NDLTD Global ETD Search
Return to search

Avaliação da evolução clínica e dos fatores prognósticos em pacientes com epilepsia mioclônica juvenil / Evaluation of clinical evolution and prognostic factors in juvenile myoclonic epilepsy patients

Description

Made available in DSpace on 2015-07-22T20:49:30Z (GMT). No. of bitstreams: 0
Previous issue date: 2010-06-30. Added 1 bitstream(s) on 2015-08-11T03:26:22Z : No. of bitstreams: 1
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:22Z : No. of bitstreams: 2
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5)
Publico-238b.pdf: 1881184 bytes, checksum: c5faae7597ff58c993732a87ae3c7d6e (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:22Z : No. of bitstreams: 3
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5)
Publico-238b.pdf: 1881184 bytes, checksum: c5faae7597ff58c993732a87ae3c7d6e (MD5)
Publico-238c.pdf: 1880956 bytes, checksum: 980548869f6e59e382509d177d9f4682 (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:23Z : No. of bitstreams: 4
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5)
Publico-238b.pdf: 1881184 bytes, checksum: c5faae7597ff58c993732a87ae3c7d6e (MD5)
Publico-238c.pdf: 1880956 bytes, checksum: 980548869f6e59e382509d177d9f4682 (MD5)
Publico-238d.pdf: 1827317 bytes, checksum: c5cd246c68ed0923d44c1fa8f26bee78 (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:23Z : No. of bitstreams: 5
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5)
Publico-238b.pdf: 1881184 bytes, checksum: c5faae7597ff58c993732a87ae3c7d6e (MD5)
Publico-238c.pdf: 1880956 bytes, checksum: 980548869f6e59e382509d177d9f4682 (MD5)
Publico-238d.pdf: 1827317 bytes, checksum: c5cd246c68ed0923d44c1fa8f26bee78 (MD5)
Publico-238e.pdf: 1739275 bytes, checksum: ebe729b79d442d3a5159cd27abb3db4b (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:23Z : No. of bitstreams: 6
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5)
Publico-238b.pdf: 1881184 bytes, checksum: c5faae7597ff58c993732a87ae3c7d6e (MD5)
Publico-238c.pdf: 1880956 bytes, checksum: 980548869f6e59e382509d177d9f4682 (MD5)
Publico-238d.pdf: 1827317 bytes, checksum: c5cd246c68ed0923d44c1fa8f26bee78 (MD5)
Publico-238e.pdf: 1739275 bytes, checksum: ebe729b79d442d3a5159cd27abb3db4b (MD5)
Publico-238f.pdf: 1583416 bytes, checksum: eaa0b1c14465213725bc36b21805696d (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:23Z : No. of bitstreams: 7
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5)
Publico-238b.pdf: 1881184 bytes, checksum: c5faae7597ff58c993732a87ae3c7d6e (MD5)
Publico-238c.pdf: 1880956 bytes, checksum: 980548869f6e59e382509d177d9f4682 (MD5)
Publico-238d.pdf: 1827317 bytes, checksum: c5cd246c68ed0923d44c1fa8f26bee78 (MD5)
Publico-238e.pdf: 1739275 bytes, checksum: ebe729b79d442d3a5159cd27abb3db4b (MD5)
Publico-238f.pdf: 1583416 bytes, checksum: eaa0b1c14465213725bc36b21805696d (MD5)
Publico-238g.pdf: 1791684 bytes, checksum: 7ce6d5ab23d099ae1873877bcc3a1fc3 (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:23Z : No. of bitstreams: 8
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5)
Publico-238b.pdf: 1881184 bytes, checksum: c5faae7597ff58c993732a87ae3c7d6e (MD5)
Publico-238c.pdf: 1880956 bytes, checksum: 980548869f6e59e382509d177d9f4682 (MD5)
