Aquired brain injury (ABI) of various etiology is one of the major causes of health impairment, disability and death in adult population. It has a wide scale of physical, psychological and social consequences impacting the lives of patients and their relatives. Neuropsychological rehabilitation (individual and group) has become an integrated part of the complex rehabilitation of ABI supported by evidence-based research and practice. Theory and research suggest new perspective on psychotherapy and its role in this process, though its use in the Czech republic may be limited. The goal of the theoretical part of this thesis was to explore the status of the knowledge and practice of neuropsychological rehabilitation of ABI with focus on group work and psychotherapy and their effectiveness. The empirical part aimed to analyze effectiveness of short-term group dynamic psychotherapy in sample of patients with ABI. The intervention was applied in a realistic setting of two selected rehabilitation centers. The patients completed European Brain Injury Questionnaire for Patients (EBIQ-P) and Zung's Self-rating Depression Scale pre-, after 6 weeks and post- intervention covering researched symptoms. The results suggest that there was a significant change in perception of various categories of problems...

The diploma thesis solves the new building of the medical facility. The building will serve as a home for people with Alzheimer's disease and other types of dementia. The facility will be equipped and equipped to provide modern nursing care that focuses on Alzheimer's clients in all stages of the disease and other types of dementia. If necessary, a nursing doctor with a nurse will be present in the facility. The nursing doctor has a separate medical office in 1st floor. In addition, a phototherapeutic beach in the 1st floor, which has a favorable influence on human psyche and helps in the treatment of Alzheimer's disease, will also serve to the clients. Furthermore, it will be possible for the clients of this facility to use the accompanying services of commuter hairdressers and pedicurists / manicurists who will use the multipurpose room (canteen) in their 2nd floor for their work. The kitchen has been designed to prepare and dispatch imported food.

Tato práce se zabývá strukturní studií dvou proteinů: proteinu Tail morphogenetic protein H (TmpH) bakteriofága 812, který napadá Zlatého stafylokoka (Staphylococcus aureus) a hexamerinu z potemníka (Tribolium castaneum). S. aureus je jedním z nejvíce rezistentních patogenů způsobující onemocnění s vysokou morbiditou a mortalitou. Bakteriofág 812 je schopen infikovat a lyzovat 95 % kmenů S. aureus a má potenciální využití ve fágové terapii. Protein TmpH je součástí virionu tohoto fága. V rámci této práce bylo připraveno několik plazmidů nesoucích gen TmpH, které byly použity pro rekombinantní expresi proteinu v buňkách E. coli BL21(DE3). Protein byl vyčištěn afinitní a gelovou chromatografií. Pro čistý protein byly optimalizovány krystalizační podmínky. Hexamerin je nejhojnějším proteinem larev a kukel hmyzu s dokonalou proměnou. V průběhu metamorfózy hexamerin slouží jako zdroj aminokyselin. V rámci této práce byl hexamerin izolován z kukel potemníka T. castaneum. Pro stanovení struktury hexamerinu byly použity dvě metody: rentgenová krystalografie a kryo-elektronová mikroskopie. Byly optimalizovány podmínky pro růst krystalů a vypěstovány krystaly vhodné pro sběr difrakčních dat. Nicméně struktura hexamerinu byla rychleji vyřešena kryo-elektronovou mikroskopií s rozlišením 3.2 . Znalost struktury hexamerinu umožní pochopení jeho funkce v regulaci vývoje hmyzu s dokonalou proměnou.

The diploma thesis Anthology of Unspoken is a form of personal therapy, a coping mechanism in the shape of an extensive personal research presented by visually eclectic web, which maps the perception of depression and melancholy in terms of historical, artistic, and partly academic discourse. AoU takes the form of a website on the border of an archive and a research blog, which visually reminds a notebook with the use of texts in the form of notes, reader view essays, and accompanying visual material (period paintings, pop-cultural references, emoticons etc.). This diploma thesis has two main goals. Firstly, it represents a way of finding means to articulate and at least fractionally understand my own problems. Secondly, it is a way of finding answers to the following questions: Is depression really a modern matter of the 21st century? Why is it so difficult to talk about it? Where do the shame and feeling of guilt, with which it is inextricably associated with, come from? Is melancholy synonymous with depression, or do these terms differ from each other? And is depression really a disease or is it only a sign of my own failure?

Diplomová práce se zabývá návrhem podnikatelského plánu pro založení soukromé kliniky řečové terapie v Brně, jako společnosti s ručením omezeným. Návrh je reakci na existenci tržní mezery v poskytování komplexích a kvalitních služeb v oblasti řečové terapie, psychoterapie a fyzioterapie. V následující práci jsou vyhodnoceny potřebné předpoklady úspěchu podnikání, zahrnující také finanční plán, včetně návrhu kroků pro samotmou realizaci firmy.

