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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
31

Seven Key Themes in Physical Therapy Advice for Patients Living With Subacromial Shoulder Pain: A Scoping Review

Meehan, Karen, Wassinger, Craig, Roy, Jean Sébastien, Sole, Gisela 01 June 2020 (has links)
Objective: To systematically scope the reported advice and education in physical therapy management of patients with subacromial shoulder pain, and to define key themes of the advice and education. Design: Scoping review. Literature Search: We searched MEDLINE, Scopus, Web of Science, and CINAHL, with publication dates from 2007 to September 2019. Study Selection Criteria: We included quantitative and qualitative research that reported on physical therapy interventions for subacromial shoulder pain. Data Synthesis: We performed a qualitative synthesis that identified items included in patient advice and education. Results: Of 89 original studies included, there were 61 randomized controlled trials; 5 prospective studies; 16 nonrandomized observational intervention studies or case series; and 7 surveys, audits of physical therapy patient records, and focus groups with physical therapists. We identified 7 key themes for advice and education: exercise intensity and pain response, activity modification advice, posture advice, pain self-management advice, pathoanatomical and diagnosis information, behavioral approaches, and pain biology advice. Conclusion: While advice focused predominantly on the local tissue pathology model, 10% of studies included information about pain neuroscience education, psychosocial factors, motor imagery, or behavior change.
32

Obesity and Rotator Cuff Tendonitis

Gupta, Miti 05 September 2008 (has links)
No description available.
33

Investigation of the Neuromuscular Control of the Shoulder When Performing Concurrent Upper Extremity Tasks

Hodder, Joanne N. 04 1900 (has links)
<p>The purpose of the thesis was to evaluate the neuromuscular control of shoulder muscles when performing concurrent shoulder and hand or elbow efforts in healthy and injured individuals. Of particular interest was the response of the supraspinatus and infraspinatus muscles to performing an additional hand task, such as gripping, while also performing different shoulder actions. Two studies were undertaken to provide the necessary groundwork for the subsequent two studies of this thesis. The first study investigated whether changes to shoulder muscle activity previously seen with gripping where the result of the novelty of using feedback to regulate grip force. This study found that changes in shoulder muscle activity with gripping are not diminished with repetition. The second study provided an improved method of normalizing electromyograms from dynamic contractions and was used in the subsequent studies of this thesis. Studies 3 and 4 of this thesis examined the response of shoulder muscles in healthy individuals during static sub-maximal efforts and maximal dynamic efforts in flexion and scapular planes with neutral and supinated forearm postures. Three conditions were tested in both studies: (i) no additional load, (ii) gripping to 30% of maximum and (iii) contracting the biceps to 30% of maximum. A prevailing theme found during sub-maximal contractions was individuality in neuromuscular recruitment strategies and precluded any significant effects of gripping or biceps contractions. During dynamic contractions, concurrent shoulder efforts with gripping and biceps contractions was found to significantly decrease deltoid, supraspinatus and infraspinatus muscle forces during flexion with supinated forearm posture. This thesis provided a thorough examination of shoulder electromyography in healthy individuals, improving our understanding of the neuromuscular control of the shoulder musculature. A common theme of this thesis was the individuality of neuromuscular strategies of the shoulder.</p> / Doctor of Science (PhD)
34

Retrospektive Analyse der subjektiven Patientenzufriedenheit nach Rotatorenmanschettenrekonstruktion anhand des Fragebogens SF-36 / Retrospective Analysis of subjective life quality after Rotator-cuff-repair by using SF-36

Üblacker, Kati 21 November 2011 (has links)
No description available.
35

Visuell bedömning av standardiserade armlyft efter rotatorkuffrupturoperation : En utvärdering av inter- och intrabedömarreliabilitet / Visual assessment of standardized arm lifts after rotator cuff rupture surgery : An evaluation of inter- and intra-rater reliability

