Spelling suggestions: "subject:"pyrrolidine""
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Radical cyclization approaches to pyrrolidines /Beşev, Magnus. January 2002 (has links)
Diss. (sammanfattning) Uppsala : Univ., 2002. / Härtill 4 uppsatser.
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A novel approach to the synthesis of polyhydroxylated indolizidine alkaloidsFarrant, Elizabeth January 1997 (has links)
No description available.
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Approaches to (-)-#alpha#-kainic acid and analogues by intramolecular anionic cyclizationRathmell, Richard E. January 1998 (has links)
No description available.
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Synthesis of tetrahydrofuran and pyrrolidine derivatives utilising radical reactions : organochalcogenides in reductive, carbonylative and group-transfer cyclisation /Ericsson, Cecilia, January 2004 (has links)
Diss. (sammanfattning) Uppsala : Univ., 2004. / Härtill 4 uppsatser.
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Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties /Rehn, Stanley, January 2004 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 4 uppsatser.
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The synthesis of substituted pyrrolidines, piperidines and hexah[y]droazepinesHill, Ralph Madison. January 1937 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1937. / Typescript. Includes abstract and vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references: leaf [52].
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An animal model of Huntington’s disease : behavioral, pharmacological and morphological changes following intrastriatal injections of kainic acidSanberg, Paul Ronald January 1978 (has links)
Compared with saline injected controls, rats with bilateral injections of kainic acid (KA) in the dorsal striatum showed temporary aphagia and adipsia, long-lasting body weight decreases, increased locomotor response to d-amphetamine, increased spontaneous nocturnal locomotor activity, increased resistance to extinction, impaired acquisition and retention of avoidance behavior and increased latencies to leave start boxes in various mazes. The KA injections resulted in loss of local neurons in the dorsal striatum, with no appreciable damage either to dopaminergic terminals or to extrinisic myelinated axons, thus supporting both the selective neurotoxic action of KA on neuronal perikarya and the proposed similarity of KA-induced striatal lesions with those found in the caudate-putamen of patients with Huntington's disease (HD). The present results demonstrate that KA striatal lesioned rats also show behavioral and pharmacological similarities
with HD patients. In addition, they support the view that HD is characterized by a "subcortical dementia syndrome". A review of HD is also presented. / Medicine, Faculty of / Graduate
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The Utilization of Sulfinimines (N-Sulfinyl Imines) in the Asymmetric Synthesis of Substituted PyrrolidinesBowen, Kerisha Andrea January 2009 (has links)
The objective of this research was the development of new methods for the asymmetric synthesis of nitrogen containing compounds. As one part of this goal, 3,4-dihydroxyprolines and their derivatives were prepared from sulfinimines (N-sulfinyl imines). During this project new methods were developed for asymmetric hydroxylation and decarboxylation of 3-oxo-2-carboxylate pyrroldines. The application of this new methodology was realized by the total synthesis of the α- and β-glycosidases inhibitor (+)-lentginosine. It was also found that electrophiles regioselectively add to the 4-position of 3-oxo-2-carboxylate-5-substituted pyrrolidines. The addition is accomplished through lithium diisopropyl amide generation of the pyrrolidine dianion. This addition was also compatible with 3-oxo-2-phosophono-5-substituted pyrroldines. Furthermore air oxidation of these pyrrolidines give the corresponding pyrroles. This procedure represents the first general preparation procedure for 2-phonopyrroles, which have been examined as HIV protease inhibitors. A range of β-amino carbonyl compounds were prepared from N-sulfinyl β-amino Weinreb amides in a concise and efficient procedure. A general method for the preparation of a variety of β-amino carbonyl compounds arose from the addition of an assortment of organometallic reagents to the Weinreb amides. The N-sulfinl β-amino Weinreb amides are prepared by reaction of the potassium enolate of N-methoxy-N-methylacetamide with sulfinimines or lithium N,O-dimethylhydroxylamine with N-sulfinyl β-amino esters. / Chemistry
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Acylations radicalaires diastéréocontrôlées : application à la synthèse de tétrahydrofuranes et pyrrolidines polysubstitués / Diastereoselective radical acylations : application to the synthesis of polysubstituted tetrahydrofurans and pyrrolidinesGrélaud, Simon 09 December 2016 (has links)
Cette thèse décrit un nouvel accès au motif tétrahydrofurane (THF)2,3,5-trisubstitué. Cette stratégie est basée sur une première étape d’addition d’un radical acyle nucléophile sur une oléfine activée de type adduit de Baylis-Hillman,suivie d’une cyclisation réductrice du motif céto-alcool-1,4 ainsi formé. De hauts niveaux de diastéréocontrôles-1,2 et -1,3 ont pu être atteints en utilisant dans ces deux étapes le tris(triméthylsilyl)silane comme agent de transfert d’hydrogène. Cette méthodologie a ensuite été appliquée à la synthèse du fragment THF de la gymnodimine puis à la première synthèse totale d’une molécule naturelle tricyclique : le no.2106A. Dans un dernier temps, l’utilisation d’adduits de type aza-Baylis-Hillman a permis d’accéder efficacement à des homologues azotés telles que les pyrrolidines mais également à des composés bicycliques tels que les indolizidinones ou les pyrrolizidines. / This thesis describes a new access to the 2,3,5-trisubstituted tetrahydrofuran moiety. This strategy includes as a first step an addition of an acylradical on to an activated olefin (Baylis-Hillman adduct), followed by a reductive cyclization of the corresponding 1,4-keto-alcohol. High levels of 1,2- and 1,3-stereocontrol were attained using, in these two steps, tris(trimethylsilyl)silane as an hydrogen transfer agent. This methodology was then applied to the synthesis of the Gymnodimine THF fragment and to the first total synthesis of a tricyclic naturalcompound : no.2106A. Finally, the use of aza-Baylis-Hillman adducts led to an efficient access to nitrogen analogues, including pyrrolidines and bicyclic compounds such as indolizidinones or pyrrolizidines.
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Development of a new PNA analogue as a potential antisense drug and tool for life-science studies /Slaitas, Andis, January 2004 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 5 uppsatser.
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