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Bakgrund: Under senare tid har mediedebatten fokuserats kring olika dieters påverkan på viktminskning och välbefinnande. De moderna dieterna har debatterats av läkare, forskare och myndigheter, då extrema lågkolhydratsdieter innehåller alltför mycket fett vilket vissa menar kan leda till framtida folksjukdomar. Syfte: Syftet var att undersöka ett begränsat antal dieters påverkan på viktminskning och välmående samt att belysa betydelsen av en helhetssyn på våra kostvanor. Metod: Denna litteraturstudie är baserad på fyra vetenskapliga artiklar som var relevanta och intressanta för syftet. Resultat: Samtliga av de artiklar som undersökte sambandet mellan olika dieter och vikt visade på en tydlig viktminskning hos alla deltagare. LCHF-dieten gav den snabbaste viktminskningen. När det gäller välmående visade samtliga i alla studiegrupper en förbättring i sitt psykologiska välbefinnande och välmående. Den undersökning som behandlade kostvanor kom fram till att det behövs en helhetssyn på skolmåltiden för att få en optimal måltidsupplevelse med tanke på elevernas hälsa och välbefinnande. Slutsats: Undersökningen visar på en tydlig viktminskning oavsett diet och att det fysiska och psykologiska välbefinnandet förbättrades, det fordras däremot ytterligare forskning för att studera de olika dieternas långsiktiga påverkan samt att det krävs en helhetssyn på våra kostvanor redan i unga år för att leva ett friskare och mer välmående liv. / B-uppsatser

The purpose of this investgation was to study the effects of repeated weight loss and physical training on the plasma levels of testosterone, growth hormone, insulin and cortisol. A further purpose of this study was to determine if changes in plasma hormone concentrations could be avoided through a nutritional education program and the addition of nutritional supplements to the diet. Lastly the effects of acute and seasonal weight loss upon mean anerobic power, peak power, and percent fatigue were measured.MethodsA total of 34 adolescent high school wrestlers ranging age from 14 to 18 years, were pair matched for age, size, percentage weight loss, and skill level (varsity or JV) and then randomly assigned into a control and treatment group. The treatment group recieved a nutritonal education program and nutritional supplements. Blood samples were taken four times throughout the study period: once in the preseason (October 14), twice in December (Dec. 7 and 14), and once in January (Jan. 13). The blood was drawn at the same time each morning after an 8 hour fast. The blood was analyzed to detect changes over time and between groups for hemoglobin, hematocrit, and plasma levels of insulin, cortisol, testosterone, and growth hormone. The wrestlers were also measured for caloric and nutrient intake, weight, height, body fat percentages, and for arm power with the Wingate test. The experimental design consisted of a pretest-posttest randomized groups test design. The hormone and power data were analyzed with a repeated measures ANOVA, and a probability level of 0.05 or above was chosen as statistical significance. Polynomial contrasts were used to determine whether significant differences over time followed linear, quadratic, or cubic trends. Post hoc tests were also used to determine where the difference did exist.ResultsThere were no significant (p<0.05) differences between the treatment and control groups in any variable tested. Over the experimental period, each group showed significant (p<0.05) decreases in weight, percent body fat, and fat free weight. No significant changes (p<0.05) in any of the power indicies occurred, but specific trends were apparent. Both groups had reductions in their absolute peak and mean power, and increases in their relative peak and mean power. Changes in percent fatigue and fatigue slope were inconsistent and nonsignificant. Serum concentrations of cortisol and insulin showed significant (p<0.05) decrements over the investigative period. The decline in serum growth hormone levels approached significance (p = 0.085), and serum testosterone levels showed a nonsignificant decreasing trend. Hormone levels per kilogram free fat weight were not changed, along with testosterone to cortisol ratios, hemoglobin and hematocrit levels.ConclusionsThe treatment of consuming a nutritional beverage (Exceed) and information on proper dieting did not produce a significant (p<0.05) difference between the groups. Over time the wrestlers lost significant amounts of weight, body fat, and fat free weight due to significant decreases in the intake of calories in the form of fat, protein and carbohydrate. There were also significant decreases in plasma levels of insulin and cortisol. These results indicate that weight loss over a wrestling season may significantly alter plasma hormone levels. / School of Physical Education

