Cervical vagal nerve stimulation (VNS) has been studied in the context of several conditions including epilepsy and depression. However, its effects on glucose metabolism, and its potentially beneficial effects in type II diabetes, have not yet been evaluated in humans. Efferent parasympathetic activation reduces hepatic glucose release and increases pancreatic insulin secretion, while afferent parasympathetic activation may increase hepatic glucose release and inhibit insulin secretion potentially through sympathetic activation. Thus, the effect of combined afferent and efferent cervical VNS is difficult to predict. We hypothesized that selective efferent VNS would decrease blood glucose concentration [Glu] and that selective afferent VNS would increase [Glu]. To investigate these potentially contrasting effects of efferent vs. afferent parasympathetic signaling, we recorded [Glu] and serum insulin and glucagon levels before and during 120 min of VNS in anesthetized rats. The nerve was left intact for combined afferent and efferent VNS (n=9) or sectioned proximal or distal from the stimulation electrode for selective efferent (n=8) of afferent (n=7) VNS, respectively. We found that afferent VNS caused a strong and sustained increase in [Glu] (+108.9±20.9% or +77.6±15.4% after 120 min of combined afferent and efferent VNS or selective afferent VNS) that was not accompanied by an increase in serum insulin concentration. Combined afferent and efferent VNS significantly increased serum glucagon concentration (57.6±23.4% at 120 min of VNS), while selective afferent VNS did not increase glucagon levels. Conversely, selective efferent VNS increased [Glu] only temporarily (+28.8±11.7% at 30 min of VNS). This response coincided with a transient increase in serum glucagon concentration at 30 min of VNS (31.6±8.3%) and a strong and sustained increase in serum insulin concentration (+71.2±27.0% after 120 min of VNS). These findings demonstrate that afferent VNS may increase [Glu] by suppressing pancreatic insulin release, while efferent VNS transiently increases [Glu] by stimulating glucagon secretion before reducing levels to or below baseline values by stimulating the release of insulin. Thus, selective efferent VNS may be potentially effective in the treatment of type II diabetes.

L'horloge de flore (The Flower Clock or Flora's Clock) by Jean Françaix was commissioned by John de Lancie, former principal oboist of the Philadelphia Orchestra in 1957. It was completed in 1959 and premiered by Mr. de Lancie and the Philadelphia Orchestra in 1961. Since that time, it has become a staple of the 20th century oboe concerto repertoire. The current piano reduction of Jean Françaix's L'horloge de Flore consists of the full orchestral score in piano score format. Since it has been only minimally edited, it is an extremely difficult accompaniment for a single pianist. Collaborative pianists must make decisions concerning which pitch material to incorporate into an accompaniment. Many oboists have expressed the need for a revised piano accompaniment to make the piece more accessible to pianists and, thus, enable the concerto to be studied and performed more frequently by oboists. The purpose of this document is to further facilitate performance of this work in a recital setting by both professional and student oboists and to encourage student oboists to study the work by revising the piano reduction. In order to do so, it will be necessary to provide commentary and background on similar oboe works by Jean Françaix, provide a theoretical analysis of L'horloge de Flore, offer performance suggestions of the work for the oboist, clearly discuss transcriptional decisions in the revised piano reduction, and create a practical, two-hand piano accompaniment.

