There is extensive research regarding the neural mechanisms that control satiety and meal termination; in contrast, there is very limited understanding of how the central nervous system regulates meal onset and thus the duration of the postprandial intermeal interval (ppIMI) and meal frequency. Based on emerging evidence, we hypothesize that dorsal hippocampal neurons, which are critical for episodic memory, form a memory of a meal and inhibit meal onset during the ppIMI. To test whether hippocampal neurons form a memory of a meal, we first determined that ingesting sucrose or isopreferred concentrations of the non-caloric sweetener saccharin increased the expression of the plasticity-related immediate early gene activity-regulated cytoskeleton-associated protein (Arc) in dorsal CA1 hippocampal (dCA1) neurons in Sprague-Dawley rats. Furthermore, repeated exposure to the sucrose meal attenuated the ability of the sucrose to induce Arc expression. Together, these data indicate that orosensory stimulation produced by a sweet taste is sufficient to induce synaptic plasticity in dCA1 neurons in an experience-dependent manner. Second, we showed that reversibly inactivating dorsal hippocampal neurons with infusions of the GABAA agonist muscimol after the end of a sucrose meal accelerated the onset of the next meal, indicating that dorsal hippocampal neurons inhibit meal onset. Lastly, using a clinically-relevant animal model of early life inflammatory injury, we found that neonatal injury (1) impairs hippocampal-dependent memory, (2) decreases the ppIMI and increases sucrose intake, (3) increases body mass, (4) attenuates sucrose-induced Arc expression in dCA1 neurons, and that (5) blocking inflammatory pain with morphine at the time of injury reverses the effects of injury on memory, energy intake and Arc expression. Collectively, the findings of this dissertation support the overarching hypothesis that dorsal hippocampal neurons inhibit meal onset during the ppIMI and suggest that dorsal hippocampal dysfunction may contribute to the development and/or maintenance of diet-induced obesity.

International students often desire to study overseas and many countries, including New Zealand, welcome them into their schools and universities. Students from Mainland China, one of the most populous countries in the world and, until quite recently closed to the rest of the world, have, in the past few years, made up the large majority of those who come to New Zealand to study. Those wishing to enter university after completing high school in China must acquire a specified level of English and successfully complete a two semester long Foundation Studies course, before being eligible for undergraduate study. Research into independent or self-regulated learning has shown that Western (mainly American) students are much more successful academically and enjoy their studies more if they are willing and able to self-regulate their learning. This research has occurred mostly in Western settings with Western participants. The present research using a mixed methods approach aimed to examine the self-regulated learning, epistemological beliefs, demographic factors and personality traits of Mainland Chinese students studying in the Foundation Studies course and to determine whether any of these factors appeared to have any appreciable effect on their experiences in the course and on their final outcomes. The research found that while no one specific factor seemed to determine experiences and outcomes, it would appear that personality characteristics of face, optimism and other Dependability scores may mediate factors such as ability (measured by grades), length of time in the country, self-regulated learning and motivational strategies (such as organisation, time management, effort regulation and self-efficacy), and previous independent learning to influence these experiences and outcomes. While it appears that the North American theory of self-regulated learning is applicable to these students, it seems that cultural beliefs may affect which self-regulatory factor is most salient in their academic outcomes. Further research would be valuable to clarify these differences.

