The focus of the research described in this section of the thesis is the synthesis of compounds expected to bind strongly to both the estrogen β and α receptors and act as estrogen agonists. Based on earlier results in our group and docking studies we prepared a series of A-CD analogs, compounds 1, in which the usual 13-methyl group was replaced by an ethyl group. Docking studies also indicated that substituents at C8 could lead to enhancement of binding to the estrogen receptor. With this in mind two such derivatives, compounds 2 were prepared. A major concern in the use of estradiol in hormone replacement therapy is its potential metabolism of dangerous ortho-quinones. The 1,2-naphthalenediol derivatives 3 avoid this possibility. They were predicted to be potent binders to the estrogen receptors with the naphthalene diol portion serving as rings A and B and the hydroxyl group taking the place of the 17-OH group of estradiol. The preparation of several derivatives of 2 is reported. The estrogen receptor binding [ERB] relative to estradiol as standard has been determined at the University of Illinois for a number of the compounds prepared in this thesis. Unfortunately, the results were not as encouraging as expected. Importantly, all of the 13-ethyl derivatives tested showed lower binding affinity compared to the 13-methyl analogs. Similarly, the derivatives with substituents at C8 do not show higher activity than those having only hydrogens at C8. Finally, the situation with the naphthalene derivatives is, at this stage, still not completely resolved. The binding for the compounds thus tested is quite low, but it must be admitted that the structures thus far synthesized have a much lower LogP than estradiol, a factor known to greatly decrease the binding constants to the estrogen receptors.

The focus of the research described in this section of the thesis is the synthesis of compounds expected to bind strongly to both the estrogen β and α receptors and act as estrogen agonists. Based on earlier results in our group and docking studies we prepared a series of A-CD analogs, compounds 1, in which the usual 13-methyl group was replaced by an ethyl group. Docking studies also indicated that substituents at C8 could lead to enhancement of binding to the estrogen receptor. With this in mind two such derivatives, compounds 2 were prepared. A major concern in the use of estradiol in hormone replacement therapy is its potential metabolism of dangerous ortho-quinones. The 1,2-naphthalenediol derivatives 3 avoid this possibility. They were predicted to be potent binders to the estrogen receptors with the naphthalene diol portion serving as rings A and B and the hydroxyl group taking the place of the 17-OH group of estradiol. The preparation of several derivatives of 2 is reported. The estrogen receptor binding [ERB] relative to estradiol as standard has been determined at the University of Illinois for a number of the compounds prepared in this thesis. Unfortunately, the results were not as encouraging as expected. Importantly, all of the 13-ethyl derivatives tested showed lower binding affinity compared to the 13-methyl analogs. Similarly, the derivatives with substituents at C8 do not show higher activity than those having only hydrogens at C8. Finally, the situation with the naphthalene derivatives is, at this stage, still not completely resolved. The binding for the compounds thus tested is quite low, but it must be admitted that the structures thus far synthesized have a much lower LogP than estradiol, a factor known to greatly decrease the binding constants to the estrogen receptors.

Abstract Since Mar. 1995, the National Health Insurance begin in Taiwan, the payment of health insurance gradually increase each year. For controlling the increasing costs, case payment was the most important method. For each hospital, using clinical pathway to control costs of case payment was an effective tool. But, there were still less literatures to discuss the efficiency of clinical pathway in Taiwan. We used a retrospective study design, to examine the length of stay, total costs and quality including the complications, morbidity and readmissions for total knee replacement surgery. The data before clinical pathway was from June 2001 to May 2002, total 219 cases. After clinical pathway, the data was from Jan. 2003 to Dec. 2003, total 207 cases. The results showed decrease length of stay from 7.4 to 6.6 days (10.8%), decrease total cost from 125,324 NTS to 119,100 NTS (4.97%) and the quality of complications and readmissions did not increase. In conclusion, the clinical pathway can improve length of stay, total costs and quality. Key words: case payment, clinical pathway, total knee replacement

Thesis (M.S.)--Ohio State University, 2008. / Title from first page of PDF file. Includes bibliographical references.

Thesis (M.S.)--West Virginia University, 2002. / Title from document title page. Document formatted into pages; contains vii, 79 p. : ill. Includes abstract. Includes bibliographical references (p. 71-79).

Thesis PlanB (M.S.)--University of Wisconsin--Stout, 2009. / Includes bibliographical references.

