Orientador: Ivanir Cozeniosque Silva / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Artes / Made available in DSpace on 2018-08-17T19:52:11Z (GMT). No. of bitstreams: 1 Barros_Denisede_M.pdf: 10375381 bytes, checksum: 9033f42e0be818a411ef9862ef7a5fb3 (MD5) Previous issue date: 2009 / Resumo: Este trabalho propõe-se a realizar um estudo sobre a interpretação poética do corpo humano, materializada pelo resgate da memória dos estímulos visuais e táteis experimentados no contato com a anatomia do corpo em cirurgias oncológicas. Apresenta a composição harmoniosa e complementar entre o repertório de relações sensoriais e cognitivas com as linguagens poéticas, expondo as essências do corpo humano através de elementos plásticos e visuais, que permeiam a criação artística das organicidades do interior do corpo humano. A observação cuidadosa desvenda superfícies, texturas, cores e camadas, num desdobramento expressivo das nuances e mistérios da vida, pulsante no corpo / Abstract: This work presents a study about the poetic interpretation of the human body, embodied by the rescue of memory of the stimuli tested in the visual and tactile contact with the anatomy of the body, in oncological surgery. The research presents the harmonious and complementary composition established between the repertoire of sensory and cognitive with the poetic language, exposing the essence of the human body through plastic and visual elements, allowing the artistic creation of organisms in the interior of the human body. A careful observation unveils surfaces, textures, colors and layers, a significant deployment of the nuances and mysteries of life, pulsating in the body / Mestrado / Artes Visuais / Mestre em Artes

Orientador: Frab Norberto Boscolo / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-08T12:56:23Z (GMT). No. of bitstreams: 1 Neves_EllenGaby_M.pdf: 11657040 bytes, checksum: 60cb751faaa4dbe2716d5d275a120464 (MD5) Previous issue date: 2007 / Resumo: O objetivo, neste trabalho, foi avaliar o efeito radioprotetor do selenito de sódio sobre o processo de reparo ósseo alveolar, decorrente de exodontias, em ratos. Foram utilizados 100 ratos machos divididos em quatro grupos experimentais: controle, selênio, irradiado e selênio irradiado. Todos os animais foram submetidos a exodontia do incisivo superior esquerdo. Os animais dos grupos selênio e selênio irradiado receberam 0,5 mg/kg de peso corpóreo do animal, de selenito de sódio e os animais dos grupos controle e irradiado receberam água destilada. Os animais dos grupos irradiado e selênio irradiado receberam na região de cabeça e pescoço, uma dose única de 15 Gy de radiação X. Aos 4, 7, 14, 21 e 28 dias da exodontia, os animais foram sacrificados e o processo de reparação óssea lveolar foi avaliado pela coloração com hematoxilina e eosina. A quantidade de osso neoformado depositado na ferida foi avaliada por meio da análise morfométrica, com auxílio de um microscópio de luz. Qualitativamente, observou-se que os grupos controle e selênio apresentavam um padrão de reparação óssea semelhante em todos os tempos, enquanto que os grupos selênio irradiado e irradiado apresentavam-se mais atrasados. Porém nos tempos de 4, 7 e 14 dias, o processo de reparo ósseo alveolar no grupo selênio irradiado apresentou-se mais adiantado que o do grupo irradiado. A quantidade de trabéculas ósseas umentava linearmente com o aumento do tempo em todos os grupos estudados; havendo diferença estatisticamente significante entre os grupos que foram irradiados e os não irradiados. Em todos os tempos estudados, não houve diferença estatística entre os grupos controle e selênio; não havendo também diferença estatística entre os grupos selênio irradiado e irradiado. A partir dos resultados obtidos foi possível concluir que quantitativamente o selenito de sódio não se comportou como um potente radioprotetor na reparação óssea alveolar, apesar de que qualitativamente o radioprotetor tenha provocado uma tênue proteção do alvéolo, com 4, 7 e 14 dias pós-cirúrgico / Abstract: The aim of this study was evaluate the radioprotective effect of sodium selenite on the socket healing in rats. For this purpose, one hundred male rats were divided in four