Marginal zone lymphomas (MZLs) are a heterogeneous group of neoplasms that resemble the normal B-cell populations of the marginal zone of a lymph node. It includes three different subtypes, nodal, splenic, and extra -nodal, each, with overlapping features and yet unique characteristics. Nodal Marginal Zone lymphoma (NMZL) accounts for only 1% of all Non-Hodgkin Lymphoma (NHL). Marginal Zone lymphoma with plasmacytic differentiation is not very common. We report a unique case of Nodal marginal zone lymphoma initially presenting with lymphocytosis and lymphadenopathy, work up indicating low grade lymphoma, subsequently developing hyper viscosity syndrome due to symptomatic IgM monoclonal gammopathy. A 68 year old female was noted to have persistent leukocytosis with lymphocytic predominance after completing treatment for a urinary tract infection. Clinical exam revealed bilateral axillary adenopathy. CT scan of neck, chest, abdomen and pelvis revealed axillary, mediastinal and retroperitoneal adenopathy with splenomegaly. Chronic lymphocytic leukemia (CLL) was suspected and work up initiated. Peripheral blood Flow-cytometry revealed 24% small B-cells with surface kappa light chain restriction consistent with mature B-cell lymphoma or leukemia without typical immune phenotype of CLL. Lab reported significant elevation of total protein at 10 g/dl. Workup for para-proteinemia consistent with IgM level over 5000 mg/dl, with serum viscosity of 8. Axillary lymph node excisional biopsy reported marginal zone lymphoma with plasmacytic differentiation. Bone marrow biopsy demonstrated 42% monoclonal B-cells without co-expression of CD5 and CD23. FISH studies positive for duplication 1q and Molecular testing negative for MYDD88 mutation. Decision was made to initiate chemo therapy with R-CVP for a total of six cycles. Her treatment course was complicated by symptomatic hyper viscosity syndrome necessitating therapeutic plasmapheresis. Patient successfully completed chemo immunotherapy with normalization of blood counts, resolution of palpable adenopathy and splenomegaly. Nodal marginal lymphoma (NMZL) originates from nodal mono-cytoid or marginal zone B cells and the pathogenesis usually involves acquired mutations in oncogenes and tumor suppressor genes involving MLL2, PTTPRD, NOTCH2, and KLF2 genes. The median age is round 70 years with slight male predominance. The clinical picture varies and usually includes generalized lymphadenopathy along with B symptoms and infrequently with mild monoclonal gammopathy (any immunoglobulin subtype-IgM uncommon). Marginal Zone lymphoma with plasmacytic differentiation is not as common and shares immuno-histochemical features with lympho-plasmacytic lymphoma (LPL). They both express B cell markers CD19, CD20, and CD22) and not CD5, CD10 or CD23. Clinically, NMZL is more likely to present with prominent lymphadenopathy, while LPL can exclusively affect the marrow without extramedullary involvement. IgM levels in NMZL tend to be lower than in LPL, typically lower than 1000 mg/d. MYD88 mutation is very common in LPL, and can be seen in 10-15% NMZL. The presence of IgM monoclonal gammopathy increases the serum viscosity which can lead to serious neurologic and ophthalmologic complications. Treatment involves emergent plasmapheresis. Our case highlights a less common NHL, presenting with significant paraproteinemia and developing hyper viscosity syndrome with impressive response to plasmapheresis and chemo immunotherapy.

No description available.

Global warming is caused by Greenhouse Gas (GHG) emissions produced from the use of fossil fuel-based energy sources. Buildings consume about 30%-35% of the global energy use, which makes buildings a major contributor to the global warming problem. A long-term plan has been established at the Thermal Processing Laboratory (TPL) at McMaster University to investigate the use of various renewable energy-based technologies to achieve Net-Zero Energy Buildings (NZEB) in Canada. This paper presents results of an investigation of the effectiveness of using a thermal buffer zone (TBZ) in real buildings. A TBZ is a closed passage built around the building that allows air to passively re-distribute heat energy from solar radiation received on the south side throughout the building. A TBZ offers an effective solution of the overheating problem usually experienced on the south side of the building and, at the same time, it helps in reducing the heating load of the north side of the building. An experimental setup employing TBZ in a model of a typical building floor has been built. An analytical model of the TBZ has been developed. The experimental data has been used to validate the developed analytical model, which then was used to simulate the performance of a TBZ implemented in a real building floor. Results showed that the effectiveness of TBZ could reach 117% in the winter (cold climate countries). Moreover, the study considered the effect of integrating the TBZ with a fan. Results showed that the use of the fan is beneficial for a certain gap width, beyond which the use of the fan is not recommended. In conclusion, results of this study confirm that the TBZ can offer an effective means of replacing parry of building consumption of fossil fuel-based energy using solar energy. / Thesis / Master of Applied Science (MASc)