Publico-238d.pdf: 1827317 bytes, checksum: c5cd246c68ed0923d44c1fa8f26bee78 (MD5)
Publico-238e.pdf: 1739275 bytes, checksum: ebe729b79d442d3a5159cd27abb3db4b (MD5)
Publico-238f.pdf: 1583416 bytes, checksum: eaa0b1c14465213725bc36b21805696d (MD5)
Publico-238g.pdf: 1791684 bytes, checksum: 7ce6d5ab23d099ae1873877bcc3a1fc3 (MD5)
Publico-238h.pdf: 1829745 bytes, checksum: 8ac7af48cb909951b3e9d6c0f97a7656 (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:23Z : No. of bitstreams: 9
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5)
Publico-238b.pdf: 1881184 bytes, checksum: c5faae7597ff58c993732a87ae3c7d6e (MD5)
Publico-238c.pdf: 1880956 bytes, checksum: 980548869f6e59e382509d177d9f4682 (MD5)
Publico-238d.pdf: 1827317 bytes, checksum: c5cd246c68ed0923d44c1fa8f26bee78 (MD5)
Publico-238e.pdf: 1739275 bytes, checksum: ebe729b79d442d3a5159cd27abb3db4b (MD5)
Publico-238f.pdf: 1583416 bytes, checksum: eaa0b1c14465213725bc36b21805696d (MD5)
Publico-238g.pdf: 1791684 bytes, checksum: 7ce6d5ab23d099ae1873877bcc3a1fc3 (MD5)
Publico-238h.pdf: 1829745 bytes, checksum: 8ac7af48cb909951b3e9d6c0f97a7656 (MD5)
Publico-238i.pdf: 1796288 bytes, checksum: bdac4809cdc6fff1a21e0827aa6f65b5 (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:23Z : No. of bitstreams: 10
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5)
Publico-238b.pdf: 1881184 bytes, checksum: c5faae7597ff58c993732a87ae3c7d6e (MD5)
Publico-238c.pdf: 1880956 bytes, checksum: 980548869f6e59e382509d177d9f4682 (MD5)
Publico-238d.pdf: 1827317 bytes, checksum: c5cd246c68ed0923d44c1fa8f26bee78 (MD5)
Publico-238e.pdf: 1739275 bytes, checksum: ebe729b79d442d3a5159cd27abb3db4b (MD5)
Publico-238f.pdf: 1583416 bytes, checksum: eaa0b1c14465213725bc36b21805696d (MD5)
Publico-238g.pdf: 1791684 bytes, checksum: 7ce6d5ab23d099ae1873877bcc3a1fc3 (MD5)
Publico-238h.pdf: 1829745 bytes, checksum: 8ac7af48cb909951b3e9d6c0f97a7656 (MD5)
Publico-238i.pdf: 1796288 bytes, checksum: bdac4809cdc6fff1a21e0827aa6f65b5 (MD5)
Publico-238j.pdf: 1668240 bytes, checksum: 3acceb770cc771a91e84a2665c528429 (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:23Z : No. of bitstreams: 11
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5)
Publico-238b.pdf: 1881184 bytes, checksum: c5faae7597ff58c993732a87ae3c7d6e (MD5)
Publico-238c.pdf: 1880956 bytes, checksum: 980548869f6e59e382509d177d9f4682 (MD5)
Publico-238d.pdf: 1827317 bytes, checksum: c5cd246c68ed0923d44c1fa8f26bee78 (MD5)
Publico-238e.pdf: 1739275 bytes, checksum: ebe729b79d442d3a5159cd27abb3db4b (MD5)
Publico-238f.pdf: 1583416 bytes, checksum: eaa0b1c14465213725bc36b21805696d (MD5)
Publico-238g.pdf: 1791684 bytes, checksum: 7ce6d5ab23d099ae1873877bcc3a1fc3 (MD5)
Publico-238h.pdf: 1829745 bytes, checksum: 8ac7af48cb909951b3e9d6c0f97a7656 (MD5)
Publico-238i.pdf: 1796288 bytes, checksum: bdac4809cdc6fff1a21e0827aa6f65b5 (MD5)
Publico-238j.pdf: 1668240 bytes, checksum: 3acceb770cc771a91e84a2665c528429 (MD5)
Publico-238k.pdf: 1732376 bytes, checksum: 3d062894478f76394226011851eb17ce (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:23Z : No. of bitstreams: 12
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5)
Publico-238b.pdf: 1881184 bytes, checksum: c5faae7597ff58c993732a87ae3c7d6e (MD5)
Publico-238c.pdf: 1880956 bytes, checksum: 980548869f6e59e382509d177d9f4682 (MD5)