experimental groups: control, selenium, irradiated and selenium irradiated. All animals were submitted to upper left incisor extraction. The animals belonging to the selenium and selenium irradiated groups received 0,5mg/kg of sodium selenite (i.p) and the animals pertaining to control and irradiated groups received only distilled water (i.p). The irradiated groups received a single exposure dose of 15Gy of X rays in the head and neck region. The animals were sacrificed in 4, 7, 14, 21 and 28 days after surgery and the process of socket healing was evaluated by hematoxylin/eosin. The amount of new-formed bone deposited on the wound was assessed by means of morphometric analysis, using a light microscope. In qualitative evaluation, for all the times studied, the control and selenium groups presented a similar pattern of socket repair. The selenium irradiated and irradiated groups presented a delayed repair process when compared to the non-irradiated groups. The selenium irradiated group presented a socket repairing process more advanced than the irradiated group in 4, 7 and 14 days. The amount of trabeculae linearly increased with the time for the all groups studied. It was observed a statistically significant difference between the irradiated groups and the non irradiated groups. It was also observed that there was not a statistically significant difference between control and selenium groups. Additionally, no statistical differences were observed between selenium irradiated and irradiated groups. Based on the quantitative data, we conclude that sodium selenite did not present a radioprotective effect on the socket healing process, although the slight protection in the 4, 7 and 14 days after surgery observed in qualitative evaluation / Mestrado / Radiologia Odontologica / Mestre em Radiologia Odontológica

Orientador: Solange Maria de Almeida / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-08T13:03:38Z (GMT). No. of bitstreams: 1 Coelho_RoselaineMoreira_M.pdf: 1689257 bytes, checksum: b7c1fd92ebcc6b99b4f459db0dac548b (MD5) Previous issue date: 2007 / Resumo: Devido à importância da radioterapia para tratamento de lesões malignas na região de cabeça e pescoço e da freqüente necessidade de extrações dentárias associada ao tratamento, este trabalho foi realizado com a finalidade de avaliar o efeito radioprotetor do pycnogenol® (Extrato da casca da pinha marítima francesa) na reparação alveolar em ratos da variedade Wistar. A amostra foi composta de 100 ratos divididos em quatro grupos experimentais: controle, irradiado, pycnogenol e pycnogenol irradiado. Todos os animais foram submetidos a cirurgia para extração do incisivo superior esquerdo. Os animais dos grupos pycnogenol e pycnogenol irradiado receberam, via intragástrica, três doses de 200mg/kg de peso corpóreo de pycnogenol®, administradas 72, 48 e 6 horas anterior à irradiação sham e à irradiação, respectivamente. Os animais dos grupos controle e irradiado receberam na mesma proporção, três doses de solução base de carboximetilcelulose e água destilada nos mesmos intervalos de tempo. Três dias após a cirurgia, o grupo irradiado e o grupo pycnogenol irradiado foram expostos a dose única de 15Gy de radiação X na região de cabeça e pescoço. Os animais foram sacrificados aos 4, 7, 14, 21 e 28 dias após a cirurgia. Após processamento histológico das peças, as lâminas foram coradas com Hematoxilina-Eosina para avaliação qualitativa, por meio da morfologia do tecido, e quantitativa, pela histometria óssea. Qualitativamente observou-se que o grupo irradiado e o grupo pycnogenol irradiado apresentaram padrão de reparação alveolar semelhante e atrasados em relação aos grupos controle e pycnogenol em todos os tempos de estudo. Os grupos controle e pycnogenol também se apresentaram semelhantes em todos os intervalos de tempo. Quantitativamente aos 4 dias não foi observada diferença estatisticamente significante entre os grupos estudados. Nos demais intervalos de tempo houve diferença estatisticamente significante entre os grupos não irradiados e os grupos irradiados. Conclui-se que morfologicamente, pelas análises qualitativa e quantitativa, não se observou a ação radioprotetora do pycnogenol® no processo