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Novos derivados sintéticos de alcaloides tetrahidroisoquinolínicosSilva, Luiz André de Araújo 27 May 2016 (has links)
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Previous issue date: 2016-05-27 / Alkaloids are secondary metabolites of great medical importance, covering a diverse group of nitrogen containing molecules in its structure, the number of alkaloid containing the tetrahidroisoquinolínico skeleton 1-substituted is extensive and impressive pharmacological versatility of this class arouses interest in experimental pharmacologists, the importance. This work has as objective, the synthesis of tetrahydroisoquinolines and provide material for future pharmacological studies both in-vivo and in-vitro. For the synthesis of phenyltetrahydroisoquinolinics alkaloids, benzyltetrahydroisoquinilinic and phenyltetrahydro-β-carboline the Pictet-Spengler reaction was aplicated. With the aim of expanding the pharmacological studies of the alkaloid (1-(3-dimethoxy-4-hydroxyphenyl)-7-methoxy-1,2,3,4,-tetrahydroisoquinoline (MTHP) your synthesis was repeated. 4 alkaloids were obtained, 2 phenyltetrahydroisoquinolinic (1-(3,5-dimethoxy-4-hydroxyphenyl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline (73%) and 1-(2-hydroxyphenyl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline (54%)), 1 phenyltetrahydro-β-carboline (1-(3,5-dimethoxy-4-hydroxyphenyl)-1,2,3,4,-tetrahydro-β-carboline (38%)) and 1 benzyltetrhydroisoquinilínic (1-(1-ethyl-3,4-metilenodioxidofenil)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (87%)). From the material available for the pharmacological MTHP tests showed low toxicity without genotoxicity, its immunomodulatory mechanism in asthma is related to regulation of TH2 profile. / Alcaloides são metabólitos secundários de grande importância medicinal, abrangendo um grupo diverso de moléculas contendo nitrogênio na sua estrutura. O número de alcaloides que contém o esqueleto tetrahidroisoquinolínico 1-substituído é extenso e a impressionante versatilidade farmacológica desta classe desperta o interesse nos farmacologistas experimentais. Visto a importância dos alcaloides isoquinolínicos, o nosso trabalho tem como objetivo a síntese de derivados tetrahidroisoquinolínicos e fornecer material para futuros estudos farmacológicos tanto in-vivo como in-vitro. Para a síntese dos alcaloides feniltetrahidroisoquinolínicos, benziltratrahidroisoquinilínicos e feniltetrahidro-β-carbolínicos foi utilizado a reação de Pictet-Spengler. Com o objetivo de ampliar os estudos farmacológicos a respeito do alcaloide (1-(3-dimetoxi-4-hidroxifenil)-7-metoxi-1,2,3,4,-tetrahidro isoquinolina (MTHP) refizemos a sua síntese como descrito na literatura. Obtivemos 4 alcaloides, sendo 2 deles feniltetrahidroisoquinolínicos (1-(3,5-dimetoxi-4-hidroxifenil)-7-metoxi-1,2,3,4,-tetrahidro isoquinolina (73%) e 1-(2-hidroxifenil)-7-metoxi-1,2,3,4,-tetrahidro isoquinolina (54%)), 1 feniltetrahidro-β-carbolínicos (1-(3,5-dimetoxi-4-hidroxifenil)-1,2,3,4,-tetrahidro-β-carbolina (38%)) e 1 benziltratrahidroisoquinilínicos (1-(1-etil-3,4-metilenodioxidofenil)-6,7-dimetoxi-1,2,3,4,-tetrahidro isoquinolina(87%)). A partir da disponibilização de material para os testes farmacológicos do MTHP, apresentou baixa toxicidade sem genotoxicidade, seu mecanismo imunomodulador na asma está relacionado a regulação do perfil TH2.
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