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Stimuli Responsive Self-Assembled Hybrid Organic-Inorganic MaterialsAl-Rehili, Safaa 11 1900 (has links)
Because of the latest developments in nanotechnology and the need to have new functions, a high demand for innovative materials is created. The technological requirements for new applications cannot be fulfilled by most of the well-developed materials like metals, plastics, or ceramics. Therefore, composite materials that can exhibit better properties in contrast to their single counterpart represents a valuable and interesting alternative for the development of new and more performing functional materials.
In the past few years, one of the most rapidly developing fields in materials chemistry is research and development of innovative hybrid materials and nanocomposites having exceptional properties. A significant reason for this is that this group of materials closes the gaps between different scientific fields and brings together the ideal properties of the different disciplines into a single system.
Conventional materials like polymers or minerals can be mixed with substances of a different kind, like biological molecules and different chemical functional groups to create unique functional materials with the help of a building block method. Inorganic and organic chemistry, physical and biological sciences are integrated in the search for new recipes in a purely interdisciplinary way to generate unique materials. Compounds that are created frequently have interesting new properties for forthcoming functional materials and technological applications. Natural materials frequently function as a model for these systems and various examples of biomimetic methods can be obtained while generating these hybrid materials. The research and development of these materials is driven by the needs of future technologies.
The research carried out in this thesis is entirely based on hybrid organic-inorganic materials; hence, it consists of soft organic/bioorganic section that makes it possible to generate multifunctional materials, whereas the hard inorganic section functions as a rigid and stable platform for developing nanocarriers and imaging agents. A key domain in materials chemistry is the creation of smart materials that have the ability to respond to environmental changes or be triggered on demand. These materials have led to the creation of new technologies, like electroactive materials, electrochromic materials, biohybrid materials, sensors and membranes, etc. The required functionality can be provided by the organic or inorganic components, or from both.
In this dissertation, the synthesis, methodology, and creation of three unique organic-inorganic hybrid stimuli responsive systems having targeted features for specific applications are examined. The first example is represented by supramolecular microtoroids created by spontaneous self-assembly of amphiphilic molecules and a hydrophilic polymer (chitosan), in the presence of iron (III) chloride. Light irradiation is the stimulus responsible for assembly/disassembly of this new supramolecular entities. The basis of the photo-response of the microtoroids is the photoreaction of the anthracene derivatives. In order to make these materials bio applicable, the microtoroid size was controlled and narrowed down to nanometers, which has led to our second system called metal organic complexes (MOCs). In this system, chitosan was replaced by PNIPAM polymer at optimized concentrations. The reversible thermo-response of MOCs comes from the phase transition ability of PNIPAM. The third hybrid material is the core-shell system consisting of mesoporous organosilica coated with iron oxide nanoparticles, used for cargo delivery and cell imaging. The magnetic-response of the core-shell system results from the strong magnetic properties of iron oxide nanoparticles, while the presence of PMOs increased its biocompatibility.
Our research on such organic-inorganic hybrid materials represents a promising development in the field of materials chemistry. Due to the possibility of mixing various properties in a single material, a variety of combinations regarding possible materials and applications have emerged.
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Complexing AIEE-Active Tetraphenylthiophene Fluorophore to Poly(N-Isopropyl acrylamide)Lai, Yi-Wen 13 July 2012 (has links)
In this article, a multiple-responsive polymer micelles system was constructed by using ionic bond to link the hydrophobic tetraphenylthiophene (TP) fluorophores, which possess the property of aggregation-induced emission enhancement (AIEE), with the hydrophilic poly(N-isopropyl acrylamide) (PNIPAM). The susceptibility of the ionic ammonium-sulfonate (Am-Sul) bonds towards metal ions, acid and base triggered the AIEE-operative fluorescence (FL) response. To exercise the idea, PNIPAM with sulfonate terminal was primarily prepared to react with TP-derivatives functionalized with ammonium groups to generate polymer complex of TP-PNIPAM. When in water, the polymer complex TP-PNIPAM formed micelles with the aggregated TP core interconnecting the hydrophilic PNIPAM shell by the ionic Am-Sul bonds. With the operative AIEE effect, the aggregated TP core of the micelles fluoresced but upon the additions of metal ions, acid and base, the ionic bonds dissociated to result in the collapse of the micelles and the FL quenching. A novel fluorogenic sensor capable to respond to multi-stimuli was therefore constructed.
