Thesis (M.Sc.)--York University, 2007. Graduate Programme in Mathematics and Statistics. / Typescript. Includes bibliographical references. Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR29300

Thesis (M.S.)--Eastern Illinois University, 2010. / Includes bibliographical references (leaves 55-64).

Thesis (Ph. D.)--University of Missouri-Columbia, 2006. / Title from title screen of research.pdf file (viewed on December 22, 2006) The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. "May 2006" Vita. Includes bibliographical references.

Thesis (M.S.)--Georgia Southern University, 2006. / "A dissertation submitted to the Graduate Faculty of Georgia Southern University in partial fulfillment of the requirements for the degree Master of Science" ETD. Includes bibliographical references (p. 38-69)

Thesis (M.Phil.) - University of Queensland, 2005. / Includes bibliography.

West Nile virus (WNV) is a geographically endemic mosquito-borne flavivirus that has spread across the United States infecting birds, mosquitos, humans, horses and other mammals. The wide spread nature of this virus is due to the ability of the mosquito vector to persist in broad, ecological diverse environments across the United States. In this study, mosquito populations in North Texas region were sampled for detection of Wolbachia, blood meal source, and WNV. The ultimate goal of this study was to examine the potential of a biocontrol agent, Wolbachia sp. that colonizes the hindgut of various insects, including mosquitos, as a natural means to interrupt virus transmission from mosquitos to other hosts, including humans. In Australia, Wolbachia sp. from fruit flies (Drosophila melanogaster) have been successfully used to block transmission of a similar pathogenic virus from mosquitos responsible for transmission of Dengue fever. Here, mosquitoes were collected using CDC style Gravid Traps in Denton, Texas, from October 2012 through September 2014. Collected mosquitoes were identified, sexed, and categorized as to the amount of host blood in their alimentary system using a Zeiss Axio Zoom microscope (Carl Zeiss Microscopy, LLC, Thornwood, NY). Culex quinquefaciatus was the dominant blood engorged species collected. Smaller populations of Culex tarsalis and Aedes albopictus, another known vector for WNV were also collected. Mosquito larva were also collected from the UNT water research field station and reared to adults. Cx. tarsalis was the dominant mosquito taken from this habitat. Samples of Cx. quinquefasciatus, Cx. tarsalis and A. albopictus were analyzed for Wolbachia sp. and to identify host blood in the mosquito alimentary system. Total DNA extraction from the pool of mosquito samples was by both commercially available DNA extraction kits (Qiagen, Valencia, CA) and salt extraction technique. Polymerase chain reaction (PCR) was used to amplify and identify Wolbachia sp. 16SrDNA and mitochondrial DNA from vertebrate blood. The maternally inherited endosymbiont, Wolbachia, were found to be uniformly distributed across the mosquitoes sampled in this study. Blood meal analysis by PCR showed that Cx. quinquefaciatus fed more on birds than on mammalian blood sources based on the previously developed primers used in this study.

West Nile virus (WNv) is an arbovirus and is transmitted by infected mosquitoes after feeding on the blood of birds carrying the virus. The Canadian WNv national surveillance system has just completed its tenth year of operation. The thesis is to evaluate the surveillance system and analyze multi-year human data. The evaluation includes the use of multiple lines of complementary methods such as the US CDC surveillance guidelines, Canadian Evaluation Framework, document review and a survey. Logistic and Poisson regressions were used for data analyses. WNv has become endemic in most parts of Canada since the virus occurred in 2001. The virus activity is peak around August. High numbers of human cases with WNv neurological syndrome identified pose a significant health concern due to the long term sequelae among affected patients. WNv national surveillance met its main objectives and there is a continual need for the surveillance.

West Nile virus (WNv) is an arbovirus and is transmitted by infected mosquitoes after feeding on the blood of birds carrying the virus. The Canadian WNv national surveillance system has just completed its tenth year of operation. The thesis is to evaluate the surveillance system and analyze multi-year human data. The evaluation includes the use of multiple lines of complementary methods such as the US CDC surveillance guidelines, Canadian Evaluation Framework, document review and a survey. Logistic and Poisson regressions were used for data analyses. WNv has become endemic in most parts of Canada since the virus occurred in 2001. The virus activity is peak around August. High numbers of human cases with WNv neurological syndrome identified pose a significant health concern due to the long term sequelae among affected patients. WNv national surveillance met its main objectives and there is a continual need for the surveillance.

West Nile Virus (WNV) first appeared in the western hemisphere in 1999, and has since spread across the United States and into Mexico and the Caribbean. It has been hypothesized that WNV has spread rapidly via migratory birds, and that various avian species may facilitate viral amplification during winter months. The goals of this research were to determine the role of American Tree Sparrows (Spizella americana) in the spread of WNV during their igrations and to determine the role of the Northern Cardinal (Cardinalis cardinalis) in winter survivorship and subsequent spring amplification of WNV. Additional wintering avian species were sampled to provide a general survey of the prevalence of WNV in winter in south-central Kansas. Blood samples were taken from the brachial vein of migratory and wintering birds captured using mist nets at four wintering feeding stations at the Wichita State University Field Station. Some samples were taken from retrapped birds within a single winter to determine if winter transmission occurs. Some birds were resampled in consecutive winters to monitor seroconversion rates. Analysis of serum samples were performed, in triplicate, using an epitope-blocking ELISA. The current study was conducted during the consecutive winters of 2003-04 and 2004-05. It was concluded that resident species had an increased incidence of WNV exposure when compared to that of migratory species. This difference suggests that migratory species may not have as important a role in the dissemination of WNV as first hypothesized. Also, minimal, if any, winter transmission occurs on communal feeding grounds. Viral amplification during the winter was not demonstrated, although one individual seroconverted during a single winter. / Thesis (M.S.)--Wichita State University, Dept. of Biological Sciences / Includes bibliographical references (leaves 35-39)

The 1,2,5-Thiadiazolidin-3-one 1,1-dioxide scaffold was used in the design and synthesis of inhibitors of Dengue Virus and West Nile Virus proteases and human tryptase. The scaffold was successfully used in the synthesis of potential inhibitors of Dengue Virus and West Nile Virus proteases. Inhibitors of Human tryptase synthesized based on the 1,2,5-Thiadiazolidin-3-one 1,1- dioxide scaffold were shown to be effective mechanism-based inhibitors of the enzyme. / Thesis (M.S.)--Wichita State University, College of Liberal Arts and Sciences, Dept. of Chemistry. / "July 2006." / Includes bibliographic references (leaves 64-66).