Submitted by PATRICIA DE FIGUEIREDO VIANA (patricia_patyfv@hotmail.com) on 2018-09-14T19:25:08Z No. of bitstreams: 1 dissertacao Patricia.docx: 903041 bytes, checksum: 045c598106e96a972706e95e8034f67d (MD5) / Rejected by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br), reason: Solicitamos que realize uma nova submissão seguindo as orientações abaixo: problema 1: o arquivo submetido deve, obrigatoriamente, estar em formato PDF. Seu arquivo está em word. Problema 2: Capa No arquivo submetido faltou a capa, item obrigatório de acordo com as normas do seu programa de pós. A capa de ver estar na cor verde e deve conter no alto o nome da Instituição e Faculdade. Assim que tiver efetuado a correção submeta o arquivo, em PDF, novamente. Agradecemos a compreensão. on 2018-09-18T16:35:31Z (GMT) / Submitted by PATRICIA DE FIGUEIREDO VIANA (patricia_patyfv@hotmail.com) on 2018-09-19T02:51:29Z No. of bitstreams: 1 dissertacaomestradopronto.pdf: 523740 bytes, checksum: 6072623628de99f805ad0a900a587f21 (MD5) / Rejected by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br), reason: Solicitamos que realize uma nova submissão seguindo as orientações abaixo: Problema 1: Capa No arquivo submetido a capa não está de acordo com as normas do seu programa de pós. Favor verificar o modelo na secretaria ou com a seção de pós-graduação. Problema 2: No arquivo atual consta uma folha adicional entre a capa e a folha de rosto. Favor verificar. O correto é capa, folha de rosto, ficha catalografica, ... Assim que tiver efetuado a correção submeta o arquivo, em PDF, novamente. Agradecemos a compreensão on 2018-09-20T13:54:20Z (GMT) / Submitted by PATRICIA DE FIGUEIREDO VIANA (patricia_patyfv@hotmail.com) on 2018-09-21T19:23:41Z No. of bitstreams: 1 Patricia_Viana PDF.pdf: 732990 bytes, checksum: c4b2e65c958375384e1f7cc84f03f2e7 (MD5) / Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2018-09-25T13:11:50Z (GMT) No. of bitstreams: 1 viana_pf_me_bot.pdf: 732990 bytes, checksum: c4b2e65c958375384e1f7cc84f03f2e7 (MD5) / Made available in DSpace on 2018-09-25T13:11:50Z (GMT). No. of bitstreams: 1 viana_pf_me_bot.pdf: 732990 bytes, checksum: c4b2e65c958375384e1f7cc84f03f2e7 (MD5) Previous issue date: 2018-07-30 / O Acidente Vascular Cerebral (AVC), ocupou o primeiro lugar das principais causas de morte no Brasil e no mundo no ano de 2015. A ocorrência dessa doença ocasiona um marco na vida dos pacientes e de suas famílias devido às limitações físicas e emocionais apresentadas após a doença. Além disso, as sequelas geram impacto negativo econômico, social e familiar. Para prevenção da ocorrência da doença, se faz necessário controle rigoroso dos fatores de risco. O objetivo principal deste estudo foi avaliar da percepção dos pacientes acometidos de AVC sobre a doença e a eficácia da profilaxia secundária instituída no âmbito ambulatorial. Foram feitas 100 entrevistas com pacientes do ambulatório de Neurovascular, através de um questionário padrão. Foi visto que os pacientes não tiveram uma boa percepção dos sintomas para reconhecer um AVC e a eficácia da profilaxia secundária instituída na alta hospitalar foi bem aderida pelos pacientes, porém a maioria não sabia o motivo pelo qual estavam fazendo uso de tal terapêutica. / Stroke was the leading cause of death in Brazil and worldwide in the year 2015. The occurrence of this disease causes a milestone in the life of patients and their families due to the physical and emotional limitations presented after the disease. In addition, the sequels generate negative economic, social and family impact. To prevent the occurrence of the disease, strict control of risk factors is necessary. The main objective of this study was to evaluate the perception of stroke patients on the disease and the efficacy of the secondary prophylaxis instituted in the outpatient setting. A 100 interview with patients from the Neurovascular Outpatient Clinic was done through a standard questionnaire. It was seen that patients did not have a good perception of symptoms to recognize a stroke and the efficacy of secondary prophylaxis instituted at hospital discharge was well adhered to by the patients, but most did not know why they were using such therapy.