Publico-238d.pdf: 1827317 bytes, checksum: c5cd246c68ed0923d44c1fa8f26bee78 (MD5)
Publico-238e.pdf: 1739275 bytes, checksum: ebe729b79d442d3a5159cd27abb3db4b (MD5)
Publico-238f.pdf: 1583416 bytes, checksum: eaa0b1c14465213725bc36b21805696d (MD5)
Publico-238g.pdf: 1791684 bytes, checksum: 7ce6d5ab23d099ae1873877bcc3a1fc3 (MD5)
Publico-238h.pdf: 1829745 bytes, checksum: 8ac7af48cb909951b3e9d6c0f97a7656 (MD5)
Publico-238i.pdf: 1796288 bytes, checksum: bdac4809cdc6fff1a21e0827aa6f65b5 (MD5)
Publico-238j.pdf: 1668240 bytes, checksum: 3acceb770cc771a91e84a2665c528429 (MD5)
Publico-238k.pdf: 1732376 bytes, checksum: 3d062894478f76394226011851eb17ce (MD5)
Publico-238l.pdf: 1672723 bytes, checksum: 9c5dc98e92d85e8961a2319fbff140f8 (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:24Z : No. of bitstreams: 13
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5)
Publico-238b.pdf: 1881184 bytes, checksum: c5faae7597ff58c993732a87ae3c7d6e (MD5)
Publico-238c.pdf: 1880956 bytes, checksum: 980548869f6e59e382509d177d9f4682 (MD5)
Publico-238d.pdf: 1827317 bytes, checksum: c5cd246c68ed0923d44c1fa8f26bee78 (MD5)
Publico-238e.pdf: 1739275 bytes, checksum: ebe729b79d442d3a5159cd27abb3db4b (MD5)
Publico-238f.pdf: 1583416 bytes, checksum: eaa0b1c14465213725bc36b21805696d (MD5)
Publico-238g.pdf: 1791684 bytes, checksum: 7ce6d5ab23d099ae1873877bcc3a1fc3 (MD5)
Publico-238h.pdf: 1829745 bytes, checksum: 8ac7af48cb909951b3e9d6c0f97a7656 (MD5)
Publico-238i.pdf: 1796288 bytes, checksum: bdac4809cdc6fff1a21e0827aa6f65b5 (MD5)
Publico-238j.pdf: 1668240 bytes, checksum: 3acceb770cc771a91e84a2665c528429 (MD5)
Publico-238k.pdf: 1732376 bytes, checksum: 3d062894478f76394226011851eb17ce (MD5)
Publico-238l.pdf: 1672723 bytes, checksum: 9c5dc98e92d85e8961a2319fbff140f8 (MD5)
Publico-238m.pdf: 2017451 bytes, checksum: 3b45e2a5cd01698f71d8a28e7f0ecab3 (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:24Z : No. of bitstreams: 14
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5)
Publico-238b.pdf: 1881184 bytes, checksum: c5faae7597ff58c993732a87ae3c7d6e (MD5)
Publico-238c.pdf: 1880956 bytes, checksum: 980548869f6e59e382509d177d9f4682 (MD5)
Publico-238d.pdf: 1827317 bytes, checksum: c5cd246c68ed0923d44c1fa8f26bee78 (MD5)
Publico-238e.pdf: 1739275 bytes, checksum: ebe729b79d442d3a5159cd27abb3db4b (MD5)
Publico-238f.pdf: 1583416 bytes, checksum: eaa0b1c14465213725bc36b21805696d (MD5)
Publico-238g.pdf: 1791684 bytes, checksum: 7ce6d5ab23d099ae1873877bcc3a1fc3 (MD5)
Publico-238h.pdf: 1829745 bytes, checksum: 8ac7af48cb909951b3e9d6c0f97a7656 (MD5)
Publico-238i.pdf: 1796288 bytes, checksum: bdac4809cdc6fff1a21e0827aa6f65b5 (MD5)
Publico-238j.pdf: 1668240 bytes, checksum: 3acceb770cc771a91e84a2665c528429 (MD5)
Publico-238k.pdf: 1732376 bytes, checksum: 3d062894478f76394226011851eb17ce (MD5)
Publico-238l.pdf: 1672723 bytes, checksum: 9c5dc98e92d85e8961a2319fbff140f8 (MD5)
Publico-238m.pdf: 2017451 bytes, checksum: 3b45e2a5cd01698f71d8a28e7f0ecab3 (MD5)
Publico-238n.pdf: 1898959 bytes, checksum: f34a29aa3f4ccfabd792c8b12fe7302d (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:24Z : No. of bitstreams: 15
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5)
Publico-238b.pdf: 1881184 bytes, checksum: c5faae7597ff58c993732a87ae3c7d6e (MD5)
