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Previous issue date: 2015-08-24 / Studies have shown that cinnamon (Cinnamomum sp), has beneficial effects on cardiometabolic risk factors. In this thesis, we present two articles. The first article, CINNAMON (CINNAMOMUM SP) AND ITS EFFECT ON THE COMPONENTS OF METABOLIC SYNDROME, aimed to provide a narrative review of cinnamon and its effect on the components of the metabolic syndrome (MS). In seven out of nine identified trials, cinnamon efficacy in modulating components of MS was demonstrated, (reduction of waist circumference, decreased systolic and diastolic blood pressure, decreased fasting glucose, reducing triglyceride levels), in other cardiometabolic risk factors [reduction of total cholesterol (TC) and LDL-c levels, postprandial blood glucose, glycated hemoglobin (HbA1C), reduced body mass index (BMI) and Body fat], and also increasing lean body mass. The only component that MS did not change with the use of cinnamon was HDL-c. The second article, original, EFFECT OF CINNAMON (CINNAMOMUM SP) INTAKE ON CARDIOMETABOLIC AND BODY COMPOSITION PARAMETERS IN ELDERLY WITH METABOLIC SYNDROME, discussed the results of a randomized clinical trial, placebo-controlled, double-blind. The aim was to verify the effectiveness of cinnamon (Cinnamomum sp) intake in cardiometabolic parameters and body composition in elderly patients with metabolic syndrome (MS).The sample was selected from elderly community day centers in Southern Brazil. 59 elderly people with MS were randomized, divided into two groups: cinnamon group (CI, n= 32) and control group (CG, n = 27). The CI received 3g/day of cinnamon (Cinnamomum zeylanicum) and the CO received placebo (12 capsules fractionated at breakfast, lunch and dinner) for 12 weeks. The diagnostic criteria for MS was the National Cholesterol Education Program Adult Treatment Panel III - revised. Cardiometabolic parameters (anthropometric, blood pressure and biochemical profile) were observed in two moments (pre-intervention and post-intervention). In the pre-intervention, it was found that the groups were homogenous, except for the fat-free mass that was significantly higher in the CI. In the post-intervention, no differences were observed. In the intragroup comparison, reduced glycated hemoglobin [(HbA1C was observed; pre-intervention = 7.18 ? 0.99; post-intervention = 6.50 ? 1.25; P = 0.023] in the CI. The decrease in waist circumference was observed in both groups; however CI group presented a significantly greater reduction than the CO (CI= -3.20?2.94; CO= -1.57?2.34; P=0.024). Conclusion: Cinnamon intake was effective in lowering both WC and HbA1C in elderly patients with MS. Further studies with larger sample sizes, different doses and cinnamon display modes are suggested (as tea is a beverage usually consumed by the elderly in Southern Brazil) in order to demonstrate the effectiveness of cinnamon in the other components of MS, as well as other cardiometabolic parameters and body composition. / Estudos t?m demonstrado que a canela (Cinnamomum sp), apresenta efeito ben?fico sobre fatores de risco cardiometab?lico. Na presente tese, s?o apresentados dois artigos. O primeiro artigo, CANELA (CINNAMOMUM SP) E SEU EFEITO NOS COMPONENTES DA S?NDROME METAB?LICA, teve por objetivo apresentar uma revis?o narrativa sobre canela e seu efeito nos componentes da s?ndrome metab?lica (SM). Dos nove ensaios cl?nicos identificados, em sete foi demonstrada a efic?cia da canela na modula??o dos componentes da SM (redu??o da circunfer?ncia da cintura, diminui??o da press?o arterial sist?lica e diast?lica; diminui??o da glicemia de jejum; redu??o dos n?veis de triglicer?deo), de outros fatores de risco cardiometab?lico [redu??o dos n?veis de colesterol total (CT) e de LDL-c, da glicemia p?s-prandial, de hemoglobina glicada (HbA1C), redu??o do ?ndice de massa corporal (IMC) e da gordura corporal], e tamb?m o aumento da massa magra. O ?nico componente da SM que n?o sofreu altera??o com a utiliza??o da canela foi o HDL-c. O segundo artigo, original, EFFECT OF CINNAMON (CINNAMOMUM SP) INTAKE ON CARDIOMETABOLIC AND BODY COMPOSITION PARAMETERS IN ELDERLY WITH METABOLIC SYNDROME, abordou os resultados do um ensaio cl?nico randomizado, controlado por placebo, duplo-cego. O objetivo foi verificar a efic?cia da ingest?o de canela (Cinnamomum sp) em par?metros cardiometab?licos e de composi??o corporal em idosos com S?ndrome Metab?lica (SM).A amostra foi selecionada em grupos de conviv?ncia para idosos do Sul do Brasil. Foram randomizados 59 idosos com SM, alocados em dois grupos: grupo canela (GCA, n= 32) e grupo controle (GCO, n= 27). O GCA recebeu 3g/dia de canela (Cinnamomum zeylanicum) e o GCO recebeu placebo (12 c?psulas fracionadas no desjejum, almo?o e jantar), durante 12 semanas. O crit?rio diagn?stico para SM utilizado foi o do National Cholesterol Education Program Adult Treatment Panel III- revisado. Os par?metros cardiometab?licos (antropom?tricos, press?o arterial e perfil bioqu?mico) foram verificados em dois momentos (pr?-interven??o e p?s-interven??o). Na pr?-interven??o, verificou-se que os grupos eram homog?neos, exceto para a massa livre de gordura que era significativamente maior no GCA. Na p?s-interven??o, n?o foram observadas diferen?as. J? na compara??o intragrupo, foi observada redu??o da hemoglobina glicada [(HbA1C); pr?-interven??o= 7.18?0.99; p?s-interven??o= 6.50?1.25; P=0.023] no GCA. A diminui??o da circunfer?ncia da cintura (CC) foi verificada tanto no GCA quanto no GCO; entretanto o GCA apresentou uma redu??o significativamente maior do que GCO (GCA= -3.20?2.94; GCO= -1.57?2.34; P= 0.024). Concluiu-se que a ingest?o de 3g/dia de canela foi eficaz na redu??o da CC e da HbA1C em idosos com SM. Sugere-se a realiza??o de novos estudos, com tamanho amostral maior, diferentes doses e modos de apresenta??o da canela (como em ch? que ? uma bebida consumida habitualmente por idosos da regi?o Sul do Brasil) visando demonstrar a efic?cia da canela nos demais componentes da SM, assim como em outros par?metros cardiometab?licos e de composi??o corporal.
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/6343 |
| Date | 24 August 2015 |
| Creators | Zanardo , Vivian Polachini Skzypek |
| Contributors | Schwanke , Carla Helena Augustin |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Gerontologia Biom?dica, PUCRS, Brasil, Faculdade de Medicina |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 4438661476953179033, 600, 600, 600, -8624664729441623247, -969369452308786627 |
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