Association between the use of protease inhibitors in Highly Active Antiretroviral Therapy (HAART) and incidence of metabolic syndrome in HIV-infected patients: A systematic review and meta-analysis

Description

Introduction: Since its introduction, Highly Active Antiretroviral Treatment (HAART) has been shown to prolong the life expectancy of HIV-infected patients. HIV and HAART, especially protease inhibitors (PIs), have been associated with the occurrence of Metabolic Syndrome (MS). The objective of this systematic review and meta-analysis was to determine whether there is an association between the use of PIs and the incidence of MS in HIV-infected patients. Methods: A comprehensive search (including databases such as MEDLINE/PubMed, CENTRAL, LILACS and EMBASE) was performed. Observational studies published until November 2015 were included. Inclusion criteria for primary studies were: study population comprised HIV-infected patients aged 18 years or older and who were receiving HAART; patients assessed according to their use of PIs; DM as defined by the primary study. Heterogeneity was assessed and a pooled analysis was performed using a random-effects model. Results: 3 articles met the inclusion criteria, describing 586 HIV patients. Use of PIs was associated with the development of MS (RR: 2.11; 95% CI 1.28 to 3.48; 〖Chi〗^2:0.04, I^2: 0%; p-value 0.003). Conclusion: Use of PIs in HIV-infected patients is associated with an increased risk of MS. These findings are of relevance for future public policy because it will increase the interest in screening and prevention of MS in an expanding population. / Tesis

Links & Downloads

1. 1. Echecopar-Sabogal J, D’Angelo-Piaggio L, Chanamé-Baca DM, Ugarte-Gil C. Association between the use of protease inhibitors in highly active antiretroviral therapy and incidence of diabetes mellitus and/or metabolic syndrome in HIV-infected patients: A systematic review and meta-analysis [Internet]. International Journal of STD & AIDS. Universidad Peruana de Ciencias Aplicadas (UPC); 2017. Available from: http://hdl.handle.net/10757/622686
2. http://hdl.handle.net/10757/622686

Tags

VIH

Síndrome metabólico

Inhibidor de la proteasa

HAART

Incidencia

Revisión sistemática

Medicina

Additional Fields

Identifer	oai:union.ndltd.org:PERUUPC/oai:repositorioacademico.upc.edu.pe:10757/622686
Date	01 January 2017
Creators	Echecopar-Sabogal, Jose, D'Angelo-Piaggio, Lorenzo
Contributors	Ugarte Gil, Cesar
Publisher	Universidad Peruana de Ciencias Aplicadas (UPC)
Source Sets	Universidad Peruana de Ciencias Aplicadas (UPC)
Language	Spanish
Detected Language	English
Type	info:eu-repo/semantics/bachelorThesis
Format	application/pdf, application/epub, application/msword
Source	Universidad Peruana de Ciencias Aplicadas (UPC), Repositorio Académico - UPC
Rights	info:eu-repo/semantics/openAccess, http://creativecommons.org/licenses/by-nc-nd/4.0/