Söderlund, Emelie, Peterson, Sofia January 2023 (has links)
Bakgrund: Rehabiliteringen efter en rotatorkuffrupturoperation är oftast lång och följer olika faser med hänsyn till senans inläkning. Behandlingsresultatet är multifaktoriellt och det rekommenderas att rehabiliteringen individanpassas. För att följa och utvärdera rehabiliteringsprocessen behövs funktionella axeltester. I dagsläget saknas reliabla och validerade funktionella axeltester under rehabiliteringens tidigare faser. Syfte: Syftet med denna studie är att undersöka reliabiliteten hos två standardiserade armlyft, Aktivt armlyft i flexion och Aktivt armlyft i skapulaplanet, med statiskt kvarhåll i 90° under 30 sekunder, för vuxna individer som genomgått enrotatorkuffrupturoperation för cirka tre månader sedan. Metod: Datainsamlingen utfördes i tre steg, först utfördes en videoinspelning av de standardiserade armlyften av två fysioterapeuter. Därefter utfördes två bedömningstillfällen av två andra fysioterapeuter. Videoinspelningarna, armlyften och bedömningarna utfördes enligt standardiserade protokoll. Inter- och intrareliabilitetsbedömningarna baserades på videoinspelningarna där de två bedömarna graderade patienternas förmåga att utföra de två standardiserade armlyften utifrån utfallsmåtten ”Klarar” eller ”Klarar ej”. Överensstämmelsen analyserades i IBM SPSS med Cohens Kappa. Resultat: Åtta manliga studiedeltagare i åldrarna 49–71 år (medelålder 59,4 år) deltog. Videoinspelningarna utfördes i genomsnitt 15,25 (±3,9) veckor efter operation. Den andra bedömningen genomfördes i genomsnitt 9 (±3,1) dagar efterförsta bedömningen. Resultatet visade att interbedömarreliabiliteten var ”God”(k=0,71) till ”Utmärkt” (k=1,00) och intrabedömareliabiliteten var ”Utmärkt”(k=1,00). Slutsats: Denna studie fann att inter- och intrabedömarreliabilitet var ”God” till”Utmärkt” gällande de två standardiserade armlyften. Resultatet bör tolkas med försiktighet på grund av det begränsade deltagarantalet och ingen säker slutsats kandras. Ytterligare forskning behövs för att fastställa klinisk betydelse. / Background: Rehabilitation after rotator cuff tear surgery is often long and follows different phases with consideration for tendon healing. The treatment result is multifactorial, and the rehabilitation is recommended to be individualized.vFunctional shoulder tests are of value and evaluate the rehabilitation process. Currently, reliable and validated functional shoulder tests are lacking during the earlier phases of rehabilitation. Purpose: The purpose of this study is to investigate the reliability of two standardized arm lifts, Active shoulder flexion and Active shoulder scaption, with astatic hold at 90° for 30 seconds, three months post-surgery. Method: Data collection was conducted in three steps. Starting with videorecordings of the standardized arm lifts by two physiotherapists. Followed by two assessment sessions with approximately one week apart, by two other physiotherapists. The video recordings, arm lifts, and assessments were performed according to standardized protocols. Inter- and intrarater reliability assessments were based on the video recordings. The examiners graded the patient’s ability to perform the two functional shoulder tests based on the outcomes "Approved" or "Non-approved". The agreement was calculated with IBM SPSS using Cohen's Kappa. Results: Eight men were included, 49-71 years (mean age 59,4 years). The videorecordings and the first evaluation were performed in mean 15,3 (±3,9) weeks postsurgery. The second evaluation was performed in mean 9,4 (±3,1) days after the first evaluation. The results showed that the interrater-reliability was “Good” (k=0,71) to“Excellent” (k=1,00), and the intrarater-reliability was “Excellent” (k=1,00). Conclusion: This study found that the inter- and intrarater reliability for the two standardized arm lifts were good to excellent. The limited number of participants requires caution with the interpretation of the results and no definitive conclusion can be drawn. Further research is needed to establish any clinical significance.
36

Validade e confiabilidade da ressonância magnética para o diagnóstico da rotura do tendão do subescapular / Validity and reliability of magnetic resonance imaging for the diagnosis of subscapularis tendon tear

