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Directed evolution of an HIV-1 LTR specific recombinase for anti-retroviral therapy- a proof of concept study

The prospect of the work presented in this thesis has been to engineer Cre recombinase to recognize and recombine a sequence from an HIV-1 Long Terminal Repeat (LTR), characterize the recombination proficiency of the evolved recombinase in mammalian cells and explore the potential of the recombinase for a novel antiretroviral strategy.

Identiferoai:union.ndltd.org:DRESDEN/oai:qucosa.de:swb:14-1169028775210-26417
Date17 January 2007
CreatorsSarkar, Indrani
ContributorsTechnische Universität Dresden, Biologie, Dr. Frank Buchholz, Dr. Frank Buchholz, Prof. Dr. Francis Stewart, Prof. Dr. Joachim Hauber
PublisherSaechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden
Source SetsHochschulschriftenserver (HSSS) der SLUB Dresden
LanguageEnglish
Detected LanguageEnglish
Typedoc-type:doctoralThesis
Formatapplication/pdf

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