Speech is one of the basic forms of human communication and disruption of communication ability can negatively affect the life of man. deals with the elaboration of logopedic theory, which serves as a basis for the follow-up design and application creation in the field of speech therapy. The thesis is divided into five chapters. The first chapter deals with the history of speech therapy with an emphasis on domestic logopaedia, the logopedic intervention process in its entirety, and the differentiation of individual types of impaired communication skills. The second chapter focuses on a specific disruption of communication skills - dyslalia.The application for the treatment of dyslalia is determined by the application, which is elaborated in the third chapter. The fourth chapter contains a detailed description of the designed and created application, including an explanation of the processes running in the application when the application is being used. The last chapter of this diploma thesis contains a summary of the results of the practical testing of the application together with suggestions for improvement of the application.

Name of the thesis: Occurence of work-related musculoskeletal disorders among physiotherapists Objective: The objective of this thesis is to determine the prevalence of work-related muskoloskeletaldisorders among physiotherapists in Czech Republic in the past 12 months, based on data acquired from a random sample of physiotherapists. Methods: The acquisition od data was done via self filled questionnaire which was inspired by WRMDs prevalence questionnaire from Kuwait made in 2010 and a WRMDs prevalence questionnaire from Nigeria made in 2008. Both previously mentioned questionnaires were based on the Standardized Scandinavian Musculoskeletal Questionnarie. In the questionnaire, closed, semi-closed and open questions were used. The questionnaire could bef illed in its printed form or electronically, depending on respondents' preferences. The sample comprised of 110 respondents. The data obtained from the questionnaire was processed via SPSS statistical program and charts made in Microsoft Excel 2007. Findings: The data obtained from the questionnaire revealed that the prevalence of WRMDs samong physiotherapists in Czech Republic in the past 12 month swas 65,5%. The body area with the highest prevalence of pain was cervical spine (41.8%). Respondents ranging from 20-30 years of age reported higher...

Title: Supervision with Visual Art Expression Author: Bc. Andrea Hanzlová ABSTRACT Although art expression has been widely used in both art therapy and supervision in the Czech Republic, its distinctive features, added value and possible drawbacks in supervision have been researched less extensively than in art therapy. Here I explore what art expression brings into supervision, what new perspectives it can offer and what obstacles may dissuade supervisors from employing certain approaches. A qualitative content analysis of semi- structured interviews on the sample of 12 respondents revealed four thematic areas: Definition of creative art process, phases and content; Drawbacks and Benefits of working with art expression; The role of education in used methods and approaches. The results show an unexpectedly wide range of methods that Czech supervisors and supervisees employ when dealing with art expression in supervision, as well as the extent or absence of some approaches. One possible reason could be the lack of legislative anchoring compared to countries such as the UK and USA. Key words: expression, visual creative process, artefact, expressive therapy, art therapy, supervision, supervision of art therapies

Background: The effectiveness of exposure therapy in the treatment of addiction is a topic of discussion. The question remains whether movie exposure can be a meaningful intervention in regimen. A research project with a similar focus has not yet taken place in the Czech Republic, although the use of movies in addictology treatment is not new. Also, only a small number of similar studies can be found worldwide. Aims: The primary goal was to verify the possibilities of movie intervention as a supplement to the standard regimen treatment of addictions in the inpatient department of men of the Department of Addictology. Methodology: The diploma thesis is based on a qualitative research methodology supplemented by a questionnaire survey. Patients were selected by deliberate targeted selection. In addition to the general criteria for entering treatment, a cut-off of min. third week of treatment. The research group consisted of 22 patients with an average age of 39 years. The obtained data were analyzed mainly by means of content analysis of focus groups, based on the method of grounded theory. The research used 3 types of questionnaires focused on the current feelings of patients, appetite for addictive substances and evaluation of predefined problems that commonly occur in treatment. Results: The focus...

This thesis includes set of published experimental results, which were obtained at the Department of Immunology, Second Faculty of Medicine Charles University within the project focused on the basal and applied research of the Primary immunedeficiencies (PID), particularly Common variable immunodeficiency (CVID). The first, theoretical part, is divided into two sections. The first section is dedicated to the general aspects of Primary antibody deficiencies (PAD). The second section is focused on epidemiology, ethiopathogenesis, classification, clinical and therapeutical aspects of CVID. The main consideration is devoted particularly to non-infectious complications, which significantly contribute to morbidity and mortality of CVID patients. The second part consists of the set of publications describing specific mechanisms of immune system dysregulation and their clinical manifestation, which are briefly commented. The spectrum of issues resolved within the project covers following basic aspects: 1) characteristics of lung complications in CVID from the point of view of bronchial asthma, 2) characteristics of associated malignancies, 3) significance of genetic background for the specific treatment, 4) therapy of CVID focused on aspects of immunoglobulin substitution. The results of the other...