Ramadan, Lucas Busnardo 19 September 2018 (has links)
INTRODUCÃO: A acurácia da ressonância magnetica (RM) para a detecção de rotura do subescapular apresenta ampla variação na literatura. Existem poucos estudos prospectivos e grande variação metodológica. Acredita-se que estas roturas sejam mais dificilmente diagnosticadas do que as posterossuperiores. O tendão do subescapular apresenta importância na biomecânica no ombro e sua rotura leva a prejuízo funcional. Uma ferramenta diagnóstica de boa acurácia é fundamental na prática clínica, influenciando o prognóstico e o planejamento cirúrgico. O objetivo deste estudo foi avaliar a validade da RM pre-operatória na identificação das roturas do subescapular, comparando os achados de imagem com os dados intra-operatórios de cirurgia artroscó pica. Como objetivo secundário, avaliamos a confiabilidade do método, por meio da concordância interobservador e intraobservador. MÈTODOS: Realizamos um estudo de acurácia diagnóstica comparando os achados da RM (teste índice) com os da artroscopia (teste de referência), em uma coorte prospectiva. Foram incluídos pacientes submetidos a artroscopia para tratamento de roturas do manguito rotador que houvessem realizado RM de alto campo magnético, sem uso de contraste. Foram excluídos casos de manipulacão cirúrgica pregressa no ombro, exames com artefatos de movimentação, indicação cirurgia por via aberta e intervalo entre a RM e procedimento cirúrgico superior a um ano. As imagens foram avaliadas por um cirurgião de ombro e dois radiologistas musculoesqueleticos, de maneira independente e cegos em relacão aos resultados da artroscopia, sendo reavaliadas apos 3 meses pelo cirurgião. Calculamos a validade (sensibilidade, especificidade, valor preditivo positivo, valor preditivo negativo e acurácia) e confiabilidade (concordancia inter e intraobservador) da RM em detectar roturas do subescapular. RESULTADOS: Avaliamos 200 ombros. A incidencia de roturas do subescapular foi de 69,5% (41,5% parciais e 28,0% transfixantes). O cirurgião de ombro apresentou sensibilidade de 51,1 a 59,0% e especificidade de 91,7% a 94,4%. Os radiologistas, 83,5 a 87,1% de sensibilidade e 41 a 45,9% de especificidade. A acura?cia variou de 60,5 a 73,0%. Os valores médios de sensibilidade, especificidade e acurácia foram 70,2%, 61,9% e 67,6%, respectivamente. A concordância interobservador foi moderada para a deteccao de roturas do subescapular (coeficiente kappa 0,463, IC 95% 0,383- 0,534, p < 0,001), assim como a intraobservador (coeficiente kappa 0,546, IC 95% 0,430-0,662, p < 0,001). Os pacientes com rotura do subescapular apresentaram maior incidencia de rotura e instabilidade do bíceps, maior degeneração gordurosa do subescapular e média de idade superior. As demais variáveis nao apresentaram diferenças estatisticamente significantes. CONCLUSAO: A RM de alto campo magneético sem contraste apresentou valores médios de sensibilidade, especificidade e acurácia de 70,2%, 61,9% e 67,6%, respectivamente. A sensibilidade foi superior nos radiologistas enquanto a especificidade no cirurgião de ombro. A concordância interobservador e intraobservador foi moderada / INTRODUCTION: The accuracy of magnetic resonance imaging (MRI) for the detection of subscapularis tear presents wide variation in the literature. There are few prospective studies and great methodological variation. It is believed that these tears are more difficult to diagnose than the posterosuperiores rotator cuff injuries. The subscapularis tendon has importance in the biomechanics in the shoulder and its rupture leads to functional impairment. A diagnostic tool of good accuracy is fundamental in clinical practice, influencing prognosis and surgical planning. The aim of this study was to evaluate the validity of preoperative MRI in the identification of the subscapularis tears, comparing the imaging findings with the intraoperative data of arthroscopic surgery. As a secondary objective, we evaluated the reliability of the method through interobserver and intraobserver agreement. METHODS: We performed a diagnostic accuracy study comparing MRI findings (index test) with those of arthroscopy (reference test), in a prospective cohort. We included patients submitted to arthroscopy for the treatment of rotator cuff tears that had undergone high magnetic field MRI without using contrast. Cases of previous surgical manipulation in the shoulder, exams with moving artifacts, indication for open surgery and interval between MRI and surgical procedure of more than one year were excluded. The images were evaluated by a shoulder surgeon and two musculoskeletal radiologists, independently and blinded to the results of arthroscopy, being reassessed after 3 months by the surgeon. We calculated the validity (sensitivity, specificity, positive predictive value, negative predictive value and accuracy) and reliability (inter- and intraobserver agreement) of MR in detecting subscapularis tears. RESULTS: We evaluated 200 shoulders. The incidence of subscapularis tears was 69.5% (41.5% partial and 28.0% transfixing). The shoulder surgeon showed sensitivity from 51.1 to 59.0% and specificity from 91.7% to 94.4%. The radiologists, 83.5 to 87.1% of sensitivity and 41 to 45.9% of specificity. Accuracy ranged from 60.5 to 73.0%. The mean values of sensitivity, specificity and accuracy were 70.2%, 61.9% and 67.6%, respectively. Interobserver agreement was moderate for the detection of subscapular tears (kappa coefficient 0.463, 95% CI 0.383-0.534, p < 0.001), as well as intraobserver agreement (kappa coefficient 0.546, 95% CI 0.430-0.662, p < 0.001). Patients with subscapular rupture had a higher incidence of biceps rupture and instability, greater fat subscapular degeneration, and higher mean age. The other variables did not present statistically significant differences. CONCLUSION: MRI of high magnetic field without contrast showed mean values of sensitivity, specificity and accuracy of 70.2%, 61.9% and 67.6%, respectively. Sensitivity was higher in radiologists while specificity in the shoulder surgeon. Interobserver and intraobserver agreement was moderate
37

