No description available.

The recent study by Cunningham, Lewis, Curnow, Glazner, and Massie [1] on the attitudes of respiratory physicians and clinic coordinators towards cystic fibrosis (CF) carrier screening drew several unsupported conclusions because the α level of 0.05 was not corrected for the large number of hypothesis tests conducted, leading to a Type 2 error and the acceptance of hypotheses that were likely false [2].

A recent study by Leonard, Lebecque, Dingemanse, and Leal [1] tested the effect of Miglustat, an alpha inhibitor on the cystic fibrosis conductance regulator gene using total chloride secretion in the nasal epithelium as the key variable estimated from basal nasal potential differences. The conclusion was drawn that “There was no evidence of a treatment effect on any nasal potential difference variable.” This conclusion may not be correct because of a slight misinterpretation of their statistical results. There also is a question of whether longer exposure periods than 8 days would have produced a more pronounced effect.

No description available.

No description available.

Thesis (D.P.H.)--University of Michigan, 1994.

Thesis (D.P.H.)--University of Michigan, 1994.

Respiratory tract infections are caused by different types of virus and bacteria and have become a global health issue. The detection and analysis of respiratory tract pathogens is nowadays performed commonly using PCR technology because of its high sensitivity. The aim of this study was to compare the performance of a new instrument, Starlet IVD with Maglead 12gC for extraction of nucleic acid from respiratory tract samples prior to real time PCR analysis. Frozen positive samples and fresh negative samples from patients were analyzed for respiratory viruses and respiratory bacteria. The samples were extracted on both Starlet IVD and Maglead 12gC. Real time PCR analysis was performed after the extraction to compare the performance between both instruments. A total of 44 virus samples were analyzed with Allplex respiratory panel 2 and 61 bacteria samples analyzed with Allplex respiratory panel 4. The result has shown an acceptable agreement of the PCR analysis (> 95%) for both panels between instruments. Starlet IVD has a higher Ct value compared to Maglead 12gC which led to a variation of 7,1% ± 3,6% in Ct value for Respiratory panel 2 and 10,1 % ± 5,3 % for Respiratory panel 4.  In conclusion, Starlet IVD is an automated instrument that will reduce hand-on-time, the risk of errors and improve the work routine for a better quality of results. Regardless the poor Ct-value, the new instrument has been able to detect almost all respiratory pathogens in the samples.

Fusafungine is an antibiotic of fungal origin with a potent local anti-inflammatory action (German-Fattal, 1995; German-Fattal, 1996). It is administered locally to the nasal and pharyngeal mucosa by spray. It can be hypothesised that the anti-inflammatory action of fusafungine may decrease the development of mucosa! inflammation in such a manner that the incidence of symptoms of upper respiratory tract infection may be reduced if it is administered before, during and after completion of an ultramarathon. Furthermore, fusafungine could also reduce the risk of secondary bacterial infection. The potential value of fusafungine in reducing the symptoms of upper respiratory tract infections or the development of bacterial upper respiratory infection is the focus of this thesis.

Diss. (sammanfattning) Linköping : Univ., 2004. / Härtill 5 uppsatser.