de reparação alveolar em ratos irradiados / Abstract: Due to importance of the radiotherapy in malignant injuries treatment in the head and neck regions and of the frequent necessity of dental extractions associated to this treatment, this study was carried through the purpose to evaluate the radioprotector effect of pycnogenol® (French maritime pine bark extract) in the alveolar healing in rats of the Wistar variety. The sample was composed of 100 rats divided in four experimental groups: control, irradiated, pycnogenol and pycnogenol irradiated. All the animals were submitted to surgery for the left superior incisor extraction. The groups pycnogenol and pycnogenol irradiated had received, orally, three doses of pycnogenol® that consisted in 200mg/kg. These doses were administrated in 72, 48 and 6 hours previous to the irradiation sham and the irradiation, respectively. The animals of the control and irradiated groups had received, in the same ratio, three doses of carboxymethylcellulose solution and distilled water in the same intervals of time. After three days of the surgery, the irradiated group and the pycnogenol irradiated group were exposed to a dose of 15Gy of x-radiation, in the head and neck regions. The animals were sacrificed after the surgery in the days 4, 7, 14, 21 and 28. After histological processing and coloration by Hematoxylin-Eosin the qualitative evaluation (by the morphology of the tissue) and the quantitative evaluation (by histometric study) were proceeded. It was observed, qualitatively, that the irradiated and the pycnogenol irradiated groups had presented seemed patterns of alveolar healing and related to the control and pycnogenol groups they were delayed in all the study times. The control and pycnogenol groups also had the same features related to all the times intervals. Quantitatively after the 4 days was not observed statistically significant difference between the studied groups. In the others intervals of time there was a statistically significant difference between the not irradiated groups and the irradiated groups. It was concluded, by the qualitative and quantitative analyses, that there was not radioprotector action of pycnogenol® in the process of alveolar healing in irradiated rats / Mestrado / Radiologia Odontologica / Mestre em Radiologia Odontológica

O metabolismo ósseo é influenciado por fatores endócrinos, genéticos, de crescimento, sistema RANK/RANKL/OPG, além de uma variedade de moléculas regulatórias, como as citocinas. Citocinas têm sido implicadas na patogênese de doenças ósseas, no entanto, ainda pouco se sabe sobre os mecanismos envolvidos na interação entre o sistema ósseo e imunológico no processo de reparo ósseo. O objetivo deste estudo foi caracterizar o papel de TNF-α e IL-10 no reparo ósseo alveolar em condições homeostáticas (controle [C]) e infecciosas (alveolite experimental [A]) pós exodontia em camundongos C57Bl/6 (WT), TNFp55KO e IL-10KO. Após a cirurgia nos grupos infectados foi induzida a alveolite por meio de isquemia do alvéolo e uma suspensão de secreção purulenta. As maxilas foram coletadas em 0h, 7, 14 e 21 dias após a extração do incisivo superior para análises histológica, histomorfométrica e molecular (RealTimePCR). Na análise histomorfométrica foram quantificados os parâmetros coágulo, células inflamatórias, fibras, fibroblastos, vasos sanguíneos, matriz óssea, osteoblastos, osteoclastos, e outros espaço do líquido intersticial e medula óssea. Na análise molecular (RealTimePCR) foram quantificados a expressão de fatores de crescimento, marcadores ósseos e de matriz extracelular, citocinas e quimiocinas envolvidos no processo. Os dados obtidos foram submetidos ao teste OneWay ANOVA seguido do teste de comparação múltipla de Tukey. Os resultados demonstraram que nos camundongos WT-C houve a formação inicial de coágulo (0 hora) com início da expressão de BMP2, BMP4, BMP7, TGFb1 and VEGFa que tiveram aumento gradativo com pico em 7 dias. A expressão de TNF-α e IL10 também tiveram seus picos aos 7 dias em paralelo com contagem de leucócitos, associado com a expressão de CCL2, CCL5 e CXCL1. Nos períodos seguintes houve uma diminuição inflamatória e o aumento de marcadores