Validade e confiabilidade da ressonância magnética para o diagnóstico da rotura do tendão do subescapular / Validity and reliability of magnetic resonance imaging for the diagnosis of subscapularis tendon tear

Lucas Busnardo Ramadan 19 September 2018 (has links)
INTRODUCÃO: A acurácia da ressonância magnetica (RM) para a detecção de rotura do subescapular apresenta ampla variação na literatura. Existem poucos estudos prospectivos e grande variação metodológica. Acredita-se que estas roturas sejam mais dificilmente diagnosticadas do que as posterossuperiores. O tendão do subescapular apresenta importância na biomecânica no ombro e sua rotura leva a prejuízo funcional. Uma ferramenta diagnóstica de boa acurácia é fundamental na prática clínica, influenciando o prognóstico e o planejamento cirúrgico. O objetivo deste estudo foi avaliar a validade da RM pre-operatória na identificação das roturas do subescapular, comparando os achados de imagem com os dados intra-operatórios de cirurgia artroscó pica. Como objetivo secundário, avaliamos a confiabilidade do método, por meio da concordância interobservador e intraobservador. MÈTODOS: Realizamos um estudo de acurácia diagnóstica comparando os achados da RM (teste índice) com os da artroscopia (teste de referência), em uma coorte prospectiva. Foram incluídos pacientes submetidos a artroscopia para tratamento de roturas do manguito rotador que houvessem realizado RM de alto campo magnético, sem uso de contraste. Foram excluídos casos de manipulacão cirúrgica pregressa no ombro, exames com artefatos de movimentação, indicação cirurgia por via aberta e intervalo entre a RM e procedimento cirúrgico superior a um ano. As imagens foram avaliadas por um cirurgião de ombro e dois radiologistas musculoesqueleticos, de maneira independente e cegos em relacão aos resultados da artroscopia, sendo reavaliadas apos 3 meses pelo cirurgião. Calculamos a validade (sensibilidade, especificidade, valor preditivo positivo, valor preditivo negativo e acurácia) e confiabilidade (concordancia inter e intraobservador) da RM em detectar roturas do subescapular. RESULTADOS: Avaliamos 200 ombros. A incidencia de roturas do subescapular foi de 69,5% (41,5% parciais e 28,0% transfixantes). O cirurgião de ombro apresentou sensibilidade de 51,1 a 59,0% e especificidade de 91,7% a 94,4%. Os radiologistas, 83,5 a 87,1% de sensibilidade e 41 a 45,9% de especificidade. A acura?cia variou de 60,5 a 73,0%. Os valores médios de sensibilidade, especificidade e acurácia foram 70,2%, 61,9% e 67,6%, respectivamente. A concordância interobservador foi moderada para a deteccao de roturas do subescapular (coeficiente kappa 0,463, IC 95% 0,383- 0,534, p < 0,001), assim como a intraobservador (coeficiente kappa 0,546, IC 95% 0,430-0,662, p < 0,001). Os pacientes com rotura do subescapular apresentaram maior incidencia de rotura e instabilidade do bíceps, maior degeneração gordurosa do subescapular e média de idade superior. As demais variáveis nao apresentaram diferenças estatisticamente significantes. CONCLUSAO: A RM de alto campo magneético sem contraste apresentou valores médios de sensibilidade, especificidade e acurácia de 70,2%, 61,9% e 67,6%, respectivamente. A sensibilidade foi superior nos radiologistas enquanto a especificidade no cirurgião de ombro. A concordância interobservador e intraobservador foi moderada / INTRODUCTION: The accuracy of magnetic resonance imaging (MRI) for the detection of subscapularis tear presents wide variation in the literature. There are few prospective studies and great methodological variation. It is believed that these tears are more difficult to diagnose than the posterosuperiores rotator cuff injuries. The subscapularis tendon has importance in the biomechanics in the shoulder and its rupture leads to functional impairment. A diagnostic tool of good accuracy is fundamental in clinical practice, influencing prognosis and surgical planning. The aim of this