Previous research in Second Language Acquisition (SLA) has shown that some of the systematic errors of second language (L2) learners can be attributed to the influence of the native language (L1). In fact, many hypotheses in generative SLA have focused on the role of L1 transfer ranging the spectrum from No Transfer to Full Transfer. The goal of this dissertation was to investigate L1 transfer by focusing on L1-L2 differences in terms of linguistic features; specifically, how differences in the featural and morpholexical organization of L1 and L2 pronominal paradigms affect SLA. In this work I operationalize L1 transfer in terms of the Feature Reassembly Hypothesis (FRH; Lardiere, 2009). The hypothesis pioneers conceptualization of L1 transfer as an initial attempt by L2 learners to establish a direct mapping between L1 and L2 forms. The FRH is particularly suitable to the study of L2 development because it predicts that when a one-to-one initial mapping is unsuccessful, L2 learners will gradually reorganize the L1 grammatical system until they attain (possibly complete) convergence. Empirical testing of the hypothesis is critical since determining when and why transfer occurs opens numerous possibilities to predict transfer errors and to develop pedagogical approaches to tackle negative transfer. In the current study I focus on the L2 acquisition of four 3rd person singular French object pronouns in the interlanguage of native speakers of English. Difficulties in the acquisition of Romance object pronouns have been amply documented in L2 research. However, most of the previous studies of the topic have focused on L2 acquisition of clitic pronouns and their syntactic properties. The present study takes a novel approach investigating the acquisition of strong as well as clitic pronouns. In my dissertation I test different kinds of knowledge including learners' comprehension of different kinds of pronouns. Going beyond production data, my experimental tasks include a grammaticality judgment task with correction, a picture selection task, and a self-paced reading task. The experimental tasks were administered to a group of native speakers (n=43) and L2 learners of French (n=87). The overall picture that emerges from the current study allows unveiling the initial mapping and subsequent reassembly of the semantic and morphosyntactic features implicated in the acquisition process of the four forms under investigation.

Staphylococcus aureus is the leading cause of infective endocarditis in the United States. Infective endocarditis (IE) is defined as an infection of the endocardium, typically involving the heart valves. The hallmark features of IE are vegetations. Vegetations are cauliflower-like, stratified biofilms of bacteria and host factors that develop on the valve leaflets of the heart. The mechanisms of how vegetations form are not well understood, and as a consequence the bacterial factors that are important for development of IE are not well defined. My studies focus on the role of a family of S. aureus exoproteins known as superantigens and their role in IE. Superantigens (SAgs) are a class of secreted virulence factors that have been extensively studied for their role in systemic diseases such as toxic shock syndrome (TSS), pneumonia, and food poisoning. The SAg protein family is comprised of 23 distinct members designated as staphylococcal enterotoxin (SE) or enterotoxin-like (SEl) and toxic shock syndrome toxin-1 (TSST-1). The term superantigen is derived from the ability of SAgs to interact with the immune system, resulting in a nearly 3000-fold increase in activation when compared to standard antigens. SAgs have a defined structure that is composed of 2 domains, a carboxy-terminal beta-grasp domain and amino-terminal oligosaccharide/oligonucleotide binding (OB) fold. Defined groups of SAgs are associated with S. aureus strains isolated from specific diseases, but few studies have been done to determine the role of SAgs in diseases outside of TSS and food poisoning. The enterotoxin gene cluster (egc) is a group of 6 SAgs (selo, selm, sei, selu, seln, and seg) assembled into an operon-like cluster that is present in the majority of S. aureus strains isolated from IE patients. My studies have determined that the egc is able to induce vegetations when expressed in avirulent S. aureus strains. This is the first time the egc has been directly associated with IE. I further characterized the capacity of the individual egc proteins to induce vegetations. Four (selo, selm, sei, and selu) of the 6 egc SAgs were able to induce vegetation formation. This is the first time the individual egc proteins have been characterized and directly associated with IE. I also demonstrated that the egc proteins may not be exclusively expressed as a single polycistronic transcript but that selu and seg contain promoter elements that may drive their individual expression. Lastly, I provide evidence that the egc SAgs may be regulated by MgrA, a global regulator of S. aureus associated with virulence factor expression.

Let R(G) denote the category of smooth representations of a p-adic group. Bernstein has constructed an indexing set B(G) such that R(G) decomposes into a direct sum over s ∈ B(G) of full subcategories Rs(G) known as Bernstein subcategories. Bushnell and Kutzko have developed a method to study the representations contained in a given subcategory. One attempts to associate to that subcategory a smooth irreducible representation (τ,W) of a compact open subgroup J < G. If the functor V ↦ HomJ(W,V) is an equivalence of categories from Rs(G) → H(G,τ)mod we call (J,τ) a type. Given a Levi subgroup L < G and a type (JL, τL) for a subcategory of representations on L, Bushnell and Kutzko further show that one can construct a type on G that “lies over” (JL, τL) by constructing an object known as a cover. In particular, a cover implements induction of H(L,τL)-modules in a manner compatible with parabolic induction of L-representations. In this thesis I construct a cover for certain representations of the Siegel Levi subgroup of Sp(2k) over an archimedean local field of characteristic zero. In partic- ular, the representations I consider are twisted by highly ramified characters. This compliments work of Bushnell, Goldberg, and Stevens on covers in the self-dual case. My construction is quite concrete, and I also show that the cover I construct has a useful property known as splitness. In fact, I prove a fairly general theorem characterizing when covers are split.

