[pt] Sistemas pneumáticos são equipamentos leves, baratos, limpos e de baixo risco, sendo apropriados para aplicações que necessitem de força e rapidez de resposta. Por outro lado, esse tipo de sistema apresenta restrições devido à principal característica do ar: sua compressibilidade confere efeitos não lineares ao sistema, desde um escoamento turbulento pelas válvulas de controle até sua atuação dentro do cilindro – a qual inclui alta sensibilidade ao atrito e volumes inativos durante o curso do pistão. Essas características particulares dificultam seu controle e posicionamento preciso e limitam sua aplicação, principalmente considerando seu emprego em um mecanismo tipo Plataforma de Stewart em escala reduzida. No presente trabalho apresenta-se a modelagem, simulação computacional e análise experimental do comportamento dinâmico de um sistema de atuação pneumático que inclui uma válvula de controle de vazão não convencional, composta de quatro válvulas proporcionais, e um atuador com haste simples de dupla ação. O objetivo deste trabalho é, baseado nos resultados experimentais, determinar as características desses componentes para desenvolver estratégias de controle em tempo real capazes de minimizar os efeitos das não linearidades típicas, visando sua utilização no mecanismo anteriormente mencionado. / [en] Pneumatic equipment is lightweight, cheap, clean and low-risk, being suitable for applications that require strength and high responsiveness. Nevertheless, this type of system has some limitations due to the air main feature: its compressibility results in nonlinear effects in the system, from the turbulent flow control valves to its performance inside the cylinder - which includes high sensitivity to friction and dead volumes during the stroke piston. These particular characteristics make its control and precise positioning difficult, limiting its application, especially when considered its use in a mechanism such as a Stewart Platform in a reduced scale. The present paper presents the modeling, computational simulation and experimental analysis of the dynamic behavior of a pneumatic actuation system that includes an unconventional flow control valve, consisting of four proportional valves, and a double acting single rod actuator. The final goal of this work is to, based on experimental results, determine the characteristics of these components in order to develop real-time control strategies which can minimize the effects of those typical nonlinearities for their use in the mechanism mentioned above.

Este projeto de pesquisa propõe desenvolver um novo modelo e uma nova abordagem para a resolução do problema da otimização Volt/VAr em redes de distribuição de energia elétrica. A otimização Volt/VAr consiste em, basicamente, determinar os ajustes das variáveis de controle tais como bancos de capacitores chaveados, transformadores com comutação de tap sob carga e reguladores de tensão, de modo a satisfazer, simultaneamente, as restrições de carga e de operação para um dado objetivo operacional. Esse problema, matematicamente, foi formulado como um problema de programação não linear, multiperíodo, e com variáveis contínuas e discretas. Algoritmos de programação não linear foram utilizados com o intuito de aproveitar as vantagens das matrizes altamente esparsas montadas ao longo do método de solução. Para utilizar tais algoritmos, as variáveis discretas são tratadas como contínuas por meio da utilização de funções senoidais que penalizam a função objetivo do problema original enquanto estas não convergirem para algum dos pontos pré-definidos no seu domínio. O caráter multiperíodo do problema, contudo, refere-se à consideração de uma restrição que relaciona os ajustes das variáveis de controle para sucessivos intervalos de tempo na medida em que limita o número de operações de chaveamento desses dispositivos para um período de 24-horas. O estudo fundamenta-se, metodologicamente, em métodos do tipo Primal-Dual Barreira-Logarítmica. Para demonstrar a eficiência do modelo proposto e a robustez dessa abordagem, a partir de dados teóricos obtidos de levantamentos bibliográficos, testes foram realizados em sistemas-teste de 10, 69 e 135 barras, e em um sistema de 442 barras do noroeste do Reino Unido. As implementações computacionais foram feitas nos softwares MATLAB, AIMMS e GAMS, utilizando o solver IPOPT como método de solução. Os resultados mostram que a abordagem proposta para a resolução do problema de programação não linear é eficaz para tratar adequadamente todas as variáveis presentes em problemas de otimização Volt/VAr. / This work proposes a new model and a new approach for solving the Volt / VAr optimization problem in distribution systems. The Volt/VAr optimization consists, basically, to determine the settings of the control variables of switched capacitor banks, on-load tap changer transformers and voltage regulators, in order to satisfy both the load and operational constraints, to a given operational objective. The problem is formulated as a nonlinear programming problem, multiperiod, and with continuous and discrete variables. Nonlinear programming algorithms were used in order to take advantage of the highly sparse matrices built along the solution method. The discrete variables are treated as continuous along the solution method by means of the use of sinusoidal functions that penalize the original objective