Fonds Français 2245 is a fifteenth-century chansonnier of the Duke of Orleans which is property of the Bibliothèque Nationale in Paris, France. This thesis describes the document and provides commentary and transcriptions.

In numerous clinical/experimental studies, multiple endpoints are measured on each subject. It is often not clear which of these endpoints should be designated as of primary importance. The desirability function approach is a way of combining multiple responses into a single unitless composite score. The response variables may include multiple types of data: binary, ordinal, count, interval data. Each response variable is transformed to a 0 to1 unitless scale with zero representing a completely undesirable response and one representing the ideal value. In desirability function methodology, weights on individual components can be incorporated to allow different levels of importance to be assigned to different outcomes. The assignment of the weight values are subjective and based on individual or group expert opinion. In this dissertation, it is our goal to find the weights or response variable transformations that optimize an external empirical objective criterion. For example, we find the optimal weights/transformations that minimize the generalized variance of a prediction regression model relating the score and response of an external variable in pre-clinical and clinical data. For application of the weighting/transformation scheme, initial weighting or transformation values must be obtained then calculation of the corresponding value of the composite score follows. Based on the selected empirical model for the analyses, parameter estimates are found using the usual iterative algorithms (e.g., Gauss Newton). A direct search algorithm (e.g., the Nelder-Mead simplex algorithm) is then used for the minimization of a given objective criterion i.e. generalized variance. The finding of optimal weights/transformations can also be viewed as a model building process. Here relative importance levels are given to each variable in the score and less important variables are minimized and essentially eliminated.

House in Heaven is a theatrical piece for five solo voices (one soprano, two mezzo sopranos, one baritone, and one bass), two trumpets, four French horns, one trombone, two flutes, two clarinets, two bassoons, string orchestra, vibraphone, timpani and a synthesizer which produces pipe organ sound. The composition consists of an introduction followed by a single act in three Scenes. The piece employs the cyclical device in engaging themes associated with particular characters. The texture grows from simple alternating dialogues to arias and, finally, to tutti passages in which all voices are combined to form a quintet, at the climactic point of the entire composition, which occurs at the end of the piece. The scenes depict imaginary events in a Church and at a flower garden. Rear-stage slide projections are used to project the scenes of these locations, and lighting is used to emphasize actions, characters and changes of scene. The singers also serve as actors. The duration of this work is approximately 20 minutes.

No description available.

L’infection par le virus de l’hépatite C est fréquente chez les patients infectés par le VIH. Chez les patients co-infectés VIH-VHC, les lésions hépatiques sont plus sévères et évoluent plus rapidement vers la cirrhose et ses complications. Cette thèse est consacrée à la description des patients co-infectés pris en charge, en France (2006-2008), à l’évaluation de la prévalence et des facteurs de stéatose hépatique chez ces patients, et à la question de l’évaluation non invasive de la fibrose hépatique. La prise en charge des patients co-infectés VIH-VHC devrait inclure un dépistage systématique de la stéatose hépatique. L’évaluation de la fibrose hépatique par l’utilisation de deux scores non invasifs (Fibroscan-Apri, Fibroscan-Fibrotest, par exemple) pourrait être envisagée. En cas de discordance entre les résultats de ces scores, une biopsie hépatique doit être réalisée. / Chronic hepatitis C virus (HCV) infection is common in patients with human immunodeficiency virus (HIV). HIV-HCV Co-infection is associated with more severe and more rapid progression of HCV, leading to increased incidence of fibrosis, cirrhosis, and end-stage liver disease. Our work is devoted to the description of HIV-HCV co-infected patients (2006-2008). We also evaluated the prevalence and factors associated with liver steatosis in these patients. Lastly, we addressed the issue of the non-invasive assessment of liver fibrosis. The management of HIV-HCV co-infected patients should comprise a systematic screening of liver steatosis. The assessment of liver fibrosis using two non-invasive tests (eg Fibroscan-Apri, Fibroscan-Fibrotest) should be considered. In case of discordance between the results of these tests, a liver biopsy must be performed.

Sinfonia is a two movement work for chamber string orchestra and percussion consisting of at least five violins I, five violins II, five violas, five cellos, three string basses, and three percussionists playing timpani, two suspended cymbals, one small crash cymbal, 2 triangles, tambourine, woodblock, five temple blocks, snare, two tom-toms, 2 glockenspiels, xylophone, and chimes. The first movement is approximately nine minutes long, the second lasts five and one third minutes making a total of approximately fourteen minutes and twenty seconds.

Thesis (M.Mus.)--Chinese University of Hong Kong, 1995. / Chapter 1. --- STRING QUARTET NO.1 / Chapter 2. --- SEA INTERLUDE / Chapter 3. --- TRAGEDY

Title from accompanying document. / Janet Anschutz, piano ; Jerry Langenkamp, tenor. / Digitized by Kansas Correctional Industries

Thesis (M.M.)--Boston University. PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you. / 2031-01-01

The clinical management of Factor XI (FXI) deficiency is problematic due to the marked phenotypic heterogeneity between individuals with this disorder and the lack of a reliable test to predict bleeding risk. FXI-deficient individuals are currently at risk of being over- or under treated, with associated risks of transfusion-related complications or haemorrhage respectively. The improvement of care of FXI-deficient patients requires the development of measures that can predict bleeding phenotype and enable the identification of individuals who need treatment at times of haemostatic challenge. In addition, for those requiring treatment, there is a need for development of tests which can determine the optimal type and dose of FXI replacement on an individually tailored basis, as well as assays which can accurately monitor the effect of treatment and guide clinicians in the requirement for further perioperative treatment. This thesis addresses these objectives by studying global haemostasis assays and bleeding scores as tools to predict bleeding tendency and by studying the utility of global haemostasis assays as potential tests by which FXI replacement treatment can be determined and monitored. For prediction of bleeding tendency, this research demonstrated that the thrombin generation assay (TGA) was able to differentiate bleeding tendency provided the sample conditions used in the assay were optimised to assess FXI involved coagulation pathways thought to be of relevance in vivo: using platelet rich plasma with inhibition of in vitro contact activation and a low tissue factor trigger. Thromboelastometry measured using the same sample type was similarly able to distinguish bleeding phenotype. However, when the potential clinical utility of the assays was compared using receiver operating characteristic curve analysis, thromboelastometry was inferior to TGA as an identifier of bleeding tendency. When the thromboelastometry sample type used was whole blood, or where assays were performed in the presence of tissue plasminogen activator the assays did not differentiate bleeding phenotype. For purposes of treatment planning, the potential of the TGA to determine the optimal dose of FXI replacement was assessed by in vitro spiking experiments using two commercially available FXI concentrates and samples from individuals with major FXI deficiency. Each concentrate improved thrombin generation, but dose response curves were found to differ, suggesting different properties for the two products. The clinical utility of the approach was then demonstrated with comparable TGA results obtained in ex vivo samples from patients treated with FXI concentrate and baseline samples spiked in vitro with equivalent amounts of the same FXI concentrate. The utility of global haemostasis assays to monitor the effect of FXI replacement in FXI-deficient individuals undergoing surgery was also tested. Improvement in assay parameters after treatment with solvent-detergent fresh frozen plasma or FXI concentrate was demonstrated suggesting assay value in FXI replacement monitoring. Finally the use of recently developed bleeding assessment tools and bleeding scores as descriptive, diagnostic or predictive measures was tested along with correlation with FXI:C levels and TGA parameters. This analysis confirmed that bleeding scores have a limited value in the clinical assessment of FXI deficiency.