This thesis deals with simulation vehicle models for lateral control. It surveys step by step to models of tire, truck and control. At the end are showed influences of model parameters to vehicles dynamics.

The aim of the diploma thesis is the reconstruction of Adamov and Rajec-Jestrebi railway stations in order to safety and track capacity of the railway section Brno – Skalice nad Svitavou increasing. The right side of Brno station head end track number 4 are designed in the Adamov railway station. The three platform edges (3x170m) are designed. The safety conditions for the movement of persons with reduced mobility are ensured. Four drive-through traffic tracks and Blansko station head are kept. New substructure and drainage of the track number 4 are designed.

The result of this work will be design the reconstruction of the railway station Ostružná and Horní Lipová to fulfil the following conditions. It must be ensured smooth movement of persons with reduced mobility in the sense amended by Decree 398/2009 Coll., also endeavor will be made an extension length of the platforms and useful length of the tracks, edit directional and height parameters to the requirements of the current standards and the associated construction of a functional drainage. However, it is avoiding the extensive work to minimize investment.

The aim of this study is to design an upgrading of station Litice nad Orlicí to meet current legislation on access of persons with reduced mobility. It is desired platform 150 m long, at least two running tracks, conservation of double-sided connection of siding and a loading track. The work also solve drainage. Two variants of layout were developed, of which one was selected for detailed processing.

This diploma thesis handles with a draft and conception of the warehouse hall and crane track where the main goal is the creation of outside and inside storage space which is covered by the trolley crane. Next point is about construction and stress calculation of the crane track and logistic ordering of the outside space with option of loading on wheel and rail transport.

This master’s thesis describes the structural design of pallet conveyor for the transport pallet unit between the ground floor and upper storey of warehouse buildings, according to given technical parameters. The work includes design and functional solution for driven roller track. It solves lifting of frame cage and roller track and the pallet unit, using traction gearless drive. There is used cable transfer 2:1. Frame cage is equipped with a mandatory safety gear. The design is verified strength calculations of the frame lift and frame cage. Part of the thesis is the drawing documentation.

The main content of this master’s thesis is design of RNAV SID and STAR routes for Brno Tuřany Airport. The study analyses usage of current conventional instrument arrivals and departures published for the aerodrome and describes its TMA. The new precision RNAV routes and the terminal area are designed based on the indentified information. A detailed construction of the chosen departure procedure is enclosed.

This master´s thesis deals with RNAV-1 departure routes for runway 03C at the Kunovice airport. Suggested routes are linked to the new RNAV-1 routes in TMA Brno. RNAV SID maps and construction of one of the departure track are also done and described in this master´s thesis. Beyond design of RNAV-1 routes are also analyzed influences and factors in the master´s thesis that affect the construction of these routes. Construction of RNAV SID routes are based on the knowledge and shortcomings conventional routes that are resulted from the analysis of the current departure routes at the Kunovice airport. In the second part of the thesis is submitted 3 variants of departure routes for Kunovice airport.

Background Waiting times of the fast-track of bladder cancer in Sweden are prolonged compared with set lead times.Aim To investigate if stage and grade of tumor affects waiting times.Method Retrospective single center observational study, Örebro University Hospital, Sweden. All patients who underwent resection of tumor or cystoscopy with biopsy via the fast-track between July 1st 2017 and December 31st 2018 were included, n=119.Result The waiting times of muscle invasive tumors were in general longer than for non-invasive tumors. Referral to TURBT - twelve days (p=0.047), referral to information of diagnosis to patient - seven days (p=0.04) and cystoscopy to TURBT - eleven days (p=0.041.Conclusion MIBC had longer waiting times to most steps of the fast-track. There are conflicting results in previous studies regarding whether extended waiting times result in worse outcomes in those with higher stage and grade of tumors or not. It is known that long waiting times results in higher mortality and psychological stress among the patients why reorganizations at the department should take place.

The main drives of development of fast track cardiac anaesthesia are the increase burden of health care cost and the shortage of intensive care beds. Fast track (FT) is multidisciplinary process that leads to rapid patient recovery and discharge without affecting morbidity and mortality. Fast track cardiac anaesthesia (FTCA) was proved to be safe, efficient and economically effective. Leipzig FT protocol was first introduced in November 2005 for elective cardiac surgery patients in the heart center of Leipzig University. It is characterized by using intraoperative remifentanil as main opioid with treating the patients postoperatively in post-anaesthesia care unit (PACU) completely bypassing ICU admission. Remifentanil was unavailable in Germany from February to July 2017, therefore the protocol had to be modified and sufentanil was used instead. The aim of this retrospective study was to compare the effects of remifentanil and sufentanil on the well-established FT concept. The primary end points were ventilation time, LOS in PACU (LOS PACU), the visual analogue score (VAS) and the piritramide consumption on the day of operation. The secondary end points were LOS in intermediate care (LOS IMC), hospital LOS, FT failure (FTF), in-hospital mortality and postoperative complications such as postoperative nausea and vomiting (PONV), delirium and the incidence of reintubation. All cardiac surgery patients consecutively admitted to PACU during the period from February to July 2017 (n=622), received sufentanil (FT-S), were compared to patients (n=679) from the same time period of the previous year treated with continuous remifentanil infusion (FT-R) according to the standard FT protocol. To minimise selection bias and to obtain comparable groups, we used a 1:1 nearest neighbour propensity score matching approach resulted in total 1218 patients divided in 2 equal groups. In FT-R, an uninterrupted continuous infusion of remifentanil (0.2-0.3 µg/kg/min) was used for maintenance of anaesthesia throughout the whole operation. In FT-S, a continuous infusion of sufentanil was used during maintenance of anaesthesia as follows: 1 µg/kg/h until sternotomy, 0.5 µg/kg/h until cardiopulmonary bypass and 0.25 µg/kg/h until chest closure, then the infusion was stopped. Otherwise, the Leipzig FT protocol was used as previously published. Remifentanil was more effective in reducing time to extubation (by 40 minutes) and length of stay in the post anaesthetic care unit during fast track cardiac anaesthesia than sufentanil. There was an increased need of piritramide when remifentanil was used. The hospital length of stay was longer in remifentanil group. There were no differences between both groups regarding postoperative complications. Clinically, a detailed and time-directed weaning protocol is more important than the use of a specific opioid during fast track treatment in cardiac surgery patients.:TABLE OF CONTENTS 1. List of Abbreviations 3 2. Bibliographic description 5 3. Abstract 5 4. Introduction 6 4.1 Fast-track cardiac anaesthesia 6 4.1.1 Definitions 6 4.1.2 Current evidence of FTCA 7 4.1.2.1 The safety of FTCA 7 4.1.2.2 The efficiency of FTCA 7 4.1.2.3 Economic Implications of FTCA 8 4.1.3 Different FTCA pathways 8 4.1.4 Patient selection and optimization 9 4.1.5 Anaesthesia aspects of FT 11 4.1.6 Cardiopulmonary bypass aspects of FT 12 4.2 Leipzig FT Protocol 12 4.3 Opioids 16 4.3.1 Remifentanil 16 4.3.2 Sufentanil 17 5. Objective of the work 19 6. Materials and Methods 19 7. Results 21 8. Discussion 26 9. Publication manuscript: „ A comparison of sufentanil versus remifentanil in fast-track cardiac surgery patients “Anaesthesia 2019, 74, 602–608“. 30 10. Summary 37 11. Bibliography 39 12. Appendix (Anlagen): 43 12.1 Declaration of Independence (Selbstständigkeitserklärung) 43 12.2 Declaration of co-authors’ contribution 44 12.3 Publications 45 12.4 Acknowledgment 46