osteoblásticos/osteogênicos. A indução da alveolite experimental em WT-A resultou no aumento marcante na expressão de TNF-α, acompanhada por uma maior expressão de CXCL1 e CCL5, contagem aumentada de leucócitos e diminuição na expressão de IL-10 que só atingiu seu pico aos 14 dias, além de proeminente infiltrado leucocitário e tecido de granulação, bem como evidências histológicas de atraso no reparo ósseo. O impacto negativo da alveolite foi atenuado nos camundongos TNFp55KO, caracterizado por um reparo adequado, diminuição no número de leucócitos e osteoclastos em relação aos WTA. Por outro lado, um atraso no reparo foi observado nos animais IL10KO, evidenciado por uma menor densidade de osteoblastos e de matriz óssea do que o respectivo controle. Em conclusão, os resultados mostraram que ambas citocinas interferem no reparo ósseo alveolar por meio de mecanismos que envolvem o controle da migração de células inflamatórias e modulação de quimiocinas e a expressão de marcadores osteogênicos, uma vez que a ausência de IL-10 está associada a uma maior atividade inflamatória e reabsorção óssea concomitante com menor formação ósseo, já a deficiência de TNF-α afeta o recrutamento de leucócitos e a cinética de reparo óssea alveolar em condições homeostáticas e infecciosas. / Bone metabolism is influenced by endocrine, genetic and growth factors, RANK/RANKL/OPG system, besides a variety of regulatory molecules, such as cytokines. Cytokines have been implicated in pathogenesis of bone diseases, however, little is known about the mechanisms involved in the interaction between skeletal and immune system in the bone repair process. The objective of this study was characterized the role of TNF-α and IL-10 in alveolar bone repair under homeostatic (control [C]) and infectious (experimental alveolitis [A]) conditions in C57Bl/6 (WT), TNFp55KO and IL-10KO mice. After surgery, in infectious groups was induced by ischemia alveolitis the well and a suspension of pus. The maxillas were collected at 0h, 7, 14 and 21 days after extraction of the maxillary incisor for histologic, histomorphometric and molecular (RealTimePCR). In histomorphometric analysis parameters were measured clot, inflammatory cells, fibers, fibroblasts, blood vessels, bone matrix, osteoblast, osteoclast, and other space - the interstitial fluid and bone mar row. Molecular analysis (RealTimePCR) were quantified the expression of growth factors, bone markers and extracellular matrix, cytokines and chemokines involved in the process. The data were submitted to the OneWay ANOVA test followed by Tukey\'s multiple comparison test. The results showed that in WT-C initial clot formation (0 hours) with early expression of BMP2, BMP4, BMP7, and TGFb1 VEGFa who had gradual increase peaking in 7 days. The expression of TNF-α and IL10 also peaked at 7 days in parallel with leukocyte count, associated with CCL2, CCL5 and CXCL1. In late periods there were decrease of inflammation and markers osteoblastic / osteogenic increased. Induction of experimental alveolitis in WT resulted in a marked increase in expression of TNF-α accompanied by increased expression of CXCL1 and CCL5, increased leukocyte count and decreased of IL10 expression that peaked at 14d, besides prominent leukocyte infiltration and granulation tissue, as well as histological evidence of delayed bone repair. Negative impact of alveolitis was attenuated in TNFp55KO mice, characterized by appropriate repair rate, decreased of the number of leukocytes and osteoclasts that WT-A. On the other hand, a lessened repair was observed in IL10KO animals, evidenced by lower density of the density of osteoblasts and bone matrix than respective control. In conclusion, the results show that both cytokines interferes in alveolar bone repair through mechanisms that involve the control of inflammatory cell migration and modulation of chemokines and osteogenic markers expression, since that the absence of IL-10 is associated with higher inflammatory activity and bone resorption concomitant with lower bone formation, while the deficiency of TNF-αa affect the recruitment of leukocytes and the kinetics of alveolar bone healing both in homeostatic and infectious conditions.

