Gegenstand der Dissertation sind die 26 Meisterlieder des Hans Sachs, die Episoden aus dem Trojanischen Krieg und von den Irrfahrten des Odysseus aufgreifen. Troja galt in Mittelalter und Früher Neuzeit als Prototyp des städtischen Gemeinwesens, so dass sich an seinem Fall - im doppelten Wortsinne - exemplarisch untersuchen ließ, was den Zusammenhalt des städtischen Lebens sicherte bzw. gefährdete. Der Sagenkreis um Troja bot sich für den Handwerker und Poeten Hans Sachs folglich in besonderer Weise dafür an, um Ordnungsvorstellungen für das städtische Gemeinwesen Nürnbergs abzuleiten. Die Arbeit geht von einer doppelten Fragestellung aus: Zum einen wird die Verarbeitung der literarischen Vorlage in den Meisterliedern untersucht, zum anderen wird danach gefragt, wie Hans Sachs mit seinen Liedern am zeitgenössischen Normenhorizont partizipiert und diesen seinerseits mitgestaltet. Dieser doppelte Ansatz wird bereits durch die äußere Form der Lieder nahegelegt, die sich in der Regel in narratio und moralisatio aufteilen. Die Untersuchung erfolgt in detaillierten Einzelanalysen, in denen die Lieder auch gerade auf mögliche interne Widersprüche hin befragt werden. Textgrundlage der Untersuchungen ist ein bereinigter Abdruck der Lieder nach der jeweils ältesten Handschrift; in den meisten Fällen handelt es sich jeweils um die Erstedition des Lieds. / Subject of the dissertation are the 26 master songs of Hans Sachs picking up episodes from the Trojan War and the wanderings of Odysseus. Troy was considered in the Middle Ages and early modern period to be a prototype of the urban community, so that in its case - in the double sense of the word - could be studied exemplarily, which ensured or undermined the cohesion of urban life. The cycle of sagas around Troy therefore offered itself to the craftsman and poet Hans Sachs in a special way to deduce concepts of order for the urban community of Nuremberg. The work is based on a double question: On the one hand, the processing of the literary prototype in the master songs is analysed, on the other hand, it is asked how Hans Sachs participates with his songs in the contemporary context of norms and, for his part, helps shape that context. This double approach is immediately suggested by the composition of the songs, which are usually divided into narratio and moralisatio. The study is performed in detailed individual analyses interviewing the songs also for possible internal contradictions. Textual basis of the studies is an adjusted copy of the songs following the oldest manuscript; in most cases it is the first edition of the song.

<p> The objective is to investigate the molecular mechanisms leading to neurodegeneration in Tay Sachs disease, a lysosomal storage disorder caused by a deficiency in the enzyme hexosaminidase A. This was accomplished using microarray analysis of normal and Tay Sachs neuroglia. Microarray data analysis was performed using Onto Express, PANTHER software, and cluster analysis. The expression levels of selected genes were validated using Real Time PCR. To establish a physiological relationship between GM2 accumulation and the expression of these genes, their expression was assessed after treatment with an inhibitor of ganglioside synthesis, nbutyldeoxynojirimycin (NBDNJ). Neuronal pentraxin 1 (NPTX1), potassium channel, subfamily K, member 2 (KCNK2), and prostaglandin synthase 1 (PTGS 1) were found to be upregulated in Tay Sachs neuroglia while heme oxygenase (HMOX1) was downregulated. The mRNA levels ofNPTX1, KCNK2, PTGS1, and HMOX1 all reverted to normal levels in response to ganglioside synthesis inhibitor. Pentraxin RNA levels were also reduced in response to sialidase overexpression, another method of GM2 reduction. Pentraxin protein levels were also increased in Tay Sachs cells in response to u-amino-3-hydroxy-5-methylisoxazole-4- propionic acid (AMPA), and were attenuated upon treatment with either NBDNJ or AMPA antagonist 2,3-dihydroxy-6-nitro-7- sulfamoyl-benzo [f]quinoxaline-2,3-dione (NBQX). Strong colocalization was seen between NPTX1 and the AMPA receptor as well as the glutamate transporter EAACI. AMP A receptor function was also enhanced as illustrated by an increase in calcium influx upon stimulation. This stimulation also resulted in increased apoptosis during AMPA receptor stimulation. In this study, our genetic profiling experiment led to the identification of NPTXl as a marker of pathogenesis in Tay Sachs Cells. The role of NPTXl in excitotoxicity implicates the latter in disease mechanism associated with Tay Sachs disease. Furthermore, this study provides evidence that TSD cells undergo programmed cell death in response to increased intracellular calcium as a result of increased glutamate receptor stimulation. </p> / Thesis / Master of Science (MSc)