The focus of highway work is shifting from new construction further into maintenance, rehabilitation, and reconstruction of existing facilities. Work zones constitute sections of highway where these efforts are actively pursued. Excessive speed is often a contributing factor to work zone accidents. One method of speed control in work zones is the deployment of unmanned, or drone, radar transmitters, to simulate and supplement police presence in work zones. A review of the literature and past research on speed control techniques was conducted, and data was collected in several work zones on Interstate 81 in Virginia. Traffic data were gathered both upstream and in the range of the unmanned radar units. Effectiveness of the unmanned radar was expressed as changes in mean speed, speed variance, percent of traffic exceeding the speed limit, and eighty-fifth percentile speed. Statistical analyses on the resulting speed distributions utilized hypothesis testing to determine the significance of differences in the measures of effectiveness among speed control conditions in work zones. User costs associated with work zones were also examined. At the sites studied, significant reductions in mean speed and in percent of traffic exceeding the speed limit were observed, as were minor reductions in speed variance and eighty-fifth percentile speed. Unmanned radar was found to be particularly effective when police presence was expected by motorists. From this research effort, recommendations were developed to assist traffic engineers in determining the most effective way to use unmanned radar to maximize their safety benefit on the traffic stream. / Master of Science

Thesis advisor: Seth C. Kruckenberg / The Potters Pond migmatite domain (PPMD) is a heterogeneous zone of migmatites located ~10 km southwest of Cascade, Idaho within the western Idaho shear zone (WISZ). The PPMD is the only known exposure of migmatites within the WISZ over its ~300 km length, occurring where the shear zone orientation changes from 020° south to 000° north of the migmatite domain. Structural mapping within the PPMD has identified multiple generations of migmatite with varied structural fabrics. Leucosome layers were sampled from distinct migmatite localities and morphologies (e.g., metatexite, diatexite) to determine the timing and duration of partial melting in the PPMD. U-Pb age determinations of zircon by means of LA-ICP-MS document two periods of protracted migmatite crystallization during the Early and Late Cretaceous. Early Cretaceous (ca. 145 to 128 Ma) migmatite crystallization ages are coeval with the collision and suturing of oceanic terranes of the Blue Mountains province with North America, and the formation of the Salmon River suture zone (SRSZ). Migmatite crystallization ages from ca. 104 to 90 Ma are associated with Late Cretaceous dextral transpression in the WISZ. Field observations and geochronology of cross cutting leucosome relationships are interpreted to record deep crustal deformation and anatexis associated with formation of the SRSZ, subsequently overprinted by solid-state deformation and renewed anatexis during the evolution of the WISZ. These data are the first direct evidence of the synmetamorphic fabric related to the SRSZ east of the initial Sr 0.706 isopleth, and that the WISZ is a temporally distinct overprinting structure. / Thesis (MS) — Boston College, 2016. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Earth and Environmental Sciences.

Reservoirs are generally created by damming rivers. The upper reaches of any reservoir is generally narrow and winding like the parent river. This is the riverine zone of the reservoir. The reservoir is deepest and widest near the dam. Here, lake-like conditions exist and the water is quiescent. This is the lacustrine zone. The transitional zone separates the lacustrine and riverine zone. It has intermediate characteristics. There are many characteristics, both physical and chemical, that differentiate between these three zones. Based on the differences in characteristics between the three zones, a method has been developed to successfully divide any reservoir into three zones. The method developed was applied to Lake Manassas and the Occoquan Reservoir located in the Occoquan watershed in Virginia. Both are man-made impoundments. Analysis of data, based on the method developed, was successfully in dividing both reservoirs into the three zones. This method may therefore be successfully applied to obtain zonation in reservoirs. / Master of Science

In this research, Fresnel zone plates were studied using an accurate, full-electromagnetic simulator based on the body-of-revolution finite-difference time-domain (BOR-FDTD) method. This tool was used to investigate zone plates for two different applications: zone plates used as antennas in communication systems and zone plates used as focusing elements in free-space, focused-beam measurement systems. Through detailed studies of zone plates for these applications, a number of general characteristics of the zone plate were given a more in-depth look than they have been given in the past. For the first application, parametric studies were performed for Soret, folded, and grooved-dielectric, phase-correcting zone plates for antenna applications. These studies were used to generate new design graphs, from which general observations are made about the effect of varying different parameters on the focusing ability of a zone plate. For the grooved-dielectric, phase-correcting zone plate, these studies show that a number of factors influence the focusing ability in ways that are unexpected, based on many of the simple techniques typically used to analyze zone plates. Each of these factors is evaluated individually. For the second application, a zone plate was designed to be used as a focusing element in a free-space, focused-beam measurement system. To determine the suitability of zone plates for this application, simulations and measurements of the electric field were used to compare this zone plate to a doubly-hyperbolic lens. A complete focused-beam system, using two zone plates as focusing elements, was used to measure the permittivity of different dielectric materials. These measurements are compared to results for a system that uses doubly-hyperbolic lenses and to published values. A technique for increasing the usable bandwidth of a zone plate in a focused-beam system was proposed and tested. Finally, as a topic for future research, the question is posed: Using the BOR-FDTD method, can a similar volume of material be shaped in a way that results in improved focusing performance compared to a traditional zone plate? Some insight into this open-ended question can be gained by examining preliminary results of the optimization of zone plates using of a genetic algorithm.