Amphiphilic micelle systems with the hydrophilic poly(N-isopropyl amide) (PNIPAM) shell and the hydrophobic tetraphenylthiophene (TP), which has the novel aggregation-induced emission enhancement (AIEE) feature, core inter-connected by ionic bonds were prepared in this study to explore the AIEE-operative emission response towards critical micelle concentration (CMC) and lower critical solution temperature (LCST). To exercise the idea, TP functionalized ammonium cations and PNIPAM with terminal sulfonate group were individually prepared and mixed together to yield three amphiphilic TP-PNIPAM complexes with different hydrophobic TP to the hydrophilic PNIPAM (x/y) ratios. When in aqueous solution, TP-PNIPAMs form micelles with the aggregated TP core, which emits strongly due to the operative AIEE effect, encompassed by the PNIPAM shell. The resultant CMC and LCST of the TP-PNIPAM micelles can be varied by changing the hydrophobic to the hydrophilic x/y ratio and can be monitored by the AIEE-dominant fluorescence responses towards concentration and temperature variables.
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Breakable silica nanoparticles for the in vitro and in vivo delivery of biomolecules / Nanoparticules de silice cassables pour le relargage in vitro et in vivo de biomoléculesDentinger, Mike 12 December 2018 (has links)
Le travail de recherche de cette thèse se concentre sur le développement de nanoparticules de silice organo-hybrides pour des applications en nanomédecine et agroalimentaire. Ces nanoconteneurs de silice, comportant des liens disulfures, sont capables de se briser en petits fragments en présence du milieu réductif intracellulaire. Des nanoparticules présentant de larges pores ont été synthétisées pour la livraison d’un siRNA PLK1 pour le traitement du carcinome hépatocellulaire et ont démontré des résultats prometteurs in vitro et in vivo. Ces particules ont été également utilisées pour charger un peptide cytotoxique, souvent utilisé comme pesticide dans l’industrie agroalimentaire. Les nanoparticules cassables ont ensuite été miniaturisées pour le relargage d’agents thérapeutiques dans des glioblastomes humains. Le système présentait un relargage plus rapide comparé à la forme liposomale actuellement sur le marché. Enfin, des nanoparticules contenant des liens répondant aux réactifs dérivés de l’oxygène ont été développées et ont démontré une fragmentation importante en présence d’oxygène singulet. / The research work presented throughout this thesis focuses on the development of organo-hybrid mesoporous silica nanoparticles for their applications in nanomedicine and crop industry. Disulfide doped silica nanocarriers, able to break down in small pieces in presence of the intracellular reductive environment have been tailored. A large pore stimuli-responsive system was developed to deliver a PLK1 siRNA within hepatocellular carcinoma cells demonstrating promising results both in vitro and in vivo. The particles were further used to deliver a venom peptide, often utilized as esticide in the crop industry. The breakable nanocarriers were further miniaturized for the delivery of chemotherapeutic agents within human glioblastoma cells. The system presented a faster delivery compared to the commercially available liposomal form. Finally, Reactive-Oxygen-Species-responsive mesoporous silica nanoparticles were developed and demonstrated fast breakability upon incubation with singlet oxygen.
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SUPRAMOLECULAR ASSEMBLY OF DENDRITIC POLYIONS INTORESPONSIVE NANOSTRUCTURESEghtesadi, Seyed Ali 24 May 2018 (has links)
No description available.