Submitted by Luiz Felipe Poli Guanais (fguanais@hotmail.com) on 2014-12-04T21:20:32Z No. of bitstreams: 1 Dissertação - Luiz Felipe Poli Guanais.pdf: 620638 bytes, checksum: 02d37cff8a2c05c0d78f721b513a6b18 (MD5) / Rejected by JOANA MARTORINI (joana.martorini@fgv.br), reason: Luiz, bom dia. Seu trabalho não está de acordo com as regras. Por gentileza entrar em contato no telefone 3799-7892. on 2014-12-05T11:28:59Z (GMT) / Submitted by Luiz Felipe Poli Guanais (fguanais@hotmail.com) on 2014-12-08T18:14:11Z No. of bitstreams: 1 Dissertação - Luiz Felipe Poli Guanais.pdf: 938612 bytes, checksum: 5e47fb061492e1f2070ebe6b698fa28f (MD5) / Approved for entry into archive by JOANA MARTORINI (joana.martorini@fgv.br) on 2014-12-08T19:02:27Z (GMT) No. of bitstreams: 1 Dissertação - Luiz Felipe Poli Guanais.pdf: 938612 bytes, checksum: 5e47fb061492e1f2070ebe6b698fa28f (MD5) / Made available in DSpace on 2014-12-08T19:03:48Z (GMT). No. of bitstreams: 1 Dissertação - Luiz Felipe Poli Guanais.pdf: 938612 bytes, checksum: 5e47fb061492e1f2070ebe6b698fa28f (MD5) Previous issue date: 2014-11-25 / O objetivo do presente trabalho foi, face ao grau de integração da economia brasileira, testar o poder explicativo do Modelo Goldman Sachs sobre os retornos esperados por um investidor estrangeiro no mercado nacional, ao longo do período 2004-2013. Em um primeiro momento, foi testado o grau de integração da economia brasileira para o período 2004-2013, buscando entender o contexto em que o Modelo Goldman Sachs foi empregado. Posteriormente, para o teste do modelo, calcularam-se os betas dos fatores de risco dos ativos analisados (risco de mercado e risco país) e procedeu-se à regressão com dados em painel dos retornos esperados sobre os betas desses ativos. Verificou-se que o risco país não se mostrou estatisticamente significante para a explicação dos retornos esperados, o que indica que é adicionado de maneira ad hoc pelos praticantes de mercado para o cálculo do custo de capital próprio de acordo com o Modelo Goldman Sachs. Assim, embora haja evidências de uma relação positiva e significante entre risco sistemático e retorno, os resultados para o risco país demonstram que o Modelo Goldman Sachs não se mostrou satisfatório para a explicação dos retornos esperados no mercado brasileiro ao longo dos últimos dez anos. / Considering the degree of integration of the Brazilian economy, this paper seeks to test the explanatory power of the Goldman Sachs Model for the expected returns by a foreign investor in the Brazilian market during the past ten years (2004-2013). It begins by testing the degree of integration of the Brazilian economy during this period, in an attempt to better understand the context in which the model has been used. In sequence, the risk factor betas (market risk and country risk) of the sample stocks were estimated and a panel regression of expected stock returns on these betas was performed. It was found that country risk is not a statistically significant explanation of expected returns, indicating that it has been added in an ad hoc fashion by market practitioners to cost of equity calculations. Thus, although there is evidence of a positive and significant relationship between systematic risk and return, the results for country risk demonstrate that the Goldman Sachs Model was not a satisfactory explanation of expected returns in the Brazilian market in the past ten years.