Since the beginning of the 21st century, the doctor-patient relationship in China has become increasingly confusing to observers. On the one hand, insiders of the medical discipline believed that the doctor-patient relationship could not even be worse. On the other hand, Chinese health care professionals appeared to be much more popular than they used to be. On the leading social media site, Weibo, many health care professionals managed to transform themselves into celebrities by producing content and interacting with ordinary social media users. These grassroots celebrity physicians have obtained tens of thousands, and even millions, of social media fans on Weibo, and they initiated online conversations about public controversies surrounding health and medicine, such as the doctor-patient relationship, health care reform, the use of Traditional Chinese Medicine, and so on. The seemingly conflicting phenomena reflected the crises Chinese health care professionals were facing and their struggles to free themselves from these crises. Distrusted by the public, health care professionals attempted to repair their reputations and to rebuild a relationship of trust through their efforts in cyberspace. In other words, health care professionals' social media activities were largely a response to the frustrations they had experienced in their professional careers. In turn, being liked by numerous social media users reflected the publics' need to have direct conversations with health care professionals. This study used textual analysis, in-depth interviews, and surveys 1) to explore Chinese celebrity physicians' motivations for and gratifications obtained from establishing a professional presence via social media; 2) to examine the online conversations between celebrity physicians and their social media fans; and 3) to discuss the potential medical, political, and cultural outcomes of their online activities. Results of the study suggested that celebrity physicians in China mainly used social media to achieve three goals: to increase public health literacy, to rebuild their professional identities, and to push the government to make changes to the current health care system. Accordingly, celebrity physicians were found to play multiple roles on Weibo: medical experts, opinion leaders, and celebrities. Each of these roles were performed and recognized by their social media fans in different ways, indicating the complexity of virtual social networks. By analyzing Chinese celebrity physicians' online narratives and examining the factors that shaped their online activities, the project further explored the sociological factors contributing to digital media use, revealed the multiple connections contributing to the formation of virtual social networks comprised of celebrity physicians and their social media followers, and studied the presentation of cultural tension in cyberspace. From the practical perspective, future scholars and advocates could use the findings of this study to better design health and science campaigns. From the theoretical perspective, this study expanded the scope of the uses and gratifications approach, proposed new angles for examining the doctor-patient and the celebrity-fan relationships, and discussed the online presentation of, and inherent nuances contributing to, cultural conflicts.

This is the thorough examination of Allyson Malandra's process of becoming a character, and the many different challenges and triumphs she has faced throughout the past three years of developing her craft. It also aims to bring into focus where the work will be headed throughout the many years to come. The goal of this process paper is to examine the many different details and intricacies that go into a role, and also how to troubleshoot problems that may arise throughout the journey. Our process is how we, as actors, attempt to create life on stage, and discover and unfold the underlying truth that connects all human beings. It is understood that each role for an actor will present a different set of chges, and therefore it is important to understand a baseline process that gets at the core of the actor's work. Through examination of this process, previous and current chges in the work will be discussed, as well as ways to move through these issues. Ideas on what is valuable in acting will be discussed, as a way of staying centered and focused, and also retaining quality in the craft. The examination will also explore three main pillars of the work--breathe, listen, and play--and how these anchor Allyson's artistry. The ultimate goals of this examination are to create a support for the process, to chge her work in the future, and to help her continue to grow and expand, both as an artist and as a person.