The high dropout rate of first year students is a major source of concern for the Department of Higher Education and Training and for Higher Education Institutions (HEI’s). Research indicated that students’ Self-Regulated Learning (SRL) skills and strategies play a significant role in achieving academic success at universities. Thus, the main aim of this study was to develop strategies for the development of SRL skills of first year university students. In order to achieve the research aim and objectives an extensive literature review was conducted on SRL and the relationship between SRL skills and the academic achievement of students at HEI’s. For the purposes of the empirical investigation, a mixed-method approach was followed. In the quantitative part of the investigation, the results of the Learning and Study Strategies Inventory (LASSI), which was administered to the 2007 cohort of first year students (n=2421) at the Potchefstroom Campus of the North-West University, were analysed to determine whether the subscales in the LASSI significantly predicted academic success and to identify variables that related to the first year students’ learning and study skills and academic achievement. In the qualitative part of the research, interviews were conducted during 2010, with a selected group of participants from the 2007 cohort of first year students who were then in their fourth year of study. The questions in the interviews were based on questions in the Self-Regulated Learning Inventory Schedule (SRLIS), and the aims were to explore the participants’ experiences with their studies and to determine which SRL skills, in addition to the skills assessed by the LASSI, influenced their studies and academic achievement. The quantitative analysis of the LASSI results revealed that: • Motivation, Time management and Information processing were the best LASSI predictors of the first year students’ academic success. • The independent biographical variables Grade 12 marks, age and gender correlated better with the first year students’ academic achievement than the LASSI subscales did. The qualitative investigation revealed that: • Successful students realised at the onset of their studies that they had to adapt their study methods to meet the challenges that studying at a university requires. • Successful students could differentiate between the different types of study material and could adapt their study methods accordingly. They could also adapt their study methods when the volume of the study material differed. • Successful students applied a repertoire of study methods in a flexible manner, and managed their time well. • Successful students conveyed knowledge of themselves as students, as well as of the different requirements that study at a university implicates. • Most of the successful students received information from parents, lecturers or principals about different study methods and could describe their learning styles and preferences clearly. • Some of the successful students could accurately infer which questions could be expected in the exam papers, and knew how and why these questions were asked. • Successful students set realistic academic goals for themselves. • Unsuccessful students did not consider their own study preferences or the academic requirements of the university. • Unsuccessful students did not manage their time well and were not motivated. On the basis of the findings, strategies were proposed for the development of SRL skills of first year students at universities. The strategies are presented as a compulsory programme that first year students have to complete in the first semester. / Thesis (PhD (Teaching and Learning))--North-West University, Potchefstroom Campus, 2012

Identifying how policy proposals are selected by policy-makers is an important question for scholars. This thesis evaluates the use of discourse and the role of actors in the exchange of ideas to support interprofessional collaboration (IPC) among Ontario’s regulatory colleges. A variation of discourse analysis was developed, based on the seven areas of reality that are constructed by language, to evaluate the interactions between state and policy actors. I argue that actors did not appear to engage in meaningful discourse because the state established the parameters of the consultative processes, which suggests the expert consultative processes were tools to legitimize the policy process for Bill 179. The state appears to have increasingly greater control of both the content and context of policy- making in this field. Further evaluation of the interactions between health professional organizations and the state is needed to better understand the importance of discourse in the health policy process.

The high dropout rate of first year students is a major source of concern for the Department of Higher Education and Training and for Higher Education Institutions (HEI’s). Research indicated that students’ Self-Regulated Learning (SRL) skills and strategies play a significant role in achieving academic success at universities. Thus, the main aim of this study was to develop strategies for the development of SRL skills of first year university students. In order to achieve the research aim and objectives an extensive literature review was conducted on SRL and the relationship between SRL skills and the academic achievement of students at HEI’s. For the purposes of the empirical investigation, a mixed-method approach was followed. In the quantitative part of the investigation, the results of the Learning and Study Strategies Inventory (LASSI), which was administered to the 2007 cohort of first year students (n=2421) at the Potchefstroom Campus of the North-West University, were analysed to determine whether the subscales in the LASSI significantly predicted academic success and to identify variables that related to the first year students’ learning and study skills and academic achievement. In the qualitative part of the research, interviews were conducted during 2010, with a selected group of participants from the 2007 cohort of first year students who were then in their fourth year of study. The questions in the interviews were based on questions in the Self-Regulated Learning Inventory Schedule (SRLIS), and the aims were to explore the participants’ experiences with their studies and to determine which SRL skills, in addition to the skills assessed by the LASSI, influenced their studies and academic achievement. The quantitative analysis of the LASSI results revealed that: • Motivation, Time management and Information processing were the best LASSI predictors of the first year students’ academic success. • The independent biographical variables Grade 12 marks, age and gender correlated better with the first year students’ academic achievement than the LASSI subscales did. The qualitative investigation revealed that: • Successful students realised at the onset of their studies that they had to adapt their study methods to meet the challenges that studying at a university requires. • Successful students could differentiate between the different types of study material and could adapt their study methods accordingly. They could also adapt their study methods when the volume of the study material differed. • Successful students applied a repertoire of study methods in a flexible manner, and managed their time well. • Successful students conveyed knowledge of themselves as students, as well as of the different requirements that study at a university implicates. • Most of the successful students received information from parents, lecturers or principals about different study methods and could describe their learning styles and preferences clearly. • Some of the successful students could accurately infer which questions could be expected in the exam papers, and knew how and why these questions were asked. • Successful students set realistic academic goals for themselves. • Unsuccessful students did not consider their own study preferences or the academic requirements of the university. • Unsuccessful students did not manage their time well and were not motivated. On the basis of the findings, strategies were proposed for the development of SRL skills of first year students at universities. The strategies are presented as a compulsory programme that first year students have to complete in the first semester. / Thesis (PhD (Teaching and Learning))--North-West University, Potchefstroom Campus, 2012

