Objectives – To measure the effect of non – asthmatic atopy (NAA) on the risk of adverse pregnancy outcomes; low birth weight (LBW), small for gestational age (SGA) and preterm birth (PTB), among primiparous women 19 – 25 years of age. Methods – Vital Statistics records from births occurring between 2004 and 2014, from approximately 60,000 primiparous women in South Carolina, aged 19 to 25 years, were linked to their Medicaid records. Maternal records were examined to determine if they had a previous diagnosis of NAA. Women with a diagnosis of NAA were frequency matched with a ratio of 1:4 to non – atopic controls by age, sex of infant, and asthma diagnosis. Next, the frequencies of LBW, SGA and PTB were compared across the two groups of women. Tests for linear trend across birth weight categories and gestational age at birth categories were then conducted after which separate Poisson regression models were estimated to measure the risk of each outcome. Results – Linear tests for increasing trend were statistically significant (p < 0.001); indicating that higher percentages of NAA are associated with higher infant birth weight. Similarly, higher percentages of NAA were associated with greater gestational age at birth. After controlling for maternal race/ethnicity, smoking during pregnancy, gestational diabetes and pre – pregnancy hypertension; mothers with a diagnosis of NAA had reduced risk for each outcome (RR = 0.96, 0.94 and 0.95 for LBW, SGA and PTB respectively). These results were not statistically significant (p > 0.05). Similar results were seen when data was further explored by maternal race/ethnicity. Conclusions – NAA could promote a healthy pregnancy and reduce the risk of adverse outcomes and should therefore be taken into account when assessing a woman’s risk of same. Until now this protection has gone unnoticed due to the increase in the risk of study outcomes that are associated with a diagnosis of asthma, and the fact that in many instances asthma is present with NAA. Additional analyses are needed to evaluate unknown factors associated with its diagnosis and treatment. Keywords: rhinitis, dermatitis, asthma, low birth weight, small for gestation age, preterm birth, race/ethnicity

Introdução: Evidências sugerem uma associação entre nascer pequeno para idade gestacional (PIG) e o risco aumentado de desenvolver problemas de comportamento. Além disso, indivíduos que relatam ter recebido menor cuidado materno apresentam mais sintomas de depressão e de ansiedade, e, de modo geral, cuidam com menos eficiência de seus filhos. Portanto, uma interação entre nascer PIG e a percepção da mãe de baixo cuidado materno recebido nos seus primeiros dezesseis anos de vida poderia estar associada a prejuízos na função cognitiva e risco aumentado para psicopatologias ao longo da vida. O objetivo deste trabalho foi avaliar a interação entre nascer PIG e o cuidado parental percebido pela mãe sobre o comportamento infantil aos 18 meses de vida. Métodos: Estudo transversal aninhado a uma coorte prospectiva canadense de nascimentos – MAVAN (Maternal Adversity, Vulnerability and Neurodevelopment) – realizada entre os anos de 2003 e 2010. Os dados analisados são provenientes de 3 questionários (Parental Bonding Instrument, PBI, Early Chidhood Behavior Questionnaire, ECBQ e Infant-Toddler Social and Emotional Assessment, ITSEA) respondidos pelas mães de 305 crianças. Para análise utilizamos Multivariate Analysis of Variance (MANOVA) com análise de interação para detecção das diferenças entre os grupos. Resultados: Observou-se uma interação entre o cuidado materno percebido pela mãe e o peso ao nascimento na habilidade atencional de crianças aos 18 meses de vida em ambos os instrumentos ECBQ e ITSEA. Crianças nascidas PIG e de mães que relataram ter recebido baixo cuidado materno alcançaram menores escores de atenção relatados nos dois questionários analisados - ECBQ (p=0,002) e ITSEA (p=0,05). Efeitos principais das variáveis preditoras peso ao nascimento sobre os domínios aconchego (p=0,011), assim como do cuidado materno sobre os domínios prazer de baixa intensidade (p=0,016) e transferência de atenção (p=0,004) do ECBQ também foram encontrados. Conclusão: Os achados reforçam a importância de uma visão sistêmica do desenvolvimento que contemple aspectos do ambiente precoce e de cuidados parentais nos primeiros anos de vida. Além disso, o comprometimento da atenção encontrado já aos 18 meses