A alveolite seca (AS) é uma das complicações pós-operatórias mais comuns e sintomáticas na odontologia, porém, até o momento não há um protocolo de tratamento definido. O composto fenólico guaiacol (Gu) é um dos materiais utilizados para revestimento intra-alveolar devido às suas propriedades analgésicas, antioxidantes e antimicrobianas. Contudo, sua desvantagem é a dificuldade de manipulação decorrente da sua baixa estabilidade, alta volatilidade e sensibilidade à oxidação. Para melhorar suas propriedades e aumentar sua aplicabilidade clínica, um complexo de inclusão de Gu com ß-ciclodextrina (ßcd) foi desenvolvido. A formação do complexo supramolecular de Gu:ßcd foi caracterizada mediante a ressonância magnética nuclear (RMN), nos experimentos de 1H e 2D ROESY. A atividade antibacteriana do Gu e Gu:ßcd frente a Escherichia coli, Staphylococcus aureus, Streptococcus mitis, Streptococcus mutans, Streptococcus sanguis e Aggregatibacter actinomycetemcomitans foi analisada pelo método da microdiluição e sua citotoxicidade em osteoblastos de calvária de rato, foi estudado com o ensaio do MTT. O processo de reparo alveolar induzido pelo Gu:ßcd foi avaliado histologicamente após tratamento de alveolite seca em molares inferiores de ratos. A RMN mostrou correlações espaciais entre os hidrogênios internos (H3 e H5) da ßcd e os hidrogênios aromáticos, H(a) e H(b) do Gu, confirmando a formação do complexo. A complexação do Gu na ßcd potencializou seu efeito antibacteriano e reduziu sua citotoxicidade em osteoblastos. O estudo in vivo evidenciou a ocorrência de ossificação no ápice alveolar dos ratos tratados com Gu:ßcd, no 7o dia. No 14o dia, as trabéculas ósseas ocuparam também o terço médio do alvéolo e no 21o dia, todo o alvéolo se encontrava preenchido por osso neoformado. Estes resultados foram similares ao controle negativo e superiores ao controle positivo (Alvogyl®). Os benefícios obtidos pela inclusão do Gu na ßcd foram demonstrados pela melhora das propriedades biológicas do Gu in vitro e o adequado reparo alveolar in vivo. / Dry socket is one of the most common and symptomatic complications in dentistry, however, there is still not a settled treatment for this condition. The phenolic compound guaiacol (Gu) is one of several alveolar dressings used in dry socket because it has analgesic, antioxidant and antimicrobial properties. Nevertheless, its disadvantage is the difficulty of manipulation due to its low stability, high volatility and sensitivity to oxidation. To improve its properties and increase its clinical applicability, an inclusion complex of Gu with ß-cyclodextrin (ßcd) was developed. The Gu:ßcd supramolecular complex was characterized by Nuclear Magnetic Ressonance (NMR), in the 1H and 2D ROESY experiments. The antibacterial activity of Gu and Gu:ßcd over Escherichia coli, Staphylococcus aureus, Streptococcus mitis, Streptococcus mutans, Streptococcus sanguis and Aggregatibacter actinomycetemcomitans was analyzed using the microdilution method and its cytotoxicity in rat calvaria-derived osteoblast was evaluated with the MTT assay. The alveolus repair process induced by Gu:ßcd was histologically studied after the treatment of dry socket in rat mandibular molars. The NMR showed spatial correlations between internal hydrogens (H3 and H5) of ßcd and aromatic hydrogens, H(a) and H(b), of Gu confirming the inclusion complex formation. Gu:ßcd complex potentiated Gu antibacterial effect and reduced its cytotoxicity in osteoblasts. The in vivo study revealed that ossification occurred in the alveolar apex of rats treated with Gu:ßcd, by day 7. In the 14th day, the trabecular bone occupied the apical and middle thirds of the socket and on the 21st day, the entire alveolus was filled by newly formed bone. These results were similar to the negative control and superior to the positive control (AlvogylTM). Benefits gained from inclusion of Gu in cyclodextrin have been particularly demonstrated by the improvement in Gu biological properties in vitro and the appropriate alveolus repair in vivo.

