Thesis (doctoral)--Karolinska Institutet, Stockholm, 1989. / Extra t.p. with thesis statement inserted. Includes bibliographical references.

Thesis (Ph. D.)--School of Biological Sciences. University of Missouri--Kansas City, 1999. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 138-153). Includes bibliographical references.

Thesis (Ph. D.)--University of Missouri--Columbia, 1999. / "May 1999." Typescript. Vita. Includes bibliographical references (leaves 108-124). Also available on the Internet.

Thesis (doctoral)--Karolinska Institutet, Stockholm, 1989. / Extra t.p. with thesis statement inserted. Includes bibliographical references.

Thesis (doctoral)--Karolinska Institutet, Stockholm, 1989. / Extra t.p. with thesis statement inserted. Includes bibliographical references.

Thesis (Ph. D.)--State University of New York at Buffalo, 1971. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 181-194).

Thesis (Ph. D.)--University of Washington, 2000. / Vita. Includes bibliographical references (leaves 197-209).

Thesis (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2014 (Department of Endodontics). / Includes bibliographic references: leaves 41-49. / Sjogren's syndrome (SS) is a chronic, multisystem inflammatory disorder of multifactorial etiology resulting in loss of secretory function in the exocrine glands including salivary and lacrimal. Even though the pathophysiology progression of SS has been subject to great amount of research, the roles of different mechanisms remain inconclusive. The main dogma is that immune system pathology drives SS; however, there is no straightforward pathogenesis theory as there are multiple autoantibodies and changing proportions of different T-cell subsets with the progression of the disease along with many other different contributors. Interestingly, increasing evidence points to structural defects, including defective E-cadherin adhesion, to be involved in the etiology of SS. Recently, the Hippo signaling pathway has emerged as one of the main pathways regulating size of the organs and proliferation/ differentiation of cells, in part via interaction with E-cadherin junctions. Despite this, the role of Hippo signaling in the ... [TRUNCATED]

Magister Scientiae Dentium - MSc(Dent) / Introduction: Xerostomia and reduced salivary flow have been reported often enough among HIV positive patients. Strong associations have also been established between HIV infection and oral effects of reduced salivary flow like xerostomia, high DMFT, increased candidial infection etc. Besides the direct effect of HIV infection, xerostomia and reduced salivary flow have also been reported as a side effect of Highly Active Anti Retroviral reatment (HAART). Studies have shown that xerostomia has a negative effect on the quality of life of people living with HIV & AIDS. Although reduced salivary flow is a main cause for xerostomia, complaints of xerostomia is also found in the absence of salivary flow deficiency. An exact correlation between the two is not always found.Aim: The aim of this study is to compare the prevalence of xerostomia and hyposalivation, in HIV positive patients on HAART, HIV positive patients not on HAART and HIV negative patients, attending Empilweni Gompo community health centre (EGCHC) in East London. Study Methods: This is a cross sectional analytical study. Xerostomia and resting & chewing- stimulated salivary flow rates were measured for 150 patients who were from three groups : group 1-HIV negative, group 2-HIV positive not on HAART and group 3-HIV positive on HAART for more than two years. Each group had 50 patients. Xerostomia was measured using a questionnaire and salivary flow rates were calculated after saliva collection over a three minute period. Results: There was significant difference in the prevalences for xerostomia (p=0.006) and less than normal chewing -stimulated flow rate (p=0.041) among the three groups with the HIV positive group not on HAART showing the greatest deficiency. HAART was not found to have a negative effect on salivary function. A statistical significance was also observed while comparing mean resting (p=0.010) and chewing –stimulated (p=0.034) salivary flow rates among the three groups. The mean salivary flow rate of those complaining of xerostomia was found to be significantly lower than that of those who did not have xerostomia (p=0.005). Conclusion: HIV positive patients not on HAART are more vulnerable to salivary gland dysfunction. HAART in itself does not to adversely affect xerostomic perceptions or salivary flow rates.The xerostomia questionnaire is a useful tool in indicating those with possible low salivary flow rates

Made available in DSpace on 2016-02-05T18:30:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-08-03. Added 1 bitstream(s) on 2016-02-05T18:34:19Z : No. of bitstreams: 1 000857811.pdf: 501182 bytes, checksum: 97ed0b747ae3422a975a5f03adaa1428 (MD5) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / A célula mioepitelial é um componente de diversos órgãos glandulares, incluindo glândulas salivares e mamárias, que auxilia na excreção do conteúdo glandular, atuando também na sua embriogênese e morfogênese. Além de suas funções normais, ação supressora tumoral tem sido atribuída a esta célula. Utilizando como modelo o Carcinoma Ex-Adenoma Pleomórfico, neoplasia maligna proveniente da malignização das células do Adenoma Pleomórfico (AP), foi estudada a influência das células mioepiteliais neoplásicas no comportamento invasivo de células epiteliais malignas, em um estudo in vitro. Para isso, células de carcinoma epidermoide bucal (CAL 27, ATCC) e de carcinoma ductal (HS578T, ATCC) foram cultivadas em câmaras de invasão, sobre matrigel, com meios condicionados de células mioepiteliais de AP por 96 h. Foi calculado o índice de invasão, quantificada a secreção de MMPs-1,-2,-8,-9 e -13 e de TIMP-1 e -2, por meio de ELISA, e a atividade proteolítica por Zimografia. Os resultados foram submetidos à análise estatística e demonstraram que os meios condicionados de células mioepiteliais provocaram aumento do potencial invasivo de ambas as células malignas. Os meios condicionados exibiram, em geral, maiores quantidades e atividades proteolíticas de MMPs-1 e -2 e quantidades de TIMPs-1 e -2 do que as células malignas. A MMP-8 apresentou baixos níveis em todas as amostras e as MMPs-9 e -13 não foram detectadas. Nestas condições experimentais, as células mioepiteliais promoveram aumento do comportamento invasivo das células epiteliais malignas e as MMPs-1 e - 2 produzidas por elas podem estar envolvidas no processo / The myoepithelial cell is a component of various glandular organs, including salivary and mammary glands, which aids in the excretion of glandular content, also acting in embryogenesis and morphogenesis of the gland. In addition to their normal functions, tumor suppressive action has been attributed to this cell. Using as a model the carcinoma ex pleomorphic adenoma, malignant neoplasm from the malignancy of pleomorphic adenoma cells (PA), the influence of neoplastic myoepithelial cells in the invasive behavior of malignant epithelial cells in an in vitro study was studied. Therefore, cells of oral squamous cell carcinoma (CAL 27, ATCC) and ductal carcinoma (HS578T, ATCC) were cultured in invasion chambers on matrigel with conditioned media of myoepithelial cells of PA for 96 hours. We calculated the invasion índex, quantified the secretion of MMP-1, -2, -8, -9 and -13 and TIMP-1 and -2 by ELISA and the proteolytic activity by zymography. The results were statistically analyzed and showed that the conditioned media of myoepithelial cells caused increased invasive potential of both malignant cells. The conditioned media showed, in general, larger amounts and proteolytic activities of MMP-1 and -2 and amounts of TIMP-1 and -2 than the malignant cells. MMP-8 was decreased in all samples and MMP-9 and -13 were not detected. Under these experimental conditions, myoepithelial cells caused an increase in invasive behavior of malignant epithelial cells and MMP-1 and -2 produced by them may be involved in the process / FAPESP: 13/03818-4