The deleterious effects of MPO make it a new target for medicinal research. The aim of our study is to find promising inhibitors of MPO for using them as starting point of new anti-inflammatory drugs. Depending on previous researches on MPO inhibitors, we selected 5-fluorotryptamine as starting compounds. Using docking experiments, we designed a series of compounds derived from 5-fluorotryptamine. Two modifications were proposed: <p>& / Doctorat en Sciences biomédicales et pharmaceutiques / info:eu-repo/semantics/nonPublished
Identifer | oai:union.ndltd.org:ulb.ac.be/oai:dipot.ulb.ac.be:2013/209402 |
Date | 09 October 2013 |
Creators | Soubhye, Jalal |
Contributors | Dufrasne, François, Neve, Jean, Amighi, Karim, Pincemail, Joël, Meyer, Franck, Li, Xiaoli, Pochet, Stéphanie, Kauffmann, Jean-Michel |
Publisher | Universite Libre de Bruxelles, Université libre de Bruxelles, Faculté de Pharmacie, Bruxelles |
Source Sets | Université libre de Bruxelles |
Language | English |
Detected Language | English |
Type | info:eu-repo/semantics/doctoralThesis, info:ulb-repo/semantics/doctoralThesis, info:ulb-repo/semantics/openurl/vlink-dissertation |
Format | 1 full-text file(s): application/pdf |
Rights | 1 full-text file(s): info:eu-repo/semantics/openAccess |
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