This thesis deals with motives of the South Africa's inclusion to BRIC countries and examines the impact of this inclusion on South Africa. It explores the question whether South Africa "deserves" the inclusion to BRIC countries and what characteristics connect it with these economies. The thesis also analyzes the BRICS bloc, the current situation in these economies, their cooperation and performing on the global scene.

La lumière que l’on reçoit du fond diffus cosmologique est décalée vers le rouge par les puits gravitationnels causés par la matière contenu dans les différentes régions de l’espace que la lumière traverse. Cet effet se nomme l’effet Sachs-Wolfe intégrée. Dans ce projet de maîtrise, nous avons calculé le terme de collision qui est dû à l’intéraction entre les photons émis par le fond diffus cosmologique et les fluctuations de densité. Ce terme vient modifier la distribution d’énergie des photons que l’on reçoit. Ce calcul est effectué en utilisant l’action de Fierz-Pauli pour trouver la section efficace de cette collision. Ce qui est nouveau dans notre démarche c’est que l’on suppose que les fluctuations de densité de l’univers entraînent un écrantage du champ gravitationnel ce qui induit une masse de Debye au graviton que l’on calcule. On utilise ensuite la théorie quantique des champs pour obtenir un terme de collision à ajouter à l’équation de Boltzmann qui dicte comment la distribution d’énergie des photons évolue. / The light we receive from the Cosmic Microwave Background is redshifted by the gravitational potential caused by the mass of the objects it meets on its way toward us. This effect is called the integrated Sachs-Wolfe effect. In this master’s thesis, we calculate a collision term between the photons and a massive scalar particle which will affect the energy distribution of the photons we observe. This calculation is made using the Fierz-Pauli action to find the cross section of this collision. What is new in our approach is that we assume that the density variation of the universe induces a shielding of the gravitational field which results in a Debye mass of the graviton. We calculate what this mass term is and we then use quantum field theory to obtain a collision term to be added to the Boltzmann equation governing how the energy distribution of photons evolves.

Orientador: Mônica Muniz Pinto de Carvalho / Dissertação (mestrado) - Universidade Federal do ABC. Programa de Pós-Graduação em Planejamento e Gestão do Território, 2013

This paper is concerned with the efficiency of aid in Masaka, Uganda which is about 140 km from the capital city Kampala. It uses the results of 300 surveys and several interviews to gather data, and a causal methodology to define results. Much of the methodology is based on theories from William Easterly, Andrew Mwenda, Dambisa Moyo, Jeffrey Sachs, and Amartya Sen. It has been concluded that there are several problems in the Masaka area. One is Uganda's federal government, which is inefficient and unaccountable. There is also lack of easily accessible health care for rural citizens, and a lack of local development due to poor governance. Conversely, the residents of Masaka are quite developed in terms of employment and education, and have rated themselves as quite free and satisfied with life. There is also a quite adequate level of gender equality, especially in terms of education.

MFA thesis paper by David Dyck

My research in this thesis covers the religious discourse of six contemporary poets who write belief from a position of calamity. Yehuda Amichai writes from the constant wars fought since the founding of the state of Israel; Anne Sexton from psychiatric illness; Seamus Heaney from the sectarian violence of Ireland; Paul Celan and Nelly Sachs from the twentieth century’s greatest calamity, the Holocaust; and Yves Bonnefoy, from the language theories of post-modernism, which are calamitous for a poet. (For complete abstract open document)

Zugl.: Jena, Univ., Diss., 2003