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New saloplastic biomaterials based on ultracentrifuged polyelectrolyte complexes / Nouveaux biomatériaux saloplastiques basés sur des complexes de polyélectrolytes ultracentrifugésTirado Viloria, Patricia Carolina 18 September 2012 (has links)
Ce travail avait pour but de développer un nouveau type de matériaux basés sur des complexes polyelectrolytes. Ces matériaux ont été obtenus par l’ultracentrifugation des complexes soit d’origine naturelle ou soit d’origine synthétique. Le système de polyélectrolytes ainsi que les conditions dans lesquelles ces matériaux peuvent être obtenus, suivi par le choix du système optimal pour des études complémentaires ont été décrits. PAA / PAH CoPECs a été choisi comme systèmes modèles de synthèse et ses propriétés physico chimiques (composition, structure et les propriétés mécaniques) ont été décrits ici en détails. Nous avons montré que les propriétés de la composition, la structure et mécanique de le PAA/PAH CoPECs peut être contrôlée en modifiant les conditions d’assemblage (pH, concentration des polyélectrolytes, [NaCl], la vitesse et la commande de l’addition). Également, les conditions environnementales ([NaCl] et pH) ont également été utilisés pour contrôler la taille des pores et porosité des PAA/PAH CoPECs . Enfin, leur capacité à servir de support pour l’immobilisation d’enzymes a également été étudiée. Nous avons optimise les conditions d’assemblage afin de maintenir le maximum quantité de l’enzyme dans le complexe. Nous avons également démontré que CoPECs fournit la stabilisation à long terme, ainsi que la protection de l’enzyme à des températures élevées. Ainsi, PAA / PAH CoPECs sont des candidats potentiels pour être utilisé comme des supports pour l’ingénierie tissulaire et pour l’immobilisation d’enzymes. / This work was aimed to the develop of a new kind of materials of polyelectrolytes complexes. These materials were obtained by the ultracentrifugation of complexes either of natural or synthetic origin. The polyelectrolytes systems as well as the conditions under which these materials could be obtained, followed by the selection of the optimal system to further studies was described. PAA/PAH CoPECs was chosen as synthetic model systems and its physiochemical properties (composition, structure and mechanical properties) were here deeply described. We demonstrated that the composition, structure and mechanical properties can be controlled by changing the assembly conditions (pH, concentration of the polyelectrolytes, [NaCl], speed and order of addition). Moreover, the environmental conditions ([NaCl] and pH) were also used to control the porosity and pores size of the PAA/PAH CoPECs. Finally their ability to serve as scaffold for enzyme immobilization was also studied. We optimized the assembly conditions to keep the maximum of the activity. We also demonstrated that the CoPECs structure provides the stabilization in long term as well as the protection of the enzyme from high temperature. Thus, PAA/PAH CoPECs is a potential and suitable candidates as scaffold for tissue engineering and for the immobilization of enzymes.
