This work deals with issue of human wrist and appropriate total wrist implant allowing a restoration of hand mobility approaching physiological condition after traumatic and degenerative diseases. Treating these diseases are very complex. These issues including a biological and medical issues. To determine the appropriate treatment method and select right total wrist implant is important to know the behavior the human wrist at all stages in terms of medical and biomechanical. For this reason, it was developed a biomechanical study including computation model of human wrist allowing solution of strain and stress of hand in physiological and pathological conditions and condition after total wrist implant. The frost remodeling of bone tissue was used for analysis of human wrist bone tissues and bone tissues after application of total wrist implant RE-MOTION™ Total Wrist.

This thesis deals with problems of biomechanics of soft tissues, namely of stress-strain analysis of abdominal aortic aneurysm (AAA). The introduction describes briefly the possibility of aneurysm occurrence with a focus on an aneurysm in the abdominal aorta.

Presented work deals with Biomechanical study of the facial skeleton. This work is focused on the fixation of the mandible after removal of a tumor from affected bone tissue. The aim of the work is to perform biomechanical study of the facial skeleton with subsequent detailed stress strain analysis of two mandible implants designed and manufactured for specific patients. The geometry model of mandible used for design of mandible implants and used for computational modelling has been obtained on the basis of CT data of two patients. A Theoretical-Clinical sub-study that deals with the comparison the CT data processing which is necessary for creating the model of geometry is a part of the thesis. Two models of mandible with applied mandible implant have been created for two specific patients with tumorous mandible bone tissue. Stress strain analysis has been performed for these two models. Results of the stress strain analysis of two models of mandibles with mandible implants are presented in the final chapters of the thesis. Findings of the biomechanical study have been published and applied in clinical practice.

Presented work deals with Biomechanical study of the facial skeleton. This work is focused on the fixation of the mandible after removal of a tumor from affected bone tissue. The aim of the work is to perform biomechanical study of the facial skeleton with subsequent detailed stress strain analysis of two mandible implants designed and manufactured for specific patients. The geometry model of mandible used for design of mandible implants and used for computational modelling has been obtained on the basis of CT data of two patients. A Theoretical-Clinical sub-study that deals with the comparison the CT data processing which is necessary for creating the model of geometry is a part of the thesis. Two models of mandible with applied mandible implant have been created for two specific patients with tumorous mandible bone tissue. Stress strain analysis has been performed for these two models. Results of the stress strain analysis of two models of mandibles with mandible implants are presented in the final chapters of the thesis. Findings of the biomechanical study have been published and applied in clinical practice.