Made available in DSpace on 2015-04-14T13:35:34Z (GMT). No. of bitstreams: 1
441495.pdf: 393716 bytes, checksum: 44d5110d0dc89507b042452bde0134c9 (MD5)
Previous issue date: 2012-08-29 / Objective: The aim of this study was to evaluate the relationship between body weight gain
and small solute transport by the peritoneum
Methods: A retrospective review was conducted of the records from 50 patients over the age
of 18 years, all of whom had undergone peritoneal dialysis for at least one year. Weight
changes were recorded at quarterly intervals until completion of one year of therapy and were
subsequently compared with the categories of peritoneal transport. Biochemical markers
including glucose, albumin and lipid profile were evaluated at the beginning of therapy and
again one year later.
Results: A significant effect of time on the mean body weight of the study participants was
detected, as shown by the Repeated Measures Analysis of Variance. The final BMI mean was
significantly higher than the initial. A significant reduction in serum albumin also occurred.
However, no significant difference was found when comparing the weight change over the
first year of treatment to the categories from the peritoneal equilibration test.
Conclusion: This study was unable to demonstrate the existence of an association between
the initial peritoneal membrane small solute transport with weight changes in patients
undergoing peritoneal dialysis. The acknowledged multifactorial nature of obesity may be a
possible explanation for our findings. The glucose uptake rate by the peritoneum does not
seem to be responsible, therefore, it is necessary to search for factors linked to peritoneal
dialysis that would have a greater influence on the observed alterations in nutritional status / Objetivo: o objetivo do presente estudo foi avaliar a rela??o entre aumento do peso corp?reo
dos pacientes em di?lise peritoneal e a fun??o de transporte de solutos pelo perit?nio.
M?todos: os registros de 50 pacientes maiores de 18 anos, que realizavam di?lise peritoneal
h? no m?nimo de um ano, foram revisados retrospectivamente. As altera??es de peso foram
registradas em intervalos trimestrais at? completarem um ano de terapia e, posteriormente,
foram comparados com as categorias de transporte peritoneal avaliadas pelo teste de
equil?brio peritoneal ?s quais pertenciam os pacientes. Marcadores bioqu?micos inclu?ram
glicose, albumina e perfil lip?dico avaliados no inicio e ap?s um ano de terapia.
Resultados: Foi detectado um efeito significativo do tempo em di?lise na m?dia de peso dos
investigados, quanto realizada a an?lise de vari?ncia para medidas repetidas. A m?dia final do
?ndice de massa corporal (IMC) mostrou-se significativamente maior que a inicial. Tamb?m
ocorreu uma redu??o significativa da albumina s?rica. A varia??o do peso ao longo do
primeiro ano de tratamento n?o foi significativamente diferente entre as categorias do teste de
equil?brio peritoneal.
Conclus?es: o presente estudo n?o demonstrou a exist?ncia de uma associa??o entre as
caracter?sticas do transporte de membrana peritoneal e absor??o de glicose, com as altera??es
de peso em pacientes em di?lise peritoneal. A reconhecida natureza multifatorial da obesidade
pode ser uma poss?vel explica??o para nossos achados. Entretanto, mais estudos s?o
necess?rios a fim de identificar quais destes fatores ligados a di?lise peritoneal teriam uma
maior influ?ncia sobre as altera??es no estado nutricional e na composi??o corporal desta
popula??o de pacientes
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/1702 |
| Date | 29 August 2012 |
| Creators | Rocha, Sulene Rosa da |
| Contributors | Figueiredo, Carlos Eduardo Poli de |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Medicina e Ci?ncias da Sa?de, PUCRS, BR, Faculdade de Medicina |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 7620745074616285884, 500, 600, -8624664729441623247 |
Page generated in 0.0019 seconds