Aim: To systematically review lifestyle interventions to treat and prevent obesity in adults, children and vulnerable subgroups. Methods: Cochrane methodology and a "best available evidence‟ approach were adopted to produce a series of published systematic reviews. Results: Adults: diets alone and with exercise and/or behaviour therapy compared with control significantly reduced weight for up to three years (weighted mean difference weight change 4 to 13 kg at one year) and prevented weight gain for up to seven years. Exercise as an adjunct to diet and also meal replacements may be effective in the long-term maintenance of weight loss. 600 kcal/day deficit or low-fat diet; diet and exercise with/without behaviour therapy; significantly reduced the risk of hypertension, type 2 diabetes and metabolic syndrome compared with control. School-children: 39% of school-based interventions significantly improved mean body-mass index compared with control. Combined diet and physical activity interventions were most effective. It is unclear what elements of interventions are consistently effective in preventing excessive weight gain. There can be significant prevention of weight gain in children from interventions not conceptualized as obesity prevention interventions. Vulnerable subgroups: lifestyle interventions can prevent excessive weight gain in pregnancy and help weight-concerned women stop smoking. Diet and exercise can reduce weight in postmenopausal women. There is insufficient evidence to inform how interventions need to be modified to meet the needs of pre-school children or ethnic minority groups within the UK. Conclusions: This evidence underpins national guidance, informs government policy and influences clinical practice. Population-wide recommendations may be effective in preventing a population increase in prevalence of obesity only as part of a government strategy that includes environmental change and is coupled with targeted interventions to reduce the prevalence of obesity caused at least in part by social inequalities.

Prior studies of immigrants to the United States show significant weight gain after 10 years of US residence. Pediatric refugees are a vulnerable population whose post-immigration weight trajectory has not been studied. We examined the longitudinal weight trajectory of 1067 pediatric refugees seen in a single university based refugee health program between the dates of September 3, 2012 and September 3, 2014 to determine how quickly significant weight gain occurs post-arrival. The most recent BMI was abstracted from the electronic health record and charts reviewed to obtain serial BMI measurements in 3 year increments after the date of US arrival. The mean arrival BMI percentile for all refugees was 47th percentile. This increased significantly to the 63rd percentile within 3 years of US arrival (p < 0.01). This rapid increase was largely attributable to African and South and Southeast Asian refugees. The overall prevalence of age and sex adjusted obesity rose from 7.4 % at arrival to 18.3 % within 9 years of US immigration exceeding the pediatric US national obesity prevalence of 16.9 %. Pediatric refugees are at increased risk of rapid weight gain after US immigration. Targeted interventions focused on prevention of weight gain in specific populations are warranted.

Class of 2010 Abstract / OBJECTIVES: To evaluate the product information and pivotal studies of injectable medications to determine if a specific size descriptor was included and if information was provided for dosing patients with extremes of body weight (body mass index < 18.5 or > 40 kg/m2). METHODS: This is a descriptive study of medications that received an approved new drug application (NDA) by the FDA between 1 January 2004 and 30 January 2009. Any information related to size descriptors, or dosing of patients with extremes of weight, was extracted and evaluated with a dosing usefulness score that ranged from a low of 0 to a high of 3. A score of 2 or greater was considered at least minimally adequate for dosing patients with extremes of weight. RESULTS: Of the 84 medications evaluated, some reference to weight descriptors was found for 23 (27%). None of the medications had information that generated a usefulness score of 2 or greater. CONCLUSIONS: The product information and pivotal studies involving newly approved medications is inadequate for dosing patients with extremes of weight and further research is needed. The FDA should mandate that product information contain the size descriptor and extremes of body weight relative to age and height that were used to develop dosing recommendations.