendency to increase with the peak in 25th minute of the therapy. There was no significant difference between the patients with lesion under or above Th5. The parameters of heart rate were significantly higher on the upper body ergometer than on Lokomat. Conclusion - The Lokomat therapy does have a positive influence to cardiovascular system of patients with complete or incomplete spinal cord injury. When using this approach, the most important benefit is the possibility to activate all parts of body. Keywords: spinal cord injury,...

Neurorehabilitation for people suffering from brain injury has traditionally focused on rehabilitation of the somatic and cognitive functions. Research into the emotional aspects of brain injury has, however, been limited. The theoretical part of this thesis was therefore to map diagnostic tools suitable for the investigation of emotional problems of patients after brain injury and to classify these tools for the needs of neuropsychological practice. In the empirical part the author focused on the adaptation and pilot verification of the EBIQ (European Brain Injury Questionnaire) neuropsychological questionnaire, for a sample of patients having experienced brain injury and their immediate family and friends. The practical outcome of work in addition to the psychometric characteristics is a Czech working version EBIQ-P (version for patients) and EBIQ-R (version for family members), including well-prepared instructions for evaluating the results and examples for use in clinical practice. EBIQ provides an alternative to the previously used questionnaires SCL-90 and MMPI-100, since these, according to our findings and the findings from other studies on the group of patients after brain injury provide invalid results.

OBJECTIVES: The S100B protein subgroup is a thermolabile acidic calcium-binding protein. S100B protein was first described in the central nervous system. Destruction of the nerve tissue results in S100B protein release from astrocytic glial cells and elevation of its levels in the cerebrospinal fluid. If the blood-brain barrier is also damaged, S100B gets into the systemic circulation and elevated blood levels of S100B are detected. Higher S100B serum levels in patients with head injury are predictive of possible development of secondary brain injury and the extent of permanent injury to the CNS. MATHERIAL AND METHODS: The authors present their results obtained in the group of 39 children aged 0 (newborns) to 17 years with isolated craniocerebral injury. RESULTS: Our group included 39 children aged 0-17 years. Excellent results (GOS - Glasgow outcome scale 4-5) were observed in 33 patients already at the time of transfer from our ICU to the neurological department. There was no death and the poor outcome group included only 6 children. Second GOS evaluation was performed 6 months later, when 36 children were in the GOS 4-5 group and only 3 children in the GOS 2-3 group. CONCLUSIONS: Due to high variability in S100B protein serum levels in children depending on age and gender, no correlation between...

This dissertation describes in detail the issue of passive safety related to the biomechanics of injuries and crash tests processed as well. Statistics of accidents for the last 10 years, which show the maximum and minimum numbers of accidents and fatalities, are presented in the first chapter, "Overview of the current state of solved problematice. There is also briefly defined legislative relationship between the driver, as road users on the one hand and vulnerable pedestrians on the other hand. The issue of injury biomechanics and especially the serious injuries of body parts (organs) are elaborated in relevant chapter. Methodological part of the thesis described and analyzed data from previously crash tests and serve as a basis for comparison with other experimental tests. Other tests means tests performed on the shock chamber. After evaluation and processing of measured data is to identify and describe the limits of the load, which is the human body when exposed to incompatible impact.

CHARLES UNIVERSITY IN PRAG Faculty of Physical Educational and Sport Department of Physiotherapy THE INFLUENCE OF THE TRAINING PROGRAM ON MUSCLE ACTIVITY OF LOWER LIMB MUSCLES IN RELATION TO THE RISK FACTORS OF HAMSTRING INJURY AT SOCCER PLAYERS Dissertation thesis Supervisor: Author: Doc. PaedDr. Dagmar Pavlů, CSc. Mgr. Iva Hnátová Consultant: PhDr. Aleš Kaplan, PhD. November 2012 SUMMARY Titel: The influence of the training program on muscle activity of lower limb muscles in relation to the risk factors of hamstring injury at soccer players. Objective: Hamstring strain is a serious injury and requires long-term treatment. Hamstring strain has a high risk of recurence. As a result of this injury is long-term lost of competition and training. Prevention is necessary because of this. The mechanism and etiology of this type of injury is still uncertain and still under discussion. Multifactorial etiology is commonly discussed. In our opinion, the best solution is the training program, which is made on the basis of cooperation the physiotherapists and coaches. The goal of this training program should be primary prevention of injury or reintegration of injured athlete in the training program or the prevention of reccurenc of injury. As the result of this cooperation should be training program with all aspects of...

Injuries in childhood belong to general healthcare problems these days. They participate in the number of hospitalized and ambulatory treated children which costs our society a lot of money. Most laics and also nursing staff understand the term injury caused by an animal most of all the biting by a dog. The topic of injury caused by an animal became wider in child age. It is caused by the increase in the number of pets, often it is a small discipline of the animal owners and keepers, especially a free movement of dogs, cats, overpopulated sewer-rats in urban parts and also the higher number of exotic animals kept by non-professionals. Concerning rabies there is a given procedure for the biting by an animal which is not familiar or it is not possible to omit the transmission of rabies by saliva. The risks of tetanus and anaerobic infections are also known. The risks of the occurrence of a serious unspecific infection or cosmetic-plastic perspectives are less considered. In children these are mostly faces, arms and parts of fingers. As the initial source of long-term to whole-life consequences, the infection is assessed in primary care. The problem of suffering, psychical deprivation and pain of children and their relatives must not be omitted. Small injuries should not be underestimated. Every injured person should immediately seek medical help. Examination and treatment in children is necessary, even if the injury is small. According to my opinion the most injuries in children are caused by underestimating of risks which exist in the child ´s environment. It is not right to think that continuous supervision is the only way to avoid injuries. The prevention of injuries in children should also be supported by the efficient education of children on imminent danger. The part of prevention should also be the creation of a secure environment for a child. The objective of the thesis was to pay attention to these problems. Further, it was to map the rate of injuries of children in South Bohemian Region treated by Health Rescue Service of South Bohemian Region and Hospital České Budějovice Inc. The thesis should contribute to active solution of problems connected to injuries caused by animals and putting up with them.

