Anxiety and regret are two concepts that are connected to each other, where the former is and can be a consequence of the latter according to previous research. Making a decision regarding a career choice can be the decision you regret the most. Previous research has shown that personality traits, from the Big Five theory, Neuroticism and Conscientiousness have been associated with multiple facets of the decision-making process. The purpose of the study was to investigate the influence and relationship of personality on regret and regarding career choice. In this questionnaire study, using the “Decision Regret Scale” and BFI-10, a total of 179 participants participated of which 134 were women and 45 were men. The result showed that Agreeableness (r = -0.157, p < .05) and Neuroticism (r = 0.190, p < .05) correlated significantly with the DRS values. However Conscientiousness did not reveal a significant correlation. The findings of this study suggest that personality traits, particularly Agreeableness and Neuroticism within the Big Five model, are linked to decision regret and regret in the context of career choices. By shedding light on this, one can possibly understand more about potential regret and its impact. The essay writers thus hope that the essay will contribute to an understanding of what it is that leads to regret in people's lives, but especially regret in the career choices one makes.