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Synthesis at different interfaces of bio-inspired films from mussels' byssus : influence of the oxidant nature at the solid/liquid interface and the addition of polymer at the air/water interface / Synthèse à différentes interfaces de films bio-inspirés du byssus de la moule : Influence de la nature de l'oxydant à l'interface solide-liquide et d'ajout de polymères à l'interface air-eauPonzio, Florian 23 September 2016 (has links)
Les matériaux à base de polydopamine (PDA) s’inspirent de la forte adhésion du byssus de la moule sous l’eau. L’oligomérisation de la dopamine dans un milieu basique permet la formation de revêtement de PDA sur n’importe quel matériau. En plus de la simplicité du procédé celui-ci est vert et versatile. La PDA a des propriétés similaires aux mélanines, d’où son utilisation dans le domaine des phénomènes de conversion d’énergie, de l’environnement et du biomédical. Cependant la structure de la PDA étant inconnue, l’élaboration de matériaux basés sur la relation structure propriétés est difficile. L’un des buts de cette thèse a été de comprendre cette relation pour élaborer de nouveaux matériaux de PDA. En choisissant l’oxydant adéquat nous avons déposé un film épais, superhydrophile et biocompatible sur n’importe quels substrats. De plus nous avons découverts la possibilité de former des films de PDA à l’interface air/eau. L’étude de ce phénomène a permis de former des membranes autosupportées et stimuli responsives. / Polydopamine (PDA) materials are inspired from mussels’ byssus strong adhesion underwater. The oligomerization of dopamine in a basic medium allows forming a PDA coating on virtually any materials. In addition to the simplicity, ecofriendly and versatility of the deposition method, PDA has properties similar to those of melanin pigments and displays many outstanding properties. Thus PDAis widely used in energy, environmental and biomedical sciences. However design of PDA based new materials with tailored properties is a challenge since its structure is still unknown. In that sense one of the aims of this thesis is to gain knowledge in PDA structure-property relationship in order to design PDA materials with new properties. By choosing the appropriate oxidant we deposited thick and superhydrophylic films on any materials for the elaboration of low fouling and biocompatible surfaces. Additionally we discovered the possibility to form PDA films at the air/water interface. The investigation of this phenomenon led to the formation of stimuli responsive free standing membranes.
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Enzyme-functionalized hybrid mesoporous nanodevices for sensing, controlled release and molecular communicationLlopis Lorente, Antoni 04 March 2019 (has links)
[ES] La presente tesis doctoral titulada "Nanodispositivos mesoporosos híbridos funcionalizados con enzimas para detección, liberación controlada y comunicación molecular" se centra en el diseño, preparación, caracterización y evaluación de distintos nanodispositivos híbridos orgánico-inorgánicos utilizando como soporte nanopartículas tipo Janus de oro y sílice mesoporosa, que se equipan con enzimas, especies fluorescentes y puertas moleculares.
Como conclusión general, los estudios realizados muestran que la incorporación de enzimas sobre nanopartículas permite introducir funciones de reconocimiento con alta especificidad y diseñar nanodispositivos avanzados para distintas finalidades. La combinación de nanopartículas híbridas con grupos orgánicos como puertas moleculares, efectores enzimáticos y especies cromo- fluorogénicas o fármacos puede resultar muy versátil; y se espera que los resultados obtenidos puedan inspirar el desarrollo de nuevos materiales inteligentes con aplicación en distintas áreas como la nanomedicina y la detección de moléculas de interés. / [CAT] La present tesi doctoral titulada "Nanodispositius mesoporosos híbrids funcionalitzats amb enzims per a detecció, alliberació controlada i comunicació molecular" es centra en el disseny, preparació, caracterització i avaluació de distints nanodispositius híbrids orgànic-inorgànics utilitzant com a suport nanopartícules tipus Janus d'or i sílice mesoporosa, que s'equipen amb enzims, espècies fluorescents i portes moleculars.
Com a conclusió general, els estudis realitzats mostren que la incorporació d'enzims sobre nanopartícules permeten introduir funcions de reconeixement amb alta especificitat i dissenyar nanodispositius avançats per a distintes finalitats. La combinació de nanopartícules híbrides amb grups orgànics com portes moleculars, efectors enzimàtics i espècies cromo-fluorogèniques o fàrmacs pot resultar molt versàtil; i s'espera que els resultats obsessos inspiren el desenvolupament de nous materials intel·ligents amb aplicació en distintes àrees com la nanomedicina i la detecció de molècules d'interés. / [EN] This PhD thesis entitled "Enzyme-functionalized hybrid mesoporous nanodevices for sensing, controlled release and molecular communication" is focused on the design, synthesis, characterization and evaluation of several hybrid organic-inorganic nanodevices using Janus gold-mesoporous silica nanoparticles as scaffolds, equipped with enzymes, fluorescent species and molecular gates.