De nombreuses familles de polluants organiques en provenance de différentes sources se retrouvent dans les milieux aquatiques continentaux et littoraux. Ces molécules, dont les lipophiles et les persistantes, sont souvent présentes à l'état de trace dans la fraction dissoute. L'utilisation de compartiments concentrateurs comme les sédiments rend alors plus accessible l'évaluation des concentrations ambiantes du milieu. L'objectif de la thèse a été d'évaluer l'exposition en zones côtières aux différentes familles de contaminants organiques « émergents » incluant les filtres UV, les alkylphénols et les alkylphénols polyéthoxylés, ainsi que « persistants-classiques » incluant les hydrocarbures aromatiques polycycliques et les polychlorobiphényles dans les sédiments et, éventuellement, dans les eaux. Un important effort de recherche a été accordé à l'étude des variations spatiales et temporelles des contaminants sélectionnés dans les sédiments, permettant ainsi l'acquisition d'un premier jeu de données nationales (libanais) représentatif pour ces familles de contaminants.Trois rivières en Méditerranée orientale et leur environnement côtier ont été pris comme cas d'étude en plus de la côte d'une petite ville et ses sites portuaires qui ont été sélectionnés afin de compléter l'étude en milieu côtier. Un premier aperçu des niveaux de ces contaminants hydrophobes dans les zones côtières recevant des apports typiques de la Méditerranée orientale est ainsi fourni. Les résultats des analyses chimiques ont clairement montré l'impact des rejets des effluents non traités dans les zones côtières via les entrées des rivières et les déversements directs le long de la côte, en absence des activités récréatives (pour les filtres UV) et de rejets industriels (pour les alkylphénols et les alkylphénols polyéthoxylés). Les zones de transition peuvent être à l'origine de la contamination de l'environnement côtier des trois rivières par ces polluants émergents en absence des apports marins. Des concentrations élevées en hydrocarbures aromatiques polycycliques et en polychlorobiphényles ont été mesurées dans les sédiments prélevés en milieu côtier. Cette contamination a persisté des années après la marée noire qui a envahi la côte Est-Méditerranéenne en 2006. Nos résultats globaux indiquent que les concentrations mesurées dans les sédiments des trois rivières étudiées et du littoral peuvent être classées parmi les niveaux les plus élevés détectés dans le pourtour du bassin méditerranéen et pouvant induire des effets toxiques chez le biota aquatique.Ce travail peut être d'une importance primordiale pour la région Est-Méditerranéenne, et plus particulièrement pour le Liban, un pays qui, malgré d'être parmi les signataires de la convention de Barcelone pour la protection de la mer Méditerranée et qui est, par la suite, impliqué dans la surveillance de la qualité de son milieu marin, souffre jusqu'à présent des rejets de différents types d'effluents non traités le long de ces côtes en absence des stations d'épuration. / Many organic pollutants issued from different sources are present into freshwater and coastal waters. Since these lipophilic contaminants are present at trace levels in water, accumulator compartments such as sediments can be used to assess their concentration in aquatic systems. The objective of the thesis was to assess the exposure in coastal areas to the various families of organic contaminants namely "emerging pollutants" including UV filters, alkylphenols, alkylphenol polyethoxylates, and "persistent pollutants" including polycyclic aromatic hydrocarbons and polychlorinated biphenyls in sediments and water. A major research effort has been given to the investigation spatial and temporal dynamics of the selected pollutants in sediment, allowing the acquisition of a first set of national data (Lebanese).Three rivers and their coastal environment in the eastern Mediterranean have been taken as a case study in addition to the small coastal city that was selected to complete the study in the coastal environment. A first overview of the levels of these hydrophobic contaminants in coastal areas receiving typical eastern Mediterranean inputs is thus provided. The results of chemical analyzes have clearly shown the impact of discharges of untreated effluents into coastal areas via inputs from rivers and direct discharges along the coast, without recreational activities (for UV filters) and industrial effluents discharges (for alkylphenols and alkylphenol polyethoxylates). Transition zones may act like a source of contamination of the three rivers coastal environment in the absence of marine inputs. Elevated concentrations of polycyclic aromatic hydrocarbons and polychlorinated biphenyls were measured in sediments in coastal environments. This contamination has persisted for years after the oil spill that has invaded the Mediterranean coast in 2006. Our overall results indicate that concentrations in sediments of the three studied rivers and the coastline can be classified among the highest levels detected in the Mediterranean basin and may induce toxic effects in aquatic biota.This work may be of paramount importance for the East-Mediterranean region, and particularly for Lebanon, a country which, despite being a signatory to the Barcelona Convention for the Protection of the Mediterranean Sea and is, subsequently involved in monitoring the quality of its marine environment, suffers far different types of discharges of untreated effluent along its coast in the absence of wastewater treatment plants.

Thesis (M.A.)--Memorial University of Newfoundland, 2005. / Includes bibliographical references (leaves 160-168).

Univ., Diss/2007--Heidelberg, 2006.