Made available in DSpace on 2015-12-06T23:46:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2013 / Associação Fundo de Incentivo à Psicofarmacologia (AFIP) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / Deficits cognitivos podem ser encontrados em pacientes com epilepsia do lobo temporal mesial (ELT). Dificuldade para identificacao e reconhecimento de faces pode ser um deles, uma vez que o giro fusiforme, que encontra-se no lobo temporal inferior, esta relacionado a esta funcao. O objetivo do presente estudo foi investigar identificacao e reconhecimento de faces em pacientes com ELT com esclerose hipocampal direita (ELT D) e ELT esquerda (ELT E) em comparacao com sujeitos saudaveis e, caso houvesse deficit, se este estendia-se a demais estimulos visuais, que nao apenas faces. Investigamos tambem o padrao de fixacao ocular nos grupos ELT D, ELT E e contole. Encontramos diferencas no desempenho dos tres grupos em relacao tanto a identificacao quanto ao reconhecimento de faces e, de forma geral, o grupo ELT D apresentou os piores desempenhos nos testes de faces e tambem em teste de identificacao visual para outros estimulos que nao faces. ELT D prejudica tanto o reconhecimento de faces ja conhecidas como a identificacao de faces (prosopagnosia aperceptiva), mas o deficit pode se estender a identificacao de formas. O grupo ELT E tambem apresentou desempenhos significativamente piores do que o grupo controle em um dos testes de reconhecimento de faces, mas ainda assim obteve desempenho mais alto do que o grupo ELT D nas testagens. Nao encontramos diferencas no padrao de fixacao ocular entre os grupos, o que nao nos permite inferir que haja diferenca entre os grupos de pacientes e o grupo saudavel em relacao ao processamento visual de faces / Cognitive deficits can be found in patients with mesial temporal lobe epilepsy (TLE). Difficulty in face recognition and identification can be one, since the fusiform gyrus, located in inferior temporal lobe, is related to this function. The aim of this study was to investigate the face recognition and identification in patients with temporal lobe epilepsy with hippocampal sclerosis right (R TLE) and left (L TLE) compared with healthy subjects , and if there was a deficit , if this extended to other visual stimuli, not just faces. We also examined the pattern of eye fixation in R and L TLE groups and control. We found significant differences in the performance of the three groups with respect to both the identification and face recognition and, in general, the group R TLE group showed the worst performance in tests of faces and also visual identification test stimuli other than faces. R TLE impairs both the recognition of already known faces as the identification of faces (aperceptive prosopagnosia), but the deficit may extend to identifying shapes. The L TLE group also presented significantly worse performance than the control group on a test of face recognition, but still got higher performance than the R TLE group on testing. We found no differences in the pattern of eye fixation between groups, which did not allow us to infer that there is a difference between the patient groups and the healthy group compared to the visual processing of faces / BV UNIFESP: Teses e dissertações

Prosopagnosia is defined as a profound deficit in facial identification which can be either acquired due to brain damage or is present from birth, i.e. congenital. Normally, faces and objects are processed in different parts of the inferotemporal cortex by distinct cortical systems for face vs. object recognition, an association of function and location. Accordingly, in acquired prosopagnosia locally restricted damage can lead to specific deficits in face recognition. However, in congenital prosopagnosia faces and objects are also processed in spatially separated areas. Accordingly, the face recognition deficit in congenital prosopagnosia can not be solely explained by the association of function and location. Rather, this observation raises the question why and how such an association evolves at all. So far, no quantitative or computational model of congenital prosopagnosia has been proposed and models of acquired prosopagnosia have focused on changes in the information processing taking place after in icting some kind of \damage" to the system. To model congenital prosopagnosia, it is thus necessary to understand how face processing in congenital prosopagnosia differs from normal face processing, how differences in neuroanatomical development can give rise to differences in processing and last but not least why facial identification requires a specialized cortical processing system in the first place. In this work, a computational model of congenital prosopagnosia is derived from formal considerations, implemented in artificial neural network models of facial information encoding, and tested in experiments with prosopagnosic subjects. The main hypothesis is that the deficit in congenital prosopagnosia is caused by a failure to obtain adequate descriptions of individual faces: A predisposition towards a reduced structural connectivity in visual cortical areas enforces descriptions of visual stimuli that lack the amount of detail necessary to distinguish a specific exemplar from its population, i.e. achieve a successful identification. Formally recognition tasks can be divided into identification tasks (separating a single individual from its sampling population) and classification tasks (partitioning the full object space into distinct classes). It is shown that a high-dimensionality in the sensory representation facilitates individuation (\blessing of dimensionality"), but complicates estimation of object class representations (\curse of dimensionality"). The dimensionality of representations is then studied explicitly in a neural network model of facial encoding. Whereas optimal encoding entails a \holistic" (high-dimensional) representation, a constraint on the network connectivity induces a decomposition of faces into localized, \featural" (low-dimensional) parts. In an experimental validation, the perceptual deficit in congenital prosopagnosia was limited to holistic face manipulations and didn''t extend to featural manipulations. Finally, an extensive and detailed investigation of face and object recognition in congenital prosopagnosia enabled a better behavioral characterization and the identification of subtypes of the deficit. In contrast to previous models of prosopagnosia, here the developmental aspect of congenital prosopagnosia is incorporated explicitly into the model, quantitative arguments for a deficit that is task specific (identification) - and not necessarily domain specific (faces) - are provided for synthetic as well as real data (face images), and the model is validated empirically in experiments with prosopagnosic subjects.