nessas crianças tem implicâncias clínicas, visto que pode servir como sinal de alerta, sugerindo a necessidade de um acompanhamento precoce para esses sujeitos. / Introduction: Evidence suggests an association between being born small for gestational age (SGA) and the increased risk for behavioral problems. Besides that, individuals who report have received lower quality of maternal care show increased prevalence of depression and anxiety, as well as in general are poorer caregivers of their offspring. Therefore, an interaction between the birth weight status and the quality of maternal care perceived by the mother could affect the cognitive functioning later in life. This study aimed to evaluate the interaction between being born SGA and the parental bonding perceived by the mother on the children’s behavior at 18 months of age. Methodology: a nested cross-sectional evaluation of a prospective Canadian birth cohort (MAVAN, Maternal Adversity, Vulnerability and Neurodevelopment), developed between the years of 2003 and 2010. Data from 305 children evaluated at 18 months of age and that had all three questionnaires completed (Parental Bonding Intrument - PBI, Early Chidhood Behavior Questionnaire - ECBQ and Infant-Toddler Social and Emotional Assessment – ITSEA) were used. Multivariate ANOVA accounting for parental interactions was used for the analysis. Results: Children born SGA from mothers reporting low maternal care had lower scores in the attentional set shifting trait (ECBQ, p=0.002) and attention construct (ITSEA, p=0.05) at 18 months of age. We also found isolated effects of SGA decreasing cuddliness (p=0.011) and high maternal care per se increased ECBQ low intensity pleasure (p=0.016) and attentional shifting (p=0.004). Conclusion: The findings reinforce the importance of a systemic developmental vision that integrates early environmental aspects and parental care in the first years of life. Besides, the effects on attention found already at 18 months have clinical relevance as it may serve as a warning sign for this population.

Introdução: Evidências sugerem uma associação entre nascer pequeno para idade gestacional (PIG) e o risco aumentado de desenvolver problemas de comportamento. Além disso, indivíduos que relatam ter recebido menor cuidado materno apresentam mais sintomas de depressão e de ansiedade, e, de modo geral, cuidam com menos eficiência de seus filhos. Portanto, uma interação entre nascer PIG e a percepção da mãe de baixo cuidado materno recebido nos seus primeiros dezesseis anos de vida poderia estar associada a prejuízos na função cognitiva e risco aumentado para psicopatologias ao longo da vida. O objetivo deste trabalho foi avaliar a interação entre nascer PIG e o cuidado parental percebido pela mãe sobre o comportamento infantil aos 18 meses de vida. Métodos: Estudo transversal aninhado a uma coorte prospectiva canadense de nascimentos – MAVAN (Maternal Adversity, Vulnerability and Neurodevelopment) – realizada entre os anos de 2003 e 2010. Os dados analisados são provenientes de 3 questionários (Parental Bonding Instrument, PBI, Early Chidhood Behavior Questionnaire, ECBQ e Infant-Toddler Social and Emotional Assessment, ITSEA) respondidos pelas mães de 305 crianças. Para análise utilizamos Multivariate Analysis of Variance (MANOVA) com análise de interação para detecção das diferenças entre os grupos. Resultados: Observou-se uma interação entre o cuidado materno percebido pela mãe e o peso ao nascimento na habilidade atencional de crianças aos 18 meses de vida em ambos os instrumentos ECBQ e ITSEA. Crianças nascidas PIG e de mães que relataram ter recebido baixo cuidado materno alcançaram menores escores de atenção relatados nos dois questionários analisados - ECBQ (p=0,002) e ITSEA (p=0,05). Efeitos principais das variáveis preditoras peso ao nascimento sobre os domínios aconchego (p=0,011), assim como do cuidado materno sobre os domínios prazer de baixa intensidade (p=0,016) e transferência de atenção (p=0,004) do ECBQ também foram encontrados. Conclusão: Os achados reforçam a importância de uma visão sistêmica do desenvolvimento que contemple aspectos do ambiente precoce e de cuidados parentais nos primeiros anos de vida. Além disso, o comprometimento da atenção encontrado já aos 18 meses nessas crianças tem implicâncias clínicas, visto que pode servir como sinal de alerta, sugerindo a necessidade de um acompanhamento precoce para esses