周邊注射安非它命能夠影響動物受試在表現與時間知覺有關的操作式制約行為作業，歷來被研究者認為是大腦多巴胺神經系統與動物時間知覺系統有關的主要證據之一。本研究所共同採用的研究方法為先注射多巴胺受體專屬拮抗劑再於大鼠受試周邊腹腔注射安非它命的方式探討安非它命影響大鼠時間知覺的大腦機制為何。實驗一利用區辨性增強低頻反應作業觀察周邊注射多巴胺受體專屬拮抗劑何者可以反制周邊安非它命對此作業的影響效果，結果發現多巴胺D1受體拮抗劑SCH23390與D2受體拮抗劑raclopride均可反制周邊安非它命的效果。實驗二同樣利用區辨性增強低頻反應作業，但是將SCH23390與raclopride分別注入海馬迴、背側中區紋狀體、腹側側邊紋狀體、依核、內側前額葉皮質以及腹側頂蓋區等六個部位，觀察何種多巴胺受體拮抗劑可在那些大腦部位產生反制周邊安非它命的效果。結果發現SCH23390可在海馬迴、依核、內側前額葉皮質以及腹側頂蓋區等四個部位產生反制周邊安非它命的效果，而raclopride可在腹側側邊紋狀體與內側前額葉皮質兩個部位產生同樣的反制效果。實驗三利用高峰時距作業觀察SCH23390在海馬迴與內側前額葉皮質是否能反制周邊安非它命對此作業的影響效果，結果發現SCH23390僅在海馬迴會影響大鼠受試的正常表現，特別是在與周邊安非它命同時注射的時候。綜合以上結果顯示，周邊注射安非它命能夠使大鼠受試在區辨性增強低頻反應作業當中表現出時間知覺變快的傾向，這個效果需要同時透過大腦內的海馬迴、依核、內側前額葉皮質以及腹側頂蓋區的多巴胺D1類受體和腹側側邊紋狀體與內側前額葉皮質的多巴胺D2類受體。 / The central dopaminergic system has been hypothesized to play a role in time perception based on the results that peripheral injections of d-amphetamine alter the responses in time-related operant conditioned behavioral tasks. The present study investigated the effect by injecting specific dopamine receptor antagonists before peripheral d-amphetamine injections in rats. Data from Experiment I showed that both peripheral the dopamine receptor D1 antagonist SCH23390 and D2 antagonist raclopride could attenuate the response alteration on differential reinforcement of low-rates responding task induced by peripheral d-amphetamine. By using the DRL task, Experiment 2 employed the microjeciton technique to determine the neural substrates for the DA receptor antagonist to attenuate the effect of peripheral d-amphetamine. The infusion sites for DA receptor antagonist were the hippocampus, the dorsomedial striatum, the ventrolateral striatum, the nucleus accumbens, the medial prefrontal cortex, and the ventral tegme ntal area. The results showed that SCH23390 infused into the hippocampus, the nucleus accumbens, the medial prefrontal cortex, the ventral tegmental area could attenuate the effect induced by peripheral d-amphetamine, and such attenuation effects were also observed for raclopride infused into the ventrolateral striatum, the medial prefrontal cortex. Experiment 3 tried to confirm the results of Experiment 2 by microinjecting SCH23390 in hippocampus and medial prefrontal cortex under peak-interval task. Only SCH23390 in the hippocampus altered the subject's normal performance in this task especially when combined with peripheral injection of d-amphetamine. In conclusion, that the response alteration on the DRL task induced by peripheral injection ofd-amphetamine suggests the subject's timing perception being accelerated. These effects of d-amphetamine were mediated by simultaneous activation of multiple dopamine receptor subtypes including D1 receptors located in the hippocampus, nucleus accumbens, medial pref rontal cortex, ventral tegmental area, as well as D2 receptors located in the ventrolateral striatum, medial prefrontal cortex.

A First Responding Officer plays a significant role at the crime scene. Failure to handle the crime scene in accordance with official directives such as the South African Police Service National Instruction 1 of 2015 and National Crime Combatting Forum Instruction 10 of 2015, which are regarded as guiding tools for the successful administration of a crime scene, may jeopardize a case. The crime scene is also regarded as the primary source of information that can assist the investigation. When the crime scene is handled in accordance with the SAPS official directives, the suspects can be more readily identified. Furthermore, the investigation can be concluded successfully whereby it may be beneficial for the community. / Mohlankedi wa maphodisa wa mathomo yo a fihlago lefelong la bosenyi o raloka tema ye bohlokwa fao tiragalong ya bosenyi. Go palelwa ke go laola tiragalo yeo ya bosenyi ka go latela ditaelo tsa semmuso tsa go swana le Taelo ya Bosetshaba ya bo 1 ya 2015 ya Tirelo ya Maphodisa ya Afrika Borwa (SAPS) le Taelo ya Bosetshaba ya bo 10 ya Seboka sa go Lwantsha Bosenyi ya 2015, e lego tseo di bonwago bjalo ka ditlabelo tseo di hlahlago maphodisa go laola tiragalo ya bosenyi ka katlego, go ka senya molato. Lefelo la bosenyi le lona le bonwa bjalo ka mothopo o bohlokwa wa tshedimoso wo o ka thusago dinyakisiso. Ge lefelo la bosenyi le ka laolwa go latela ditaelo tsa semmuso tsa SAPS, bagononelwa ba ka utollwa gabonolo. Godimo ga fao, dinyakisiso di ka phethwa ka katlego fao e lego gore se se ka hola setshaba. / Motlhankedi yo o tsibogang la ntlha o na le seabe sa botlhokwa kwa lefelong la bosenyi. Go retelelwa ke go diragatsa mo lefelong la bosenyi go ya ka dikaelo tsa semmuso di tshwana le Taelo ya Bosetshaba ya bo1 ya 2015 ya Tirelo ya Sepodisi sa Aforikaborwa (SAPS) le Taelo ya bo 10 ya 2015 ya Foramo ya Bosetshaba ya Twantsho ya Bosenyi, tse di tsewang e le didiriswa tsa kaelo tsa tsamaiso e e atlegileng ya lefelo la bosenyi, go ka nna matshosetsi mo kgetsing. Gape lefelo la bosenyi le tsewa e le motswedi wa ntlha wa tshedimosetso o o ka thusang ka dipatlisiso. Fa tiragatso ya mo lefelong la bosenyi e dirwa go ya ka dikaelo tsa semmuso tsa SAPS, go ka supiwa babelaelwa ka bonako. Mo godimo ga moo, dipatlisiso di ka konosediwa ka katlego mme seo se ka nna mosola mo baaging. / Criminology and Security Science / M. Tech. (Forensic Investigation)