Abbreviations
ALT – alanine aminotransferase
AST – aspartate aminotransferase
BMI – body mass index
CHC – chronic hepatitis C
EBR – early biochemical response
EHR – early histological response
EIA – enzyme immunoassay
EVR – early virological response
HAI – hepatitis activity index
HCV – hepatitis C virus
HCV RNA - hepatitis C virus ribonucleic acid
Helicobacter spp. – Helicobacter species
H. pylory – Helicobacter pylori
IFN – interferon α-2b
PCR – polymerase chain reaction
PEG IFN – peginterferon
RBV – ribavirin
SVR – sustained virological response
SBR – Sustained biochemical response
INTRODUCTION
Chronic hepatitis due to hepatitis C virus (HCV) infection is a worldwide disease representing a serious public health problem. Chronic hepatitis C (CHC) infection affects nearly 170-200 million people worldwide. The prevalence of anti-HCV at this time in the general adult population of Lithuania is nearly 50 thousand (0.9%).
Without effective treatment strategies, hepatitis C - related morbidity and mortality is expected to increase nearly 3-fold by the year 2015. Current hepatitis C therapies are aimed at achieving eradication of HCV infection as a means of delaying progression to end-stage liver disease and preventing the development of hepatocellular carcinoma. The treatment options include interferon (IFN), ribavirin (RBV) and peg interferon’s a-2a and a-2b (PEG IFN). IFN-based regiments for the treatment of CHC have become increasingly effective and are to eradicate virus... [to full text]
| Identifer | oai:union.ndltd.org:LABT_ETD/oai:elaba.lt:LT-eLABa-0001:E.02~2005~D_20050606_220244-71931 |
| Date | 06 June 2005 |
| Creators | Petrenkienė, Vitalija |
| Contributors | Kiudelis, Gediminas, Pangonytė, Dalia, Sederevičius, Antanas, Miciulevičienė, Jolanta, Endzinas, Žilvinas, Laurinavičius, Arvydas, Laiškonis, Alvydas Pranas, Kaunas University of Medicine |
| Publisher | Lithuanian Academic Libraries Network (LABT), Kaunas University of Medicine |
| Source Sets | Lithuanian ETD submission system |
| Language | Lithuanian |
| Detected Language | English |
| Type | Doctoral thesis |
| Format | application/pdf |
| Source | http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20050606_220244-71931 |
| Rights | Unrestricted |
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