sujeitos. / Introduction: Evidence suggests an association between being born small for gestational age (SGA) and the increased risk for behavioral problems. Besides that, individuals who report have received lower quality of maternal care show increased prevalence of depression and anxiety, as well as in general are poorer caregivers of their offspring. Therefore, an interaction between the birth weight status and the quality of maternal care perceived by the mother could affect the cognitive functioning later in life. This study aimed to evaluate the interaction between being born SGA and the parental bonding perceived by the mother on the children’s behavior at 18 months of age. Methodology: a nested cross-sectional evaluation of a prospective Canadian birth cohort (MAVAN, Maternal Adversity, Vulnerability and Neurodevelopment), developed between the years of 2003 and 2010. Data from 305 children evaluated at 18 months of age and that had all three questionnaires completed (Parental Bonding Intrument - PBI, Early Chidhood Behavior Questionnaire - ECBQ and Infant-Toddler Social and Emotional Assessment – ITSEA) were used. Multivariate ANOVA accounting for parental interactions was used for the analysis. Results: Children born SGA from mothers reporting low maternal care had lower scores in the attentional set shifting trait (ECBQ, p=0.002) and attention construct (ITSEA, p=0.05) at 18 months of age. We also found isolated effects of SGA decreasing cuddliness (p=0.011) and high maternal care per se increased ECBQ low intensity pleasure (p=0.016) and attentional shifting (p=0.004). Conclusion: The findings reinforce the importance of a systemic developmental vision that integrates early environmental aspects and parental care in the first years of life. Besides, the effects on attention found already at 18 months have clinical relevance as it may serve as a warning sign for this population.

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第20613号 / 医博第4262号 / 新制||医||1023(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 小川 修, 教授 篠原 隆司, 教授 近藤 玄 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

Yes / Objectives Preterm birth (PTB) and small for gestational age (SGA) are major causes of perinatal mortality and morbidity. Previous studies indicated a range of risk factors associated with these poor outcomes, including maternal psychosocial and economic wellbeing. This paper will explore a range of psycho-social and economic factors in an ethnically diverse population. Methods The UK’s Born in Bradford cohort study recruited pregnant women attending a routine antenatal appointment at 26–28 weeks’ gestation at the Bradford Royal Infirmary (2007–2010). This analysis includes 9680 women with singleton live births who completed the baseline questionnaire. Data regarding maternal socio-demographic and mental health were recorded. Outcome data were collected prospectively, and analysed using multivariate regression models. The primary outcomes measured were: PTB (<37 weeks’ gestation) and SGA (<10th customised centile). Results After adjustment for socio-demographic and medical factors, financial strain was associated with a 45 % increase in PTB (OR 1.45: 95 % CI 1.06–1.98). Contrary to expectation, maternal distress in Pakistani women was negatively associated with SGA (OR 0.65: CI 0.48–0.88). Obesity in White British women was protective for PTB (OR 0.67: CI 0.45–0.98). Previously recognized risk factors, such as smoking in pregnancy and hypertension, were confirmed. Conclusions This study confirms known risk factors for PTB and SGA, along with a new variable of interest, financial strain. It also reveals a difference in the risk factors between ethnicities. In order to develop appropriate targeted preventative strategies to improve perinatal outcome in disadvantaged groups, a greater understanding of ethno-specific risk factors is required