Publico-238c.pdf: 1880956 bytes, checksum: 980548869f6e59e382509d177d9f4682 (MD5)
Publico-238d.pdf: 1827317 bytes, checksum: c5cd246c68ed0923d44c1fa8f26bee78 (MD5)
Publico-238e.pdf: 1739275 bytes, checksum: ebe729b79d442d3a5159cd27abb3db4b (MD5)
Publico-238f.pdf: 1583416 bytes, checksum: eaa0b1c14465213725bc36b21805696d (MD5)
Publico-238g.pdf: 1791684 bytes, checksum: 7ce6d5ab23d099ae1873877bcc3a1fc3 (MD5)
Publico-238h.pdf: 1829745 bytes, checksum: 8ac7af48cb909951b3e9d6c0f97a7656 (MD5)
Publico-238i.pdf: 1796288 bytes, checksum: bdac4809cdc6fff1a21e0827aa6f65b5 (MD5)
Publico-238j.pdf: 1668240 bytes, checksum: 3acceb770cc771a91e84a2665c528429 (MD5)
Publico-238k.pdf: 1732376 bytes, checksum: 3d062894478f76394226011851eb17ce (MD5)
Publico-238l.pdf: 1672723 bytes, checksum: 9c5dc98e92d85e8961a2319fbff140f8 (MD5)
Publico-238m.pdf: 2017451 bytes, checksum: 3b45e2a5cd01698f71d8a28e7f0ecab3 (MD5)
Publico-238n.pdf: 1898959 bytes, checksum: f34a29aa3f4ccfabd792c8b12fe7302d (MD5)
Publico-238o.pdf: 1970130 bytes, checksum: 61c00ccc80c9834cc84b98f0f6c69ae2 (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:24Z : No. of bitstreams: 16
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5)
Publico-238b.pdf: 1881184 bytes, checksum: c5faae7597ff58c993732a87ae3c7d6e (MD5)
Publico-238c.pdf: 1880956 bytes, checksum: 980548869f6e59e382509d177d9f4682 (MD5)
Publico-238d.pdf: 1827317 bytes, checksum: c5cd246c68ed0923d44c1fa8f26bee78 (MD5)
Publico-238e.pdf: 1739275 bytes, checksum: ebe729b79d442d3a5159cd27abb3db4b (MD5)
Publico-238f.pdf: 1583416 bytes, checksum: eaa0b1c14465213725bc36b21805696d (MD5)
Publico-238g.pdf: 1791684 bytes, checksum: 7ce6d5ab23d099ae1873877bcc3a1fc3 (MD5)
Publico-238h.pdf: 1829745 bytes, checksum: 8ac7af48cb909951b3e9d6c0f97a7656 (MD5)
Publico-238i.pdf: 1796288 bytes, checksum: bdac4809cdc6fff1a21e0827aa6f65b5 (MD5)
Publico-238j.pdf: 1668240 bytes, checksum: 3acceb770cc771a91e84a2665c528429 (MD5)
Publico-238k.pdf: 1732376 bytes, checksum: 3d062894478f76394226011851eb17ce (MD5)
Publico-238l.pdf: 1672723 bytes, checksum: 9c5dc98e92d85e8961a2319fbff140f8 (MD5)
Publico-238m.pdf: 2017451 bytes, checksum: 3b45e2a5cd01698f71d8a28e7f0ecab3 (MD5)
Publico-238n.pdf: 1898959 bytes, checksum: f34a29aa3f4ccfabd792c8b12fe7302d (MD5)
Publico-238o.pdf: 1970130 bytes, checksum: 61c00ccc80c9834cc84b98f0f6c69ae2 (MD5)
Publico-238p.pdf: 2029182 bytes, checksum: 1743db4280c1e2ffee0335943b4ebe74 (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:24Z : No. of bitstreams: 17
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5)
Publico-238b.pdf: 1881184 bytes, checksum: c5faae7597ff58c993732a87ae3c7d6e (MD5)
Publico-238c.pdf: 1880956 bytes, checksum: 980548869f6e59e382509d177d9f4682 (MD5)
Publico-238d.pdf: 1827317 bytes, checksum: c5cd246c68ed0923d44c1fa8f26bee78 (MD5)
Publico-238e.pdf: 1739275 bytes, checksum: ebe729b79d442d3a5159cd27abb3db4b (MD5)
Publico-238f.pdf: 1583416 bytes, checksum: eaa0b1c14465213725bc36b21805696d (MD5)
Publico-238g.pdf: 1791684 bytes, checksum: 7ce6d5ab23d099ae1873877bcc3a1fc3 (MD5)
Publico-238h.pdf: 1829745 bytes, checksum: 8ac7af48cb909951b3e9d6c0f97a7656 (MD5)
Publico-238i.pdf: 1796288 bytes, checksum: bdac4809cdc6fff1a21e0827aa6f65b5 (MD5)
Publico-238j.pdf: 1668240 bytes, checksum: 3acceb770cc771a91e84a2665c528429 (MD5)
