Cancer is a global problem, and many people in low-income countries do not have access to the treatment options, such as radiation therapy, that are available in wealthy countries. Where radiation therapy is available, it is often delivered using older Co-60 equipment that has not been updated to modern standards. Previous research has indicated that an updated Co-60 radiation therapy machine could deliver treatments that are equivalent to those performed with modern linear accelerators. Among the key features of these modern treatments is a tightly conformal dose distribution-- the radiation dose is shaped in three dimensions to closely match the tumour, with minimal irradiation of surrounding normal tissues. Very accurate alignment of the patient in the beam is therefore necessary to avoid missing the tumour, so all modern radiotherapy machines include imaging systems to verify the patient's position before treatment. Imaging with the treatment beam is relatively cost-effective, as it avoids the need for a second radiation source and the associated control systems. The dose rate from a Co-60 therapy source, though, is more than an order of magnitude too high to use for computed tomography (CT) imaging of a patient. Digital tomosynthesis (DT), a limited-arc imaging method that can be thought of as a hybrid of CT and conventional radiography, allows some of the three-dimensional selectivity of CT but with shorter imaging times and a five- to fifteen-fold reduction in dose. In the present work, a prototype Co-60 DT imaging system was developed and characterized. A class of clinically useful Co-60 DT protocols has been identified, based on the filtered backprojection algorithm originally designed for CT, with images acquired over a relatively small arc. Parts of the reconstruction algorithm must be modified for the DT case, and a way to reduce the beam intensity will be necessary to reduce the imaging dose to acceptable levels. Some additional study is required to determine whether improvements made to the DT imaging protocol translate to improvements in the accuracy of the image guidance process, but it is clear that Co-60 DT is feasible and will probably be practical for clinical use. / Thesis (Master, Physics, Engineering Physics and Astronomy) -- Queen's University, 2012-01-30 12:56:56.075

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A system for visual guidance in patient set-up for external-beam radiotherapy procedures was developed using augmented reality. The system uses video cameras to obtain views of the linear accelerator, and the live images are displayed on a monitor in the treatment room. A 3D model of the patient's external surface, obtained from planning CT data, is superimposed onto the treatment couch in the camera images. The augmented monitor can then be viewed, and alignment performed against the virtual contour. The system provides an intuitive method for set-up guidance, and allows non-rigid deformations to patient pose to be visualised. It also allows changes to patient geometry between treatment fractions to become observable, and can remain in operation throughout the treatment procedure, so that patient motion becomes apparent. Coordinate registration between the camera view and the linac is performed using a cube which is aligned with the linac isocentre using room lasers or cone-beam CT. The AR tracking software detects planar fiducial tracking markers attached to the cube faces, and determines their positions in order to perform pose estimation of the 3D model on-screen. Experimental results with an anthropomorphic phantom in a clinical environment have shown that the system can be used to position a rigid-body with a translational error of 3 mm, and a rotational error of 0.19 degrees, 0.06 degrees and 0.27 degrees, corresponding to pitch, roll and yaw respectively. With further developments to optimise the system accuracy and its interface, it could be made into a valuable tool for radiotherapy clinics. The outcome of the project has been encouraging, and has shown that augmented reality for patient set-up guidance has great potential.

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The linear attenuation coefficient and buildup factor are a few of the important characteristics that need to be studied and determined prior to using a material clinically in radiation treatment and protection. The linear attenuation coefficient and buildup factor, as well as several other properties, will be determined for MCP-96 alloy to assess its use in radiation therapy. A narrow collimated beam of γ-rays from sources with varying energies will pass through various thicknesses of MCP-96 alloy. The attenuation in the intensity of the beam will be determined for each varying thickness of the alloy. Plotting the thickness of the alloy versus the corresponding logarithmic intensity of the beam will allow calculation of the linear attenuation coefficient. The narrow beam geometry will then be replaced by the broad beam geometry to determine the buildup factor. Additional radiation is obtained through the broad beam geometry as a result of scattering and secondary radiation. Comparing the broad beam geometry to the narrow beam geometry allows determination of the buildup factor. Since the buildup factor depends upon the thickness of the MCP-96 attenuator, the energy of the beam, and the source-to-attenuator (STA) distance, it will be calculated using three parameters. It will be calculated as a function of thickness of MCP-96 alloy by using various thicknesses of the alloy; as a function of the energy of the incident radiation beam by using several sources with different beam energies; and finally, as a function of the source-to-attenuator distance by changing the position of the MCP-96 attenuators. / Department of Physics and Astronomy

The goal of this research is to present a framework to accelerate the execution of software legacy systems without having to redesign them or limit future changes. The speedup is accomplished through hardware acceleration, based on a semi-automatic infrastructure which supports design decisions and simulate their impact. Many programs are available for translating code written in C into VHDL (Very High Speed Integrated Circuit Hardware Description Language). What is missing is simpler and more direct strategies to incorporate encapsulatable portions of the code, translate them to VHDL and to allow the VHDL code and the C code to communicate through a flexible interface. SHARP is a streamlined, easily understood infrastructure which facilitates this process in two phases. In the first part, the SHARP GUI (An interactive Graphical User Interface) is used to load a program written in a high level general purpose programming language, to scan the code for SHARP POINTs (Portions Only Including Non-interscoping Types) based on user defined constraints, and then automatically translate such POINTs to a HDL. Finally the infrastructure needed to co-execute the updated program is generated. SHARP POINTs have a clearly defined interface and can be used by the SHARP scheduler. In the second part, the SHARP scheduler allows the SHARP POINTs to run on the chosen reconfigurable hardware, here an FPGA (Field Programmable Gate Array) and to commu- nicate cleanly with the original processor (for the software). The resulting system will be a good (though not necessarily optimal) acceleration of the original software application, that is easily maintained as the code continues to develop and evolve. / Graduate

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