Global ETD Search

21	Expression des nétrines dans la rétine de souris adulte Simard, Mathieu 12 1900 (has links) Les nétrines sont une petite famille de protéines de guidage axonal qui peuvent attirer des axones ou en repousser d’autres lors du développement neuronal. Lors du développement de la rétine, les axones des cellules ganglionnaires de la rétine (CGR) sont attirés vers une source de nétrines au niveau du disque optique leur permettant de quitter la rétine et de former le nerf optique. Afin de pouvoir caractériser le rôle des nétrines dans le système visuel adulte, nous avons investigué l’expression des nétrines et leurs récepteurs dans la rétine de souris adulte. Alors qu’aucune expression de la nétrine-1 n’a été détectée dans la rétine adulte, l’expression de la nétrine-3 a été abondamment détectée au niveau des CGR et des cellules amacrines. Nous démontrons aussi que les récepteurs des nétrines sont exprimés dans la rétine adulte. Alors que DCC semble être confiné au niveau des axones des CGR, néogénine est retrouvé dans les dendrites des CGR et des cellules horizontales. Quant aux protéines de la famille des récepteurs homologues à UNC-5, UNC5B a été détecté dans les somas des CGR et UNC5C dans les cellules de Müller. La découverte que nétrine-3 et ses récepteurs sont abondamment exprimés dans plusieurs types cellulaires de la rétine adulte leur suggère un rôle dans le fonctionnement du système visuel mature. / The netrins are a small family of axonal guidance proteins that can attract or repulse growing axons during neural development. During development of the retina, retinal ganglion cells (RGCs) axons are attracted by a netrin source at the optic disc that permits them to exit the retina and form the optic nerve. To characterise the role of netrins in the adult visual system, we investigated the expression of netrins and their receptors in the adult mouse retina. While expression of netrin-1 has not been detected in the adult retina, netrin- 3 has been abundantly found in RGCs amacrine cells. We also demonstrate that netrin receptors are expressed in the adult retina. DCC was found to be restricted in RGCs axons and neogenin in dendrites of RGCs and horizontal cells. UNC5B proteins were detected at RGC soma and UNC5C proteins in the Müller cells. The finding that netrin-3 and its receptors are abundantly expressed in many cell types of the adult retina suggests a funtional role for them in the mature visual system. Rétine Adulte Nétrine Néogénine Dcc Unc-5 retina adult netrin neogenin
22	Expression des nétrines dans la rétine de souris adulte Simard, Mathieu 12 1900 (has links) Les nétrines sont une petite famille de protéines de guidage axonal qui peuvent attirer des axones ou en repousser d’autres lors du développement neuronal. Lors du développement de la rétine, les axones des cellules ganglionnaires de la rétine (CGR) sont attirés vers une source de nétrines au niveau du disque optique leur permettant de quitter la rétine et de former le nerf optique. Afin de pouvoir caractériser le rôle des nétrines dans le système visuel adulte, nous avons investigué l’expression des nétrines et leurs récepteurs dans la rétine de souris adulte. Alors qu’aucune expression de la nétrine-1 n’a été détectée dans la rétine adulte, l’expression de la nétrine-3 a été abondamment détectée au niveau des CGR et des cellules amacrines. Nous démontrons aussi que les récepteurs des nétrines sont exprimés dans la rétine adulte. Alors que DCC semble être confiné au niveau des axones des CGR, néogénine est retrouvé dans les dendrites des CGR et des cellules horizontales. Quant aux protéines de la famille des récepteurs homologues à UNC-5, UNC5B a été détecté dans les somas des CGR et UNC5C dans les cellules de Müller. La découverte que nétrine-3 et ses récepteurs sont abondamment exprimés dans plusieurs types cellulaires de la rétine adulte leur suggère un rôle dans le fonctionnement du système visuel mature. / The netrins are a small family of axonal guidance proteins that can attract or repulse growing axons during neural development. During development of the retina, retinal ganglion cells (RGCs) axons are attracted by a netrin source at the optic disc that permits them to exit the retina and form the optic nerve. To characterise the role of netrins in the adult visual system, we investigated the expression of netrins and their receptors in the adult mouse retina. While expression of netrin-1 has not been detected in the adult retina, netrin- 3 has been abundantly found in RGCs amacrine cells. We also demonstrate that netrin receptors are expressed in the adult retina. DCC was found to be restricted in RGCs axons and neogenin in dendrites of RGCs and horizontal cells. UNC5B proteins were detected at RGC soma and UNC5C proteins in the Müller cells. The finding that netrin-3 and its receptors are abundantly expressed in many cell types of the adult retina suggests a funtional role for them in the mature visual system. Rétine Adulte Nétrine Néogénine Dcc Unc-5 retina adult netrin neogenin
