Global ETD Search

11	The effects of supplementary multivitamins on stress Southgate, H. M. A. (Hilary Mildred Annette) 11 1900 (has links) This study was undertaken with the objective of assessing whether the ingestion of a Multivitamin Complex with Calcium and Magnesium would be efficacious in reducing stress. Tlrree hundred subjects who were suffering from stress were selected in Gauteng and Kwa-Zulu Natal, South Africa. The selection was based on a stress questionnaire. The subjects took a battery of tests and questionnaires to assess the level ofthe stress they were experiencing. A 30 day supply of effeiVescent tablets was given to all subjects - half placebos and half the vitamin supplement. These were randomly allocated. At the end of30 days a further battery oftests were administered. The results were statistically analysed. It was found that both the placebo and the vitamin supplement proved beneficial but the Multivitamin Complex with Calcium and Magnesium had a greater effect in reducing and helping to manage stress. / Psychology / M.A. (Psychology) Stress reduction Stress management Vitamin and mineral supplement Nutritional supplement Diet Vitamin benefits Placebo effect Healthy lifestyle Health practices 155.9042 Stress (Psychology) Vitamin therapy Stress management Nutrition Medicine and psychology
12	Investigating the porphyrias through analysis of biochemical pathways. Ruegg, Evonne Teresa Nicole January 2014 (has links) ABSTRACT The porphyrias are a diverse group of metabolic disorders arising from diminished activity of enzymes in the heme biosynthetic pathway. They can present with acute neurovisceral symptoms, cutaneous symptoms, or both. The complexity of these disorders is demonstrated by the fact that some acute porphyria patients with the underlying genetic defect(s) are latent and asymptomatic while others present with severe symptoms. This indicates that there is at least one other risk factor required in addition to the genetic defect for symptom manifestation. A systematic review of the heme biosynthetic pathway highlighted the involvement of a number of micronutrient cofactors. An exhaustive review of the medical literature uncovered numerous reports of micronutrient deficiencies in the porphyrias as well as successful case reports of treatments with micronutrients. Many micronutrient deficiencies present with symptoms similar to those in porphyria, in particular vitamin B6. It is hypothesized that a vitamin B6 deficiency and related micronutrient deficiencies may play a major role in the pathogenesis of the acute porphyrias. In order to further investigate the porphyrias, a computational model of the heme biosynthetic pathway was developed based on kinetic parameters derived from a careful analysis of the literature. This model demonstrated aspects of normal heme biosynthesis and illustrated some of the disordered biochemistry of acute intermittent porphyria (AIP). The testing of this model highlighted the modifications necessary to develop a more comprehensive model with the potential to investigated hypotheses of the disordered biochemistry of the porphyrias as well as the discovery of new methods of treatment and symptom control. It is concluded that vitamin B6 deficiency might be the risk factor necessary in conjunction with the genetic defect to trigger porphyria symptoms. Acute attack Acute intermittent porphyria Aminolevulinate Aminolevulinate dehydratase Aminolevulinate synthase B vitamins Biomodeling Cofactors Computational modeling Congenital erythopoietic porphyria Coproporphyrinogen oxidase Erythropoietic protoporphyria Ferrochelatase GABA Glucose therapy Glycine Heme Heme biosynthesis Heme deficiency Heme therapy Hepatoerythropoietic porphyria Hepatorenal Tyrosemia Hereditary coproporphyria Iron Iron deficiency anemia Kinetics Lead poisoning Liver transplant Micronutrients PLP Porphobilinogen Porphobilinogen deaminase Porphyria Porphyria cutanea tarda Porphyrins Prophylaxis Protoporphyrinogen oxidase Pyridoxal Pyridoxal phosphate Pyridoxine Serotonin Succinyl-CoA TCA cycle Tryptophan Tryptophan pyrrolase Uroporphyrinogen decarboxylase Uroporphyrinogen synthase Variegate porphyria Vitamin B6 Vitamin therapy Vitamins X-linked protoporphyria X-linked sideroblastic anemia

Search results

The effects of supplementary multivitamins on stress

Investigating the porphyrias through analysis of biochemical pathways.