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11	Combined Systemic Drug Treatment with Proton Therapy: Investigations on Patient-Derived Organoids Naumann, Max, Czempiel, Tabea, Lößner, Anna Jana, Pape, Kristin, Beyreuther, Elke, Löck, Steffen, Drukewitz, Stephan, Hennig, Alexander, von Neubeck, Cläre, Klink, Barbara, Krause, Mechthild, William, Doreen, E. Stange, Daniel, Bütof, Rebecca, Dietrich, Antje 06 December 2023 (has links) To optimize neoadjuvant radiochemotherapy of pancreatic ductal adenocarcinoma (PDAC), the value of new irradiation modalities such as proton therapy needs to be investigated in relevant preclinical models. We studied individual treatment responses to RCT using patient-derived PDAC organoids (PDO). Four PDO lines were treated with gemcitabine, 5-fluorouracile (5FU), photon and proton irradiation and combined RCT. Therapy response was subsequently measured via viability assays. In addition, treatment-naive PDOs were characterized via whole exome sequencing and tumorigenicity was investigated in NMRI Foxn1nu/nu mice. We found a mutational pattern containing common mutations associated with PDAC within the PDOs. Although we could unravel potential complications of the viability assay for PDOs in radiobiology, distinct synergistic effects of gemcitabine and 5FU with proton irradiation were observed in two PDO lines that may lead to further mechanistical studies. We could demonstrate that PDOs are a powerful tool for translational proton radiation research. info:eu-repo/classification/ddc/571.978 ddc:571.978
12	Adjuvante Radiochemotherapie beim lokal fortgeschrittenen Rektumkarzinom. Behandlungsergebnisse der Strahlentherapie und Evaluation. / Eine retrospektive Analyse im Zeitraum 01/97-12/06 am Städtischen Klinikum Lüneburg / Adjuvant radiochemotherapy in locally advanced rectal cancer. Therapy outcome in the Clinicum of Lüneburg, Lower Saxony / A retrospective analysis of treatment results from 1997 until 2006 Garbe, Amelie 08 March 2017 (has links) No description available. 610 Rektumkarzinom lokal fortgeschrittenes Rektumkarzinom postoperative Radiochemotherapie Klinikum Lüneburg radiochemotherapy rectumcarcinoma Clinicum Lüneburg locally advanced rectal cancer Medizin (PPN619874732)
13	Analyse der Expression von Chemokinen und Chemokinrezeptoren in HNO-Tumorzellen unter Radiochemotherapie / Analysis of chemokine and chemokine receptor expression in squamous cell carcinoma of the head and neck cell lines Holzer, Claudia Anna 13 March 2017 (has links) No description available. 610 Chemokine Chemokinrezeptoren Radiochemotherapie Cisplatin CXCL12 CXCL1 CXCL3 CCL20 CXCR4 CXCR1 CCR6 CCR7 Koloniebildungsversuch Real-time PCR SCCHN Radiochemotherapy chemokines chemokine receptors CXCL12 CXCL1 CXCL3 CCL20 CXCR4 CXCR1 CCR6 CCR7 Cisplatin real-time PCR colony forming assays Oto-Rhino-Laryngologie (PPN619876220)

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Combined Systemic Drug Treatment with Proton Therapy: Investigations on Patient-Derived Organoids

Analyse der Expression von Chemokinen und Chemokinrezeptoren in HNO-Tumorzellen unter Radiochemotherapie / Analysis of chemokine and chemokine receptor expression in squamous cell carcinoma of the head and neck cell lines