Syftet med uppsatsen var att studera de olika problemtyper, lösningsstrategier och samarbetsformer som användes i grundskolans årskurs 4-6 vid arbete med problemlösning i matematik. För att genomföra studien observerades tre olika klasser; en årskurs 4, en årskurs 5 och en årskurs 6. Lärarna i respektive klass intervjuades för att undersöka tankarna bakom den undervisning de bedrev.   De sorters problem eleverna arbetade med varierade och det gjorde även strategierna som de använde. De strategier som var mest frekvent förekommande var emellertid att rita bilder, gissa och pröva samt att välja en eller flera operationer att arbeta med.   Eleverna arbetade både enskilt, i mindre grupper och i helklass när de arbetade med problemlösning. Helst skulle alla dessa tre delar tillgodoses, ansåg flera av de intervjuade lärarna. / The purpose of this thesis was to study the different types or problems, strategies for solving and forms of cooperation used in Swedish elementary school grades 4-6 when working with problem solving in mathematics. Three different grades were studied in this thesis; one 4th grade, one 5th grade and one 6th grade. The teachers in each class were interviewed to study the ideas behind the teaching methods they were using.   The types of problems students worked with varied and so did the strategies that they used. The most frequent strategies, however, was to draw pictures, guess and try and select one or several operations to work with.   The students worked individually, in small groups and everyone in the class together, when they solved problems. Several of the interviewed teachers wanted all of these three forms of learning to be part of their teaching.

The study examined how 5 adult Korean learners of English developed self-regulated learning (SRL) skills to overcome lexical problems in their English writing. Empirical studies have consistently shown that many of the greatest problems for ESL learners in writing are lexical in nature. The goal of the present study was to help participants to address these problems, first through tutored assistance and then more independently by controlling their uses of strategies through planning, monitoring, and evaluation processes. The study involved two phases: Phase 1 was exploratory in nature, in which I attempted to identify typical lexical problems Korean learners of English encounter in writing. Phase 2 included an intervention in the form of one-on-one tutoring that followed the cyclic model of SRL proposed by Zimmerman, Bonner, and Kovach (1996). I worked with 5 participants through the SRL cycle individually as they wrote and revised 3 argumentative essays. The intervention lasted for 9 weeks, focusing on developing the participants’ SRL skills in writing through the use of various strategies that were devised in Phase 1 and refined throughout Phase 2. I analyzed the participants’ difficulties and uses of strategies, self-ratings on their essays, and several measures of essay quality to examine changes in their SRL skills, self-efficacy, and writing skills. The participants initially encountered various types of difficulties in their English writing and primarily relied on self-employed strategies to cope with their difficulties. Over the course of the intervention, the participants’ attention to their difficulties and uses of various linguistic resources became progressively more focused and specific. Initially, the participants largely depended on their L1 to write their L2 essays, being chiefly occupied with the grammatical encoding of their communicative intentions. Subsequently, the participants displayed unique patterns in developing their SRL skills, which exerted positive influences on building their self-efficacy beliefs as writers and on improving the quality of their essays. Based on these findings, I emphasize the growing need for L2 writing teachers to incorporate language-focused, vocabulary-centered, and corpora-based instruction into their teaching practices. In turn, students require individual support and untimed writing tasks to develop SRL skills in writing.