Objetivo: Analisar a influência dos cuidados maternos percebidos pelas mães sobre a frequência de aleitamento materno e aleitamento materno exclusivo, aos 3 e 6 meses de vida da criança em uma amostra expostas a diferentes ambientes intrauterinos. Métodos: Estudo observacional longitudinal, utilizando uma amostra de conveniência de mães e seus recém-nascidos, no qual os grupos foram classificados de acordo com as exposições maternas ocorridas no período gestacional, como diabetes mellitus, tabagismo ou desfecho do recém-nascido, como pequeno para idade gestacional, além de um grupo controle. Para algumas análises, os grupos em estudo foram subdivididos em grupo de condições intrauterinas adversas e grupo controle. A amostra foi selecionada em três hospitais de Porto Alegre, Rio Grande do Sul, Brasil, no período de 2011 a 2015. As mães e seus recém-nascidos foram avaliados ao nascimento, 7 e 15 dias, primeiro, terceiro e sexto mês de vida da criança. O aleitamento materno e o aleitamento materno exclusivo foram avaliados desde a entrevista do 15º dia até a entrevista do sexto mês de vida. Os questionários Parental Bonding Instrument (PBI), que avalia a percepção dos cuidados maternos e Edinburgh Postnatal Depression Scale (EPDS), que avalia a presença de sintomas depressivos após o parto, foram autoaplicados na entrevista do terceiro mês. Os testes utilizados foram ANOVA com post hoc de Tukey, teste Kruskal-Wallis com post hoc de Dunn, ANOVA de duas vias, ANCOVA e a Regressão de Poisson. As análises foram realizadas no programa Statistical Package for the Social Sciences versão 18.0. Resultados: A amostra foi composta de 212 duplas mãe/criança, 40 no grupo de mães com diabetes mellitus, 55 no grupo de tabagistas, 21 no grupo de nascidos pequenos para idade gestacional e 96 no grupo controle. A associação entre cuidado materno e amamentação entre os grupos em estudo mostrou que as mães que não praticavam mais o aleitamento materno no 3º mês de vida da criança apresentaram maiores escores na percepção de proteção e menores escores na percepção de cuidados maternos do que aquelas crianças que estavam em aleitamento materno exclusivo (p=0,038; p=0,017, respectivamente). O grupo controle apresentou maior escore na percepção de cuidados e menor escore na percepção de proteção materna em relação ao grupo de ambientes intrauterinos adversos (p=0,005, p=0,049, respectivamente). Em relação aos resultados da análise de regressão de Poisson entre amamentação, grupos, PBI e EPDS os dados mostram que, a cada um ponto a mais no protocolo de EPDS, o risco de não amamentar até 3 meses aumenta em 10,4% e até os 6 meses aumenta em 4,7% (p<0,001 e 0,004, respectivamente). Em relação ao aleitamento materno exclusivo, a cada um ponto a mais no protocolo de EPDS, o risco de não amamentar até 6 meses aumenta em 5,4% (p=0,002). As puérperas que perceberam restrição de carinho de suas mães aos 6 meses, apresentaram risco de 2,42% em relação à categoria de cuidado ótimo para não amamentar. Aquelas mães que perceberam suas mães como negligentes, apresentaram tendência de maior risco de 2,53% em relação à categoria de cuidado ótimo para não amamentar aos 6 meses de vida da criança. Conclusão: Os achados deste estudo sugerem que o estilo parental de baixo cuidado e de superproteção percebidos durante a infancia, interfere na frequencia do aleitamento materno e leva a sintomas depressivos após o parto. Demonstram, ainda, que os sintomas depressivos maternos após o parto influencia na frequencia da amamentação. / Objective: To analyze the influence of maternal care perceived by mothers on the frequency of breastfeeding and exclusive breastfeeding at 3 and 6 months of the child's life in a sample exposed to different intrauterine environments. Methods: A longitudinal observational study used a convenience sample of mothers and their newborns. They were classified according to maternal exposure occurring during pregnancy, such as diabetes mellitus, smoking or outcome newborn, the small for gestational age, and a control group. For some analyzes, the study groups were divided into two groups: the group of adverse intrauterine conditions and control group. The recruitment of participants was in three hospitals in Porto Alegre, Rio Grande do Sul, Brazil, from 2011 to 2015. The mothers and their newborns were evaluated at the newborns birth, 7 and 15 days, first, third and sixth month of child’s life. Breastfeeding and exclusive breastfeeding was evaluated from the 15th day to the sixth month of life, through questionnaires. The Parental Bonding Instrument questionnaires (PBI), which evaluates the perception of maternal care and Edinburgh Postnatal Depression Scale (EPDS), to assess the presence of depressive symptoms after delivery, were self-administered in the third month interview. The statistical tests used were ANOVA one-way with post hoc Tukey, Kruskal-Wallis test with post hoc Dunn, The two-way ANOVA, ANCOVA test and Poisson regression. Analyzes were