function while the control variables do not converge to any of the predefined discrete points in its domain. The multiperiod, or dynamic, characteristic of the problem, however, refers to the use of a constraint that relates the settings of the control variables for successive time intervals that limits the control devices switching operations number for a period of 24-hours. The study is based, methodologically, on Primal-Dual Logarithmic Barrier method. To demonstrate the effectiveness of the proposed model and the robustness of this approach, the data were obtained from theoretical literature surveys, and tests were performed on test-systems of 10, 69 and 135 buses, and in a 442 buses located in the Northwest of the United Kingdom. The computational implementation was accomplished in the softwares MATLAB, AIMMS and GAMS, using the IPOPT solver as solution method. The results have shown the approach for solving nonlinear programming problems is effective to appropriate cope with all the variables presented in Volt/VAr optimization problems.

Doctor of Philosophy(PhD) / Owing to its strategic position in the liver sinusoid, pathologic and morphologic alterations of the Liver Sinusoidal Endothelial Cell (LSEC) have far-reaching repercussions for the whole liver and systemic metabolism. LSECs are perforated with fenestrations, which are pores that facilitate the transfer of lipoproteins and macromolecules between blood and hepatocytes. Loss of LSEC porosity is termed defenestration, which can result from loss of fenestrations and/ or decreases in fenestration diameter. Gram negative bacterial endotoxin (Lipopolysaccharide, LPS) has marked effects on LSEC morphology, including induction LSEC defenestration. Sepsis is associated with hyperlipidemia, and proposed mechanisms include inhibition of tissue lipoprotein lipase and increased triglyceride production by the liver. The LSEC has an increasingly recognized role in hyperlipidemia. Conditions associated with reduced numbers of fenestrations such as ageing and bacterial infections are associated with impaired lipoprotein and chylomicron remnant uptake by the liver and consequent hyperlipidemia. Given the role of the LSEC in liver allograft rejection and hyperlipidemia, changes in the LSEC induced by LPS may have significant clinical implications. In this thesis, the following major hypotheses are explored: 1. The Pseudomonas aeruginosa toxin pyocyanin induces defenestration of the LSEC both in vitro and in vivo 2. The effects of pyocyanin on the LSEC are mediated by oxidative stress 3. Defenestration induced by old age and poloxamer 407 causes intrahepatocytic hypoxia and upregulation of hypoxia-related responses 4. Defenestration of the LSEC seen in old age can be exacerbated by diabetes mellitus and prevented or ameliorated by caloric restriction commencing early in life

In vivo studies of hepatobiliary disposition are challenging. The hepatobiliary system is complex, as its physiological localization, complex cellular structure with numerous transporters and enzymes, and the interindividual variability in protein expression and biliary flow will all affect the in vivo disposition of a drug under investigation. The research included in this thesis has focused on the involvement of hepatic transport proteins in the hepatobiliary disposition of rosuvastatin. The impact that several transport inhibitors had on the pharmacokinetics of rosuvastatin was investigated in healthy volunteers and in pigs. The effects were considerable, following inhibition of sinusoidal transport proteins by cyclosporine and rifampicin. These inhibitors significantly reduced the hepatic extraction of rosuvastatin by 50 and 35%, respectively, and the plasma exposure increased by factors of 9.1 and 6.3, respectively. Drug-drug interactions (DDI) resulting in markedly higher plasma exposures are important from a drug safety perspective as increased extrahepatic exposure of statins is associated with an increased risk of severe side-effects, such as myopathy which in rare cases could develop into rhabdomyolysis. The DDI caused by cyclosporine and rifampicin can probably be attributed to inhibition of hepatic uptake transporters. In contrast, inhibition of canalicular transporters by imatinib did not significantly affect the pharmacokinetics of rosuvastatin, which suggests that the intracellular concentration of the inhibitor in the hepatocyte was insufficient to affect the transport of rosuvastatin, or that imatinib is not a sufficiently potent inhibitor in vivo. Furthermore, gemfibrozil administered as a single dose into the jejunum in healthy volunteers and pigs did not affect the plasma or biliary pharmacokinetics of rosuvastatin. The previously reported DDI in humans upon repeated dosing with gemfibrozil might be explained by the accumulation of metabolites able to affect the disposition of rosuvastatin. The investigations presented in this thesis conclude that transport proteins are of considerable importance for the hepatobiliary disposition of rosuvastatin in vivo. The Loc-I-Gut catheter can be applied for the investigation of biliary accumulation and to determine bile specific metabolites, however it has limitations when conducting quantitative measurements. In the porcine model, hepatic bile can be collected for up to six hours and enables the determination of the hepatic extraction in vivo.