Developmentally regulated G-proteins (DRGs) are a highly conserved family of GTP binding proteins found in archaea, plants, fungi and animals. Their function is poorly understood but they are implicated in cell division, proliferation, and growth, as well as several human medical conditions. The research reported here has utilised a variety of approaches including structural biology, biochemistry, expression profiling, and mutant analysis in order to investigate the cellular function of DRG proteins in plants. Recombinant, biologically active atDRG1 and atDRG2 protein from Arabidopsis thaliana was purified using in vitro refolding and was used in both structural studies and biochemical analysis. Crystallographic studies were carried out for both atDRG1 and atDRG2 across 3840 unique, independent crystallisation conditions for each protein. Heterogeneous nucleation was also used in a separate crystallography screen in order to induce nucleation and subsequent crystal growth however no diffraction quality protein crystal were produced in this study. The nucleotide binding and hydrolysis properties of recombinant atDRG1 and atDRG2 were measured in vitro, representing the first biochemical characterisation of DRG proteins. Both atDRG1 and atDRG2 were found to bind GDP and GTP in vitro without the assistance of exogenous exchange or activation factors. The Kcat for GTP hydrolysis by atDRG1 and atDRG2 was found to be 7.44 x 10-4 min-1 and 1.18 x 10-3 min-1 respectively which is consistent with proteins related to the DRG subfamily. An Arabidopsis thaliana atDRG2a knockout mutant was identified and characterised in this study as well representing the first DRG knockout mutant in a multicellular organism. We found that complete knockout of atDRG2a is not lethal in Arabidopsis and that the nearly identical atDRG2b protein is not upregulated in response to an absence of atDRG2a in the cell. The mutant did not display an obvious phenotype compared to wild-type. The expression profiles of the three Arabidopsis thaliana drg genes, drg1, drg2a, and drg2b, were characterised using drg promoter:GUS Arabidopsis transgenics and revealed several interesting features. Under normal conditions, drg1 and drg2a transcripts are present in all cells whilst drg2b transcripts are undetectable. When heat stress is applied, drg2b and drg1 are specifically up regulated and drg2a is not. During seed imbibition, drg2a and drg1 are specifically upregulated whilst drg2b is not. The expression pattern of the drg family closely mirrors that of chaperone/heat shock proteins and this would agree with previous research that suggests that DRG2a may perform a chaperone role. The ability of DRGs to bind nucleotides without assistance, their slow rate of GTP hydrolysis, heat stress activation, abundance in seeds, cytosolic localization, and domain conservation, all agree with the models proposed for spoOB associated G-protein (Obg) function, whereby Obgs stabilise or refold ribosomes or other proteins in response to stress. It is possible that DRGs perform a similar and complementary function to Obgs, specifically during heat stress, despite the low level of sequence conservation between Obgs and DRGs.

abstract: Community college students are attracted to courses with alternative delivery formats such as hybrid courses because the more flexible delivery associated with such courses provides convenience for busy students. In a hybrid course, face-to-face, structured seat time is exchanged for online components. In such courses, students take more responsibility for their learning because they assume additional responsibility for learning more of the course material on their own. Thus, self-regulated learning (SRL) behaviors have the potential to be useful for students to successfully navigate hybrid courses because the online components require exercise of more personal control over the autonomous learning situations inherent in hybrid courses. Self-regulated learning theory includes three components: metacognition, motivation, and behavioral actions. In the current study, this theoretical framework is used to examine how inducing self-regulated learning activities among students taking a hybrid course influence performance in a community college science course. The intervention for this action research study consisted of a suite of activities that engage students in self-regulated learning behaviors to foster student performance. The specific SRL activities included predicting grades, reflections on coursework and study efforts in course preparation logs, explanation of SRL procedures in response to a vignette, photo ethnography work on their personal use of SRL approaches, and a personalized study plan. A mixed method approach was employed to gather evidence for the study. Results indicate that community college students use a variety of self-regulated learning strategies to support their learning of course material. Further, engaging community college students in learning reflection activities appears to afford some students with opportunities to refine their SRL skills and influence their learning. The discussion focuses on integrating the quantitative and qualitative data and explanation of the findings using the SRL framework. Additionally, lessons learned, limitations, and implications for practice and research are discussed. Specifically, it is suggested that instructors can foster student learning in hybrid courses by teaching students to engage in SRL processes and behaviors rather than merely focusing on delivery of course content. Such SRL behaviors allow students to exercise greater control over the autonomous learning situations inherent in hybrid courses. / Dissertation/Thesis / Ed.D. Leadership and Innovation 2013

The emergence of new trends sometimes carries the risk that established, well-proven concepts rooted in other disciplines are not properly integrated into new approaches. As Learning Analytics seems to be evolving into a highly multidisciplinary field, we would like to demonstrate the importance of embedding classic theories and concepts into a Learning Analytics, system-data-driven setting. Our results confirm that classical factors that are operationalized with the help of system-generated data outperform more recent survey-based models. Therefore, we want to stress the point that system-generated data should not be left behind in the quickly evolving field of Learning Analytics.