The topic of this thesis is ?Nursing care for patients with craniocerebral trauma?. Three goals were set. We tried to find what the specifics of nursing care for patients with craniocerebral trauma are. We also examined whether nurses were aware of the specifics of nursing care for patients with craniocerebral trauma. The last goal was to find out whether nurses used basal stimulation in these patients. The research was based on a non-standardized interview. The interviews were performed with twelve nurses caring about these patients in the České Budějovice Hospital and the Faculty Hospital Královské Vinohrady. Three research questions were set. 1: What are the specifics of nursing care for patients with craniocerebral trauma? The research has shown that elevated head position, monitoring of GCS, pupil state and response, administering of bolus analgosedation doses in some nursing activities, ensuring detention administration and list of valuables are the specifics. We have also included CT examination, pre-operation preparation, care of invasive inputs, drains, operation wounds, careful handling with patients, constipation problems, care of a disturbed or aggressive patient and special approach to communication with these patients. 2: Are nurses aware of the specifics of nursing care for patients with craniocerebral trauma? We found that respondents knew the above mentioned specifics. However we found two drawbacks. The first one was in the unawareness of the possibility to increase ICP during defecation among the respondents, the other one was in communication with disturbed or aggressive patients. 3: Do nurses use basal stimulation in patients with craniocerebral trauma? The research has shown that the respondents do apply the concept of basal stimulation, but they only use some of the stimulation elements. This thesis may serve as study material for new nurses starting at the department, where they will care about these patients. The research results and the Standard nursing procedure of Basal stimulation elaborated by us will be offered to managers of both the hospitals where the interviews with nurses were performed.

A spinal cord injury (SCI) is a damage to the spinal cord that causes permanent or temporary changes in motor and sensory functions. In humans, the traumatic impact to spinal cord is mostly directed from the ventral part of the spinal column, even though SCI models are principally directed from the dorsal part of the spinal column due to easier surgery. The aim of the work described in this thesis was to develop clinically more relevant, easily reproducible and relatively inexpensive model of the ventral spinal cord lesion in rats which replicates SCI in humans as closely as possible by its pathology, completeness, level and regeneration. For the surgery we used a modification of a balloon- compression technique. The balloon of the 2F embolectomy Fogarty's catheter was placed to the anterior epidural space via laminectomy at the level of T10 and when the final position of the catheter was achieved at the spinal level T8 in front of the anterior median fissure, a balloon was rapidly inflated with 10 μl or 15 μl of water for 5 minutes. Other two groups - laminectomy only and ventral placement of the catheter without inflation were used as controls. The motor functions were evaluated by the BBB test and ladder walking test. In BBB test we observed significantly impaired motor functions in the 15 μl...

CHARLES UNIVERSITY IN PRAG Faculty of Physical Educational and Sport Department of Physiotherapy THE INFLUENCE OF THE TRAINING PROGRAM ON MUSCLE ACTIVITY OF LOWER LIMB MUSCLES IN RELATION TO THE RISK FACTORS OF HAMSTRING INJURY AT SOCCER PLAYERS Dissertation thesis Supervisor: Author: Doc. PaedDr. Dagmar Pavlů, CSc. Mgr. Iva Hnátová Consultant: PhDr. Aleš Kaplan, PhD. November 2012 SUMMARY Titel: The influence of the training program on muscle activity of lower limb muscles in relation to the risk factors of hamstring injury at soccer players. Objective: Hamstring strain is a serious injury and requires long-term treatment. Hamstring strain has a high risk of recurence. As a result of this injury is long-term lost of competition and training. Prevention is necessary because of this. The mechanism and etiology of this type of injury is still uncertain and still under discussion. Multifactorial etiology is commonly discussed. In our opinion, the best solution is the training program, which is made on the basis of cooperation the physiotherapists and coaches. The goal of this training program should be primary prevention of injury or reintegration of injured athlete in the training program or the prevention of reccurenc of injury. As the result of this cooperation should be training program with all aspects of...

Cutaneous wound healing could be distinguished into two main types: embryonic and adult. Embryonic healing in contrast to adult is faster, scar-less and consists of early, middle, and late phases. Actin ring is formed during the early phase and its cables pull the edges of the wound towards apposite sites during the following middle phase. De novo expression of healing specific genes is initiated also during middle phase. However, process of the wound healing continues under the closed wound in the late phase which has been poorly described. Adult wound healing is more complex, longer, and is divided into 4 phases: haemostasis, inflammation, proliferation, and remodelling phase. Adult wound healing might end with the scar. Pivotal role in the wound healing is given to matrix metalloproteinases (MMPs). These remodelling enzymes are important for releasing cytokines, inducing apoptosis, and degradation of extracellular matrix. Our laboratory performed temporal RNA-sequencing of the healing tissue using tailbud stage and swimming tadpole embryos. Results showed predominant expression of four mmps: mmp1.L, mmp7.S, mmp8.S, and mmp9.L. Injury or amputation caused the upregulation and their expression level peaked at 3-6 hours post injury which corresponds with late phase of healing. Thus, I focused on...