yes / This study aimed to develop a clinical test of face perception which is applicable to a wide range of patients and can capture normal variability. The Caledonian face test utilises synthetic faces which combine simplicity with sufficient realism to permit individual identification. Face discrimination thresholds (i.e. minimum difference between faces required for accurate discrimination) were determined in an "odd-one-out" task. The difference between faces was controlled by an adaptive QUEST procedure. A broad range of face discrimination sensitivity was determined from a group (N=52) of young adults (mean 5.75%; SD 1.18; range 3.33-8.84%). The test is fast (3-4min), repeatable (test-re-test r2=0.795) and demonstrates a significant inversion effect. The potential to identify impairments of face discrimination was evaluated by testing LM who reported a lifelong difficulty with face perception. While LM's impairment for two established face tests was close to the criterion for significance (Z-scores of -2.20 and -2.27) for the Caledonian face test, her Z-score was -7.26, implying a more than threefold higher sensitivity. The new face test provides a quantifiable and repeatable assessment of face discrimination ability. The enhanced sensitivity suggests that the Caledonian face test may be capable of detecting more subtle impairments of face perception than available tests. / None

Il existe de grandes variations interindividuelles dans les habiletés pour la reconnaissance des visages. Alors que plusieurs avenues ont été explorées pour expliquer ces variations, leur source reste inconnue. L’utilisation d’information visuelle étant reliée à la performance pour n’importe quelle tâche, l’objectif du projet était d’utiliser la méthode des Bulles pour évaluer comment l’information visuelle utilisée est liée aux habiletés. Ainsi, les habiletés pour la reconnaissance des visages ont été mesurées chez 107 participants, un large échantillon d’individus normaux provenant du spectre complet d’habiletés, incluant les extrêmes de ce spectre (i.e. prosopagnosie développementale et super-reconnaissance). Ensuite, une tâche de reconnaissance de visages célèbres a été complétée, utilisant la méthode des Bulles pour échantillonner aléatoirement l’information visuelle à chaque essai (1000). Une régression a permis de déterminer quelle information était échantillonnée de façon systématique lors des essais où le participant a répondu correctement. Cette opération résulte en une image de classification pour chaque participant, montrant l’information visuelle utilisée. Enfin, grâce à une régression de deuxième ordre, nous avons pu déterminer quelles sont les régions du visage dont l’utilisation permet de prédire les habiletés dans quatre tâches différentes. Les résultats montrent que 59% de la variation dans les habiletés peut être expliquée grâce à l’utilisation de certaines régions du visage. Plus spécifiquement, plus les participants font usage systématiquement de la région de l’œil gauche du point de vue de l'observateur, plus ils sont habiles. / Abilities for face recognition largely vary among neurotypical individuals. The source of these variations remains largely unknown. Because use of visual information affects performance for a task, the main objective of the project was to better understand the way in which visual information is used affects abilities for face recognition. To this end, we have used the Bubbles method to evaluate use of information in neurotypical participants from the complete spectrum of abilities for face recognition, including extreme cases (developmental prosopagnosics and super-recognizers). Therefore, face recognition abilities were measured in 107 participants prior to evaluating the visual information they use. In 1000 trials where participants were asked to identify a celebrity’s face, visual information was spatially randomly sampled using the Bubbles method. A regression was then applied between the location of the sampled information and accuracy on each trial, determining which information was systematically sampled when participants correctly identified faces. A second-order regression was then used, which determined the utilization of which regions of the face predicts ability scores, measured in four different tests. Results show that 59% of variations in abilities can be explained by the use of visual information for face recognition. Specifically, the more systematically participants use the region of the left eye, the more accurate they tend to be.