This dissertation is concerned with the problem of describing the singing voice within the audio signal of a song. This work is motivated by the fact that the lead vocal is the element that attracts the attention of most listeners. For this reason it is common for music listeners to organize and browse music collections using information related to the singing voice such as the singer name. Our research concentrates on the three major problems of music information retrieval: the localization of the source to be described (i.e. the recognition of the elements corresponding to the singing voice in the signal of a mixture of instruments), the search of pertinent features to describe the singing voice, and finally the development of pattern recognition methods based on these features to identify the singer. For this purpose we propose a set of novel features computed on the temporal variations of the fundamental frequency of the sung melody. These features, which aim to describe the vibrato and the portamento, are obtained with the aid of a dedicated model. In practice, these features are computed on the time-varying frequency of partials obtained using the sinusoidal model. In the first experiment we show that partials corresponding to the singing voice can be accurately differentiated from the partials produced by other instruments using decisions based on the parameters of the vibrato and the portamento. Once the partials emitted by the singer are identified, the segments of the song containing singing can be directly localized. To improve the recognition of the partials emitted by the singer we propose to group partials that are related harmonically. Partials are clustered according to their degree of similarity. This similarity is computed using a set of CASA cues including their temporal frequency variations (i.e. the vibrato and the portamento). The clusters of harmonically related partials corresponding to the singing voice are identified using the vocal vibrato and the portamento parameters. Groups of vocal partials can then be re-synthesized to isolate the voice. The result of the partial grouping can also be used to transcribe the sung melody. We then propose to go further with these features and study if the vibrato and portamento characteristics can be considered as a part of the singers' signature. Previous works on singer identification describe audio signals using features extracted on the short-term amplitude spectrum. The latter features aim to characterize the timbre of the sound, which, in the case of singing, is related to the vocal tract of the singer. The features we develop in this document capture long-term information related to the intonation of the singer, which is relevant to the style and the technique of the singer. We propose a method to combine these two complementary descriptions of the singing voice to increase the recognition rate of singer identification. In addition we evaluate the robustness of each type of feature against a set of variations. We show the singing voice is a highly variable instrument. To obtain a representative model of a singer's voice it is thus necessary to build models using a large set of examples covering the full tessitura of a singer. In addition, we show that features extracted directly from the partials are more robust to the presence of an instrumental accompaniment than features derived from the amplitude spectrum.

