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Previous issue date: 2012-08-28 / Introduction: Although temporal lobe epilepsy is associated with high rates of psychiatric comorbidities, investigations about the temperament of these patients have been neglected. Previous studies have suggested that epileptiform and clinical variables may have a role in this context. Objectives: The present study characterized, through a reliable instrument, the temperament of patients with mesial temporal lobe epilepsy, compared them to controls and established relationships with disease-related variables. Methods: Temperament was assessed in 42 (forty-two) adult patients with unilateral mesial temporal lobe epilepsy and 84 (eighty-four) control, through the questionnaire AFECTS (Affective and Emotional Composite Temperament Scale). Among patients, variables related to epilepsy were collected prospectively as well as the scales of the BDI and BAI. Results: Statistically significant correlations were observed between disease duration and higher BDI against temperaments "Depressive" and "Anxious" and the emotional dimension of temperament "Fear." The number of antiepileptic drugs correlated inversely with the temperament "Obsessive." Regarding laterality, patients with lesion in the left lobe had lower average in the emotional dimension "Sensitivity". Discussion: Even though some findings, such as higher BDI scores in patients with temperament "Depressive" and "Anxious" could be justified by the bigger prevalence of psychiatric disorders in patients with mesial temporal lobe epilepsy, statistically significant correlations were found between affective dimensions and variables, independently. Lower means of "Sensitivity" in patients with left itcal focus were consistent with recent data about neurobiological basis of temperament. Conclusion: While they should be interpreted with caution, the results suggest a possible role of mesial temporal lobe epilepsy, directly and through lesion, as one of the determinants of temperament in these patients. / Introdu??o: Embora a epilepsia do lobo temporal esteja associada a altas taxas de comorbidades psiqui?tricas, investiga??es acerca do temperamento destes pacientes t?m sido negligenciadas. Estudos pr?vios t?m sugerido que vari?veis cl?nicas e epileptiformes possam exercer um papel fundamental neste contexto. Objetivos: O presente estudo caracterizou, atrav?s de instrumento confi?vel, o temperamento de pacientes com epilepsia temporal mesial, comparando-os a controles e estabelecendo rela??es com vari?veis associadas ? doen?a. M?todos: O temperamento foi analisado em 42 adultos, portadores de epilepsia mesial temporal unilateral e 84 controles, atrav?s do question?rio AFECTS (Affective and Emotional Composite Temperament Scale). Entre os pacientes, as vari?veis relacionadas ? epilepsia foram coletadas prospectivamente, assim como as escalas de BDI e BAI. Resultados: Correla??es estatisticamente significativa foram observadas entre dura??o da doen?a e altos ?ndices no BDI aos temperamentos Depressivo e Ansioso e ? dimens?o emocional do temperamento Medo. O n?mero de drogas antiepil?pticas correlacionou-se inversamente ao temperamento Obsessivo. Quanto ? lateralidade, pacientes com les?o ? esquerda apresentaram m?dias menores na dimens?o emocional Sensibilidade. Discuss?o: Mesmo que alguns achados, como os elevados ?ndices no BDI em pacientes com temperamento Depressivo e Ansioso possam ser justificados pela maior preval?ncia de dist?rbios psiqui?tricos em indiv?duos com epilepsia temporal mesial, correla??es estatisticamente significativas encontradas entre dimens?es afetivas e vari?veis epileptiformes foram independentes. Menores m?dias de Sensibilidade em pacientes com foco itcal ? esquerda foram condizentes com dados recentes sobre as bases neurobiol?gicas do temperamento. Conclus?o: Embora devam ser interpretados com cautela, os resultados sugerem um poss?vel papel da epilepsia mesial temporal, de maneira direta e lesional, como um dos determinantes do temperamento nestes pacientes.
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/1707 |
| Date | 28 August 2012 |
| Creators | Posenato, Naiana |
| Contributors | Palmini, Andr? Luis Fernandes |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Medicina e Ci?ncias da Sa?de, PUCRS, BR, Faculdade de Medicina |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 7620745074616285884, 500, 600, -8624664729441623247 |
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