performed using the Statistical Package for the Social Sciences version 18.0. Results: The sample was composed of 212 mothers with their child, 40 pairs in the diabetes mellitus group, 55 in the smokers group, 21 in small for gestational age group and 96 in the control group. The association between maternal care and breastfeeding among study groups showed that mothers who no longer practiced breastfeeding in the 3rd month of the child's life had higher scores in the perception of protection and lower scores in the perception of maternal care than those children who were in exclusive breastfeeding (p = 0.038, p = 0.017, respectively). The control group had higher scores of perceived care and lower perception of maternal protection in relation to the adverse intrauterine environment group (p=0.005, p=0.049, respectively). Regarding the results of the Poisson regression analysis between breastfeeding groups, PBI, and EPDS data show that each additional point on the EPDS protocol, the risk of not breastfeeding up to 3 months increased by 10.4% and up 6 months increases by 4.7% (p <0.001 and 0.004, respectively). Compared with exclusive breastfeeding, each additional point on the EPDS protocol, the risk of not breastfeeding up to 6 months increased by 5.4% (p = 0.002). The mothers realized that restriction affection from their mothers at 6 months had a risk of 2.42% compared to the great care category to not breastfeed. Those mothers who perceived their mothers as negligent tended to increase the risk of 2.53% compared to the great care category for not breastfeeding at 6 months of child's life. Conclusion: The findings of this study suggest that low care and overprotection parenting style perceived during childhood, interfere with the frequency of breastfeeding and leads to depressive symptoms after delivery. They also demonstrated those maternal depressive symptoms after birth influences breastfeeding frequency.

In the past decades there has been an improvement in the medical treatment of children born preterm or with reduced foetal growth. This has resulted in a much higher survival rate of these children, but also in a higher number of surviving children with chronic conditions. These changes have, in turn, increased interest in investigating the connection between birth-characteristics and outcomes in later life. The overall aim of the present thesis was to study the relations between birth-characteristics, subsequent hospitalisations, and childbearing by means of data available in Swedish population-based registries. The study population in this thesis consisted of women (and men in Paper III) born in 1973-75 according to the Medical Birth Register and the Total Population Register. Information available in other registries, such as the Hospital Discharge Register, was obtained by individual record linkage. In Paper I, 148,281 women, alive and living in Sweden at 13 years of age, were included. Of the women, 4.1% were born preterm and 5.4% were born small for gestational age, and approximately 30% of all women had given birth between 13 and 27 years of age. We found that reduced foetal growth and possibly preterm birth were related to the likelihood of giving birth during the study period. The intergenerational effects of preterm birth and reduced foetal growth were investigated in Paper II and the study population consisted of 38,720 mother-offspring pairs. An intergenerational effect of reduced foetal growth was found, and reduced foetal growth in the mother also increased the risk for preterm birth in the child. Paper III was concerned with 304,275 men and women living in Sweden at 13 years of age. Of these men and women, 30% were hospitalised during adolescence and early adulthood (i.e. between 12 and 23 years of age). We found that men and women born small for gestational age or preterm were more likely to be hospitalised, and that those born small for gestational age seemed to be more at risk compared to those born preterm. Finally, in Paper IV, the relation between hospitalisations during adolescence and the likelihood of giving birth was studied in 142,998 women living in Sweden at 20 years of age. We found that a majority of the causes of hospitalisation during adolescence were positively connected to the likelihood of giving birth between 20 and 27 years of age. The relations presented in Papers I-IV were evident although socio-economic characteristics were adjusted for.