La capacité à reconnaître les visages de nos collègues, de nos amis et de nos proches est essentielle à notre réussite en tant qu'êtres sociaux. Notre cerveau accomplit cet exploit facilement et rapidement, dans une série d’opérations se déroulant en quelques dizaines de millisecondes à travers un vaste réseau cérébral du système visuel ventral. L’habileté à reconnaître les visages, par contre, varie considérablement d’une personne à l’autre. Certains individus, appelés «super-recognisers», sont capables de reconnaître des visages vus une seule fois dans la rue des années plus tôt. D’autres, appelés «prosopagnosiques», sont incapables de reconnaître le visage de leurs collègues ou leurs proches, même avec une vision parfaite. Une question simple reste encore largement sans réponse : quels mécanismes expliquent que certains individus sont meilleurs à reconnaître des visages? Cette thèse rapporte cinq articles étudiant les mécanismes perceptifs (articles 1, 2, 3) et cérébraux (articles 4, 5) derrière ces variations à travers différentes populations d’individus. L’article 1 décrit le contenu des représentations visuelles faciales chez une population avec un diagnostic de schizophrénie et d’anxiété sociale à l’aide d’une technique psychophysique Bubbles. Nous révélons pour la première fois les mécanismes en reconnaissance des expressions de cette population: un déficit de reconnaissance est accompagné par i) une sous-utilisation de la région des yeux des visages expressifs et ii) une sous-utilisation des détails fins. L’article 2 valide ensuite une nouvelle technique permettant de révéler simultanément le contenu visuel dans trois dimensions psychophysiques centrales pour le système visuel — la position, les fréquences spatiales, et l’orientation. L’article 3 a mesuré, à l'aide de cette nouvelle technique, le contenu représentationnel de 120 individus pendant la discrimination faciale du sexe et des expressions ( >500,000 observations). Nous avons observé de fortes corrélations entre l’habileté à discriminer le sexe et les expressions des visages, ainsi qu'entre l’habileté à discriminer le sexe et l’identité. Crucialement, plus un individu est habile en reconnaissance faciale, plus il utilise un contenu représentationnel similaire entre les tâches. L’article 4 a examiné les computations cérébrales de super-recognisers en utilisant l’électroencéphalographie haute-densité (EEG) et l’apprentissage automatique. Ces outils ont permis de décoder, pour la première fois, l’habileté en reconnaissance faciale à partir du cerveau avec jusqu’à 80% d’exactitude –– et ce à partir d’une seule seconde d’activité cérébrale. Nous avons ensuite utilisé la Representational Similarity Analysis (RSA) pour comparer les représentations cérébrales de nos participants à celles de modèles d’apprentissage profond visuels et langagiers. Les super-recognisers, comparé aux individus avec une habileté typique, ont des représentations cérébrales plus similaires aux computations visuelles et sémantiques de ces modèles optimaux. L’article 5 rapporte une investigation des computations cérébrales chez le cas le plus spécifique et documenté de prosopagnosie acquise, la patiente PS. Les mêmes outils computationnels et d’imagerie que ceux de l’article 4 ont permis i) de décoder les déficits d’identification faciale de PS à partir de son activité cérébrale EEG, et ii) de montrer pour la première fois que la prosopagnosie est associée à un déficit des computations visuelles de haut niveau et des computations cérébrales sémantiques. / The ability to recognise the faces of our colleagues, friends, and family members is critical to our success as social beings. Our brains accomplish this feat with astonishing ease and speed, in a series of operations taking place in tens of milliseconds across a vast brain network of the visual system. The ability to recognise faces, however, varies considerably from one person to another. Some individuals, called "super-recognisers", are able to recognise faces seen only once years earlier. Others, called "prosopagnosics", are unable to recognise the faces of their colleagues or relatives, even with perfect vision and typical intelligence. A simple question remains largely unanswered: what mechanisms explain why some individuals are better at recognizing faces? This thesis reports five articles studying the perceptual (article 1, 2, 3) and neural (article 4, 5) mechanisms behind these variations across different populations of individuals. Article 1 describes the content of visual representations of faces in a population with a comorbid diagnosis of schizophrenia and social anxiety disorder using an established psychophysical technique, Bubbles. We reveal for the first time the perceptual mechanisms of expression recognition in this population: a recognition deficit is accompanied by i) an underutilization of the eye region of