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Previous issue date: 2017-04-27 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Organic changes caused by aging cause clinical manifestations in several
situations common to elderly patients. Among them, the aging process is associated with a
decline in muscle mass and strength. Several factors are involved in this mechanism, among
them low D vitamin. OBJECTIVES: verify the effect of D vitamin supplementation on handgrip
strength and body composition in elderly women. METHODS: A longitudinal, interventional,
uncontrolled study with 54 elderly women at community who do not have severe disabling
diseases and do not take D vitamin supplementation. Serum (25 (OH) D) below 30 ng / mL
were inclusion criteria in the study. The elderly women performed handgrip strength test (FM),
body composition examination by DXA and laboratory tests (parathyroid hormone (PTH), urea
(Ur), creatinine (Cr), serum calcium (Ca++) and interleukin-6)). Participants with serum vitamin
D levels between 20-29.9 ng/mL were supplemented with 2000 IU per day of cholecalciferol
for twelve weeks and those with levels below 20 ng/mL received 10000 IU per day of
cholecalciferol for the same period. All had concomitant taking of calcium carbonate 1 g per
day. At the end, handgrip strength test, biochemical evaluation and body composition were
repeated. For the description of the sample, mean, standard deviation and percentage were used.
For data correlation with normal distribution were used Pearson correlation test, and for
comparison, Student's T test and for data with non-normal distribution, median, Spearman,
Mann-Whitney U and Wilcoxon correlation test. RESULTS: Of the 54 elderly women included
in the study, 52 concluded. The mean age was 72 ? 9 years. The mean value before and after
supplementation were 25 (OH) D 18.9 ? 6.65 and 38.15 (24.4 ? 126.2) (p= 0,000), PTH 87.15
? 40.08 and 67.55 ? 30.04 (p = 0,000), IL-6 3.6 (1.5 ? 15.8) and 2.25 (1.5 ? 45.9) (p = 0.04),
FM 42.17 ? 14.12 and 42.55 ? 12.78 (p = 0,733), MM 38663 ? 5546 and 38159 ? 6186
(p = 0,132), Ca++ 9,56 ? 0,4 and 9,4 ? 0,35 (p = 0,004). The correlation analysis between
variables after the intervention showed an inverse correlation between 25 (OH) D and PTH,
FM and IL-6 and between Ca++ and IL-6. Direct correlations occurred between FM and MM
and between FM and Ca++. CONCLUSION: Vitamin D supplementation increased serum levels
of 25 (OH) D significantly, as well as reduced serum PTH and IL-6 levels, without changes in
handgrip strength and total body lean mass. / Mudan?as org?nicas provocadas pelo envelhecimento originam
manifesta??es cl?nicas em v?rias situa??es habituais aos pacientes idosos. Dentre elas, o
processo de envelhecimento est? associado a um decl?nio na massa e for?a muscular. V?rios
fatores est?o envolvidos nesse mecanismo, dentre eles, destaca-se a defici?ncia da vitamina D.
OBJETIVO: verificar o efeito da suplementa??o de vitamina D na for?a de preens?o palmar e
composi??o corporal em idosas. M?TODOS: Estudo longitudinal, intervencionista, n?o
controlado com 54 idosas da comunidade que n?o possuam doen?as incapacitantes graves e que
n?o utilizem reposi??o de vitamina D. N?veis s?ricos de vitamina D (25(OH)D) inferiores a
30 ng/mL foram crit?rios de inclus?o no estudo. As idosas realizaram teste de for?a de preens?o
manual (FM), exame de composi??o corporal por DXA e exames laboratoriais (paratorm?nio
(PTH), ureia (Ur), creatinina (Cr), c?lcio s?rico (Ca++) e interleucina-6 (IL-6)). As participantes
com n?veis s?ricos de vitamina D entre 20 ? 29,9 ng/mL foram suplementadas com 2000 UI ao
dia de colecalciferol durante dozes semanas e as com n?veis inferiores a 20 ng/mL receberam
10000 UI ao dia de colecalciferol pelo mesmo per?odo. Todas fizeram uso concomitante de
carbonato de c?lcio 1 g ao dia. Ao final do per?odo de reposi??o, foram repetidos os testes de
for?a manual, avalia??o bioqu?mica e composi??o corporal. Para a descri??o da amostra, foram
utilizados m?dia, desvio-padr?o e percentual. Para a correla??o dos dados com distribui??o
normal foi utilizado o teste de correla??o de Pearson, e para compara??o, teste T de Student e
para os dados com distribui??o n?o-normal, utilizou-se o teste de correla??o de Spearman,
Mann-Whitney U e Wilcoxon. RESULTADOS: Das 54 participantes, 52 idosas aderiram ao
estudo, com idade m?dia de 72 ? 9 anos. Os valores m?dios antes e depois da interven??o foram
25(OH)D 18,9 ? 6,65 e 38,15 (24,4 ? 126,2) (p= 0,000), PTH 87,15 ? 40,08 e 67,55 ? 30,04
(p = 0,000), IL-6 3,6 (1,5 ? 15,8) e 2,25 (1,5 ? 45,9) (p = 0,04), FM 42,17 ? 14,12 e
42,55 ? 12,78 (p = 0,733) , Massa Magra (MM) 38663 ? 5546 e 38159 ? 6186 (p = 0,132), Ca++
9,56 ? 0,4 e 9,4 ? 0,35 (p = 0,004). A an?lise de correla??o entre as vari?veis ap?s a interven??o
demonstrou rela??o inversa entre 25(OH)D e PTH, FM e IL -6 e entre Ca++ e IL-6. Correla??es
diretas ocorreram entre FM e MM e entre FM e Ca++ CONCLUS?O: A suplementa??o de
vitamina D aumentou os n?veis s?ricos de 25(OH)D, bem como reduziu os valores de PTH e
IL-6, n?o havendo modifica??es na for?a de preens?o palmar e massa magra corporal total.
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/7600 |
| Date | 27 April 2017 |
| Creators | Silva, Patr?cia Zambone da |
| Contributors | Schneider, Rodolfo Herberto |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Gerontologia Biom?dica, PUCRS, Brasil, Instituto de Geriatria e Gerontologia |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 4438661476953179033, 500, 500, 500, 600, 2296420844541114010, -969369452308786627, 2075167498588264571 |
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