Publico-238k.pdf: 1732376 bytes, checksum: 3d062894478f76394226011851eb17ce (MD5)
Publico-238l.pdf: 1672723 bytes, checksum: 9c5dc98e92d85e8961a2319fbff140f8 (MD5)
Publico-238m.pdf: 2017451 bytes, checksum: 3b45e2a5cd01698f71d8a28e7f0ecab3 (MD5)
Publico-238n.pdf: 1898959 bytes, checksum: f34a29aa3f4ccfabd792c8b12fe7302d (MD5)
Publico-238o.pdf: 1970130 bytes, checksum: 61c00ccc80c9834cc84b98f0f6c69ae2 (MD5)
Publico-238p.pdf: 2029182 bytes, checksum: 1743db4280c1e2ffee0335943b4ebe74 (MD5)
Publico-238q.pdf: 1838189 bytes, checksum: 2f93c6b081b4b331d847611b23e090d9 (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:24Z : No. of bitstreams: 18
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5)
Publico-238b.pdf: 1881184 bytes, checksum: c5faae7597ff58c993732a87ae3c7d6e (MD5)
Publico-238c.pdf: 1880956 bytes, checksum: 980548869f6e59e382509d177d9f4682 (MD5)
Publico-238d.pdf: 1827317 bytes, checksum: c5cd246c68ed0923d44c1fa8f26bee78 (MD5)
Publico-238e.pdf: 1739275 bytes, checksum: ebe729b79d442d3a5159cd27abb3db4b (MD5)
Publico-238f.pdf: 1583416 bytes, checksum: eaa0b1c14465213725bc36b21805696d (MD5)
Publico-238g.pdf: 1791684 bytes, checksum: 7ce6d5ab23d099ae1873877bcc3a1fc3 (MD5)
Publico-238h.pdf: 1829745 bytes, checksum: 8ac7af48cb909951b3e9d6c0f97a7656 (MD5)
Publico-238i.pdf: 1796288 bytes, checksum: bdac4809cdc6fff1a21e0827aa6f65b5 (MD5)
Publico-238j.pdf: 1668240 bytes, checksum: 3acceb770cc771a91e84a2665c528429 (MD5)
Publico-238k.pdf: 1732376 bytes, checksum: 3d062894478f76394226011851eb17ce (MD5)
Publico-238l.pdf: 1672723 bytes, checksum: 9c5dc98e92d85e8961a2319fbff140f8 (MD5)
Publico-238m.pdf: 2017451 bytes, checksum: 3b45e2a5cd01698f71d8a28e7f0ecab3 (MD5)
Publico-238n.pdf: 1898959 bytes, checksum: f34a29aa3f4ccfabd792c8b12fe7302d (MD5)
Publico-238o.pdf: 1970130 bytes, checksum: 61c00ccc80c9834cc84b98f0f6c69ae2 (MD5)
Publico-238p.pdf: 2029182 bytes, checksum: 1743db4280c1e2ffee0335943b4ebe74 (MD5)
Publico-238q.pdf: 1838189 bytes, checksum: 2f93c6b081b4b331d847611b23e090d9 (MD5)
Publico-238r.pdf: 1969172 bytes, checksum: cadef8ce461926c1f96d90dbf7c75eb8 (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:24Z : No. of bitstreams: 19
Publico-238a.pdf: 2039350 bytes, checksum: 86bdc74274c3689283e5ff87f9e33f79 (MD5)
Publico-238b.pdf: 1881184 bytes, checksum: c5faae7597ff58c993732a87ae3c7d6e (MD5)
Publico-238c.pdf: 1880956 bytes, checksum: 980548869f6e59e382509d177d9f4682 (MD5)
Publico-238d.pdf: 1827317 bytes, checksum: c5cd246c68ed0923d44c1fa8f26bee78 (MD5)
Publico-238e.pdf: 1739275 bytes, checksum: ebe729b79d442d3a5159cd27abb3db4b (MD5)
Publico-238f.pdf: 1583416 bytes, checksum: eaa0b1c14465213725bc36b21805696d (MD5)
Publico-238g.pdf: 1791684 bytes, checksum: 7ce6d5ab23d099ae1873877bcc3a1fc3 (MD5)
Publico-238h.pdf: 1829745 bytes, checksum: 8ac7af48cb909951b3e9d6c0f97a7656 (MD5)
Publico-238i.pdf: 1796288 bytes, checksum: bdac4809cdc6fff1a21e0827aa6f65b5 (MD5)
Publico-238j.pdf: 1668240 bytes, checksum: 3acceb770cc771a91e84a2665c528429 (MD5)
Publico-238k.pdf: 1732376 bytes, checksum: 3d062894478f76394226011851eb17ce (MD5)
Publico-238l.pdf: 1672723 bytes, checksum: 9c5dc98e92d85e8961a2319fbff140f8 (MD5)
Publico-238m.pdf: 2017451 bytes, checksum: 3b45e2a5cd01698f71d8a28e7f0ecab3 (MD5)
Publico-238n.pdf: 1898959 bytes, checksum: f34a29aa3f4ccfabd792c8b12fe7302d (MD5)