23	Six4/5 Family Transcription Factor UNC-39 Controls the Development of RID Neuron in Caenorhabditis elegans Laskova, Valeriya 15 July 2013 (has links) Members of the Six4/5 family of homeobox transcription factors have been implicated in multiple human disorders, including type I mytonic dystrophy, branchio-oto-renal syndrome, and holoprosencephaly, suggesting a role for these factors in the nervous system development. Using a forward genetics approach, we identified unc-39, a C. elegans homologue of the human SIX5 gene, as a novel regulator of the development of a specific neuron, called RID. Our data support the role of unc-39 early in C. elegans development and suggest a possibility of complete absence of RID neuron in unc-39 mutants. unc-39 mutant has a similar locomotion phenotype to the RID-ablated animals, which provides further support to the hypothesis that the absence of RID contributes to the locomotion phenotype observed in the mutant. We show that unc-39 functions at multiple points in the lineage that gives rise to the RID neuron, and that its function is context-dependent. C. elegans neuronal development RID Six4/5 Six5 unc-39 genetics cell fate transcription factor homeobox homeodomain 0369
24	Six4/5 Family Transcription Factor UNC-39 Controls the Development of RID Neuron in Caenorhabditis elegans Laskova, Valeriya 15 July 2013 (has links) Members of the Six4/5 family of homeobox transcription factors have been implicated in multiple human disorders, including type I mytonic dystrophy, branchio-oto-renal syndrome, and holoprosencephaly, suggesting a role for these factors in the nervous system development. Using a forward genetics approach, we identified unc-39, a C. elegans homologue of the human SIX5 gene, as a novel regulator of the development of a specific neuron, called RID. Our data support the role of unc-39 early in C. elegans development and suggest a possibility of complete absence of RID neuron in unc-39 mutants. unc-39 mutant has a similar locomotion phenotype to the RID-ablated animals, which provides further support to the hypothesis that the absence of RID contributes to the locomotion phenotype observed in the mutant. We show that unc-39 functions at multiple points in the lineage that gives rise to the RID neuron, and that its function is context-dependent. C. elegans neuronal development RID Six4/5 Six5 unc-39 genetics cell fate transcription factor homeobox homeodomain 0369
25	Rho-Family GTPase Signaling in the Nervous System: An Analysis of the <i>C. elegans</i> RhoGEF UNC-73 Hoop, Alyssa N. January 2014 (has links) No description available. Biology Molecular Biology Neurosciences Neurobiology UNC-73 nervous system Rho-Family GTPases C elegans Sec14 Secretory pathway neurotransmission axon guidance
26	The Evolution of Learning Technologies within the UNC German Consortium 2000-2016: A Hermeneutic Phenomenlogical Analysis of German Faculty Member Experiences Underwood, Zackary W. 08 1900 (has links) Beginning in 2000 and continuing today, the University of North Carolina (UNC) German Consortium offers online German courses to undergraduate students across sixteen of the seventeen UNC public universities. The delivery of online classes differs per faculty member and little previous research investigated the UNC German Consortium's learning technologies. This dissertation investigates the evolution of learning technologies within the UNC German Consortium over the last sixteen years among German faculty from different UNC public universities. Seven faculty and one administrator shared their experiences through interviews. The methodology for this research was hermeneutic phenomenology. Interviewees shared their experiences with learning technology and teaching in the UNC German Consortium including how learning technologies changed over time. Interviews were transcribed, coded, and analyzed to deduce themes. Themes included the importance of the North Carolina Research Education Network (NC REN) for teaching German online, an asynchronous versus synchronous debate, how professors taught in synchronous courses, the importance of learning management systems (LMS) systems, the resilient characteristics of UNC German Consortium faculty, and the need for continual learning as an instructor. UNC German Consortium Learning Technologies Synchronous and Asynchronous Teaching Online Education Web-based instruction -- North Carolina.
27	Synaptic Ultrastructure and Regulation of Synaptic Transmission in Caenorhabditis elegans / Synaptische Ultrastruktur und Regulation der Synaptischen Transmission in Caenorhabditis elegans Kittelmann, Maike 21 June 2012 (has links) No description available. 570 Biowissenschaften Biologie WF 200 Elektronenmikroskopie Tomographie Aktive Zone SYD-2 liprin-α ELKS RSY-1 C. elegans synaptische Vesikel neuromuskuläre Synapse Transport UNC-104 Kinesin-3 Hochdruckgefrieren electron microscopy tomography active zone dense projection SYD-2 liprin-α ELKS RSY-1 C. elegans synaptic vesicle neuromuscular junction transport UNC-104 kinesin-3 High Pressure Freezing 42.13 42.15

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