The effects of caffeine (250 mg) and placebo on healthy controls were studied in a double-blind, cross over study on 24 healthy subjects who performed a working memory n-back task. Reaction time and accuracy levels were tested using the n-back working memory measure in cognitive neuroscience. An experimental study tested on the 1, 2 and 3-back tasks under the placebo/coffee condition. Based on the empirical results obtained in this thesis it can be concluded that changes produced by caffeine ingestion support the hypothesis that caffeine acts as a stimulant. However, it cannot be proven that the stimulant translates into enhanced motor processes with an improvement in performance.

The experiments reported within this thesis use psychophysical techniques to examine the factors which determine perceived multisensory timing in humans. Chapters 1 and 2 describe anatomical and psychophysical features of temporal processing, respectively, whilst Chapter 3 introduces the reader to psychophysical methods. Chapter 4 examines the relationship between two measures of sensory latency, reaction time (RT) and crossmodal temporal order judgment (TOJ). Despite task and attentional manipulations the two measures do not correlate, suggesting that they measure some fundamentally different aspect(s) of temporal perception. Chapter 5 examines the effects of adaptation to asynchronous stimulus pairs on perceived audiovisual (AV), audiotactile (AT) and visuotactile (VT) temporal order. Significant temporal shifts are recorded in all three conditions. Evidence is also presented showing that crossmodal TOJs are intransitive. Chapter 6 shows that concurrent adaptation to two sets of asynchronous AV stimulus pairs causes perceived AV temporal order to recalibrate at two locations simultaneously, and that AV asynchrony adaptation effects are significantly affected by observers' attention during adaptation. Finally, Chapter 7 shows that when observers are accustomed to a physical delay between motor actions and sensory events, an event presented at a reduced delay appears to precede the causative motor action. The data are well-described by a simple model based on a strong prior assumption of physical synchrony between motor actions and their sensory consequences.

The experiments reported within this thesis use psychophysical techniques to examine the factors which determine perceived multisensory timing in humans. Chapters 1 and 2 describe anatomical and psychophysical features of temporal processing, respectively, whilst Chapter 3 introduces the reader to psychophysical methods. Chapter 4 examines the relationship between two measures of sensory latency, reaction time (RT) and crossmodal temporal order judgment (TOJ). Despite task and attentional manipulations the two measures do not correlate, suggesting that they measure some fundamentally different aspect(s) of temporal perception. Chapter 5 examines the effects of adaptation to asynchronous stimulus pairs on perceived audiovisual (AV), audiotactile (AT) and visuotactile (VT) temporal order. Significant temporal shifts are recorded in all three conditions. Evidence is also presented showing that crossmodal TOJs are intransitive. Chapter 6 shows that concurrent adaptation to two sets of asynchronous AV stimulus pairs causes perceived AV temporal order to recalibrate at two locations simultaneously, and that AV asynchrony adaptation effects are significantly affected by observers¿ attention during adaptation. Finally, Chapter 7 shows that when observers are accustomed to a physical delay between motor actions and sensory events, an event presented at a reduced delay appears to precede the causative motor action. The data are well-described by a simple model based on a strong prior assumption of physical synchrony between motor actions and their sensory consequences.

First-person shooter (FPS) games are frequently associated with immersion due to their use of a first-person perspective camera, which gives players the impression that they are a part of the game world. When combined with the proteus effect and identification, players can achieve a complete sense of immersion in the character they are portraying. The objective of this study is to delve into the cognitive benefits of engaging in FPS games and to establish a correlation between the level of immersion and cognitive transfer. The data collected from participants who completed reaction tasks were analyzed in conjunction with the IEQ (Immersive experience questionnaire) scores. The IEQ provided quantitative data on immersion. By assessing the participants' cognitive abilities based on their reaction task performance, the study found that playing FPS games can improve accuracy but not affect reaction time. Furthermore, the study found no correlation between immersion and cognitive transfer.

Nous avons étudié les effets de la baisse de la vigilance sur les mécanismes de contrôle de l'erreur lors d'une tâche de temps de réaction de choix (TR). Lors de la première expérience, la baisse de vigilance a été obtenue par un éveil prolongé de 26 heures. Dans les expériences deux et trois, on a diminué le niveau de vigilance par voie pharmacologique en choisissant de n'affecter qu'une des voies neurochimiques impliquées dans l'éveil (voie histaminergique puis voie dopaminergique) pour déterminer si les indices du contrôle de l'erreur seraient ou non affectés de la même façon qu'après un éveil prolongé. Si oui, cela supposerait un effet redondant des systèmes neurochimiques impliqués dans l'éveil sur le contrôle de l'erreur, dans le cas contraire, cela supposerait une influence spécifique de ces différents systèmes sur le contrôle de l'erreur. Le contrôle de l'erreur peut être décomposé en contrôle proactif et contrôle réactif. Ce contrôle de l'erreur est dit en ligne s'il opère au cours d'un essai, hors-ligne s'il s'opère d'un essai sur l'autre.La privation de sommeil affecte le contrôle de l'erreur proactif en ligne et le contrôle de l'erreur réactif. La baisse de l'activité histaminergique n'affecte que le contrôle de l'erreur réactif et on n'a pas mis en évidence d'effets de la déplétion dopaminergique sur le contrôle de l'erreur. Les effets observés sur le contrôle de l'erreur par la baisse de vigilance induite par la privation de sommeil n'étaient pas reproduits par la baisse de vigilance induite par les déplétions des activités dopaminergiques et histaminergiques, suggérant des influences spécifiques de ces deux voies sur le contrôle de l'erreur. / To study the impact of a vigilance decrease on error monitoring mechanisms in healthy participants, electromyogram and electroencephalogram were recorded during a choice reaction time task. The aim of experiment one was to decipher which indices of error monitoring at the behavioral and electrophysiological levels, were altered by sleep deprivation. In experiments two and three, decreases in vigilance were obtained through pharmacological treatments. We attempted to selectively inhibit one arousal system (either by acting on the histaminergic or on the dopaminergic pathway), so as to determine whether indices of error monitoring would be affected in the same way than after extended wakefulness. Proactive (implemented before an error execution) and reactive modes (implemented after an error execution) of error monitoring were distinguished. Within each mode, we further distinguished on-line (implemented within-trial) and off-line (between-trials) processes.Proactive off-line monitoring was unaffected by the decrease in vigilance, whether this caused by extended wakefulness, histaminergic depeltion or dopaminergic depletion). Sleep deprivation affected proactive on-line and off-line monitoring and reactive control. Histaminergic depletion affected only reactive control and reactive control seemed insensitive to dopaminergic depletion.As sleep deprivation, both histaminergic and dopaminergic depletion induced decrease in vigilance. However, effects of sleep deprivation on error monitoring were entirely reproduced neither by histaminergic nor by dopaminergic depletion, suggesting specific influences of the corresponding systems on error monitoring.