Kardiopulmonale Adaptation und Therapie von wachstumsretardierten Frühgeborenen mit intrauteriner Perfusionsstörung im Vergleich zu nicht-wachstumsretardierten Frühgeborenen ohne intrauterine Perfusionsstörung Eingereicht von: Christin Lenk, geb. Demolt angefertigt in der Universitätsklinik und Poliklinik für Kinder und Jugendliche in Leipzig, Neonatologische Intensivstation betreut von Frau Prof. Dr. med. Eva Robel-Tillig Juli 2012 Chronische intrauterine Hypoxie bedingt durch uterine, feto-maternale und fetale Perfusionsstörung führt zur fetalen Wachstumsrestriktion und Erhöhung der fetalen und neonatalen Morbidität und Mortalität. Die pränatale Kreislaufzentralisation stellt einen pathophysiologischen Kompensationsmechanismus dar, der durch Umverteilung des Blutflusses eine Versorgung lebenswichtiger Organe des Feten sichert (Rizzo et al. 2008), (Robel-Tillig 2003), (Robel 1994), (Saling 1966). In den letzten Jahren haben sich Studien mit der postnatalen Adaptation der wachstumsretardierten Neonaten beschäftigt und wesentliche Risiken im Verlauf der ersten Lebenstage definiert. Wenige validierte Aussagen existieren jedoch zur Kreislaufsituation der betroffenen Kinder und der kardialen Leistungsfähigkeit auch über die erste Lebenswoche hinaus. Die vorliegende Studie vergleicht unter dieser Fragestellung eine Gruppe von 43 Frühgeborenen mit intrauteriner Wachstumsrestriktion auf der Grundlage einer Perfusionsstörung und 33 Frühgeborene mit appropriatem Wachstum und ungestörter pränataler Perfusion während der ersten 42 Lebenstage hinsichtlich der unmittelbaren postnatalen pulmonalen und kardialen Adaptationsparameter und des weiteren klinischen Verlaufs. Besonderer Schwerpunkt wird dabei auf die dopplersonographisch erfasste kardiale Funktion der Kinder gelegt. Als wesentlichstes Ergebnis der dopplersonographischen Messungen lässt sich bei den Frühgeborenen mit pränataler Perfusionsstörung ein signifikant erhöhtes Herzminutenvolumen rechts- und linksventrikulär im Vergleich zur Gruppe der Frühgeborenen mit ungestörter Perfusion darstellen (Robel-Tillig 2003), (Leipälä et al. 2003), Martinussen 1997}, (Guajardo, Mandelbaum & Linderkamp 1994), (Lindner et al. 1990). Die unmittelbar postnatale Adaptation zeigt hinsichtlich des arteriellen Nabelschnur-pH-Wertes eine schlechtere Anpassung der Frühgeborenen mit pränataler Perfusionsstörung auf. Im weiteren Verlauf der ersten Tage benötigen diese Frühgeborenen seltener eine maschinelle Beatmung oder CPAP-Atemhilfe als die Frühgeborenen ohne Wachstumsrestriktion. Bis zum 42. Lebenstag kehrt sich dieser Befund jedoch um. Die Frühgeborenen mit Wachstumsrestriktion bedürfen nun signifikant länger und häufiger einer Atemhilfe und zusätzlicher Sauerstoffsupplementierung. Als Komplikation trat bei den wachstumsretardierten Frühgeborenen eine höhere Rate an bronchopulmonaler Dysplasie auf. Ein weiterer Unterschied wird hinsichtlich der Transfusionshäufigkeit dargestellt. Frühgeborene mit Wachstumsrestriktion erhielten häufiger eine Erythrozytentransfusion und länger eine Transfusion von zusätzlichem Volumen. Zusammenfassend weisen die ermittelten Befunde auf ein Persistieren der intrauterin bestehenden Kompensation der beeinträchtigten Kreislaufsituation hin. Eine genaue Kenntnis der speziellen Probleme dieser Patientengruppe ist zur Vermeidung postnatal anhaltender hämodynamischer Störungen erforderlich.