In conclusion, these studies show that the incorporation of enzymes on nanoparticles allows to introduce recognition capabilities with high specificity and to design advanced nanodevices for different purposes. The combination of hybrid nanoparticles with organic groups such as molecular gates, enzymatic effectors and chromo-fluorogenic species or drugs can be very versatile; and we hope that the obtained results inspire the development of new smart materials with application in different areas such as nanomedice and sensing. / Llopis Lorente, A. (2019). Enzyme-functionalized hybrid mesoporous nanodevices for sensing, controlled release and molecular communication [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/117612 / TESIS
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Design and engineering of light-driven dynamic films for bioelectronic interfacing / Design och konstruktion av ljusdrivna dynamiska filmer för bioelektroniska gränssnittTerenzi, Luca January 2023 (has links)
In the realm of neuroelectronics, the challenge lies in achieving finer observations of physiological processes to comprehend neuronal interactions and computations. This necessitates the development of more compliant and biomimetic interfaces for improved integration with biological tissues, enabling finer physiological process observations. Commonly used flat and static electrode interfaces contrast sharply with the dynamic, complex, and three dimensional (3D) extracellular matrix (ECM) in which cells reside. Introducing 3D patterns on electrode surfaces enhances cell-chip coupling, improving the signal recording. Moreover, inorganic electrodes are stiff and rigid, creating mechanical mismatches with softer biological tissues, and they fail to fully capture ionic conduction.This thesis addresses these challenges by focusing on designing and engineering a multi-layer dynamic and stimuli-responsive bioelectronic interface. The system combines light-responsive, deformable polymers like Poly(Disperse Red 1-methacrylate) (pDR1m) with conductive polymers such as Poly(3,4-ethylenedioxythiophene): poly(stirensulfonate) (PEDOT:PSS). pDR1m responds to light, exhibiting 3D surface topography deformation, while PEDOT:PSS facilitates electrical recording and stimulation of cells, offering mixed electronic and ionic conduction as well as good mechanical properties. The potential use of an intermediate Polydimethylsiloxane (PDMS) film to improve layer adhesion is also explored. The individual and multi-layer samples were first optimized for spin coating manufacturing, and then thoroughly characterized to investigate their thickness, morphology, optical and electrochemical properties. Patterning of pDR1m-based samples was carried out using laser scanning confocal microscopy and a Lloyd’s mirror interferometer.The pDR1m\PEDOT:PSS sample demonstrates promising morphological and conductive properties, and the presence of PEDOT:PSS does not alter the absorption spectra of pDR1m. The multi-layer approach also supports efficient inscription of 3D surface reliefs without damaging the conductive layer. In conclusion, this work successfully designs conductive and dynamic light-driven films, which showcase good potential for bioelectronics and neuroelectronic interfaces. These interfaces could lead to enhanced investigations into combined electromechanical stimulation on cells and provide a more biomimetic coupling with biological tissues. / Inom neuroelektronikens område ligger utmaningen i att uppnå finare observationer av fysiologiska processer för att förstå neuronala interaktioner och beräkningar. Detta kräver utveckling av mer följsamma och biomimetiska gränssnitt för förbättrad integration med biologiska vävnader, vilket möjliggör finare fysiologiska processobservationer. Vanligt använda platta och statiska elektrodgränssnitt står i skarp kontrast till den dynamiska, komplexa och tredimensionella (3D) extracellulära matrisen (ECM) i vilken celler finns. Att introducera 3D-mönster på elektrodytor förbättrar cell-chip-kopplingen, vilket förbättrar signalinspelningen. Dessutom är oorganiska elektroder styva och stela, vilket skapar mekaniska felmatchningar med mjukare biologiska vävnader, och de lyckas inte helt fånga jonledning.Den här avhandlingen tar upp dessa utmaningar genom att fokusera på att designa och konstruera ett