The purpose of the thesis is to present a foundation for selecting an appropriate model while building a concurrent network server, focusing on a comparison between a select() based server and one thread for each connection. The test conducted herein is based two echo servers ( the message sent is echoed back to the sender ) and the time they take to serve a number of clients. The programs written for it are run on both Windows and Linux to show if the choice of platform affects the methods efficiency. Also looking at the return time of select() when we have a number of sockets, as well the time it takes to create a set number of threads. The conclusion drawn in this thesis is that for up to 512 sockets there is really no significant difference in the time it takes for the test program to return, this was true for both the Windows and the Linux test. Note however that the threading implementation requires much more memory than the select based one. So in the end it is basically up to personal preferences. / E-Mail: Nicklas.Franzen@gmail.com Mobile: 0703-506904

SYSTeam is an IT solutions supplier company that wants to develop a product which permits users to communicate with each other, over the Internet, in a secure way. The solution creates communication between two subnets which are connected through a Virtual Private Network (VPN) Gateway. The security of the communication is implemented at the application layer by using the Secure Socket Layer (SSL) protocol which carries, encrypted within it, a session layer technology called Sock-et-s (SOCKS). The communication prototype is developed in a Linux platform with the Integrated Development Environment (IDE) Eclipse and Java programming language.   There are many similar software-hardware based products in the market, but these solutions usually demand high budgets. This thesis shows the development of a communication prototype of a new, and low cost, alternative product. This report also describes how the Java SOCKS methods are increased with further functionality in order to reach the designed communication infrastructure. The entire implementation is tested by using a network analyzer software called Wireshark and a log function which writes out messages in order for us to know which part of the code is running.

Persons with transfemoral (above knee) and transtibial (below knee) prostheses experience changes in the volume of their residual limb during the course of the day. These changes in volume unavoidably lead to changes in quality of fit of the prosthesis, skin irritations, and soft tissue injuries. The associated pain and discomfort can become debilitating by reducing one's ability to perform daily activities. While significant advancements have been made in prostheses, the undesirable pain and discomfort that occurs due to the volume change is still a major challenge that needs to be solved. The overall goal of this research is to develop smart prosthetic sockets that can accommodate for volume fluctuations in the residual limb. In this research, fluidic flexible matrix composite wafers (f2mc) are integrated into the prosthetic socket for volume regulation. The f2mc's are flexible tubular elements embedded in a flexible matrix. These tubular elements are connected to a reservoir, and contain an internal fluid such as air or water. Fluid flow between the tubes and reservoir is controlled by valves. A linear finite element model has been created to better understand output response and stiffness of the f2mc wafers for different design variables. Results demonstrate that wind angle, latex thickness, and material selection can be used to tailor the wafers for different applications. Through experiments, f2mc's have been shown to achieve nearly 100% strain through the thickness when pressurized to about 482.6 kPa (70 psi). The displacement results shown through these tests show great promise in applications of socket integration to compensate for volume change. / Master of Science

