This thesis deals with monitoring the thermodynamic stability of thaumasite and monitoring it is properties in the long term. The aim was to synthesize thaumasite under different conditions and to evaluate it using X-ray diffraction analysis and thermal analysis.

The main goal of this thesis is design of simple digital audio synthesizer. The synthesis of piano tones are descrribed. Final part is devoted to the basic principle of sound sample processing.

The aim of this work is to design digital synthesizer and modulator on embedded sys- tems. Work is exploring existing digital synthesizer and modulators in embedded systems and PC and with that gained knowledge is presenting possible solution of design on Field Programmable Gate Array.

This diploma thesis deals with the preparation of modified tricalcium aluminate phases using sodium ions, and the study of their hydration processes and products. The X-ray diffraction analysis, isothermal calorimetry, laser diffraction, and scanning electron microscopy with energy dispersion analysis were used to solve this task. The preparation of modified tricalcium aluminate phases using high temperature methods has been described in the experimental section. Furthermore, the X-ray diffraction analysis was used to determine the purity of the prepared phases and the scanning electron microscopy with energy dispersion analysis was used to define the volume of sodium. Laser diffraction was used to measure a particle size distribution in the individual phases. Subsequently, hydration of the pure phases was performed in an isothermal calorimeter. It was followed by hydration of phases in the presence of different gypsum content and then in the presence of saturated portlandite solution. Hydration of some samples was stopped in order to better understand the hydration process. Hydration products were studied by X-ray diffraction analysis. The obtained results were compared with each other and the influence of sodium ions on both the structure of the prepared phases and the course of hydration and its products has been discussed. The effect of adding different volumes of gypsum and portlandite on the course of hydration of the individual phases was also compared.

The aim of this work was to create an online platform for multi-user sound creation with original sound synthesis tools. The educational context of the application was also taken into account by hiding the controls of the sound parameters behind the subconsciously known physical phenomena and the game form of the application. A substantial part of the logic and all graphics of the instruments is written in the JavaScript programming language and its library p5.js. It is located on the client side and communicates with the Node.js-based server via a web socket. The audio part is on another server in the SuperCollider environment, it is transmitted via IceCast and communicates with the main OSC message server. The application contains 3 instruments for generating sounds and one effects module. Each instrument is designed for multiple users and requires their cooperation. Acceptable transmission speeds and minimum computational demands have been achieved by optimizing the instrument's internal algorithms, the way in which the graphic content is displayed and the appropriate routing of the individual sound modules. The sound is specific for each instrument. The instruments in the application are tuned and designed so that the user can both achieve interesting sound results himself and play his role as a whole with others. Methods such as granular synthesis, chaotic oscillators, string instrument modeling, filter combinations, and so on are used to generate sound. Great emphasis in the development of the application was placed on the separation of roles, simultaneous control of one instrument by several players and communication of users through playing the instruments and text expression - chat. An important part is also a block for displaying descriptive information.

Předkládaná práce se zabývá problémem automatizované syntézy pravděpodobnostních systémů: máme-li rodinu Markovských řetězců, jak lze efektivně identifikovat ten který odpovídá zadané specifikaci? Takové rodiny často vznikají v nejrůznějších oblastech inženýrství při modelování systémů s neurčitostí a rozhodování i těch nejjednodušších syntézních otázek představuje NP-těžký problém. V dané práci my zkoumáme existující techniky založené na protipříklady řízené induktivní syntéze (counterexample-guided inductive synthesis, CEGIS) a na zjemňování abstrakce (counterexample-guided abstraction refinement, CEGAR) a navrhujeme novou integrovanou metodu pro pravděpodobnostní syntézu. Experimenty nad relevantními modely demonstrují, že navržená technika je nejenom srovnatelná s moderními metodami, ale ve většině případů dokáže výrazně překonat, někdy i o několik řádů, existující přístupy.

