201 |
The Effect of Alendronate and Risedronate on Bone Remodeling in the Canine MaxillaCallegari, Brent Joseph January 1999 (has links)
Indiana University-Purdue University Indianapolis (IUPUI) / Bisphosphonates, effective inhibitors of bone resorption, are used in the treatment of postmenopausal osteoporosis. At present, the effects of bisphosphonate therapy on the maxilla have not been quantitatively studied. As part of the masticatory system, dentate alveolar bone is exposed to a unique pattern of loading. As such, data obtained from bisphosphonate studies of other bones may not be applicable to the cortical bone of the dentate maxilla. The objective of this study is to histomorphometrically quantify the effects of alendronate and risedronate therapy on alveolar bone of the dog maxilla (MX) and to determine if this site is affected differently than the cortical bone in the rib (R) from these same animals. Twenty-two female dogs were divided into three treatment groups of 1 mg/kg/day alendronate, 0.5 mg/kg/day risedronate, and a saline vehicle control. Fluorochrome labels were used to mark sites of bone formation. Maxillary and rib specimens from each dog were prepared for analysis of static and dynamic histomorphometric parameters. MX cortical bone surrounding the third premolar was further analyzed by side (buccal vs. lingual) and region (coronal vs. apical). Mineralizing surface (MS/BS) and bone formation rate (BFR) in the coronal maxilla of the control group is significantly (p < 0.05) higher than that of the bisphosphonate groups. In bisphosphonate treated animals, MS/BS, BFR, and activation frequency (AcF) were significantly (p < 0.05) higher in the R than in the MX. In all treatment groups, very little osteoid was detected, and no significant difference in the mineral apposition rate (MAR) was noted. These results indicate that: (1) bisphosphonate dosages used in this study effectively inhibited remodeling within the dog maxilla; (2) alveolar bone remodeling was decreased more than remodeling in rib cortical bone; (3) within the dentate maxilla, alveolar bone remodeling was decreased more in the coronal than in the apical region, and (4) none of the groups appears to show inhibition of mineralization.
|
202 |
Educational Video Impact On College Student Knowledge, Opinions, And Referral Attitudes Regarding Attention-Deficit/Hyperactivity DisorderPritchard, Nichol Frances 13 December 2008 (has links)
The interaction of osteoclasts and osteoblasts regulates bone density and the maintenance of osseointegration of implants. To investigate osteoblastic response to strain, rat osteosarcoma cells were cultured on titanium plates and subjected to one of three treatments: a neutral control (0 microstrain), tension (1000 microstrain), and compression (1000 microstrain). Treatments were applied via 4 point bending for fifteen minutes each day to a strain of 1mm/m at a sinusoidal frequency of 1Hz. Cells were measured for DNA as indicator of proliferation, alkaline phosphatase as indicator of phenotype and total protein and calcium deposition as indicators of matrix formation. Results indicated that DNA and total protein differed significantly between treatments. The alkaline phosphatase levels and calcification of matrix did not. The differences in the levels of DNA indicate different growth patterns between treatments. The total protein levels imply distinctions in matrix deposition. The alkaline phosphatase and calcium levels did not vary significantly, implying no difference in bone-specificity or calcification.
|
203 |
Investigation of the Molecular Function of CHD7, the Protein Implicated in CHARGE Syndrome, Using Next-Generation GenomicsSchnetz, Michael Paul January 2010 (has links)
No description available.
|
204 |
Exploring the Role and Therapeutic Potential of Gbeta/gamma-GRK2 Inhibition in Cardiac Fibroblasts, Fibrosis and RemodelingTravers, Joshua G. January 2017 (has links)
No description available.
|
205 |
A Critical Role for Eosinophils and CCR3 Signal Transduction in Allergic Airway DiseaseFulkerson, Patricia C. 28 September 2005 (has links)
No description available.
|
206 |
The Role of Type VI Collagen In Cardiac Remodeling Following Myocardial Infarction In Mice.Luther, Daniel J. 12 August 2013 (has links)
No description available.
|
207 |
Radiographic, Computed Tomographic, And Histologic Study Of Central Tarsal Bone Fractures In Racing GreyhoundsBergh, Mary Sarah 09 September 2008 (has links)
No description available.
|
208 |
Bone Remodeling Surrounding Primary Teeth in the Maxilla and Mandible of Skeletally Immature DogsRandall, Letitia E. 23 August 2010 (has links)
No description available.
|
209 |
Brg1 is required to maintain colorectal cancer stem cells / Brg1は大腸癌幹細胞の維持に必要であるYoshikawa, Takaaki 23 March 2022 (has links)
京都大学 / 新制・課程博士 / 博士(医学) / 甲第23797号 / 医博第4843号 / 新制||医||1058(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 川口 義弥, 教授 藤田 恭之, 教授 小濱 和貴 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM
|
210 |
Pennsylvania Station: a system of reuseRuppel, Barbara Spillers January 1984 (has links)
The purpose of this thesis is to examine the possibilities for the revitalization of an abandoned railroad station and to derive from the project significant issues and strategies which can be applied to any reuse project. / Master of Architecture
|
Page generated in 0.0815 seconds