Portable X-ray fluorescence (pXRF) provides a new alternative to destructive methods of raw material characterization, such as X-ray fluorescence (XRF), neutron activation analysis (NAA), and traditional thin section petrography, although its effectiveness on coarse-grained materials, such as granite, has been questioned. This project addressed this question by determining the effectiveness of pXRF in characterizing granites from Belize and in sourcing granite ground stone tools from Maya sites in Belize. Geochemical fingerprints were defined for three potential source areas (granite plutons in the Maya Mountains of Belize) using outcrop samples. Samples were analyzed using pXRF, XRF, electron microprobe (EMPA), and thin section analyses. PXRF data from archaeological collections of granite ground stone tools from sites in Belize were then compared to the pluton geochemical signatures. There were two principle results of this research. First, analyses indicated that pXRF can accurately characterize the geochemistry of granites from Belize on a suite of elements. Second, this research demonstrated that the Maya of Belize exploited multiple granite outcrops and participated in different kinds of exchange networks to acquire granite, sometimes acquiring stone from the nearest outcrops and sometimes not. While Mountain Pine Ridge was the dominant source outcrop that was exploited, Cockscomb Basin and Hummingbird Ridge granites were also quarried or scavenged. Sometimes the closest source was used, as is the case at Alabama, who exploited the locally available Cockscomb Basin granite. Through this study it appears that the nearest pluton was not always used. Instead Mountain Pine Ridge granite tools were imported from a greater distance, implying that there were additional factors, such as economic partners and changing political powers, which lead to Mountain Pine Ridge granite being the most pervasive in most archaeological collections within Belize.

Nowadays, the world is facing a lot of serious problems because of the population explosion and the resource shortage. Overcrowded living area creates economic and social issues, and the limitation of material choices not only lowers the quality of house holding merchandise, but also leads to the raise of the price. Due to all these complicated factors, multi-function furniture becomes one of the solutions for space sustainability. Multi-function furniture combines different functions into one piece to control the material consumption, creates opportunities for the interaction between the object and human, and effectively save user's space. At the same time, the price of multi-function furniture, by contrast, is usually more reasonable than purchasing several furniture pieces together. This kind of design becomes more and more popular among young generation, and it is the trend of today's furniture design. Through the exploration of human's living habits and the study of contemporary multi-function furniture, I designed a piece of furniture, Chinese Bench with the concept of space and material sustainability. This thesis is based on the field study of ergonomics and furniture design theory, illustrates the final prototypes of my multi-functional furniture. The design can be served as sit, table and storage, and it emphasizes the importance of space use and valuable customization for user at the same time. The design aims to provide a more efficient living mode in limited space, and reduce the material consumption. At the same time, the pattern and graphic forms are adapted in this design; they can meet people's need for beauty and function at the same time, let the user obtain the sympathy and entertainment from the design

The Fayúm Province of Egypt covers an almost continuous time span from the middle Eocene through the early Oligocene and has produced a number of vertebrate fossils important to evolutionary history. This area includes early crocodylids inaccurately assigned to crown-group Crocodylus, which has been shown through molecular and morphological phylogenetic analyses to have diverged during the Miocene. We reviewed two taxa from the early Oligocene Gebel Qatrani Formation, Crocodylus megarhinus Andrews 1905 and Crocodylus articeps Andrews 1905, which had previously been synonymized, with C. articeps thought to be based on a juvenile specimen of C. megarhinus. Crocodylus megarhinus outwardly resembles most living species of Crocodylus, however it is a basal crocodylid lacking diagnostic features for the crown genus. The holotype of C. articeps is now lost, but based on a cast and published images of the original material, it was a slender-snouted form that can be distinguished from smaller specimens of C. megarhinus. Although not synonymous with C. megarhinus, C. articeps cannot be diagnosed or scored for existing character matrices sufficiently to allow precise phylogenetic placement. Previous analyses of C. megarhinus included information from C. articeps; recoding C. megarhinus based only on material referable to that species does not change its phylogenetic position, but it forces a reconsideration of the polarity of character states in clades leading to the origin of crown-genus Crocodylus which, in turn, may inform efforts to resolve the relationships among living crocodylid lineages. Based on its confirmed phylogenetic position as a basal crocodylid, C. megarhinus provides insight into the ancestral conditions of all crocodylids and supports an African origin for Crocodylidae.