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Přípravné testy na osmiletá gymnázia pro žáky 5. tříd základních škol / Tests for preparing 5th grade elementary school children to pass grammar school entrance examsHALADOVÁ, Lucie January 2018 (has links)
The main aim of diploma thesis is to create a collection of tests which helps the students to prepare for the admission exam to eight - year grammar school. The theoretical part of diploma thesis focuses on the admission exam in school year 2016/2017 and the analysis of mathematical didactic test. The practical part contains a processing of seven tests. Each test includes a task, a solution and an answer key. Furthermore, the research is processed here for which the second test from diploma thesis has been used. Even children participating in mathematical Olympiad can use the tests from diploma thesis for practising. The teachers can also make mathematics lesson more varied by the right choice of exercises.
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Electrostaticanalisys the Ras active siteKhan, Abdul Kareem 05 March 2009 (has links)
La preorganització electrostàtica del centre actiu s'ha postulat com el mecanisme genèric de l'acció dels enzims. Així, alguns residus "estratègics" es disposarien per catalitzar reaccions interaccionant en una forma més forta amb l'estat de transició, baixant d'aquesta manera el valor de l'energia dactivació g cat. S'ha proposat que aquesta preorientació electrostática s'hauria de poder mostrar analitzant l'estabilitat electrostàtica de residus individuals en el centre actiu.Ras es una proteïna essencial de senyalització i actúa com un interruptor cel.lular. Les característiques estructurals de Ras en el seu estat actiu (ON) són diferents de les que té a l'estat inactiu (OFF). En aquesta tesi es duu a terme una anàlisi exhaustiva de l'estabilitat dels residus del centre actiu deRas en l'estat actiu i inactiu. / The electrostatic preorganization of the active site has been put forward as the general framework of action of enzymes. Thus, enzymes would position "strategic" residues in such a way to be prepared to catalyze reactions byinteracting in a stronger way with the transition state, in this way decreasing the activation energy g cat for the catalytic process. It has been proposed thatsuch electrostatic preorientation should be shown by analyzing the electrostatic stability of individual residues in the active site.Ras protein is an essential signaling molecule and functions as a switch in thecell. The structural features of the Ras protein in its active state (ON state) are different than those in its inactive state (OFF state). In this thesis, an exhaustive analysis of the stability of residues in the active and inactive Ras active site is performed.
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