This work presents the direct torque control (DTC) techniques, implemented in four- and six-switch inverter, for brushless dc (BLDC) motors with non-sinusoidal back- EMF using two and three-phase conduction modes. First of all, the classical direct torque control of permanent magnet synchronous motor (PMSM) with sinusoidal back-EMF is discussed in detail. Secondly, the proposed two-phase conduction mode for DTC of BLDC motors is introduced in the constant torque region. In this control scheme, only two phases conduct at any instant of time using a six-switch inverter. By properly selecting the inverter voltage space vectors of the two-phase conduction mode from a simple look-up table the desired quasi-square wave current is obtained. Therefore, it is possible to achieve DTC of a BLDC motor drive with faster torque response while the stator flux linkage amplitude is deliberately kept almost constant by ignoring the flux control in the constant torque region. Third, the avarege current controlled boost power factor correction (PFC) method is applied to the previously discussed proposed DTC of BLDC motor drive in the constant torque region. The test results verify that the proposed PFC for DTC of BLDC motor drive improves the power factor from 0.77 to about 0.9997 irrespective of the load. Fourth, the DTC technique for BLDC motor using four-switch inverter in the constant torque region is studied. For effective torque control in two phase conduction mode, a novel switching pattern incorporating the voltage vector look-up table is designed and implemented for four-switch inverter to produce the desired torque characteristics. As a result, it is possible to achieve two-phase conduction DTC of a BLDC motor drive using four-switch inverter with faster torque response due to the fact that the voltage space vectors are directly controlled.. Finally, the position sensorless direct torque and indirect flux control (DTIFC) of BLDC motor with non-sinusoidal back-EMF has been extensively investigated using three-phase conduction scheme with six-switch inverter. In this work, a novel and simple approach to achieve a low-frequency torque ripple-free direct torque control with maximum efficiency based on dq reference frame similar to permanent magnet synchronous motor (PMSM) drives is presented.

MPEG audio compression techniques significantly reduces the storage and transmission requirements for high quality digital audio. However, compression complicates the processing of audio in many applications. If a compressed audio signal is to be processed, a direct method would be to decode the compressed signal, process the decoded signal and re-encode it. This is computationally expensive due to the complexity of the MPEG filter bank. This thesis deals with processing of MPEG compressed audio. The main contributions of this thesis are a) Extracting wavelet coefficients in the MPEG compressed domain. b) Wavelet based pitch extraction in MPEG compressed domain. c) Time Scale Modifications of MPEG audio. d) Watermarking of MPEG audio. The research contributions starts with a technique for calculating several levels of wavelet coefficients from the output of the MPEG analysis filter bank. The technique exploits the toeplitz structure which arises when the MPEG and wavelet filter banks are represented in a matrix form, The computational complexity for extracting several levels of wavelet coefficients after decoding the compressed signal and directly from the output of the MPEG analysis filter bank are compared. The proposed technique is found to be computationally efficient for extracting higher levels of wavelet coefficients. Extracting pitch in the compressed domain becomes essential when large multimedia databases need to be indexed. For example one may be interested in listening to a particular speaker or to listen to male female audio segments in a multimedia document. For this application, pitch information is one of the very basic and important features required. Pitch is basically the time interval between two successive glottal closures. Glottal closures are accompanied by sharp transients in the speech signal which in turn gives rise to a local maxima in the wavelet coefficients. Pitch can be calculated by finding the time interval between two successive maxima in the wavelet coefficients. It is shown that the computational complexity for extracting pitch in the compressed domain is less than 7% of the uncompressed domain processing. An algorithm for extracting pitch in the compressed domain is proposed. The result of this algorithm for synthetic signals, and utterances