expressive faces and ii) an underutilization of fine details. Article 2 then validates a new psychophysical technique that simultaneously reveals the visual content in three dimensions central to the visual system — position, spatial frequencies, and orientation. We do not know, however, whether skilled individuals perform well across a variety of facial recognition tasks and, if so, how they accomplish this feat. Article 3 measured, using the technique validated in article 2, the perceptual representations of 120 individuals during facial discrimination of gender and expressions (total of >500,000 trials). We observed strong correlations between the ability to discriminate gender and facial expressions, as well as between the ability to discriminate gender and identify faces. More importantly, we found a positive correlation between individual ability and the similarity of perceptual representations used across these tasks. Article 4 examined differences in brain dynamics between super-recognizers and typical individuals using high-density electroencephalography (EEG) and machine learning. These tools allowed us to decode, for the first time, facial recognition ability from the brain with up to 80% accuracy — using a mere second of brain activity. We then used Representational Similarity Analysis (RSA) to compare our participants' brain representations to those of deep learning models of object and language classification. This showed that super-recognisers, compared to individuals with typical perceptual abilites, had brain representations more similar to the visual and semantic computations of these optimal models. Article 5 reports an investigation of brain computations in the most specific and documented case of acquired prosopagnosia, patient PS. The same computational tools used in article 4 enabled us to decode PS's facial identification deficits from her brain dynamics. Crucially, associations between brain deep learning models showed for the first time that prosopagnosia is associated with deficits in high-level visual and semantic brain computations.

L’objectif de cette recherche est la création d’une plateforme en ligne qui permettrait d’examiner les différences individuelles de stratégies de traitement de l’information visuelle dans différentes tâches de catégorisation des visages. Le but d’une telle plateforme est de récolter des données de participants géographiquement dispersés et dont les habiletés en reconnaissance des visages sont variables. En effet, de nombreuses études ont montré qu’il existe de grande variabilité dans le spectre des habiletés à reconnaître les visages, allant de la prosopagnosie développementale (Susilo & Duchaine, 2013), un trouble de reconnaissance des visages en l’absence de lésion cérébrale, aux super-recognizers, des individus dont les habiletés en reconnaissance des visages sont au-dessus de la moyenne (Russell, Duchaine & Nakayama, 2009). Entre ces deux extrêmes, les habiletés en reconnaissance des visages dans la population normale varient. Afin de démontrer la faisabilité de la création d’une telle plateforme pour des individus d’habiletés très variables, nous avons adapté une tâche de reconnaissance de l’identité des visages de célébrités utilisant la méthode Bubbles (Gosselin & Schyns, 2001) et avons recruté 14 sujets contrôles et un sujet présentant une prosopagnosie développementale. Nous avons pu mettre en évidence l’importance des yeux et de la bouche dans l’identification des visages chez les sujets « normaux ». Les meilleurs participants semblent, au contraire, utiliser majoritairement le côté gauche du visage (l’œil gauche et le côté gauche de la bouche). / The present study aims to create a web-based platform that would examine individual differences in face processing strategies in different categorization tasks. The purpose of this platform is to collect data from geographically dispersed participants with variable face recognition abilities. Indeed, many studies have shown that there is high variability in the spectrum of face recognition ability, ranging from developmental prosopagnosia (Duchaine & Susilo, 2013), a disorder of face recognition in the absence of brain damage, to super-recognizers, individuals with extraordinary face recognition ability (Russell, Duchaine & Nakayama, 2009). Between these extremes, people vary substantially in their ability to recognize faces. To demonstrate the reliability of creating such a platform for individuals of widely varying abilities, we adapted a recognition task of the identity of famous faces using the Bubbles method (Gosselin & Schyns, 2001) and recruited 12 control subjects and a subject with developmental prosopagnosia. We were able to highlight the importance of the eyes and the mouth in face identification. The best observers seem mostly to use the left side of the face (left eye and the left side of the mouth).