study was to evaluate the validity of preoperative MRI in the identification of the subscapularis tears, comparing the imaging findings with the intraoperative data of arthroscopic surgery. As a secondary objective, we evaluated the reliability of the method through interobserver and intraobserver agreement. METHODS: We performed a diagnostic accuracy study comparing MRI findings (index test) with those of arthroscopy (reference test), in a prospective cohort. We included patients submitted to arthroscopy for the treatment of rotator cuff tears that had undergone high magnetic field MRI without using contrast. Cases of previous surgical manipulation in the shoulder, exams with moving artifacts, indication for open surgery and interval between MRI and surgical procedure of more than one year were excluded. The images were evaluated by a shoulder surgeon and two musculoskeletal radiologists, independently and blinded to the results of arthroscopy, being reassessed after 3 months by the surgeon. We calculated the validity (sensitivity, specificity, positive predictive value, negative predictive value and accuracy) and reliability (inter- and intraobserver agreement) of MR in detecting subscapularis tears. RESULTS: We evaluated 200 shoulders. The incidence of subscapularis tears was 69.5% (41.5% partial and 28.0% transfixing). The shoulder surgeon showed sensitivity from 51.1 to 59.0% and specificity from 91.7% to 94.4%. The radiologists, 83.5 to 87.1% of sensitivity and 41 to 45.9% of specificity. Accuracy ranged from 60.5 to 73.0%. The mean values of sensitivity, specificity and accuracy were 70.2%, 61.9% and 67.6%, respectively. Interobserver agreement was moderate for the detection of subscapular tears (kappa coefficient 0.463, 95% CI 0.383-0.534, p < 0.001), as well as intraobserver agreement (kappa coefficient 0.546, 95% CI 0.430-0.662, p < 0.001). Patients with subscapular rupture had a higher incidence of biceps rupture and instability, greater fat subscapular degeneration, and higher mean age. The other variables did not present statistically significant differences. CONCLUSION: MRI of high magnetic field without contrast showed mean values of sensitivity, specificity and accuracy of 70.2%, 61.9% and 67.6%, respectively. Sensitivity was higher in radiologists while specificity in the shoulder surgeon. Interobserver and intraobserver agreement was moderate
38

The immediate effect of manipulation of selected cervical spinal segments on the peak torque of the rotator cuff muscles in asymptomatic patients with and without a mechanical cervical spine dysfunction

Dixon, Tamsyn Louise January 2005 (has links)
Thesis (M.Tech.: Chiropractic)-Dept. of Chiropractic, Durban Institute of Technology, 2005 xiii, 70 leaves ; 30 cm / Although studies of manipulation-induced peripheral changes in the muscles have been done, inconsistencies noted by the author’s call for further investigation into the reflex effects of manipulation. Additionally, according to the literature, no effective treatment protocol for the painful shoulder has been found. Therefore this research aimed at addressing these discrepancies by quantifying the immediate effect of cervical spine manipulation in terms of peak torque on rotator cuff musculature in asymptomatic patients with both a cervical spine dysfunction and without. And thus by investigating cervical manipulation to the C4-C7 spinal segment, as a possible added intervention for improving rotator cuff muscle peak torque, a more efficient and effective management protocol for the painful shoulder could be attained. Thus the aims for this study included: 1) To evaluate whether manipulation has an effect on rotator cuff peak torque or not, utilizing the Cybex Orthotron II Isokinetic Rehabilitation System; 2) To ascertain whether manipulation of the specific levels has an effect on the rotator cuff peak torque or not and 3) To ascertain whether the presence or absence
39