Introdução: Após a exodontia, a cicatrização natural do alvéolo provoca alterações dimensionais no rebordo alveolar, com diminuição dos tecidos moles e duros. Diferentes técnicas podem ser utilizadas para tentar diminuir essas alterações, com a intenção de facilitar a reabilitação estética e funcional com implantes, principalmente em áreas de dentes anteriores. Objetivos: Os objetivos deste estudo foram verificar a eficácia da utilização do material de origem xenógena Orthogen® na preservação do rebordo alveolar pós-exodontia e avaliar as características histológicas após 4 meses de reparo. Materiais e Métodos: 20 pacientes foram divididos aleatoriamente em 2 grupos, de acordo com a abordagem que iriam receber após a exodontia de uma raiz residual. No grupo teste, os alvéolos foram preenchidos com Orthogen® e selados com EGL (Enxerto Gengival Livre). No grupo controle, um coágulo foi preservado no alvéolo e o mesmo também foi selado com EGL, sem a utilização do Orthogen®. Em ambos os grupos as exodontias foram realizadas de maneira minimamente traumática, com o Kit de Extração Atraumática Neodent®. Modelos de gesso obtidos antes das exodontias (tempo 1) e após 4 meses (tempo 2), momentos antes da instalação dos implantes, foram utilizadas para as medidas dimensionais, através do escanemento dos modelos e medidas no programa Orthoanalyzer®. Amostras ósseas obtidas após 4 meses de reparo foram utilizadas para a análise histológica descritiva. Resultados: Os resultados demonstraram que, após 4 meses de reparo alveolar, os dois grupos apresentaram remodelação do rebordo alveolar e diminuição nas medidas realizadas. Porém, a remodelação do rebordo foi mais evidente no grupo controle (coágulo). Histologicamente foi possível observar formação de novo osso ao redor das partículas do Orthogen®. Conclusões: A utilização do Orthogen® para preenchimento dos alvéolos e preservação do rebordo alveolar foi eficaz na diminuição das alterações dimensionais nos tecidos duro e mole do rebordo alveolar pós-exodontia. / Introduction: After tooth extraction, the natural healing of the socket is followed by dimensional changes of ridge contour, with marked reduce of hard and soft tissues. Socket reservation techniques can be used to improve functional and esthetics of the dental implants in this areas, especially in anterior teeth areas. Objectives: The aims of this study are to verify the efficacy of use Orthogen® to ridge preservation and analysis the histological characteristics after 4 months repair of the sockets. Material and Methods: 20 patients were randomly distributed in 2 groups, according with the treatments. In test group, the sockets were filled with Orthogen® and closed with a gingival free graft. In control group, the clots were preserved into the socket and free gingival graft was sutured in the deepithelialized marginal tissue of the socket. Stone casts were used to analyze the ridge dimensional changes with the Orthoanalyzer® software. After 4 months, bone samples were obtained during the dental implant procedure and were used to describe the histological characteristics. Results: The results showed that, after 4 months of wound healing, both groups showed a decrease in the measurements. However, the remodeling of the ridge was most evident in the control group (clot). Histological images showed the formation of new bone around the Orthogen® particles. Conclusion: The use of Orthogen® to socket preservation can collaborate to reduce the dimensional changes of the hard and soft tissue in post-extraction alveolar ridge sites.

The main objective of this thesis work is to develop communication link between Runrev Revolution (IDE) and JADE (Multi-Agent System) through Socket programming using TCP/IP layer. These two independent platforms are connected using socket programming technique. Socket programming is considered to be newly emerging technology among these two platforms, the work done in this thesis work is considered to be a prototype.A Graphical simulation model is developed by salixphere (Company in Hedemora) to simulate logistic problems using Runrev Revolution (IDE). The simulation software/program is called “BIOSIM”. The logistic problems are complex, and conventional optimization techniques are unlikely very successful. “BIOSIM” can demonstrate the graphical representation of logistic problems depending upon the problem domains. As this simulation model is developed in revolution programming language (Transcript) which is dynamically typed and English-like language, it is quite slow compared to other high level programming languages. The object of this thesis work is to add intelligent behaviour in graphical objects and develop communication link between Runrev revolution (IDE) and JADE (Multi-Agent System) using TCP/IP layers.The test shows the intelligent behaviour in the graphical objects and successful communication between Runrev Revolution (IDE) and JADE (Multi-Agent System).