Objetivo: Analisar a influência dos cuidados maternos percebidos pelas mães sobre a frequência de aleitamento materno e aleitamento materno exclusivo, aos 3 e 6 meses de vida da criança em uma amostra expostas a diferentes ambientes intrauterinos. Métodos: Estudo observacional longitudinal, utilizando uma amostra de conveniência de mães e seus recém-nascidos, no qual os grupos foram classificados de acordo com as exposições maternas ocorridas no período gestacional, como diabetes mellitus, tabagismo ou desfecho do recém-nascido, como pequeno para idade gestacional, além de um grupo controle. Para algumas análises, os grupos em estudo foram subdivididos em grupo de condições intrauterinas adversas e grupo controle. A amostra foi selecionada em três hospitais de Porto Alegre, Rio Grande do Sul, Brasil, no período de 2011 a 2015. As mães e seus recém-nascidos foram avaliados ao nascimento, 7 e 15 dias, primeiro, terceiro e sexto mês de vida da criança. O aleitamento materno e o aleitamento materno exclusivo foram avaliados desde a entrevista do 15º dia até a entrevista do sexto mês de vida. Os questionários Parental Bonding Instrument (PBI), que avalia a percepção dos cuidados maternos e Edinburgh Postnatal Depression Scale (EPDS), que avalia a presença de sintomas depressivos após o parto, foram autoaplicados na entrevista do terceiro mês. Os testes utilizados foram ANOVA com post hoc de Tukey, teste Kruskal-Wallis com post hoc de Dunn, ANOVA de duas vias, ANCOVA e a Regressão de Poisson. As análises foram realizadas no programa Statistical Package for the Social Sciences versão 18.0. Resultados: A amostra foi composta de 212 duplas mãe/criança, 40 no grupo de mães com diabetes mellitus, 55 no grupo de tabagistas, 21 no grupo de nascidos pequenos para idade gestacional e 96 no grupo controle. A associação entre cuidado materno e amamentação entre os grupos em estudo mostrou que as mães que não praticavam mais o aleitamento materno no 3º mês de vida da criança apresentaram maiores escores na percepção de proteção e menores escores na percepção de cuidados maternos do que aquelas crianças que estavam em aleitamento materno exclusivo (p=0,038; p=0,017, respectivamente). O grupo controle apresentou maior escore na percepção de cuidados e menor escore na percepção de proteção materna em relação ao grupo de ambientes intrauterinos adversos (p=0,005, p=0,049, respectivamente). Em relação aos resultados da análise de regressão de Poisson entre amamentação, grupos, PBI e EPDS os dados mostram que, a cada um ponto a mais no protocolo de EPDS, o risco de não amamentar até 3 meses aumenta em 10,4% e até os 6 meses aumenta em 4,7% (p<0,001 e 0,004, respectivamente). Em relação ao aleitamento materno exclusivo, a cada um ponto a mais no protocolo de EPDS, o risco de não amamentar até 6 meses aumenta em 5,4% (p=0,002). As puérperas que perceberam restrição de carinho de suas mães aos 6 meses, apresentaram risco de 2,42% em relação à categoria de cuidado ótimo para não amamentar. Aquelas mães que perceberam suas mães como negligentes, apresentaram tendência de maior risco de 2,53% em relação à categoria de cuidado ótimo para não amamentar aos 6 meses de vida da criança. Conclusão: Os achados deste estudo sugerem que o estilo parental de baixo cuidado e de superproteção percebidos durante a infancia, interfere na frequencia do aleitamento materno e leva a sintomas depressivos após o parto. Demonstram, ainda, que os sintomas depressivos maternos após o parto influencia na frequencia da amamentação. / Objective: To analyze the influence of maternal care perceived by mothers on the frequency of breastfeeding and exclusive breastfeeding at 3 and 6 months of the child's life in a sample exposed to different intrauterine environments. Methods: A longitudinal observational study used a convenience sample of mothers and their newborns. They were classified according to maternal exposure occurring during pregnancy, such as diabetes mellitus, smoking or outcome newborn, the small for gestational age, and a control group. For some analyzes, the study groups were divided into two groups: the group of adverse intrauterine conditions and control group. The recruitment of participants was in three hospitals in Porto Alegre, Rio Grande do Sul, Brazil, from 2011 to 2015. The mothers and their newborns were evaluated at the newborns birth, 7 and 15 days, first, third and sixth month of child’s life. Breastfeeding and exclusive breastfeeding was evaluated from the 15th day to the sixth month of life, through questionnaires. The Parental Bonding Instrument questionnaires (PBI), which evaluates the perception of maternal care and Edinburgh Postnatal Depression Scale (EPDS), to assess the presence of depressive symptoms after delivery, were self-administered in the third month interview. The