Publico-238o.pdf: 1970130 bytes, checksum: 61c00ccc80c9834cc84b98f0f6c69ae2 (MD5)
Publico-238p.pdf: 2029182 bytes, checksum: 1743db4280c1e2ffee0335943b4ebe74 (MD5)
Publico-238q.pdf: 1838189 bytes, checksum: 2f93c6b081b4b331d847611b23e090d9 (MD5)
Publico-238r.pdf: 1969172 bytes, checksum: cadef8ce461926c1f96d90dbf7c75eb8 (MD5)
Publico-238s.pdf: 1240894 bytes, checksum: 934b73572d5b717f099e2a652d713d89 (MD5) / Objetivo: Investigar se variações fenotípicas, incluindo expressão de traços reflexos têm implicações prognósticas na epilepsia mioclônica juvenil (EMJ). Métodos: Setenta e seis pacientes com EMJ participaram de um protocolo neuropsicológico por vídeo-EEG (VNPP) e métodos habituais de ativação. Sessenta e cinco deles foram acompanhados por pelo menos três anos. Os traços reflexos foram definidos como indução de crises e/ou descargas ao EEG pelo fechamento ocular, fotoestimulação intermitente, linguagem, praxia ou cálculo. Os pacientes tiveram avaliação psiquiátrica e responderam ao IDATE (Inventário Diagnóstico de Ansiedade Traço-Estado). O controle de crises foi classificado de acordo com Prasad e cols. (2003). Os pacientes foram divididos em Grupo 1: controle satisfatório de crises e Grupo 2: controle moderado ou pobre de crises. A avaliação por Video-EEG/EEG foi repetida após uma média de 4,4 anos em 21 pacientes. Resultados: Vinte e nove dos 76 (38,2%) pacientes apresentaram efeito provocativo e a inibição foi encontrada em 28/31 (90,3 %). Os métodos habituais de ativação foram mais eficazes em provocar descargas no EEG. As tarefas de programação-ação, especialmente aquelas envolvendo a praxia manual foram mais eficazes como métodos de ativação que as de pensamento. O efeito inibitório foi mais freqüente durante o cálculo mental. Os pacientes com distúrbios de ansiedade tiveram maiores índices de descarga e não tiveram efeito inibitório pelo VNPP. Quarenta de 65 (61,5%) pacientes acompanhados atingiram controle satisfatório de crises, 25 (38,5%) deles tornaram-se livres de crises. Os pacientes do Grupo 2 tiveram duração mais longa da epilepsia; maior prevalência da combinação dos três tipos de crises; descargas no EEG de base; registro de crises e sensibilidade à praxia. Comparados aos pacientes livres de crises, aqueles com crises persistentes apresentaram início mais precoce da epilepsia; maior prevalência de transtornos de personalidade; maiores escores no IDATE-Traço e maior prevalência da sensibilidade à praxia e à linguagem. A repetição do EEG/video-EEG sugeriu uma evolução paralela entre o desaparecimento dos traços reflexos e o controle das crises. Conclusões: Dentre as tarefas neuropsicológicas, a praxia exerceu o efeito provocativo mais marcado. A expressão de traços reflexos e algumas características fenotípicas em pacientes com EMJ apresentam implicações negativas para o prognóstico. / Purpose: To investigate if phenotypic variations including reflex traits expression have prognostic implications in Juvenile Myoclonic Epilepsy (JME). Methods: Seventy-six patients with JME underwent a video-EEG neuropsychological protocol (VNPP) and habitual methods of activation. Sixty-five of them were followed for at least three years. Reflex traits were defined as seizures and/or EEG discharges induction by