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Caracterização dos efeitos da exposição aos componentes do cigarro sobre o controle neural do sistema cardiovascular em ratos normotensos e ratos espontaneamente hipertensos / Characterization of sidestream cigarette smoke effects on neural control of cardiovascular system in normotensive and spontaneously hypertensive rats

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Publico-12851d.pdf: 1909278 bytes, checksum: 7f3b132a4365c4aeab410fd8f4041429 (MD5) / Objetivos: avaliar os efeitos da fumaça lateral de cigarro (FLC) sobre o controle neural do sistema cardiovascular em ratos normotensos e ratos espontaneamente hipertensos (SHR). Método: ratos Wistar, Wistar-Kyoto (WKY) e SHR foram expostos à FLC durante três semanas, cinco dias por semana, 180 minutos por dia numa concentração de monóxido de carbono entre 100 e 300 ppm. Barorreflexo foi estimulado por uma dose vasodepressora de nitroprussiato de sódio (NPNa, 50Og/kg, i.v.) e uma dose pressora de fenilefrina (PE, 8Og/kg , i.v.). Para avaliar os efeitos da inibição da catalase no quarto ventrículo cerebral (4ºV) sobre as respostas cardiovasculares, foi injetado o inibidor de catalase 3-amino-1,2,4-triazole (ATZ, 0,01Og/100OL). Resultados: nos ratos Wistar expostos à FLC, foi observado que a inibição da catalase causou respostas mais intensas quanto a FC basal e ao pico bradicárdico. A inibição da catalase afetou de maneira mais intensa a FC basal e o pico bradicárdico, nos ratos WKY expostos à FLC. Por outro lado, nos animais SHR a exposição à FLC afetou o pico taquicárdico após inibição central de catalase de maneira mais intensa. Conclusão: a exposição à FLC altera os componentes simpáticos do barorreflexo em ratos WKY e SHR, além de causar respostas cardiovasculares mais intensas perante a inibição de catalase no 4ºV em ratos Wistar e WKY. / Objectives: To evaluate the effects of sidestream cigarette smoke (SSCS) on neural control of cardiovascular system in normotensive and spontaneously hypertensive rats (SHR). Method: Wistar, Wistar-Kyoto rats (WKY) and SHR were exposed to SSCS for three weeks, five days per week, 180 minutes per day at a concentration of carbon monoxide between 100 and 300 ppm. Baroreflex was stimulated with a vasodepressor dose of sodium nitroprusside (NPNa, 50ìg/kg, iv) and with a pressor dose of phenylephrine (PE, 8ìg/kg, iv). In order to evaluate the effects of catalase inhibition into the fourth cerebral ventricle (4th V) on cardiovascular responses, we injected the catalase inhibitor 3-amino-1,2,4-triazole (ATZ, ìg/100ìL 0.01). Results: It was observed in Wistar rats exposed to SSCS that catalase inhibition caused more intense responses on basal HR and bradycardic peak. Central catalase inhibition affected in a higher intensity baseline HR and bradycardic peak WKY rats exposed to SSCS. On the other hand, in SHR SSCS exposure affected the tachycardic peak after central inhibition of catalase in a higher intensuty. Conclusion: Exposure to SSCS alters the sympathetic component of the baroreflex in WKY and SHR and caused more severe cardiovascular responses to catalase inhibition into the 4th V in Wistar and WKY rats. / TEDE / BV UNIFESP: Teses e dissertações

Identiferoai:union.ndltd.org:IBICT/oai:repositorio.unifesp.br:11600/9177
Date29 June 2011
CreatorsValenti, Vitor Engrácia [UNIFESP]
ContributorsUniversidade Federal de São Paulo (UNIFESP), Ferreira, Celso [UNIFESP]
PublisherUniversidade Federal de São Paulo (UNIFESP)
Source SetsIBICT Brazilian ETDs
LanguagePortuguese
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis
Format207 p.
Sourcereponame:Repositório Institucional da UNIFESP, instname:Universidade Federal de São Paulo, instacron:UNIFESP
Rightsinfo:eu-repo/semantics/openAccess

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