V této práci byl popsán princip fotokatalýzy. Práce se soustřeďuje na kovové oxidy, které mají široké využití ve fotokatalytických aplikacích. Bylo také popsáno různé použití fotokatalytických materiálů. Tato práce se zaměřuje zejména na využití fotokatalytických materiálů pro rozklad organických vodu znečisťujících látek. Popsaný fotokatalyzátor je oxid měďný, který má velmi dobré vlastnosti pro rozklad organických látek pomocí fotokatalýzy. Schopnost rozkladu organických látek oxidu měďného byla popsána na rozkladu organického barviva methylová oranž.

Pravdepodobnostné programy zohrávajú rozhodujúcu úlohu v rôznych technických doménach, ako napríklad počítačové siete, vstavané systémy, stratégie riadenia spotreby energie alebo softvérové produčkné linky. PAYNT je nástroj na automatizovanú syntézu pravdepodobnostných programov vyhovujúcich zadaným špecifikáciam. V tejto práci rozširujeme tento nástroj predovšetkým o podporu optimálnej syntézy a syntézy viacerých špecifikácií. Ďalej sme navrhli a implementovali novú metódu, ktorá dokáže efektívne syntetizovať parametre so spojitým definičným oborom ovplyvňujúce pravdepodobnostné prechody popri syntéze topológie programov, t.j., podporu pre syntézu topológie aj parametrov súčasne. Demonštrujeme užitočnosť a výkonnosť nástroja PAYNT na širokej škále prípadových štúdií z rôznych aplikačných domén ktoré majú uplatnenie v reálnom svete. Pri náročných problémoch syntézy môže PAYNT výrazne znížiť dobu behu až z dní na minúty a zároveň zaistiť úplnosť procesu syntézy.

This work deals with carborane and metallacarborane clusters, in terms of their fundamental chemistry and complexation with cyclodextrins, and in the context of emerging pharmacophores applicable in medicinal chemistry. Arguably, the most important part of this work is the preparation of cobalt bis(dicarbollide) sulfamide derivatives. The sulfamido group is attached to the metallacarborane carbon vertex by an alkyl chain that may be modified in its length. This was accomplished by, firstly, the abstraction of the acidic hydrogen, located on the {CH}-vertex from the metallacarborane, by reaction with lithium base, followed by, secondly, reaction with electrophilic agents (PFA, oxirane and oxetane), which leads to a cascade of reactions to give the desired sulfamide derivatives. These compounds were then tested by collaborators in other institutes for in vitro and in vivo activity towards Carbonic Anhydrase IX (CA IX), which is an enzyme associated with tumour growth. In vivo tests on mice have shown that these types of substances are able to effectively reduce tumour size by 30%. The synthetic research continued with the preparation of sulfonamide compounds of the isomers of the carborane series. The reactions began exclusively with propylhydroxy carborane starting materials, which provide optimum...

Influenza viruses cause respiratory illnesses which can vary in severity depending on the strain of the virus, as well as the age and health condition of the host. Influenza remains a major threat to public health due to its nature prone to suffer mutations. As a result, vaccines have to be reformulated annually and new strains may cause sporadic global pandemics. Furthermore, the recent emergence of resistant strains of the virus against the current standard of care (oseltamivir and zanamivir) underlines the need of novel anti-influenza therapeutics. The aim of this dissertation work is to contribute to the discovery of new anti-influenza inhibitors either by rational drug-design and optimization of oseltamivir structure, or by developing screening assays suitable for the discovery of novel inhibitors of the enzymes neuraminidase or RNA-polymerase. Scheme 1. Overview of the strategy used for the development of new anti-influenza therapeutics. The dashed arrows indicate the inhibitors that were converted into probes and their corresponding target enzymes Two main modification points were explored for the improvement of oseltamivir properties (Scheme 1); modifications at carbon C-3 aimed to overcome oseltamivir resistance caused by common mutations like H274Y, meanwhile modifications at carbon C-5...