eye-closure, photic stimulation, language, praxis or calculation. Patients had psychiatric evaluation and answered to STAI (State-Trait Anxiety Inventory). Seizure control was classified according to Prasad et al. (2003). Patients were divided into Group 1: good seizure control and Group 2: moderate or poor seizure control. Video-EEG/EEG evaluation was repeated after a mean of 4.4 yrs. in 21 patients. Results:. Twenty-nine out of the 76 (38.2%) presented provocative effect and inhibition was seen in 28/31 (90.3 %). Habitual methods of activation were more effective in provoking discharges than VNPP. Action-programming tasks, especially those involving manual praxis, were more effective as activation method than thinking. Inhibitory effect was higher in mental calculation. Patients with anxiety disorders had greater discharge indexes and no significant inhibitory effect on VNPP. Forty of 65 (61.5%) patients followed reached good seizure control, 25 (38.5%) of whom became seizure free. Group 2 patients had longer epilepsy duration; higher prevalence of the combination of all three seizure types; discharges in baseline EEG; seizure recording and sensitivity to praxis. Compared to seizure-free patients, those with persistent seizures presented younger age at epilepsy onset; higher prevalence of personality disorders; higher scores in STAI-Trait and higher incidence of sensitivity to praxis and to language tasks. Repetition of EEG/video-EEG suggested a parallel evolution of reflex traits disappearance and seizure control. Conclusions: Praxis exerted the most remarkable provocative effect, in accordance with the hypothesis of a motor circuitry hyperexcitability in JME. This study suggests that reflex traits expression and some other phenotypic features in JME patients have negative implications in prognosis. / TEDE / BV UNIFESP: Teses e dissertações

Links & Downloads
  1. GUARANHA, Mirian Salvadori Bittar. Avaliação da evolução clínica e dos fatores prognósticos em pacientes com epilepsia mioclônica juvenil. 2010. Tese (Doutorado) - Universidade Federal de São Paulo (UNIFESP), São Paulo, 2010.
  2. http://repositorio.unifesp.br/handle/11600/9018
  3. Publico-238a.pdf
  4. Publico-238b.pdf
  5. Publico-238c.pdf
  6. Publico-238d.pdf
  7. Publico-238e.pdf
  8. Publico-238f.pdf
  9. Publico-238g.pdf
  10. Publico-238h.pdf
  11. Publico-238i.pdf
  12. Publico-238j.pdf
  13. Publico-238k.pdf
  14. Publico-238l.pdf
  15. Publico-238m.pdf
  16. Publico-238n.pdf
  17. Publico-238o.pdf
  18. Publico-238p.pdf
  19. Publico-238q.pdf
  20. Publico-238r.pdf
  21. Publico-238s.pdf
Tags
Cognição
Eletroencefalografia
Evolução clínica
Fenótipo
Prognóstico
Additional Fields
Identiferoai:union.ndltd.org:IBICT/oai:repositorio.unifesp.br:11600/9018
Date30 June 2010
CreatorsGuaranha, Mirian Salvadori Bittar [UNIFESP]
ContributorsUniversidade Federal de São Paulo (UNIFESP), Yacubian, Elza Márcia Targas [UNIFESP]
PublisherUniversidade Federal de São Paulo (UNIFESP)
Source SetsIBICT Brazilian ETDs
LanguagePortuguese
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis
Format199 p.
Sourcereponame:Repositório Institucional da UNIFESP, instname:Universidade Federal de São Paulo, instacron:UNIFESP
Rightsinfo:eu-repo/semantics/openAccess

Page generated in 0.0037 seconds