Thesis--M. Phil., University of Hong Kong, 1979. / Xeorx copy of typescript.

The Aztec empire emerged in AD 1428 as a result of the triple alliance among the city-states of Tenochtitlan, Texcoco, and Tlacopan. Although it is well documented that the Aztecs conquered numerous polities in the Basin of Mexico over the next 100 years, the demographic consequences of this expansion remain unclear. At the influential Otomi city-state of Xaltocan, for example, colonial documents suggest that the Aztec conquest led to a replacement of the original Otomi population, whereas archaeological finds suggest that a significant portion of the original population may have remained at the city under Aztec rule. To help resolve questions about Xaltocan’s population history during this period, I extracted ancient DNA from 21 individuals that can be divided into two temporal subpopulations (roughly predating and postdating the hypothesized replacement event). I determined mitochondrial DNA haplogroups through RFLP analyses and constructed haplotypes based on 372 bp of HVR1 sequence. Statistical analyses show significant differences between the mitochondrial composition of the two subpopulations. Altogether, the results of this study support the hypothesis that matrilines at Xaltocan underwent a significant replacement event following the Aztec conquest, and they suggest that the Aztec expansion may have had a substantial genetic impact on certain Mesoamerican populations. / text

Stambiųjų sąnarių endoprotezavimas – viena sėkmingiausių operacijų ortopedijoje, sumažinanti pažeisto sąnario skausmus, atstatanti jo funkciją bei ekonomiškai efektyvi. Tačiau vien tik operacinis gydymas neužtikrina gerų rezultatų, tinkama pooperacinė reabilitacija padeda grąžinti ligoniui savarankiškumą. Skausmas ir nerimas stipriai veikia pooperacinį judėjimo funkcijų atsikūrimą bei pacientų fizinę ir psichinę gerovę, todėl svarbu sudaryti veiksmingą kineziterapijos programą, kuri sumažintų neigiamą šių veiksnių įtaką reabilitacijos kokybei. Krioterapija – efektyvus, tačiau mažai mokslininkų tirtas būdas skausmui po šios operacijos malšinti. Atsipalaidavimo pratimai – būdas sumažinti fizinę bei psichologinę įtampą, norint įveikti nerimą ir depresiją. Tyrimo tikslas. Nustatyti krioterapijos ir atsipalaidavimo pratimų poveikį pacientų skausmui, nerimui bei judėjimo funkcijai po kelio sąnario pakeitimo operacijų. Uždaviniai. 1. Įvertinti kineziterapijos poveikį pacientų skausmui, nerimui bei judėjimo funkcijai po kelio sąnario pakeitimo operacijų. 2. Įvertinti kineziterapijos, derinamos su krioterapija bei atsipalaidavimo pratimais, poveikį pacientų skausmui, nerimui bei judėjimo funkcijai po kelio sąnario pakeitimo operacijų. 3. Palyginti skirtingų kineziterapijos programų efektyvumą. Tyrimo hipotezė. Manome, kad kineziterapija derinama su krioterapija bei atsipalaidavimo pratimais yra efektyvesnė nei tradicinė kineziterapija atgaunant judėjimo funkcijas pacientams... [toliau žr. visą tekstą] / Endoprothesis replacement of a major joint is one of the most successful orthopaedic operations which relieves the pain of the affected joint, repairs its functions, and is economically effective. However, the surgical operation alone does not guarantee good results. An appropriate post-surgical rehabilitation helps return self-dependence to the patient. Pain and anxiety markedly affect the post-surgical recovery of motor functions as well as the patient’s physical and psychical well-being. Therefore, it is important to draw up an effective physical therapy programme which would reduce the influence of these factors on the rehabilitation quality. Cryotherapy is an effective, however, little examined by scientists’ way to relieve the pain after such surgical operations. Relaxation exercises are a way to lessen physical and psychological tension in order to overcome anxiety and depression. Research objective: To ascertain the influence of cryoptherapy and relaxation exercises on patients’ pain, anxiety and motor function after the endoprosthesis replacement of a knee joint. Tasks: 1. To evaluate the influence of physical therapy on patients’ pain, anxiety and motor function after the replacement of a knee joint. 2. To evaluate the influence of physical therapy combined with cryotherapy and relaxation exercises on patients’ pain, anxiety and motor function after the replacement of a knee joint. 3. To compare the effectiveness of different physical therapy programmes. Research... [to full text]

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