flerlagers dynamiskt och stimuli-responsivt bioelektroniskt gränssnitt. Systemet kombinerar ljuskänsliga, deformerbara polymerer som Poly(Disperse Red 1-methacrylate) (pDR1m) med ledande polymerer som Poly(3,4-etylendioxitiofen): poly(stirensulfonat) (PEDOT:PSS). pDR1m reagerar på ljus och uppvisar 3D-yttopografideformation, medan PEDOT:PSS underlättar elektrisk inspelning och stimulering av celler, erbjuder blandad elektronisk och jonledning samt goda mekaniska egenskaper. Den potentiella användningen av en mellanliggande polydimetylsiloxan (PDMS) film för att förbättra skiktvidhäftningen undersöks också. De individuella och flerskiktiga proverna optimerades först för spinnbeläggningstillverkning och karakteriserades sedan grundligt för att undersöka deras tjocklek, morfologi, optiska och elektrokemiska egenskaper. Mönster av pDR1m-baserade prover utfördes med laserskanning konfokalmikroskopi och en Lloyds spegelinterferometer.pDR1m\PEDOT:PSS-provet visar lovande morfologiska och ledande egenskaper, och närvaron av PEDOT:PSS förändrar inte absorptionsspektra för pDR1m. Flerskiktsmetoden stöder också effektiv inskription av 3D-ytreliefer utan att skada det ledande lagret. Sammanfattningsvis designar detta arbete framgångsrikt ledande och dynamiska ljusdrivna filmer, som visar upp god potential för bioelektronik och neuroelektroniska gränssnitt. Dessa gränssnitt kan leda till förbättrade undersökningar av kombinerad elektromekanisk stimulering på celler och ge en mer biomimetisk koppling med biologiska vävnader.
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Stimuli-responsive Materials From Thiol-based NetworksBrenn, William Alexander 01 June 2017 (has links)
No description available.
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DEVELOPMENT OF NOVEL MULTI-RESPONSIVE MATERIALS CHARACTERIZED BY POTENTIAL CONTROLLED RELEASE PROPERTIESChikh Alard, Ibaa 05 December 2018 (has links) (PDF)
With the emergence of novel and more effective drug therapies, increased importance is being placed upon the methods by which these drugs are being delivered to the body. In conventional drug delivery systems, there is very little control over the release of drug. The effective concentration at the target site can be achieved by intermittent administration of grossly excessive doses, which, often results in constantly, unpredictable variations in plasma concentrations, with the risk of reaching levels below or above the therapeutic range leading to marked side effects. A plethora of formulation strategies mainly based on polymeric/lipid nanoparticles, are described in literature. Even though these systems are therapeutically advantageous in comparison to conventional systems, they remain insensitive to the changing metabolic states of the body although the symptoms of most metabolic diseases follow a rhythmic pattern.A more appropriate and effective approach of managing some of these conditions lies in the chronotherapy. This approach allows for pulsed or self-regulated drug delivery which is adjusted to the staging of biological rhythms, since the onset of certain diseases exhibits strong circadian temporal dependence. In order to reach the objective of mimicking the biophysical and biochemical processes of pathological states, many innovations in material design for drug delivery systems (DDS) that are able to release the therapeutic payload-on-demand were done to release the therapeutic agent only when it is required, according to the physiological need. The development of multidisciplinary research teams has brought huge advantages in the design, fabrication and utilization of such smart systems, especially in the pharmaceutical field. Interestingly, numerous smart polymeric materials exhibit a response to a specific stimulus. A step further, the elaboration of purpose-built monomers can give rise to compounds with tunable sensitivities or multi-stimuli responsiveness. These smart polymers demonstrate an active responsiveness to environmental (or external) signals and change their physicochemical properties as designed (e.g. conformation, solubility, shape, charge or size). As far as the stimuli are concerned, they consist of physical (e.g. temperature, ultrasound, light, electricity, magnetic or mechanical stress), chemical (e.g. pH, ionic strength) and biological signals (e.g. enzymes, biomolecules). Due