of words by male/female is reported. In a number of important applications, one needs to modify an audio signal to render it more useful than its original. Typical applications include changing the time evolution of an audio signal (increase or decrease the rate of articulation of a speaker),or to adapt a given audio sequence to a given video sequence. In this thesis, time scale modifications are obtained in the subband domain such that when the modified subband signals are given to the MPEG synthesis filter bank, the desired time scale modification of the decoded signal is achieved. This is done by making use of sinusoidal modeling [I]. Here, each of the subband signal is modeled in terms of parameters such as amplitude phase and frequencies and are subsequently synthesised by using these parameters with Ls = k La where Ls is the length of the synthesis window , k is the time scale factor and La is the length of the analysis window. As the PCM version of the time scaled signal is not available, psychoacoustic model based bit allocation cannot be used. Hence a new bit allocation is done by using a subband coding algorithm. This method has been satisfactorily tested for time scale expansion and compression of speech and music signals. The recent growth of multimedia systems has increased the need for protecting digital media. Digital watermarking has been proposed as a method for protecting digital documents. The watermark needs to be added to the signal in such a way that it does not cause audible distortions. However the idea behind the lossy MPEC encoders is to remove or make insignificant those portions of the signal which does not affect human hearing. This renders the watermark insignificant and hence proving ownership of the signal becomes difficult when an audio signal is compressed. The existing compressed domain methods merely change the bits or the scale factors according to a key. Though simple, these methods are not robust to attacks. Further these methods require original signal to be available in the verification process. In this thesis we propose a watermarking method based on spread spectrum technique which does not require original signal during the verification process. It is also shown to be more robust than the existing methods. In our method the watermark is spread across many subband samples. Here two factors need to be considered, a) the watermark is to be embedded only in those subbands which will make the addition of the noise inaudible. b) The watermark should be added to those subbands which has sufficient bit allocation so that the watermark does not become insignificant due to lack of bit allocation. Embedding the watermark in the lower subbands would cause distortion and in the higher subbands would prove futile as the bit allocation in these subbands are practically zero. Considering a11 these factors, one can introduce noise to samples across many frames corresponding to subbands 4 to 8. In the verification process, it is sufficient to have the key/code and the possibly attacked signal. This method has been satisfactorily tested for robustness to scalefactor, LSB change and MPEG decoding and re-encoding.

Doctor of Philosophy(PhD) / Owing to its strategic position in the liver sinusoid, pathologic and morphologic alterations of the Liver Sinusoidal Endothelial Cell (LSEC) have far-reaching repercussions for the whole liver and systemic metabolism. LSECs are perforated with fenestrations, which are pores that facilitate the transfer of lipoproteins and macromolecules between blood and hepatocytes. Loss of LSEC porosity is termed defenestration, which can result from loss of fenestrations and/ or decreases in fenestration diameter. Gram negative bacterial endotoxin (Lipopolysaccharide, LPS) has marked effects on LSEC morphology, including induction LSEC defenestration. Sepsis is associated with hyperlipidemia, and proposed mechanisms include inhibition of tissue lipoprotein lipase and increased triglyceride production by the liver. The LSEC has an increasingly recognized role in hyperlipidemia. Conditions associated with reduced numbers of fenestrations such as ageing and bacterial infections are associated with impaired lipoprotein and chylomicron remnant uptake by the liver and consequent hyperlipidemia. Given the role of the LSEC in liver allograft rejection and hyperlipidemia, changes in the LSEC induced by LPS may have significant clinical implications. In this thesis, the following major hypotheses are explored: 1. The Pseudomonas aeruginosa toxin pyocyanin induces defenestration of the LSEC both in vitro and in vivo 2. The effects of pyocyanin on the LSEC are mediated by oxidative stress 3. Defenestration induced by old age and poloxamer 407 causes intrahepatocytic hypoxia and upregulation of hypoxia-related responses 4. Defenestration of the LSEC seen in old age can be exacerbated by diabetes mellitus and prevented or ameliorated by caloric restriction commencing early in life

