This study explores natural convection heat transfer and fluid flow from a vertical plate in a radiating gas accounting for real gas spectral behavior. Finite volume techniques are used to solve the coupled nonlinear partial differential equations for mass, momentum, and energy conservation, while radiation transfer is modeled using the Discrete Ordinates finite volume finite angle method. Real gas spectral behavior is accounted for using the Rank Correlated Spectral Line Weighted-sum-of-gray-gases method. It is found that gas temperature and velocity are higher in the boundary layer, thickening the thermal and hydrodynamic boundary layers compared to the limiting case of pure convection. Gas species and concentration significantly impact boundary layer development, affecting radiative heating, temperature, velocity, and wall heat fluxes. Wall radiation transport dominates over convective transport. Increasing the wall temperature for the same wall-quiescent surroundings temperature difference increases local radiative heating, temperature, and velocity, and results in higher wall heat fluxes. As Rayleigh number increases, convection gains importance relative to radiation. Higher total gas pressures moderately increase radiative heating, temperature, and velocity, while reducing wall heat fluxes and convective transport. Increased wall emissivity raises radiative heating, temperature, and velocity, while raising wall heat flux and reducing convective flux. It is concluded that the neglect of participating gas radiation effects can result in significant errors in the predicted flow and thermal behavior, and the total transport. These insights advance understanding of radiation-convection interplay in radiating gas scenarios.

Background. Several methods have been used to simulate soft body deformation, such as mass-spring systems and position-based dynamics. This has been done using tetrahedral mesh models for preservation of shape and volume. In real-time applications however, there is a limitation to how high resolution the model can be, creating the need for optimizations. Objectives. To achieve better performance for high resolution models, tetrahedral deformation is used, making it possible for the tetrahedral mesh and triangle mesh to use different resolutions. In combination with this, the GPU is used to execute the simulation in parallel, improving performance further. Methods. For evaluation of performance and accuracy, an implementation was created to simulate soft body deformation using extended position-based dynamics and the Vulkan graphics API, with the option to use tetrahedral deformation. By experimentation, comparisons are made between using different resolutions on the tetrahedral mesh to the full resolution in terms of performance and accuracy. Results. The results show that performance and accuracy are altered when using tetrahedral deformation on lower resolution tetrahedral mesh. The performance is improved based on the decrease in workload, such as with higher base resolution models or multiple soft bodies. The accuracy is however not correlated to the reduction of resolution, but instead dependant on the rest shape of the model used. Conclusions. The implementation created demonstrates a new optimization that can be used to simulate soft body deformation in parallel on the GPU, with a smaller change in accuracy. Improvements exist in areas of usability, features and other optimizations that can be further explored in future research.

Primary glioblastoma (GBM), IDH-wildtype, especially with multifocal appearance/growth (mGBM), is associated with very poor prognosis. Several clinical parameters have been identified to provide prognostic value in both unifocal GBM (uGBM) and mGBM, but information about the influence of radiological parameters on survival for mGBM cohorts is scarce. This study evaluated the prognostic value of several volumetric parameters derived from magnetic resonance imaging (MRI). Data from the Department of Neurosurgery, Leipzig University Hospital, were retrospectively analyzed. Patients treated between 2014 and 2019, aged older than 18 years and with adequate peri-operative MRI were included. Volumetric assessment was performed manually. One hundred and eighty-three patients were included. Survival of patients with mGBM was significantly shorter (p < 0.0001). Univariate analysis revealed extent of resection, adjuvant therapy regimen, residual tumor volume, tumor necrosis volume and ratio of tumor necrosis to initial volume as statistically significant for overall survival. In multivariate Cox regression, however, only EOR (for uGBM and the entire cohort) and adjuvant therapy were independently significant for survival. Decreased ratio of tumor necrosis to initial tumor volume and extent of resection were associated with prolonged survival in mGBM but failed to achieve statistical significance in multivariate analysis.

In summary the tilting mechanism helps to explain the overall flow structure and the stability of the leading edge vortex.; The leading edge vortex has been identified as the most critical flow structure for producing lift in flapping wing flight. Its stability depends on the transport of the entrained vorticity into the wake via spanwise flow. This study proposes a hypothesis for the generation and enhancement of spanwise flow based on the chordwise vorticity that results from the tilting of the leading edge vortex and trailing edge vortex. We investigate this phenomenon using dynamically scaled robotic model wings. Two different wing shapes, one rectangular and one based on Drosophila melanogaster (fruit fly), are submerged in a tank of mineral oil and driven in a flapping motion. Two separate kinematics, one of constant angular velocity and one of sinusoidal angular velocity are implemented. In order to visualize the flow structure, a novel three dimensional particle image velocimetry system is utilized. From the three dimensional information obtained the chordwise vorticity resulting from the vortex tilting is shown using isosurfaces and planar slices in the wake of the wing. It is observed that the largest spanwise flow is located in the area between the chordwise vorticity of the leading edge vortex and the chordwise vorticity of the trailing edge vortex, supporting the hypothesis that the vortex tilting enhances the spanwise flow. Additionally the LEV on the rectangular wing is found to detach at about 80% span as opposed to 60% span for the elliptical wing. Also, two distinct regions of spanwise flow, one at the base and one at the tip, are observed at the beginning of the sinusoidal kinematic, and as the velocity of the wing increases these two regions unionize into one. Lastly, the general distribution of vorticity around each wing is found to be nearly the same, indicating that different wing shapes do not greatly affect the distribution of vorticity nor stability mechanisms in flapping flight.

I. An isothermal titration microcalorimeter having a colume of 4 ml and capable of temerature control to ±2 x 10-5°C is described. Major components include a constant temperature water bath controlled to ±3 x 10-4°C, a platinum reation vessel, and an isothermal control circuit consisting of constant Peltier thermoelectric cooling and variable Joule heating controlled by a thermistor in an AC Wheatstone bridge circuit. The calorimeter was tested by measuring the heat of ionization of water and was found to produce data accurate to ± 0.1% where small samples are used such as in the investigation of many biological systems.

The design, construction, and calibration of a precision thermometric titration calorimeter is described. This calorimeter was tested by determining the enthalpy change for ionization of water. The result, 13.34 ±0.03 kcal/mole (standard deviation), is in exact agreement with the best literature values. This standard deviation indicates that, using this calorimeter, ΔH values can be determined with an accuracy of ±0.0.5 kcal/mole. A calorimetric procedure has been developed for the, simultaneous determination of the equilibrium constant, the enthalpy change, and the entropy change for a chemical reaction from a single titration (Entropy Titration). This procedure has been tested by determining pK, ΔH, and ΔS for proton ionization from HPO42- and HSO4-. The method has also been used to determine pK, ΔH, and ΔS values for proton ionization from Adenosine and Ribese. The resultant pK tor each system has an accuracy of about ±0.05 pK unit. Enthalpy and entropy changes for proton ionization have been determined for twenty-six carboxylic acids. The results are discussed in terms of three previous approaches (i.e. inductive, electrostatic, and the linear relation between ΔH° and ΔS°). The results are shown not to fit any of these theories well and reasons for this are proposed. An alternate explanation is proposed based on the observed fit of the carboxylic acid data to a linear ΔG° vs ΔS° plot. The site of proton ionization from adenosine is established to be the ribose moiety. It is also shown that both the 2' and 3' hydroxyl groups are necessary for this acidity to exist in aqueous solution.

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