to the intrapersonal variabilities which may make internal stimuli hazardous, externally controlled systems rely on externally applied stimuli that are produced by stimuli-generating devices, which results in pulsed drug delivery. This type of delivery may be rapid and allows a transient release of a determined amount of drug within a short period of time immediately after a pre-determined off-release period. A novel strategy for the formation of multi-stimuli responsive materials endowed with pH, magnetic and light sensitivity was achieved. The approach relied on the incorporation of magnetic tetrahalogenoferrate(III) anions along a polymeric backbone based on poly(2-(N,N-dimethylamino) ethyl meth-acrylate) (PDMAEMA). Starting from the same PDMAEMA, quaternized pending amine groups with various halide derivatives gave rise to magnetic materials after anion metathesis. Measuring the magnetic susceptibility of these materials exhibited that the magnetic susceptibility increased as the substituted group size decreased (become smaller) which was apparently related to the steric hindrance around the ionic pendants. Additionally, a good correlation between the magnetic susceptibility and ferric content was found. Additional experimental and theoretical Raman analyses allowed the determination of the nature of the magnetic species constituting the materials. This strategy further offers the opportunity to tailor the magnetic response through partial ammonium salt formation. In order to merge the magnetic properties of ferric-based materials with another stimuli-responsive functionality, random copolymers containing DMAEMA (D) with diazobenzene (A) unit were prepared. So, three copolymers PDA were synthesized (with targeted D/A ratios 4/6 (PDA4), 6/4 (PDA6) and 8/2 (PDA8)). Meanwhile, different degrees of amine quaternization (10, 50 and 100 %) were applied, which led to the following polymeric salts PDAX/Y where X = 4, 6, 8 (referring to the percentage of the DMAEMA unit) and Y = 10, 50 and 100 (referring to the percentage of quaternized amine groups). Finally, the aforementioned materials were converted into magnetic polymers by anion exchange. As a result, magnetic responses correlated well with amount of iron oxide in these compounds and the amount of ionic pending groups along the backbone. Moreover, the remaining tertiary amines conferred pH sensitivity to the polymers whereas the diazobenzene units ensured light responsiveness through the well-established trans-to-cis isomerization.In order to functionalize these materials in the pharmaceutical field, an intelligent delivery system was prepared. Firstly, an attempt to formulate riboflavin-5’-phosphate sodium (RPS) loaded on PDA8 microspheres was made using double emulsion evaporation method. Meanwhile, prednisolone (PRD) microspheres were prepared using s/o/w emulsion technique. Subsequently, coating systems of cochineal red tablets were developed. These tablets were coated with polymer solution (using each of three types of copolymers: PDA8, PDA6, and PDA4) until the desired percentage of the coating was achieved (10, 15, and 20 % w/w). The cumulative release profiles of cochineal red tablets coated with PDA8, PDA6, and PDA4 showed a pH-sensitive release behavior. The release in the neutral media (pH ≈ 7.0) was very slow (less than 3 % after one hour). Then, after changing the pH to 1.2, an increase in the release of cochineal was observed. Furthermore, the cumulative release of cochineal red was at the highest value for the PDA8 and the lowest for PDA4 depending on the percentage of PDMAEMA moieties. Moreover, by increasing the percentage of the coating from (10, 15 to 20 % w/w), the cumulative release of cochineal decreased. Therefore, the copolymer PDAX can be used for controlling the release of drug by changing the pH value.Finally, the cochineal tablets coated with PDA6 (10 %) showed features of light sensitivity. The release of cochineal red from coated tablets was only due to the switching in the conformational trans/cis isomerization of azobenzene moieties upon irradiation, which was confirmed by comparing the release of coated tablets with uncoated tablets upon irradiation. / Doctorat en Sciences biomédicales et pharmaceutiques (Pharmacie) / info:eu-repo/semantics/nonPublished
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