statistical tests used were ANOVA one-way with post hoc Tukey, Kruskal-Wallis test with post hoc Dunn, The two-way ANOVA, ANCOVA test and Poisson regression. Analyzes were performed using the Statistical Package for the Social Sciences version 18.0. Results: The sample was composed of 212 mothers with their child, 40 pairs in the diabetes mellitus group, 55 in the smokers group, 21 in small for gestational age group and 96 in the control group. The association between maternal care and breastfeeding among study groups showed that mothers who no longer practiced breastfeeding in the 3rd month of the child's life had higher scores in the perception of protection and lower scores in the perception of maternal care than those children who were in exclusive breastfeeding (p = 0.038, p = 0.017, respectively). The control group had higher scores of perceived care and lower perception of maternal protection in relation to the adverse intrauterine environment group (p=0.005, p=0.049, respectively). Regarding the results of the Poisson regression analysis between breastfeeding groups, PBI, and EPDS data show that each additional point on the EPDS protocol, the risk of not breastfeeding up to 3 months increased by 10.4% and up 6 months increases by 4.7% (p <0.001 and 0.004, respectively). Compared with exclusive breastfeeding, each additional point on the EPDS protocol, the risk of not breastfeeding up to 6 months increased by 5.4% (p = 0.002). The mothers realized that restriction affection from their mothers at 6 months had a risk of 2.42% compared to the great care category to not breastfeed. Those mothers who perceived their mothers as negligent tended to increase the risk of 2.53% compared to the great care category for not breastfeeding at 6 months of child's life. Conclusion: The findings of this study suggest that low care and overprotection parenting style perceived during childhood, interfere with the frequency of breastfeeding and leads to depressive symptoms after delivery. They also demonstrated those maternal depressive symptoms after birth influences breastfeeding frequency.

Objetivo: Avaliar, em uma coorte de bebês prematuros de muito baixo peso de nascimento, a influência da idade gestacional e da nutrição perinatal no desenvolvimento aos 24 meses de idade corrigida. Método: Foram estudadas 125 crianças pré-termo de muito baixo peso de nascimento nascidas ou internadas em uma unidade de terapia intensiva neonatal nas primeiras 48 horas de vida. Os bebês foram classificados como pequenos para a idade gestacional no nascimento (PIG) e na alta (PIG/PIG); adequados para a idade gestacional no nascimento (AIG) e pequenos para idade gestacional na alta (AIG/PIG); e adequados para a idade gestacional no nascimento (AIG) e na alta (AIG/AIG). A Bayley Scales of Infant and Toddler Development III (BSID-III) foi utilizada para a avaliação do neurodesenvolvimento aos 24 meses de idade corrigida. Resultados: 15 recém-nascidos nasceram ≤ 27 semanas, 73 entre 28-31 semanas e 37 > 31 semanas, as menores pontuações na BSID-III ocorreram no grupo mais imaturo. Por outro lado, 56 foram classificados como PIG/PIG, 55 como AIG/PIG, e 14 como AIG/AIG, não havendo diferença na BSID-III entre estes grupos, embora o grupo PIG/PIG tenha apresentado idade gestacional significativamente maior. Conclusão: Os recém-nascidos que foram PIG/PIG tinham idade gestacional maior do que os outros, e tiveram avaliação do neurodesenvolvimento semelhante, sugerindo que a nutrição perinatal desempenha um papel importante no desenvolvimento aos 2 anos de idade corrigida. / Aim: To assess the influence of gestational age and perinatal nutrition on development at 24 months corrected age in a cohort of very low birth weight preterm infants. Method: 125 very low birth weight preterm infants admitted to a neonatal intensive care unit within the first 48 hours of life were studied. The infants were classified as born small for gestational age (SGA) and still SGA at discharge (SGA/SGA); born adequate for gestational age (AGA) and SGA at discharge (AGA/SGA); and born AGA and still AGA age at discharge (AGA/AGA). The Bayley Scales of Infant and Toddler Development III (BSID-III) were used for assessment of neurodevelopment at 24 months corrected age. Results: 15 neonates were born at ≤27 weeks, 73 at 28–31 weeks, and 37 at >31 weeks with lowest BSID-III scores in the more immature group. 56 were classified as SGA/SGA, 55 as AGA/SGA, and 14 as AGA/AGA with no difference in BSID-III among the groups even though SGA/SGA group had significantly higher gestational age. Conclusion: Neonates who were SGA/SGA had higher gestational age than the others, and they had similar neurodevelopment assessment suggesting that perinatal nutrition plays an important role in development at 2 years corrected age.