Supraspinatus Musculotendinous Architecture: A Cadaveric and In Vivo Ultrasound Investigation of the Normal and Pathological Muscle

Kim, Soo Young 24 September 2009 (has links)
The purpose of the study was to investigate the static and dynamic architecture of supraspinatus throughout its volume in the normal and pathological state. The architecture was first investigated in cadaveric specimens free of any tendon pathology. Using a serial dissection and digitization method tailored for supraspinatus, the musculotendinous architecture was modeled in situ. The 3D model reconstructed in Autodesk MayaTM allowed for visualization and quantification of the fiber bundle architecture i.e. fiber bundle length (FBL), pennation angle (PA), muscle volume (MV) and tendon dimensions. Based on attachment sites and architectural parameters, the supraspinatus was found to have two architecturally distinct regions, anterior and posterior, each with three subdivisions. The findings from the cadaveric investigation served as a map and platform for the development of an ultrasound (US) protocol that allowed for the dynamic fiber bundle architecture to be quantified in vivo in normal subjects and subjects with a full-thickness supraspinatus tendon tear. The architecture was studied in the relaxed state and in three contracted states (60º abduction with either neutral rotation, 80º external rotation, or 80º internal rotation). The dynamic changes in the architecture within the distinct regions of the muscle were not uniform and varied as a function of joint position. Mean FBL in the anterior region shortened significantly with contraction (p<0.05) but not in the posterior. In the anterior region, mean PA was significantly smaller in the middle part compared to the deep (p<0.05). Comparison of the normal and pathological muscle found large differences in the percentage change of FBL and PA with contraction. The architectural parameter that showed the largest changes with tendon pathology was PA. In sum, the results showed that the static and dynamic fiber bundle architecture of supraspinatus is heterogeneous throughout the muscle volume and may influence tendon stresses. The architectural data collected in this study and the 3D muscle model can be used to develop future contractile models. The US protocol may serve as an assessment tool to predict the functional outcome of rehabilitative exercises and surgery.
40

The role of glutamate in rotator cuff tendinopathy : glutamate in rotator cuff tendinopathy

Dean, Benjamin J. F. January 2015 (has links)
Thesis questions: • Is the glutaminergic system altered in rotator cuff tendinopathy? • Is the glutaminergic system altered by common treatments? • Are glutaminergic changes related to pain symptoms? • What are the effects of glutamate and glutamate receptor modulation on tendon derived cells? Summary answers: • The glutaminergic system is altered in rotator cuff tendinopathy • Changes within this system are seen after common treatments • Specific glutaminergic changes are associated with the resolution of pain following shoulder surgery but do not predict the severity of pain symptoms • Glutamate has significant effects on tendon derived cells. What is known: It is known that extracellular glutamate concentrations are increased in both Achilles and patellar tendinopathy. It has also been previously shown that the glutamate receptors NMDAR1 and mGluR5 are upregulated in patellar tendinopathy. What this thesis adds: This thesis has shown for the first time that glutamate and NMDAR1 are increased in rotator cuff tendinopathy. Increases in cell proliferation, vascularity and HIF1α are seen after surgical rotator cuff repair and these features are not seen after glucocorticoid injection. There are significant differences between painful and pain-free rotator cuff tendons in terms of glutamate receptor expression (KA1, mGluR7 and mGluR2) and inflammatory cell numbers (CD45 and CD206). Exposure to 1.875mM glutamate for 72 hours results in reduced cell viability, decreased collagen (COL1A1 and COL3A1) and increased aggrecan gene expression; NMDAR antagonism with MK-801 attenuates the deleterious effect on cell viability but had no effect on the changes in matrix gene expression. Bias, confounding and other reasons for caution: The observational histological work was limited by the control tissue. Some control tissue was not age matched, while some of the pain-free control tendons were post-surgical intervention. Confounding factors include tendon structure, length of symptoms and previous treatments. Caution must be applied when discussing the in vivo implications of the in vitro work.

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