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Der NewsLetter ist eine Publikation des Instituts für Kommunikationswissenschaft, in der regelmäßig Themen rund um das Institut aktuell aufgegriffen werden. Die wissenschaftliche Arbeit erhält dabei ebenso Raum wie studentische Belange. Es werden Projekte und Personen vorgestellt, Hintergrundinformationen werden aufbereitet. Vergangene Veranstaltungen im Umkreis des Instituts bilden die Grundlage von Berichten.

Informationen über die Fakultät Informatik der TU Dresden, Daten und Fakten sowie eine Auswahl aktueller Forschungsprojekte, 2013 / Information about the Faculty of Computer Science of the Technische Universität Dresden, data and facts and a selection of current research projects, 2013

Information about the faculty of Computer Science of the TU Dresden, data and facts and a selection of current research projects, 2013 / Informationen über die Fakultät Informatik der TU Dresden, Daten und Fakten sowie eine Auswahl aktueller Forschungsprojekte, 2013

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Aus dem Begleitwort: "schön, dass Sie diese Broschüre zur Hand genommen haben. Die Mitarbeiter unseres Alumni-Teams haben in fleißiger Arbeit eine Menge Informationen zusammengetragen, von denen wir annehmen, dass sie Ihnen nützen werden. Doch zunächst möchte ich Ihnen zu Ihrem Studienerfolg sehr herzlich sowohl im Namen des Rektorats der TU Dresden als auch ganz persönlich gratulieren. Hinter Ihnen liegen viele Stunden voller Ausdauer, Fleiß und Selbstdisziplin. Diese Stunden haben sich nun ausgezahlt, denn mit einem Abschluss der TU Dresden haben Sie sich eine Position erarbeitet, die Ihnen ein hervorragendes Rüstzeug für einen Start in den Beruf oder für die Fortsetzung Ihrer akademischen Laufbahn bietet."

The clinical diagnostics of olfactory dysfunction in children turns out to be challenging due to low attention span, insufficient linguistic development and lack of odor experiences. Several smell tests have been developed for adults. Most of these examinations take a relatively long time and require a high level of concentration. Therefore, the aim of the current study was to evaluate an odor discrimination and olfactory threshold test using the frequently used “Sniffin’ Sticks” in children and adolescents in a simplified two-alternative-forced-choice version (2AFC) and compare it to the original three-alternative-forced-choice test (3AFC). One-hundred-twenty-one healthy participants aged between 5 and 17 years took part in this study. Within each of the two sessions participants underwent olfactory testing using the modified 2AFC as well as the standard 3AFC method. A better test-retest reliability was achieved using the original 3AFC method compared to the modified 2AFC. This was true for the odor discrimination as well as the olfactory threshold. Age had a significant influence on both tests, which should be considered when testing young children. We discuss these findings with relation to the existing norms and recommend using the 3AFC version due to a better test-retest reliability to measure olfactory function in children.

There have recently been considerable advances in our understanding of the neuronal mechanisms underlying multitasking, but the role of multimodal integration for this faculty has remained rather unclear. We examined this issue by comparing different modality combinations in a multitasking (stop-change) paradigm. In-depth neurophysiological analyses of event-related potentials (ERPs) were conducted to complement the obtained behavioral data. Specifically, we applied signal decomposition using second order blind identification (SOBI) to the multi-subject ERP data and source localization. We found that both general multimodal information integration and modality-specific aspects (potentially related to task difficulty) modulate behavioral performance and associated neurophysiological correlates. Simultaneous multimodal input generally increased early attentional processing of visual stimuli (i.e. P1 and N1 amplitudes) as well as measures of cognitive effort and conflict (i.e. central P3 amplitudes). Yet, tactile-visual input caused larger impairments in multitasking than audio-visual input. General aspects of multimodal information integration modulated the activity in the premotor cortex (BA 6) as well as different visual association areas concerned with the integration of visual information with input from other modalities (BA 19, BA 21, BA 37). On top of this, differences in the specific combination of modalities also affected performance and measures of conflict/effort originating in prefrontal regions (BA 6).

During tissue invasion individual tumor cells exhibit two interconvertible migration modes, namely mesenchymal and amoeboid migration. The cellular microenvironment triggers the switch between both modes, thereby allowing adaptation to dynamic conditions. It is, however, unclear if this amoeboid-mesenchymal migration plasticity contributes to a more effective tumor invasion. We address this question with a mathematical model, where the amoeboid-mesenchymal migration plasticity is regulated in response to local extracellular matrix resistance. Our numerical analysis reveals that extracellular matrix structure and presence of a chemotactic gradient are key determinants of the model behavior. Only in complex microenvironments, if the extracellular matrix is highly heterogeneous and a chemotactic gradient directs migration, the amoeboid-mesenchymal migration plasticity allows a more widespread invasion compared to the non-switching amoeboid and mesenchymal modes. Importantly, these specific conditions are characteristic for in vivo tumor invasion. Thus, our study suggests that in vitro systems aiming at unraveling the underlying molecular mechanisms of tumor invasion should take into account the complexity of the microenvironment by considering the combined effects of structural heterogeneities and chemical gradients on cell migration.