Orientador: Arthur Oscar Shelp / Resumo: O Acidente Vascular Cerebral (AVC), ocupou o primeiro lugar das principais causas de morte no Brasil e no mundo no ano de 2015. A ocorrência dessa doença ocasiona um marco na vida dos pacientes e de suas famílias devido às limitações físicas e emocionais apresentadas após a doença. Além disso, as sequelas geram impacto negativo econômico, social e familiar. Para prevenção da ocorrência da doença, se faz necessário controle rigoroso dos fatores de risco. O objetivo principal deste estudo foi avaliar da percepção dos pacientes acometidos de AVC sobre a doença e a eficácia da profilaxia secundária instituída no âmbito ambulatorial. Foram feitas 100 entrevistas com pacientes do ambulatório de Neurovascular, através de um questionário padrão. Foi visto que os pacientes não tiveram uma boa percepção dos sintomas para reconhecer um AVC e a eficácia da profilaxia secundária instituída na alta hospitalar foi bem aderida pelos pacientes, porém a maioria não sabia o motivo pelo qual estavam fazendo uso de tal terapêutica. / Abstract: Stroke was the leading cause of death in Brazil and worldwide in the year 2015. The occurrence of this disease causes a milestone in the life of patients and their families due to the physical and emotional limitations presented after the disease. In addition, the sequels generate negative economic, social and family impact. To prevent the occurrence of the disease, strict control of risk factors is necessary. The main objective of this study was to evaluate the perception of stroke patients on the disease and the efficacy of the secondary prophylaxis instituted in the outpatient setting. A 100 interview with patients from the Neurovascular Outpatient Clinic was done through a standard questionnaire. It was seen that patients did not have a good perception of symptoms to recognize a stroke and the efficacy of secondary prophylaxis instituted at hospital discharge was well adhered to by the patients, but most did not know why they were using such therapy. / Mestre

A recent systematic literature and meta-analysis reported relative efficacy of trimethoprim-sulfamethoxazole (TMP-SMX) for the treatment of toxoplasmic encephalitis (TE) in HIV-infected adults. Here, we estimated relapse rates during secondary prophylaxis with TMP-SMX, and further explored differences in relapse rates prior to introduction of highly active antiretroviral therapy (HAART) and the widespread adoption of HAART. A systematic search of PubMed, Embase, and Cochrane Central Register of Controlled Trials yielded 707 studies whereby 663 were excluded after abstract screening, and 38 were excluded after full review leaving 6 studies for extraction. We performed double data extraction with a third-party adjudicator. Study designs varied with only one randomized study, four prospective cohorts and one retrospective cohort. Relapse rates were transformed using the Freeman-Tukey method and pooled using both fixed-effect and random-effects meta-analysis models. The TMP-SMX relapse rate was 16.4% (95% CI = 6.2% to 30.3%) based on random-effects models. When the disaggregated pre-HAART studies (n = 4) were included, the relapse rate was 14.9% (random effects; 95% CI = 3.7% to 31.9%). Analysis of two post-HAART studies indicated a relapse rate of 19.2% (random effects; 95% CI = 2.8% to 45.6%). Comparing the relapse rates between pre- and post-HAART studies were contrary to what might be expected based on known benefits of HAART therapy in this population. Nevertheless, cautious interpretation is necessary considering the heterogeneity of the included studies and a limited number of subjects receiving TMP-SMX reported in the post-HAART era.