Η παρούσα διπλωματική εργασία πραγματεύεται τη μελέτη και κατασκευή ενός μετατροπέα για την οδήγηση ενός μονοφασικού επαγωγικού κινητήρα. Η εργασία αυτή εκπονήθηκε στο Εργαστήριο Ηλεκτρομηχανικής Μετατροπής Ενέργειας του Τμήματος Ηλεκτρολόγων Μηχανικών και Τεχνολογίας Υπολογιστών της Πολυτεχνικής Σχολής του Πανεπιστημίου Πατρών. Σκοπός είναι η μελέτη και κατασκευή ενός τριφασικού αντιστροφέα τάσης για τη λειτουργία και τον έλεγχο των στροφών ενός μονοφασικού επαγωγικού κινητήρα. Αρχικά μελετάται η βασική αρχή λειτουργίας του μονοφασικού επαγωγικού κινητήρα και αναλύονται οι τεχνικές εκκίνησης που χρησιμοποιούνται για σύνδεση του κινητήρα απευθείας στο δίκτυο. Ακόμα παρουσιάζονται τα ισοδύναμα κυκλώματα λειτουργίας του μονοφασικού επαγωγικού κινητήρα, η εξίσωση της ηλεκτρομαγνητικής ροπής του και προσομοιώνεται η λειτουργία του για τη μελέτη της στατικής συμπεριφοράς του. Στη συνέχεια γίνεται μια θεωρητική ανάλυση του κυκλώματος του τριφασικού αντιστροφέα τάσης που κατασκευάστηκε, καθώς και όλων των υπόλοιπων κυκλωμάτων που είναι αναγκαία για τη λειτουργία του. Επιπροσθέτως αναλύεται η μέθοδος παλμοδότησης των διακοπτικών στοιχείων του αντιστροφέα τάσης, που είναι η "Ημιτονοειδής Διαμόρφωση του Εύρους των Παλμών" (SPWM). Στο επόμενο βήμα αναλύονται τα τεχνικά χαρακτηριστικά όλων των κυκλωμάτων που κατασκευάστηκαν, και περιγράφεται ο κώδικας του προγράμματος του μικροελεγκτή, που χρησιμοποιήθηκε για την παραγωγή των παλμών. Τέλος, παραθέτουμε παλμογραφήματα και μετρήσεις που προέκυψαν από τα πειράματα που διενεργήθηκαν μετά την ολοκλήρωση της κατασκευής. / This diploma thesis discourse the analysis and construction of a converter topology for single phase induction motor drives. The project was based in the Laboratory of Electromechanical Energy Conversion of the department of Electrical and Computer Engineering of School Engineering of University of Patras. The objective of this project is the analysis and construction of a three phase voltage inverter to control the speed of a single phase induction motor. The first stage of this work is the study of the basic principle of operation of the single phase induction motor and the analysis of the starting techniques, used for the direct connection to the power grid. The equivalent circuits of the running single phase induction motor and the equation of the electromagnetic torque are also presented in this project. Following, there is a theoretical analysis of the three phase voltage inverter circuit, as well of all the remaining circuit, necessary for its function. Moreover the method of pulse generation for the switching elements of the voltage inverter is analyzed, which is the “Sinusoidal Pulse Width Modulation”. The next step is the analysis of the technical characteristics all of the circuits developed, as well the description of the program code for the microcontroller, used to produce the pulses. Finally oscillograph figures and measurements, occurred from the experiments transacted after the finalization of the construction, are adduced.

Οι ηλεκτρονικοί αρμονικοί ταλαντωτές είναι βαθμίδες με ευρεία εφαρμογή σε τηλεπικοινωνιακά συστήματα, σε συστήματα επεξεργασίας σήματος και σε ηλεκτρονικά ισχύος. Στην εργασία αυτή, προτείνεται μια νέα γενική τοπολογία ταλαντωτή πολλαπλών φάσεων, η οποία λειτουργεί στο πεδίο του υπερβολικού ημιτόνου. Κύρια πλεονεκτήματα είναι η δυνατότητα λειτουργίας σε περιβάλλον χαμηλής τάσης τροφοδοσίας και η ηλεκτρονική ρύθμιση της συμπεριφοράς του ταλαντωτή. Ως παράδειγμα σχεδίασης δίνεται ένας αρμονικός ταλαντωτής πολλαπλών φάσεων εξόδου 3ης/6ης τάξης, που η εξομοίωση της λειτουργίας του έγινε με τη χρήση του λογισμικού Analog Design Environment της Cadence. / Electronic harmonic oscillators are stages with wide application in telecommunication systems, in signal processing systems and power electronics. In this project, a new multiphase oscillator topology is proposed, designed to operate in sinh domain. Main advantages are the ability to operate at low voltage and the electronic tuning of the oscillator’s behavior. A multiphase sinusoidal oscillator, 3rd/6th order, is given as an example. The validity of the proposed methods is verified through simulation results using the Cadence Analog Design Environment software.